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Phosphatases / Related Products
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ALX-165-020 Revised 21-Feb-03
Protein Tyrosine Phosphatase Substrate
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SYNONYMS Tyrosine Phosphatase Substrate
PRODUCT LINE Signal Transduction
PRODUCT CATEGORY Protein Tyrosine Phosphatases Other Products
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Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-165-020-M001   1 mg 140.00 USD Add To Cart
ALX-165-020-M005   5 mg 560.00 USD Add To Cart
Product Specification
SEQUENCE: H-Thr-Glu-Pro-Glu-Tyr(PO3H2)-Gln-Pro-Gly-Glu-NH2
FORMULA: C45H66N11O21P
MW: 1128.1
PURITY: ≥97%
APPEARANCE: White lyophilized powder.
SOLUBILITY: Soluble in water.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
Product Description
Substrate for protein tyrosine phosphatases, suitable for continuous fluorimetric assays, based on the effect of phosphate substitution on the intrinsic fluorescence of the dephosphorylated peptide.
Product Specific Literature References
Synthesis and fluorescence properties of a substrate for a continuous fluorimetric assay of protein tyrosine phosphatases: C. Garcia-Echeverria & D.H. Rich; Bioorg. Med. Chem. Lett. 3, 1601 (1993)
Further Categories Containing This Product:
Peptides
 
 
ALX-350-323 Revised 20-Jun-08
Psoralidin
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PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Natural Products - Antitumor Reagents
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ALX-350-323-M001   1 mg 170.00 USD Add To Cart
Product Specification
FORMULA: C20H16O5
MW: 336.3
CAS NUMBER: 18642-23-4
SOURCE/HOST: Isolated from Psoralea corylifolia.
PURITY: ≥97% (HPLC)
APPEARANCE: Yellow solid.
SOLUBILITY: Soluble in DMSO.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
HANDLING: Protect from light.
HAZARD: TOXIC.
IDENTITY: Identity determined by 1H-NMR, 13C-NMR and MS.

Product Description
Antineoplastic compound. Cytotoxic against stomach cancer cell lines. Shows antibacterial activity against Shigella sonnei and S. flexneri. Shows strong antioxidant activity and inhibits tyrosine phosphatase 1B (PTP1B) activity. Was shown to possess potent antidepressant properties.
Product Specific Literature References
Influence of nitrogen on accumulation of isosojagol (a newly detected coumestan in soybean) and associated isoflavonoids in roots and nodules of mycorrhizal and non-mycorrhizal soybean: D. Morandi and J.L. Le Quere; New Phytol. 117, 75 (1991) Full Text
The cytotoxicity of psoralidin from Psoralea corylifolia: Y.M. Yang, et al.; Planta Med. 62, 353 (1996) Abstract
Coumarins: A. Estevez-Braun and A.G. Gonzalez; Nat. Prod. Rep. 14, 465 (1997) Abstract
Cytotoxic constituents of Psoralea corylifolia: W. Mar, et al.; Arch. Pharm. Res. 24, 211 (2001) Abstract
Antibacterial compounds from the seeds of Psoralea corylifolia: N.A. Khatune, et al.; Fitoterapia 75, 228 (2004) Abstract
Inducible flavone in oats (Avena sativa) is a novel defense against plant-parasitic nematodes: I. R. Soriano, et al.; Nematology 94, 1207 (2004) Full Text
Antioxidants from a Chinese medicinal herb - Psoralea corylifolia L.: G. Jiangning, et al.; Food Chem. 91, 287 (2005)
In vitro protein tyrosine phosphatase 1B inhibitory phenols from the seeds of Psoralea corylifolia: Y.C. Kim, et al.; Planta Med. 71, 87 (2005) Abstract
Antidepressant-like effects of psoralidin isolated from the seeds of Psoralea Corylifolia in the forced swimming test in mice: L.T. Yi, et al.; Prog. Neuropsychopharmacol. Biol. Psychiatry 32, 510 (2008) Abstract
Further Categories Containing This Product:
Monoamine Neurotransmitters & Receptors Other Products • Antitumor Agents (Anti-proliferative) • Natural Products with Antibiotic Activity • Natural Products - Antioxidants • Natural Products - Other Signal Transduction Pathway Modulators • Protein Tyrosine Phosphatases Other Products
 
 
ALX-430-047 Revised 24-Feb-05
Resmethrin
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SYNONYMS 5-Benzyl-3-furylmethyl(1R,S)-cis,trans-chrysanthemate
PRODUCT LINE Signal Transduction
PRODUCT CATEGORY Protein Serine / Threonine Phosphatases Other Products
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Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-430-047-M010   10 mg 25.00 USD Add To Cart
ALX-430-047-M025   25 mg 50.00 USD Add To Cart
ALX-430-047-M100   100 mg 200.00 USD Add To Cart
Product Specification
FORMULA: C22H26O3
MW: 338.4
CAS NUMBER: 10453-86-8
PURITY: ≥90%
APPEARANCE: White solid.
SOLUBILITY: Soluble in DMSO or 100% ethanol; insoluble in water.
SHIPPING: AMBIENT
LONG TERM STORAGE: +4°C
HANDLING: Protect from light.
HAZARD: TOXIC.

Product Description
Type I pyrethroid. Weakly active negative control for studies of calcineurin inhibition by the more active type II pyrethroids.
Product Specific Literature References
Specific inhibition of calcineurin by type II synthetic pyrethroid insecticides: E. Enan & F. Matsumura; Biochem. Pharmacol. 43, 1777 (1992) Abstract
Further Categories Containing This Product:
Pyrethroids
 
 
ALX-380-205 Revised 08-Apr-08
RK-682
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SYNONYMS 3-Hexadecanoyl-5-hydroxymethyl-tetronic acid
TAN 1364B
CI 010
PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Antibiotics - Other Signal Transduction Pathway Modulators
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ALX-380-205-MC05   0.5 mg 240.00 USD Add To Cart
Product Specification
FORMULA: C21H36O5
MW: 368.5
CAS NUMBER: 154639-24-4
SOURCE/HOST: Isolated from Streptomyces sp. MST-AS5358.
PURITY: ≥95% (HPLC as Ca salt)
APPEARANCE: White to off-white solid.
SOLUBILITY: Soluble in 100% ethanol, methanol, dimethyl formamide or DMSO.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C

Product Description

Tetronic acid derivative with potent activity against HIV-1 protease. Inhibits protein tyrosine phosphatase and heparanase.
Product Specific Literature References
3-Alkanoyl-5-hydroxymethyl tetronic acid homologues and resistomycin: new inhibitors of HIV-1 protease. I. Fermentation, isolation and biological activity: B.E. Roggo, et al.; J. Antibiot. (Tokyo) 47, 136 (1994) Abstract
The mechanism of ATP-induced long-term potentiation involves extracellular phosphorylation of membrane proteins in guinea-pig hippocampal CA1 neurons: S. Fujii, et al.; Neurosci. Lett. 187, 130 (1995) Abstract
RK-682, a potent inhibitor of tyrosine phosphatase, arrested the mammalian cell cycle progression at G1phase: T. Hamaguchi, et al.; FEBS Lett. 372, 54 (1995) Abstract; Full Text
Design and synthesis of a dimeric derivative of RK-682 with increased inhibitory activity against VHR, a dual-specificity ERK phosphatase: implications for the molecular mechanism of the inhibition: T. Usui, et al.; Chem. Biol. 8, 1209 (2001) Abstract; Full Text
Further Categories Containing This Product:
Antibiotics - Antiviral / Anti-HIV • Protein Tyrosine Phosphatases Other Products
 
 
ALX-270-428 Revised 25-Feb-08
Salubrinal
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PRODUCT LINE Signal Transduction
PRODUCT CATEGORY Phosphatases Other Products
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ALX-270-428-M001   1 mg 30.00 USD Add To Cart
ALX-270-428-M005   5 mg 110.00 USD Add To Cart
Product Specification
FORMULA: C21H20Cl3N4OS
MW: 479.8
CAS NUMBER: 405060-95-9
PURITY: ≥98%
APPEARANCE: White to off-white powder.
SOLUBILITY: Soluble in DMSO (10mg/ml).
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
USE/STABILITY: Product may darken when exposed to air. Stock solutions are stable for up to 3 months when stored at -20°C.
HANDLING: Protect from light. Keep under inert gas.

Product Description
Cell permeable and selective inhibitor of the phosphatase complexes that dephosphorylate eukaryotic translation initiation factor 2 subunit α (eIF-2α). Protects ER stress-induced apoptosis (EC50~15µM in PC12 cells stimulated with 750ng/ml of tunicamycin (Prod. No. ALX-380-047)).
Product Specific Literature References
A selective inhibitor of eIF2alpha dephosphorylation protects cells from ER stress: M. Boyce, et al.; Science 307, 935 (2005) Abstract
A pharmacoproteomic approach implicates eukaryotic elongation factor 2 kinase in ER stress-induced cell death: M. Boyce, et al.; Cell Death Differ. 15, 589 (2008) Abstract
Related Products
Further Categories Containing This Product:
Endoplasmatic Reticulum Stress • Translation Initiation Factors / Related Products • Apoptosis Inducers & Inhibitors Other Products
 
 
ALX-400-032 Revised 14-May-08
Sodium orthovanadate
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SYNONYMS Decavandate
Sodium vanadate
PRODUCT LINE Signal Transduction
PRODUCT CATEGORY Oxovanadates
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ALX-400-032-G005   5 g 15.00 USD Add To Cart
ALX-400-032-G025   25 g 60.00 USD Add To Cart
Product Specification
FORMULA: Na3VO4
MW: 183.9
CAS NUMBER: 13721-39-6
RTECS: YW1120000
PURITY: ≥90% (on dry basis)
APPEARANCE: White to light blue powder.
SOLUBILITY: Soluble in water.
SHIPPING: AMBIENT
LONG TERM STORAGE: +20°C
HAZARD: MAY BE MUTAGENIC. HARMFUL.
Product Description
Potent inhibitor of alkaline phosphatase and tyrosine phosphates. Regarding decavandate: across the pH range of 1-13, simple aqueous solutions of [VO4]3- ion involve a dozen or more ionic species, both monomeric and oligomeric, whose abundances depend strongly on pH and [VO4]3- concentration. At pH 3.75 a stable complex can be prepared (see below in Fohr et al.) which contains ten vanadium atoms and hence is a decavanadate ion. When diluted to pH 7.2, the decavandate species has a half-life time of about 2 hours. Fohr et al., also provide directions for generating control solutions of mixed vanadate complexes in which decavandate is absent and monomeric orthovanadate is present. Decavandate inhibits inositol 1,4,5-trisphosphate- (IP3) induced calcium release from permeabilized endocrine cells and the binding of [3H]IP3 to its receptor in cerebellar and adrenal cortical membranes.
Product Specific Literature References
3rd Edition of interscience (New York): F.A. Cotton & G. Wilkinson; Adv. Inorg. Chem. 3, 820 (1972)
Inhibition of human alkaline phosphatases by vanadate: L.E. Seargeant and R.A. Stinson; Biochem. J. 181, 247 (1979) Abstract
Inhibition of membrane phosphotyrosyl-protein phosphatase activity by vanadate: G. Swarup, et al.; BBRC 107, 1104 (1982) Abstract
Characterization of the inositol 1,4,5-trisphosphate-induced calcium release from permeabilized endocrine cells and its inhibition by decavanadate and p-hydroxymercuribenzoate: K.J. Fohr, et al.; Biochem. J. 262, 83 (1989) Abstract
Is decavanadate a specific inositol 1,4,5-trisphosphate receptor antagonist? [letter]: J. Strupish, et al.; Biochem J. 277, 294 (1991) Abstract
 
 
ALX-380-041 Revised 08-Aug-08
Tautomycin
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PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Antibiotics - Other Signal Transduction Pathway Modulators
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Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-380-041-C025   25 µg 180.00 USD Add To Cart
ALX-380-041-C050   50 µg 235.00 USD Add To Cart
ALX-380-041-C100   100 µg 440.00 USD Add To Cart
Product Specification
FORMULA: C41H66O13
MW: 767.0
CAS NUMBER: 109946-35-2
RTECS: WX1000000
SOURCE/HOST: Isolated from Streptomyces spiroverticillatus.
PURITY: ≥90% (HPLC)
APPEARANCE: White to off-white powder.
SOLUBILITY: Soluble in 100% ethanol, methanol, ethyl acetate or DMSO.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
HANDLING: Protect from light and moisture.
HAZARD: VERY TOXIC.

Product Description
Cell permeable, potent protein phosphatase inhibitor. Apoptosis inducer. Mixture of two isomers.
Product Specific Literature References
A new antibiotic, tautomycin: X.C. Cheng, et al.; J. Antibiot. (Tokyo) 40, 907 (1987) Abstract
Comparison of the effect of tautomycin and phorbol ester on protein kinase C in a cell-free system: J. Magae, et al.; J. Antibiot. 42, 1290 (1989) Abstract
Tautomycin from the bacterium Streptomyces verticillatus. Another potent and specific inhibitor of protein phosphatases 1 and 2A: C. MacKintosh & S. Klumpp; FEBS Lett. 277, 137 (1990) Abstract
Myosin light chain phosphatase activities and the effects of phosphatase inhibitors in tonic and phasic smooth muscle: M.C. Gong, et al.; J. Biol. Chem. 267, 14662 (1992) Abstract; Full Text
Structurally different members of the okadaic acid class selectively inhibit protein serine/threonine but not tyrosine phosphatase activity: M. Suganuma, et al.; Toxicon 30, 873 (1992) Abstract
Molecular shape analysis and activity of tautomycin, a protein phosphatase inhibitor: Y. Sugiyama, et al.; Bioorg. Med. Chem. Lett. 6, 3 (1996)
The apoptosis-inducing activity of the two protein phosphatase inhibitors, tautomycin and thyrsiferyl 23-acetate, is not due to the inhibition of protein phosphatases PP1 and PP2A: K. Kikuchi, et al.; Int. J. Mol. Med. 4, 395 (1999), Review Abstract
Further Categories Containing This Product:
Protein Serine / Threonine Phosphatases Other Products • Antibiotics - Apoptosis Inducers & Inhibitors
 
 
ALX-850-300 Revised 25-Sep-08
TRAP5 (human) ImmunoCapture Enzyme-Activity Assay Kit
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PRODUCT LINE Signal Transduction
PRODUCT CATEGORY TRAP5 [TRACP]
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ALX-850-300-KI01   1 Kit 852.00 USD Add To Cart
Product Specification
SENSITIVITY: 0.4U/l (range 0.2 to 4U/l)
QUANTITY: 96 wells (~80 tests)
APPLICATION: For the quantitative determination of human TRAP5 in serum and plasma. The kit measures only the TRAP5 proteins exhibiting enzymatic activity. Weakly cross-reacts with dog, monkey and rabbit TRAP5. Does not cross-react with mouse and rat sera.
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: +4°C
General Information
TRAP5b is claimed to be a specific marker of bone resorption [2-4]. Both osteopontin and bone sialoprotein are colocalized with TRAP5 in the resorption lacuna of osteoclasts and dephosphorylation of osteopontin impair its ability to promote adhesion as well as migration of osteoclasts in vitro [5].
MANUFACTURER Manufactured by BioVendor.
General Literature References
[1] Purification and N-terminal sequence of two tartrate-resistant acid phosphatases type-5 from the hairy cell leukemia spleen: J.J. Stepan, et al.; BBRC 165, 1027 (1989) Abstract
[2] Tartrate-resistant acid phosphatase 5b: a novel serum marker of bone resorption: J.M. Halleen, et al.; J. Bone Miner. Res 15, 1337 (2000) Abstract
[3] Tartrate-resistant acid phosphatase isoform 5b as serum marker for osteoclastic activity: A.J. Janckila, et al.; Clin. Chem. 47, 74 (2001) Abstract
[4] Clinical performance of immunoreactive tartrate-resistant acid phosphatase isoform 5b as a marker of bone resorption: R.A. Hannon, et al.; Bone 34, 187 (2001) Abstract
[5] TRACP as an osteopontin phosphatase: G. Andersson, et al.; J. Bone Miner. Res 18, 1912 (2003) Abstract
Further Categories Containing This Product:
ELISA & EIA Kits
 
 
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