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JAK / STAT Signalling Pathway Other Products
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ALX-270-425 Revised 10-Apr-08
Indirubin-3’-(2,3-dihydroxypropyl)oximether
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SYNONYMS E804
PRODUCT LINE Signal Transduction
PRODUCT CATEGORY Src Family Kinases / Related Products
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-270-425-M001   1 mg 120.00 USD Add To Cart
Product Specification
FORMULA: C19H17N3O4
MW: 351.4
PURITY: ≥96% (1H-NMR)
FORMULATION: Dark red solid.
SOLUBILITY: Soluble in DMSO (1M).
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C

Product Description
Inhibitor of c-Src (IC50=0.43µM) blocking downstream STAT3 signalling. Induces apoptosis in human cancer cells.
Product Specific Literature References
Indirubin derivatives inhibit Stat3 signaling and induce apoptosis in human cancer cells: S. Nam, et al.; PNAS 102, 5998 (2005) Abstract
Further Categories Containing This Product:
JAK / STAT Signalling Pathway Other Products • Apoptosis Inducers & Inhibitors Other Products
 
 
ALX-270-483 Revised 07-Apr-08
WP1066
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SYNONYMS 3-(6-Bromo-2-pyridinyl)-2-cyano-N-[(1S)-1-phenylethyl]-2-propenamide
PRODUCT LINE Cancer
PRODUCT CATEGORY Antitumor Agents (Apoptosis Inducers)
Ordering Information
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ALX-270-483-M001   1 mg 190.00 USD Add To Cart
Product Specification
FORMULA: C17H14BrN3O
MW: 356.2
CAS NUMBER: 857064-38-1
PURITY: ≥95%
APPEARANCE: Yellow solid.
SOLUBILITY: Soluble in DMSO (>5mg/ml).
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
HANDLING: Protect from light.
IDENTITY: Identity determined by 1H-NMR.

Product Description

Cell permeable STAT3 inhibitor. Activates Bax. Shows potent anticancer effect on malignant glioma cells. Induces apoptosis and inhibits the growth of tumors. Acts as a potent immune adjuvant by upregulating CD80 and CD86 and inducing proliferation of effector T cells.
Product Specific Literature References
A novel small molecule inhibitor of signal transducers and activators of transcription 3 reverses immune tolerance in malignant glioma patients: S.F. Hussain, et al.; Cancer Res. 67, 9630 (2007) Abstract
A novel inhibitor of the STAT3 pathway induces apoptosis in malignant glioma cells both in vitro and in vivo: A. Iwamaru, et al.; Oncogene 26, 2435 (2007) Abstract
Further Categories Containing This Product:
Bax / Related Products • JAK / STAT Signalling Pathway Other Products • T Cell Regulation Other Products • Immunomodulators Other Products
 
 
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