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G-Protein Coupled Receptor Signalling
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ALX-106-023 Revised 13-Dec-02
5-Hydroxy-L-tryptophan
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PRODUCT LINE Neurobiology
PRODUCT CATEGORY Serotonergics & Serotonin Receptors / Related Products
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ALX-106-023-M500   500 mg 20.00 USD Add To Cart
Product Specification
FORMULA: C11H12N2O3
MW: 220.2
CAS NUMBER: 56-69-9
APPEARANCE: White solid.
SOLUBILITY: Soluble in water.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
HANDLING: Protect from light.

Product Description
Serotonin precursor.
Further Categories Containing This Product:
Special Amino Acids • Glutamate Receptors (Metabotropic) / Related Products
 
 
ALX-106-024 Revised 14-Oct-08
O-Phospho-L-serine
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SYNONYMS L-Phosphoserine
L-Serine-O-phosphate
PRODUCT LINE Neurobiology
PRODUCT CATEGORY NMDA Receptors / Related Products
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ALX-106-024-G001   1 g 10.00 USD Add To Cart
Product Specification
FORMULA: C3H8NO6P
MW: 185.1
CAS NUMBER: 407-41-0
PURITY: ≥97% (HPLC)
APPEARANCE: White to off-white solid.
SOLUBILITY: Soluble in water (50mg/ml).
SHIPPING: AMBIENT
LONG TERM STORAGE: +4°C
HANDLING: Store tightly sealed. Use fresh solutions.

Product Description
L-AP4 agonist. Competitive NMDA antagonist. Has affinity for type IV, but not type I, metabotropic glutamate receptor.
Product Specific Literature References
L-phosphoserine, a metabolite elevated in Alzheimer's disease, interacts with specific L-glutamate receptor subtypes: W.E. Klunk, et al.; J. Neurochem. 56, 1997 (1991) Abstract
Serine-O-phosphate has affinity for type IV, but not type I, metabotropic glutamate receptor: C. Thomsen & P.D. Suzdak; Neuroreport 4, 1099 (1993) Abstract
Agonists and antagonists for metabotropic glutamate receptors: P.L. Ornstein, et al.; Curr. Pharm. Design 1, 355 (1995), (Review)
Decreased expression of the metabotropic glutamate receptor-4 gene is associated with neuronal apoptosis: K. Borodezt & S.R. D'Mello; J. Neurosci. Res. 53, 531 (1998) Abstract
Further Categories Containing This Product:
Special Amino Acids • Glutamate Receptors (Metabotropic) / Related Products
 
 
ALX-151-020 Revised 10-Feb-05
N-Acetyl-Asp-Glu-OH
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SYNONYMS α-NAAG
Spaglumic acid
PRODUCT LINE Neurobiology
PRODUCT CATEGORY Glutamate Receptors (Metabotropic) / Related Products
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ALX-151-020-M010   10 mg 35.00 USD Add To Cart
ALX-151-020-M050   50 mg 140.00 USD Add To Cart
Product Specification
FORMULA: C11H16N2O8
MW: 304.3
CAS NUMBER: 3106-85-2
PURITY: ≥98%
SOLUBILITY: Soluble in water.
SHIPPING: AMBIENT
LONG TERM STORAGE: +4°C
Product Description
Endogenous neurotransmitter with high affinity for the brain glutamate receptor. N-acetylated α-linked acidic dipeptidase (NAALADase), a membrane-bound peptidase, hydrolyzes α-NAAG, a major brain peptide, to N-acetylaspartate and glutamate. Discriminates between mGluR2 and mGluR3. mGluR3 activator. NMDA receptor antagonist. Neuroprotective.
Product Specific Literature References
N-acetylaspartylglutamate: an endogenous peptide with high affinity for a brain glutamate receptor: R. Zaczek, et al.; PNAS 80, 1116 (1983) Abstract
Characterization of the interactions of N-acetyl-aspartyl-glutamate with [3H]L-glutamate receptors: K.J. Koller & J.T. Coyle; Eur. J. Pharmacol. 98, 193 (1984) Abstract
The neurobiology of N-acetylaspartylglutamate: R.D. Blakely & J.T. Coyle; Int. Rev. Neurobiol. 30, 39 (1988) Abstract
Design, synthesis, and biological activity of a potent inhibitor of the neuropeptidase N-acetylated alpha-linked acidic dipeptidase: P.F. Jackson, et al.; J. Med. Chem. 39, 619 (1996) Abstract
The nagging question of the function of N-acetylaspartylglutamate: J.T. Coyle; Neurobiol. Dis. 4, 231 (1997) Abstract
N-acetylaspartylglutamate stimulates metabotropic glutamate receptor 3 to regulate expression of the GABA(A) alpha6 subunit in cerebellar granule cells: S. Ghose, et al.; J. Neurochem. 69, 2326 (1997) Abstract
N-acetylaspartylglutamate (NAAG) protects against rat striatal quinolinic acid lesions in vivo: L.R. Orlando, et al.; Neurosci. Lett. 236, 91 (1997) Abstract
N-acetylaspartylglutamate, N-acetylaspartate, and N-acetylated alpha-linked acidic dipeptidase in human brain and their alterations in Huntington and Alzheimer's diseases: L.A. Passani, et al.; Mol. Chem. Neuropathol. 31, 97 (1997) Abstract
Distribution of N-acetylaspartylglutamate immunoreactivity in human brain and its alteration in neurodegenerative disease: L.A. Passani, et al.; Brain Res. 772, 9 (1997) Abstract
N-acetylaspartylglutamate selectively activates mGluR3 receptors in transfected cells: B. Wroblewska, et al.; J. Neurochem. 69, 174 (1997) Abstract
Neuroprotective activity of N-acetylaspartylglutamate in cultured cortical cells: V. Bruno, et al.; Neuroscience 85, 751 (1998) Abstract
N-acetylaspartylglutamate activates cyclic AMP-coupled metabotropic glutamate receptors in cerebellar astrocytes: B. Wroblewska, et al.; Glia 24, 172 (1998) Abstract
A.P. Burlina, et al.; Eur. J. Pediatr. 158, 406 (1999) Abstract
Further Categories Containing This Product:
NMDA Receptors / Related Products • NAALADase / Related Products • Peptides
 
 
ALX-152-001 Revised 26-Sep-08
Big Endothelin-1 (1-38) (human)
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SYNONYMS Big ET-1 (1-38) (human)
PRODUCT LINE Signal Transduction
PRODUCT CATEGORY Endothelins [ETs] & Endothelin Receptors / Related Products
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ALX-152-001-PC01   0.1 mg* 100.00 USD Add To Cart
ALX-152-001-PC05   0.5 mg* 400.00 USD Add To Cart
ALX-152-001-P001   1 mg* 650.00 USD Add To Cart
Product Specification
SEQUENCE: H-Cys-Ser-Cys-Ser-Ser-Leu-Met-Asp-Lys-Glu-Cys-Val-Tyr-Phe-Cys-His-Leu-Asp-Ile-Ile-Trp-Val-Asn-Thr-Pro-Glu-His-Val-Val-Pro-Tyr-Gly-Leu-Gly-Ser-Pro-Arg-Ser-OH
(Disulfide bonds between Cys1-Cys15and Cys3-Cys11)
FORMULA: C189H282N48O56S5
MW: 4283.0
CAS NUMBER: 121014-53-7
QUANTITY: *Sold as net peptide weight.
PURITY: ≥98% (HPLC)
APPEARANCE: White to off-white powder.
SOLUBILITY: 1mg/ml soluble in water; also soluble in 0.5% acetic acid.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
Product Specific Literature References
Cloning and sequence analysis of cDNA encoding the precursor of a human endothelium-derived vasoconstrictor peptide, endothelin: identity of human and porcine endothelin: Y. Itoh, et al.; FEBS Lett. 231, 440 (1988) Abstract
Putative precursors of endothelin have less vasoconstrictor activity in vitro but a potent pressor effect in vivo: T. Kashiwabara, et al.; FEBS Lett. 247, 73 (1989) Abstract
Further Categories Containing This Product:
Peptides
 
 
ALX-152-002 Revised 26-Nov-04
Big Endothelin-1 (1-39) (pig)
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SYNONYMS Big ET-1 (1-39) (pig)
PRODUCT LINE Signal Transduction
PRODUCT CATEGORY Endothelins [ETs] & Endothelin Receptors / Related Products
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ALX-152-002-PC01   0.1 mg* 140.00 USD Add To Cart
ALX-152-002-PC05   0.5 mg* 560.00 USD Add To Cart
Product Specification
SEQUENCE: H-Cys-Ser-Cys-Ser-Ser-Leu-Met-Asp-Lys-Glu-Cys-Val-Tyr-Phe-Cys-His-Leu-Asp-Ile-Ile-Trp-Val-Asn-Thr-Pro-Glu-His-Ile-Val-Pro-Tyr-Gly-Leu-Gly-Ser-Pro-Ser-Arg-Ser-OH
(Disulfide bonds between Cys1-Cys15and Cys3-Cys11)
FORMULA: C193H289N49O58S5
MW: 4384.1
CAS NUMBER: 121014-54-8
QUANTITY: *Sold as net peptide weight.
PURITY: ≥97%
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
Product Specific Literature References
Cloning and sequence analysis of cDNA encoding the precursor of a human endothelium-derived vasoconstrictor peptide, endothelin: identity of human and porcine endothelin: Y. Itoh, et al.; FEBS Lett. 231, 440 (1988) Abstract
A novel potent vasoconstrictor peptide produced by vascular endothelial cells [see comments]: M. Yanagisawa, et al.; Nature 332, 411 (1988) Abstract
Putative precursors of endothelin have less vasoconstrictor activity in vitro but a potent pressor effect in vivo: T. Kashiwabara, et al.; FEBS Lett. 247, 73 (1989) Abstract
Further Categories Containing This Product:
Peptides
 
 
ALX-152-003 Revised 26-Nov-04
Big Endothelin-1 (1-39) (rat)
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SYNONYMS Big ET-1 (1-39) (rat)
PRODUCT LINE Signal Transduction
PRODUCT CATEGORY Endothelins [ETs] & Endothelin Receptors / Related Products
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ALX-152-003-PC01   0.1 mg* 110.00 USD Add To Cart
ALX-152-003-PC05   0.5 mg* 390.00 USD Add To Cart
Product Specification
SEQUENCE: H-Cys-Ser-Cys-Ser-Ser-Leu-Met-Asp-Lys-Glu-Cys-Val-Tyr-Phe-Cys-His-Leu-Asp-Ile-Ile-Trp-Val-Asn-Thr-Pro-Glu-Arg-Val-Val-Pro-Tyr-Gly-Leu-Gly-Ser-Pro-Ser-Arg-Ser-OH
(Disulfide bonds between Cys1-Cys15and Cys3-Cys11)
FORMULA: C192H292N50O58S5
MW: 4389.1
CAS NUMBER: 135842-15-8
QUANTITY: *Sold as net peptide weight.
PURITY: ≥97%
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
Product Specific Literature References
cDNA cloning, sequence analysis and tissue distribution of rat preproendothelin-1 mRNA: T. Sakurai, et al.; BBRC 175, 44 (1991) Abstract
Further Categories Containing This Product:
Peptides
 
 
ALX-152-004 Revised 12-May-03
Big Endothelin-2 (1-37) (human)
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SYNONYMS Big ET-2 (1-37) (human)
PRODUCT LINE Signal Transduction
PRODUCT CATEGORY Endothelins [ETs] & Endothelin Receptors / Related Products
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-152-004-PC01   0.1 mg* 110.00 USD Add To Cart
ALX-152-004-PC05   0.5 mg* 390.00 USD Add To Cart
Product Specification
SEQUENCE: H-Cys-Ser-Cys-Ser-Ser-Trp-Leu-Asp-Lys-Glu-Cys-Val-Tyr-Phe-Cys-His-Leu-Asp-Ile-Ile-Trp-Val-Asn-Thr-Pro-Glu-Gln-Thr-Ala-Pro-Tyr-Gly-Leu-Gly-Asn-Pro-Pro-OH
(Disulfide bonds between Cys1-Cys15and Cys3-Cys11)
FORMULA: C188H269N45O56S4
MW: 4183.8
QUANTITY: *Sold as net peptide weight.
PURITY: ≥98%
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
Product Specific Literature References
Specific expression of human endothelin-2 (ET-2) gene in a renal adenocarcinoma cell line. Molecular cloning of cDNA encoding the precursor of ET-2 and its characterization: S. Ohkubo, et al.; FEBS Lett. 274, 136 (1990) Abstract
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Peptides
 
 
ALX-152-006 Revised 23-Jan-07
Bradykinin
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PRODUCT LINE Neurobiology
PRODUCT CATEGORY Bradykinin Receptor / Related Products
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ALX-152-006-M005   5 mg 22.00 USD Add To Cart
ALX-152-006-M025   25 mg 86.00 USD Add To Cart
Product Specification
SEQUENCE: H-Arg-Pro-Pro-Gly-Phe-Ser-Pro-Phe-Arg-OH
FORMULA: C50H73N15O11
MW: 1060.3
CAS NUMBER: 5979-11-3
MERCK INDEX: 14: 1359
PURITY: ≥98% (HPLC)
APPEARANCE: White to off-white solid.
SOLUBILITY: Soluble in 5% acetic acid.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
HANDLING: Protect from light.
Product Description
Activator of eNOS (NOS III).
Product Specific Literature References
Different activation of L-arginine pathway by bradykinin, serotonin, and clonidine in coronary arteries: V. Richard, et al.; Am. J. Physiol. 259, H1433 (1990) Abstract
Bradykinin and ATP stimulate L-arginine uptake and nitric oxide release in vascular endothelial cells: R.G. Bogle, et al.; BBRC 180, 926 (1991) Abstract
Activation of a small-conductance Ca(2+)-dependent K+ channel contributes to bradykinin-induced stimulation of nitric oxide synthesis in pig aortic endothelial cells: K. Groschner, et al.; Biochim. Biophys. Acta 1137, 162 (1992) Abstract
G proteins in aortic endothelial cells and bradykinin-induced formation of nitric oxide: J. Gil-Longo, et al.; Eur. J. Pharmacol. 247, 119 (1993) Abstract
Simultaneous measurements of Ca2+ and nitric oxide in bradykinin-stimulated vascular endothelial cells: L.A. Blatter, et al.; Circ. Res. 76, 922 (1995) Abstract; Full Text
Biosynthesis of endothelium-derived nitric oxide by bradykinin as endogenous precursor: A.R. Volpe, et al.; Immunopharmacology 33, 287 (1996) Abstract
Nitric oxide as mediator of bradykinin-induced pancreatic circulatory and metabolic responses: W.W. Pawlik, et al.; J. Physiol. Pharmacol. 48, 751 (1997) Abstract
Bradykinin-regulated interactions of the mitogen-activated protein kinase pathway with the endothelial nitric-oxide synthase: S.G. Bernier, et al.; J. Biol. Chem. 275, 30707 (2000) Abstract; Full Text
Reciprocal phosphorylation and regulation of endothelial nitric-oxide synthase in response to bradykinin stimulation: M.B. Harris, et al.; J. Biol. Chem. 276, 16587 (2001) Abstract; Full Text
Bradykinin down-regulates, whereas arginine analogs up-regulates, endothelial nitric-oxide synthase expression in coronary endothelial cells: N.D. Vaziri, et al.; J. Pharmacol. Exp. Ther. 313, 121 (2005) Abstract; Full Text
Bradykinin mediates phosphorylation of eNOS in odontoblasts: Y. Korkmaz, et al.; J. Dent. Res. 85, 536 (2006) Abstract
Further Categories Containing This Product:
Peptides • NOS Regulation • Cell Stress, Oxidative Stress & Redox Signalling Other Products
 
 
ALX-152-007 Revised 14-Dec-04
Big Endothelin-1 (1-39) (bovine)
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SYNONYMS Big ET-1 (1-39) (bovine)
PRODUCT LINE Signal Transduction
PRODUCT CATEGORY Endothelins [ETs] & Endothelin Receptors / Related Products
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-152-007-PC01   0.1 mg* 140.00 USD Add To Cart
ALX-152-007-PC05   0.5 mg* 560.00 USD Add To Cart
Product Specification
SEQUENCE: H-Cys-Ser-Cys-Ser-Ser-Leu-Met-Asp-Lys-Glu-Cys-Val-Tyr-Phe-Cys-His-Leu-Asp-Ile-Ile-Trp-Val-Asn-Thr-Pro-Glu-His-Val-Val-Pro-Tyr-Gly-Leu-Gly-Ser-Pro-Ser-Arg-Ser-OH
(Disulfide bonds between Cys1-Cys15and Cys3-Cys11)
FORMULA: C192H287N49O58S5
MW: 4370.0
QUANTITY: *Sold as net peptide weight.
PURITY: ≥98%
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
Product Specific Literature References
Cloning and sequencing of a bovine preproendothelin cDNA: G.J. Price & L. Malone; Nucl. Acid Res. 18, 3658 (1990) Abstract
Further Categories Containing This Product:
Peptides
 
 
ALX-152-012 Revised 14-Dec-04
Big Endothelin-1 (22-38) (human)
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SYNONYMS Big ET-1 (22-38) (human)
PRODUCT LINE Signal Transduction
PRODUCT CATEGORY Endothelins [ETs] & Endothelin Receptors / Related Products
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-152-012-MC05   0.5 mg 100.00 USD Add To Cart
ALX-152-012-M001   1 mg 180.00 USD Add To Cart
Product Specification
SEQUENCE: H-Val-Asn-Thr-Pro-Glu-His-Val-Val-Pro-Tyr-Gly-Leu-Gly-Ser-Pro-Arg-Ser-OH
FORMULA: C80H125N23O25
MW: 1809.0
PURITY: ≥98%
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
Product Specific Literature References
Cloning and sequence analysis of cDNA encoding the precursor of a human endothelium-derived vasoconstrictor peptide, endothelin: identity of human and porcine endothelin: Y. Itoh, et al.; FEBS Lett. 231, 440 (1988) Abstract
Further Categories Containing This Product:
Peptides
 
 
ALX-152-014 Revised 13-Jan-05
Big Endothelin-1 (19-37) (human), [Phe22]-
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SYNONYMS [Phe22]-Big ET-1 (19-37) (human)
PRODUCT LINE Signal Transduction
PRODUCT CATEGORY Endothelins [ETs] & Endothelin Receptors / Related Products
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Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-152-014-MC05   0.5 mg 120.00 USD Add To Cart
ALX-152-014-M001