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Adenylyl Cyclase Inhibitors
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ALX-480-048 Revised 06-Mar-07
2',3'-Dideoxyadenosine
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PRODUCT LINE Signal Transduction
PRODUCT CATEGORY Adenosine Derivatives Other Products
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ALX-480-048-M001   1 mg 15.00 USD Add To Cart
ALX-480-048-M005   5 mg 30.00 USD Add To Cart
Product Specification
FORMULA: C10H13N5O2
MW: 235.2
CAS NUMBER: 4097-22-7
MERCK INDEX: 14: 3101
PURITY: ≥97%
APPEARANCE: White to off-white solid.
SOLUBILITY: Soluble in water or DMSO.
SHIPPING: AMBIENT
LONG TERM STORAGE: +4°C

Product Description
Inhibitor of adenylate cyclase. Useful tool in antiviral and anticancer studies. Blocks viral reverse transcription from RNA to DNA. Inhibitor of adenosine deaminase.
Product Specific Literature References
Interpretation of the roles of adenylosuccinate lyase and of AMP deaminase in the anti-HIV activity of 2',3'-dideoxyadenosine and 2',3'- dideoxyinosine: V. Nair & T.B. Sells; Biochim. Biophys. Acta 1119, 201 (1992) Abstract
Long-term inhibn. of human T-lymphotropic virus type III/lymphadenopathy-associated virus DNA synthesis and RNA expression in T cells protected by 2',3'-dideoxynucleosides in vitro: H. Mitsuya, et al.; PNAS 84, 2033 (1987) Abstract
Further Categories Containing This Product:
Adenylyl Cyclase Inhibitors • Antiviral Agents Other Products
 
 
ALX-480-049 Revised 03-Jun-08
2',5'-Dideoxyadenosine
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PRODUCT LINE Signal Transduction
PRODUCT CATEGORY Adenosine Derivatives Other Products
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ALX-480-049-M001   1 mg 30.00 USD Add To Cart
ALX-480-049-M005   5 mg 90.00 USD Add To Cart
Product Specification
FORMULA: C10H13N5O2
MW: 235.2
CAS NUMBER: 6698-26-6
PURITY: ≥98% (TLC)
APPEARANCE: White to off-white solid.
SOLUBILITY: Soluble in water (20mg/ml at 50°C) or DMSO (30mg/ml).
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
USE/STABILITY: Solutions are stable for up to 3 months when stored at -20°C.

Product Description
Cell permeable inhibitor of adenylate cyclase (ID50=250µM [1]; inhibition also reported at 1mM [2]). Inhibits growth and causes cell differentiation (1.5µM) in K562 cells [6].
Product Specific Literature References
[1] Role of adenylate cyclase in immunologic release of mediators from rat mast cells: agonist and antagonist effects of purine- and ribose- modified adenosine analogs: S.T. Holgate, et al.; PNAS 77, 6800 (1980) Abstract
[2] Inhibition of adenylate cyclase attenuates adenosine receptor-mediated relaxation in coronary artery: M.H. Sabouni, et al.; J. Pharmacol. Exp. Ther. 259, 508 (1991) Abstract
[3] Direct inhibitory effect of neurotensin on isolated gastric smooth muscle cells of guinea pig via the cyclic GMP system: Y. Chijiiwa, et al.; Digestion 54, 135 (1993) Abstract
[4] Isoproterenol antagonistic effect of 2',5'-dideoxyadenosine in the isolated perfused guinea-pig heart: M. Hartmann & J. Schrader; J. Mol. Cell. Cardiol. 25, 331 (1993) Abstract
[5] Erythroid differentiation and growth inhibition of K562 cells by 2',5'-dideoxyadenosine: synergism with interferon-alpha: K. Ogawa, et al.; Leuk. Res. 19, 749 (1995) Abstract
Further Categories Containing This Product:
Adenylyl Cyclase Inhibitors • Antiviral Agents Other Products
 
 
ALX-300-147 Revised 11-Jul-08
Dihomo-γ-linolenylethanolamide
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SYNONYMS N-(2-Hydroxyethyl)-8Z,11Z,14Z-eicosatrienamide
HEA
PRODUCT LINE Neurobiology
PRODUCT CATEGORY Endocannabinoids
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ALX-300-147-M005   5 mg 63.00 USD Add To Cart
Product Specification
FORMULA: C22H39NO2
MW: 349.6
CAS NUMBER: 150314-34-4
PURITY: ≥98%
FORMULATION: Liquid. Solution in ethanol.
SOLUBILITY: Soluble in  DMSO (30mg/ml) or dimethyl formamide (10mg/ml); 8mg/ml soluble in a 1:2 solution of ethanol:PBS (pH 7.2) (dilute the ethanol solution with PBS).
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: -20°C
USE/STABILITY: Stable for at least 1 year after receipt when stored at -20°C. We do not recommend storing aqueous solutions for more than one day.
HANDLING: Protect from light.

Product Description
Endocannabinoid. Binds to recombinant human CB1 (Ki=857nM) and CB2 receptor (Ki=598nM). Also inhibits adenylyl cyclase (IC50=109nM).
Product Specific Literature References
Two new unsaturated fatty acid ethanolamides in brain that bind to the cannabinoid receptor: L. Hanus, et al.; J. Med. Chem. 36, 3032 (1993) Abstract
Anandamide, an endogenous cannabimimetic eicosanoid, binds to the cloned human cannabinoid receptor and stimulates receptor-mediated signal transduction: C.C. Felder, et al.; PNAS 90, 7656 (1993) Abstract
Cannabinomimetic behavioral effects of and adenylate cyclase inhibition by two new endogenous anandamides: J. Barg, et al.; Eur. J. Pharmacol. 287, 145 (1995) Abstract
Comparison of the pharmacology and signal transduction of the human cannabinoid CB1 and CB2 receptors: C.C. Felder, et al.; Mol. Pharmacol. 48, 443 (1995) Abstract
Astrocytes in culture produce anandamide and other acylethanolamides: L. Walter, et al.; Biol. Chem. 277, 20869 (2002) Abstract
General Information
BACKGROUND/TECHNICAL INFORMATION To change the solvent, evaporate the ethanol under a gentle stream of nitrogen and immediately add the solvent of choice.
Further Categories Containing This Product:
Adenylyl Cyclase Inhibitors
 
 
ALX-300-148 Revised 11-Jul-08
Docosatetraenylethanolamide
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SYNONYMS N-(2-Hydroxyethyl)-7Z,10Z,13Z,16Z-docosatetraenamide
DEA
PRODUCT LINE Neurobiology
PRODUCT CATEGORY Endocannabinoids
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ALX-300-148-M005   5 mg 63.00 USD Add To Cart
Product Specification
FORMULA: C24H41NO2
MW: 375.6
CAS NUMBER: 150314-35-5
PURITY: ≥98%
FORMULATION: Liquid. Solution in ethanol.
SOLUBILITY: 10mg/ml soluble in DMSO or dimethyl formamide; 8mg/ml soluble in 1:2 solution of ethanol:PBS (pH 7.2) (dilute the ethanol solution with PBS).
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: -20°C
USE/STABILITY: Stable for at least 1 year after receipt when stored at -20°C. We do not recommend storing aqueous solutions for more than one day.
HANDLING: Protect from light.

Product Description
Endocannabinoid. Also inhibits adenylate cyclase (IC50=117nM). Does also bind to TRPV1 (Ki=5.63µM).
Product Specific Literature References
Two new unsaturated fatty acid ethanolamides in brain that bind to the cannabinoid receptor: L. Hanus, et al.; J. Med. Chem. 36, 3032 (1993) Abstract
Anandamide, an endogenous cannabimimetic eicosanoid, binds to the cloned human cannabinoid receptor and stimulates receptor-mediated signal transduction: C.C. Felder, et al.; PNAS 90, 7656 (1993) Abstract
Cannabinomimetic behavioral effects of and adenylate cyclase inhibition by two new endogenous anandamides: J. Barg, et al.; Eur. J. Pharmacol. 287, 145 (1995) Abstract
Structure-activity relationship for the endogenous cannabinoid, anandamide, and certain of its analogues at vanilloid receptors in transfected cells and vas deferens: R.A. Ross, et al.; Br. J. Pharmacol. 132, 631 (2001) Abstract
Astrocytes in culture produce anandamide and other acylethanolamides: L. Walter, et al.; J. Biol. Chem. 277, 20869 (2002) Abstract
General Information
BACKGROUND/TECHNICAL INFORMATION To change the solvent, evaporate the ethanol under a gentle stream of nitrogen and immediately add the solvent of choice.
Further Categories Containing This Product:
Adenylyl Cyclase Inhibitors • TRPV1 Agonists and Antagonists / Related Products • Fatty Acids
 
 
ALX-270-080 Revised 17-Apr-08
MDL-12,330A . hydrochloride
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SYNONYMS cis-N-(2-Phenylcyclopentyl)azacyclotridec-1-en-2-amine . HCl
PRODUCT LINE Signal Transduction
PRODUCT CATEGORY Adenylyl Cyclase Inhibitors
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ALX-270-080-M001   1 mg 28.00 USD Add To Cart
ALX-270-080-M005   5 mg 75.00 USD Add To Cart
Product Specification
FORMULA: C23H36N2 . HCl
MW: 340.6 . 36.5
CAS NUMBER: 40297-09-4
PURITY: ≥98% (HPLC)
APPEARANCE: White to off-white solid.
SOLUBILITY: Soluble in water (2.75mg/ml), 100% ethanol (>10mg/ml), DMSO (7mg/ml) or hot 0.1N HCl (0.5 mg/ml); insoluble in 0.1N NaOH. .
SHIPPING: AMBIENT
LONG TERM STORAGE: +4°C

Product Description
Cell permeable irreversible inhibitor of adenylate cyclase (IC50= 250µM).
Product Specific Literature References
Actions of vasopressin and isoprenaline on the ionic transport across the isolated frog skin in the presence and the absence of adenyl cyclase inhibitors MDL12330A and SQ22536: C. Lippe & C. Ardizzone; Comp. Biochem. Physiol. 99, 209 (1991) Abstract
Tonic adenosine A2A receptor activation modulates nicotinic autoreceptor function at the rat neuromuscular junction: P. Correia-de-Sa & J.A. Ribeiro; Eur. J. Pharmacol. 271, 349 (1994) Abstract
 
 
ALX-165-026 Revised 15-Aug-08
PACAP (6-38) (human, sheep, rat)
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PRODUCT LINE Signal Transduction
PRODUCT CATEGORY Adenylyl Cyclase Inhibitors
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ALX-165-026-MC05   0.5 mg 210.00 USD Add To Cart
ALX-165-026-M001   1 mg 390.00 USD Add To Cart
Product Specification
SEQUENCE: H-Phe-Thr-Asp-Ser-Tyr-Ser-Arg-Tyr-Arg-Lys-Gln-Met-Ala-Val-Lys-Lys-Tyr-Leu-Ala-Ala-Val-Leu-Gly-Lys-Arg-Tyr-Lys-Gln-Arg-Val-Lys-Asn-Lys-NH2
FORMULA: C182H300N56O45S
MW: 4024.8
PURITY: ≥98% (HPLC)
APPEARANCE: White to off-white powder.
SOLUBILITY: Soluble in water (1mg/ml).
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
Product Description
Potent and selective inhibitor of PACAP (1-27) (human, sheep, rat) (Prod. No. ALX-165-003) stimulated pituitary adenylate cyclase.
Product Specific Literature References
Structural requirements for the occupancy of pituitary adenylate- cyclase-activating-peptide (PACAP) receptors and adenylate cyclase activation in human neuroblastoma NB-OK-1 cell membranes. Discovery of PACAP(6-38) as a potent antagonist: P. Robberecht, et al.; Eur. J. Biochem. 207, 239 (1992) Abstract
Receptor occupancy and adenylate cyclase activation in AR 4-2J rat pancreatic acinar cell membranes by analogs of pituitary adenylate cyclase-activating peptides amino-terminally shortened or modified at position 1, 2, 3, 20, or 21: P. Robberecht, et al.; Mol. Pharmacol. 42, 347 (1992) Abstract
Further Categories Containing This Product:
Peptides
 
 
ALX-480-060 Revised 05-Aug-08
SQ 22,536
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SYNONYMS 9-(Tetrahydro-2-furanyl)-9H-purin-6-amine
PRODUCT LINE Signal Transduction
PRODUCT CATEGORY Adenylyl Cyclase Inhibitors
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ALX-480-060-M001   1 mg 30.00 USD Add To Cart
ALX-480-060-M005   5 mg 86.00 USD Add To Cart
Product Specification
FORMULA: C9H11N5O
MW: 205.2
CAS NUMBER: 17318-31-9
PURITY: ≥98% (TLC)
APPEARANCE: White to off-white solid.
SOLUBILITY: Soluble in water (25mg/ml) or DMSO.
SHIPPING: AMBIENT
LONG TERM STORAGE: +4°C
USE/STABILITY: Stock solutions are stable for up to 3 months at -20°C.

Product Description
Cell permeable adenylate cyclase inhibitor. Blocks PTH-stimulation of adenylate cyclase. Reduces PGE2-induced inhibition of O2- production. Useful as a probe for adenylate cyclase in a variety of receptor systems including prostaglandins and neurotransmitters.
Product Specific Literature References
Inhibition of adenylate cyclase of catfish and rat hepatocyte membranes by 9-(tetrahydro-2-furyl)adenine (SQ 22536): E. Fabbri, et al.; J. Enzym. Inhib. 5, 87 (1991) Abstract
Reversal of synaptic depression by serotonin at Aplysia sensory neuron synapses involves activation of adenylyl cyclase: B.A. Goldsmith & T.W. Abrams; PNAS 88, 9021 (1991) Abstract
Actions of vasopressin and isoprenaline on the ionic transport across the isolated frog skin in the presence and the absence of adenyl cyclase inhibitors MDL12330A and SQ22536: C Lippe & C. Ardizzone; Comp. Biochem. Physiol. 99, 209 (1991) Abstract
cAMP modulates multiple K+ currents, increasing spike duration and excitability in Aplysia sensory neurons: B.A. Goldsmith & T.W. Abrams; PNAS 89, 11481 (1992) Abstract
Roles of intracellular cAMP and protein kinase A in the actions of dopamine and neurotensin on midbrain dopamine neurons: W.X. Shi & B.S. Bunney; J. Neurosci. 12, 2433 (1992) Abstract
Relaxation and inhibition of contractile response to electrical field stimulation by Beraprost sodium in canine airway smooth muscle: J. Tamaoki, et al.; Proaglandins 45, 363 (1993) Abstract
Characterization of the PGE receptor subtype mediating inhibition of superoxide production in human neutrophils: E. Talpain, et al.; Br. J. Pharmacol. 114, 1459 (1995) Abstract
 
 
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