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Items 9 of 9
ALX-804-831
Revised 22-Sep-05
Monoclonal Antibody to SARM (human) (Sarmy-1)
SYNONYMS
anti-TIR-1 (human) MAb (Sarmy-1)
anti-Sterile α and TIR Motif-containing Protein 1 (human) MAb (Sarmy-1)
anti-SAM and ARM-containing Protein (human) MAb (Sarmy-1)
anti-Sterile α Motif and Armadillo Repeat-containing Protein (human) MAb (Sarmy-1)
PRODUCT LINE
Inflammation
PRODUCT CATEGORY
Toll-IL-1 Receptor Adaptors / Related Products
Ordering Information
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ALX-804-831-C100
100 µg
320.00 USD
Product Specification
SPECIES CROSSREACTIVITY:
Human
CLONE:
Sarmy-1
ISOTYPE:
Mouse IgG2b
SOURCE/HOST:
Purified from concentrated hybridoma tissue culture supernatant.
CONCENTRATION:
1mg/ml
PURITY:
≥95% (SDS-PAGE)
FORMULATION:
Liquid. In PBS containing 10% glycerol and 0.02% sodium azide.
IMMUNOGEN:
Recombinant human SARM (aa 93-292).
SPECIFICITY:
Recognizes human SARM.
APPLICATION:
Immunoprecipitation (1:200)
Note:
Does not work for Western Blot.
SHIPPING:
SHIPPED ON BLUE ICE
SHORT TERM STORAGE:
+4°C
LONG TERM STORAGE:
-20°C
USE/STABILITY:
Stable for at least 1 year after receipt when stored at -20°C.
HANDLING:
Avoid freeze/thaw cycles.
General Information
In mammals, TIR domain adapters, including Myd88, TIRAP, TICAM-1 (also called TRIF), and TRAM, act in Toll-like receptor (TLR) signaling pathway. The last member of this family called SARM (sterile and armadillo motifs) is highly conserved but has no known function in any organism. SARM is the only mammalian TIR-domain adapter proteins conserved in C. elegans, suggesting that SARM is the most ancient member of this class of signaling proteins. Overexpression of SARM fails to activate either NF-kB- or IRF-3-dependent reporter gene expression, two transcription factors that are sensitive to TLR signaling, suggesting that SARM is functionally distinct from other mammalian TIR domain-containing proteins.
MANUFACTURER
Manufactured by Apotech Corporation.
General Literature References
Requirement for a conserved Toll/interleukin-1 resistance domain protein in the Caenorhabditis elegans immune response:
N.T. Liberati, et al.; PNAS
101
, 6593 (2004)
Abstract
TLR-independent control of innate immunity in Caenorhabditis elegans by the TIR domain adaptor protein TIR-1, an ortholog of human SARM:
C. Couillault, et al.; Nat. Immunol.
5
, 488 (2004)
Abstract
Further Categories Containing This Product:
Monoclonal Antibodies
ALX-804-829
Revised 31-Oct-06
Monoclonal Antibody to TIRAP (human) (Sebi-1)
SYNONYMS
anti-Toll-interleukin 1 Receptor Domain-containing Adapter Protein (human) MAb (Sebi-1)
anti-Mal (human) MAb (Sebi-1)
anti-MyD88 Adapter-like Protein (human) MAb (Sebi-1)
PRODUCT LINE
Inflammation
PRODUCT CATEGORY
Toll-IL-1 Receptor Adaptors / Related Products
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
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ALX-804-829-C100
100 µg
320.00 USD
Product Specification
SPECIES CROSSREACTIVITY:
Human
CLONE:
Sebi-1
ISOTYPE:
Rat IgG2a
SOURCE/HOST:
Purified from concentrated hybridoma tissue culture supernatant.
CONCENTRATION:
1mg/ml
PURITY:
≥95% (SDS-PAGE)
FORMULATION:
Liquid. Purified antibody in PBS containing 0.02% sodium azide.
IMMUNOGEN:
Recombinant human TIRAP (Mal) (aa 1-215).
SPECIFICITY:
Recognizes human TIRAP (Mal).
APPLICATION:
Immunoprecipitation (1:200)
Western Blot (1:500)
SHIPPING:
SHIPPED ON BLUE ICE
SHORT TERM STORAGE:
+4°C
LONG TERM STORAGE:
-20°C
USE/STABILITY:
Stable for at least 1 year after receipt when stored at -20°C.
HANDLING:
Avoid freeze/thaw cycles.
General Information
Toll-like receptors (TLRs) play an essential role in the detection and elimination of invading pathogens. Recognition of microbial components by TLRs triggers activation of the innate immune system. Upon stimulation, these receptors interact with specific TIR domain-containing adaptor proteins. Five such adaptors have been discovered to date, MyD88, Trif (TIR-domain-containing adaptor inducing interferon-β), TIRAP (TIR domain-containing adaptor protein)/Mal (MyD88 adaptor-like), TRAM (Trif-related adaptor molecule) and SARM (SAM and ARM-containing protein). MyD88 is common to all TLR-mediated pathways, which lead to the production of inflammatory cytokines, whereas TRIF mediates induction of IFN-β in TLR3 and TLR4 signalling pathways. TIRAP/Mal is implicated in the TLR2- and TLR4-mediated MyD88-dependent signalling pathway. TRAM is specifically involved in the TLR4-mediated TRIF-dependent pathway. Thus, TIR domain-containing adaptors provide specificity of TLR signalling.
General Literature References
TIRAP: an adapter molecule in the Toll signaling pathway:
T. Horng, et al.; Nat. Immunol.
2
, 835 (2001)
Abstract
;
Full Text
Inferences, questions and possibilities in Toll-like receptor signalling:
B. Beutler; Nature
430
, 257 (2004)
Abstract
Further Categories Containing This Product:
Monoclonal Antibodies
ALX-804-132
Revised 21-Aug-08
Monoclonal Antibody to Tollip (Kimmy-1)
PRODUCT LINE
Inflammation
PRODUCT CATEGORY
Toll-IL-1 Receptor Adaptors / Related Products
Ordering Information
Product Numbers:
Format:
Size:
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ALX-804-132-C100
100 µg
360.00 USD
Product Specification
SPECIES CROSSREACTIVITY:
Human
Mouse
CLONE:
Kimmy-1
ISOTYPE:
Rat IgG2a
CONCENTRATION:
1mg/ml
PURITY:
≥95% (SDS-PAGE).
FORMULATION:
Liquid. In PBS containing 0.02% sodium azide.
IMMUNOGEN:
Recombinant mouse Tollip.
SPECIFICITY:
Recognizes human and mouse Tollip.
APPLICATION:
Immunoprecipitation
Western Blot (5µg/ml)
SHIPPING:
SHIPPED ON BLUE ICE
LONG TERM STORAGE:
+4°C
USE/STABILITY:
Stable for at least 6 months after receipt when stored at +4°C undiluted.
HANDLING:
Do not freeze/thaw.
Product Images
Please click on thumbnails to enlarge.
Product Specific Literature References
Tollip, a new component of the IL-1RI pathway, links IRAK to the IL-1 receptor
:
K. Burns, et al.; Nat. Cell Biol.
2
, 346 (2000)
Abstract
Threonine 66 in the death domain of IRAK-1 is critical for interaction with signaling molecules but is not a target site for autophosphorylation:
D. Neumann, et al.; J. Leukoc. Biol.
84
, 807 (2008)
Abstract
General Information
MANUFACTURER
Manufactured by Apotech Corporation.
Further Categories Containing This Product:
Monoclonal Antibodies
ALX-804-154
Revised 16-Jun-08
Monoclonal Antibody to Tollip (Kimmy-2)
PRODUCT LINE
Inflammation
PRODUCT CATEGORY
Toll-IL-1 Receptor Adaptors / Related Products
Ordering Information
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Format:
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ALX-804-154-C100
100 µg
360.00 USD
ALX-804-154B-C100
Biotin
100 µg
390.00 USD
Product Specification
SPECIES CROSSREACTIVITY:
Mouse
CLONE:
Kimmy-2
ISOTYPE:
Mouse IgG1
SOURCE/HOST:
Purified from concentrated hybridoma tissue supernatant.
CONCENTRATION:
1mg/ml
PURITY:
95% (SDS-PAGE)
FORMULATION:
Liquid. In PBS containing 0.02% sodium azide.
IMMUNOGEN:
Recombinant mouse Tollip (aa 1-274).
SPECIFICITY:
Recognizes mouse and human (weak) Tollip.
APPLICATION:
Immunocytochemistry (1:100)
Immunoprecipitation
Western Blot (1µg/ml)
SHIPPING:
SHIPPED ON BLUE ICE
SHORT TERM STORAGE:
+4°C
USE/STABILITY:
Stable for at least 1 year after receipt when stored at -20°C.
HANDLING:
For long term storage keep unconjugated antibody at -20°C. Avoid freeze/thaw cycles. Keep conjugated formats at +4°C. Do not freeze. Protect from light.
Product Images
Please click on thumbnails to enlarge.
General Information
MANUFACTURER
Manufactured by Apotech Corporation.
Further Categories Containing This Product:
Monoclonal Antibodies
ALX-210-900
Revised 25-Jan-08
Polyclonal Antibody to MyD88
SYNONYMS
anti-Myeloid Differentiation Primary Response Protein PAb
PRODUCT LINE
Inflammation
PRODUCT CATEGORY
Toll-IL-1 Receptor Adaptors / Related Products
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ALX-210-900-R100
100 µl
360.00 USD
Product Specification
SPECIES CROSSREACTIVITY:
Human
Mouse
SOURCE/HOST:
From rabbit.
FORMULATION:
Liquid. Neat serum.
IMMUNOGEN:
Recombinant human MyD88 (myeloid differentiation primary response protein) (aa 1-172).
SPECIFICITY:
Recognizes the death domain of human and mouse MyD88.
APPLICATION:
Western Blot (1:5'000-1:8'000)
SHIPPING:
SHIPPED ON BLUE ICE
LONG TERM STORAGE:
+4°C
USE/STABILITY:
Stable for at least 6 months after receipt when stored at +4°C undiluted.
HANDLING:
Do not freeze/thaw.
Product Images
Please click on thumbnails to enlarge.
Product Specific Literature References
Tollip, a new component of the IL-1RI pathway, links IRAK to the IL-1 receptor
:
K. Burns, et al.; Nat. Cell Biol.
2
, 346 (2000)
Abstract
Roles of toll-like receptors in C-C chemokine production by renal tubular epithelial cells
:
N. Tsuboi, et al.; J. Immunol.
169
, 2026 (2002)
Abstract
General Information
MANUFACTURER
Manufactured by Apotech Corporation.
General Literature References
IRAK (Pelle) family member IRAK-2 and MyD88 as proximal mediators of IL- 1 signaling :
M. Muzio, et al.; Science
278
, 1612 (1997)
Abstract
Targeted disruption of the MyD88 gene results in loss of IL-1- and IL- 18-mediated function :
O. Adachi, et al.; Immunity
9
, 143 (1998)
Abstract
MyD88, an adapter protein involved in interleukin-1 signaling :
K. Burns, et al.; J. Biol. Chem.
273
, 12203 (1998)
Abstract
;
Full Text
MyD88 is an adaptor protein in the hToll/IL-1 receptor family signaling pathways:
R. Medzhitov, et al.; Mol. Cell
2
, 253 (1998)
Abstract
Unresponsiveness of MyD88-deficient mice to endotoxin:
T. Kawai, et al.; Immunity
11
, 115 (1999)
Abstract
The apoptotic signaling pathway activated by toll-like receptor-2
:
A.O. Aliprantis, et al.; EMBO J.
19
, 3325 (2000)
Abstract
;
Full Text
Further Categories Containing This Product:
Polyclonal Antibodies
ALX-210-366
Revised 23-Sep-05
Polyclonal Antibody to TIRAP (Pearl-1)
SYNONYMS
anti-Toll-interleukin 1 Receptor Domain-containing Adapter Protein PAb (Pearl-1)
anti-Mal PAb (Pearl-1)
anti-MyD88 Adapter-like Protein PAb (Pearl-1)
PRODUCT LINE
Inflammation
PRODUCT CATEGORY
Toll-IL-1 Receptor Adaptors / Related Products
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
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ALX-210-366-R100
100 µl
290.00 USD
Product Specification
SPECIES CROSSREACTIVITY:
Human
Mouse
SOURCE/HOST:
From rabbit.
FORMULATION:
Liquid. Neat serum containing 0.02% sodium azide.
IMMUNOGEN:
Recombinant human TIRAP (Mal).
SPECIFICITY:
Recognizes human and mouse TIRAP (Mal). Does not cross-react with MyD88.
APPLICATION:
Western Blot (1:500)
SHIPPING:
SHIPPED ON BLUE ICE
SHORT TERM STORAGE:
+4°C
LONG TERM STORAGE:
-20°C
Product Images
Please click on thumbnails to enlarge.
General Literature References
The Toll-IL-1 receptor adaptor family grows to five members
:
L.A. O'Neill; Trends. Immunol.
24
, 286 (2003)
Further Categories Containing This Product:
Polyclonal Antibodies
ALX-210-914
Revised 25-Jan-08
Polyclonal Antibody to TRAM (human) (AL239)
SYNONYMS
anti-TRIF-related Adaptor Molecule (human) PAb (AL239)
anti-TIRP (human) PAb (AL239)
anti-Toll-Interleukin 1 Receptor [TIR] Domain-containing Protein (human) PAb (AL239)
anti-TICAM-2 (human) PAb (AL239)
anti-TIR-containing Adaptor Molecule-2 (human) PAb (AL239)
PRODUCT LINE
Inflammation
PRODUCT CATEGORY
Toll-IL-1 Receptor Adaptors / Related Products
Ordering Information
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ALX-210-914-R050
50 µl
190.00 USD
Product Specification
SPECIES CROSSREACTIVITY:
Human
SOURCE/HOST:
From rabbit.
FORMULATION:
Liquid. Neat serum.
IMMUNOGEN:
Synthetic peptide corresponding to aa 2-29 (G
2
IGKSKINSC
PLSLSWGKRHSVDTSPGY
29
) of human TRAM (TRIF-related adaptor molecule).
SPECIFICITY:
Recognizes human TRAM.
APPLICATION:
Western Blot (1:1’000).
SHIPPING:
SHIPPED ON BLUE ICE
SHORT TERM STORAGE:
+4°C
LONG TERM STORAGE:
-20°C
HANDLING:
Avoid freeze/thaw cycles.
Product Images
Please click on thumbnails to enlarge.
Product Specific Literature References
Interferon regulatory factor 3-dependent responses to lipopolysaccharide are selectively blunted in cord blood cells:
E. Aksoy, et al.; Blood
109
, 2887 (2007)
Abstract
;
Full Text
General Information
MANUFACTURER
Manufactured by Apotech Corporation.
General Literature References
TIRP, a novel Toll/interleukin-1 receptor (TIR) domain-containing adapter protein involved in TIR signaling
:
L.H. Bin, et al.; J. Biol. Chem.
278
, 24526 (2003)
Abstract
;
Full Text
TRAM is specifically involved in the Toll-like receptor 4-mediated MyD88-independent signaling pathway
:
M. Yamamoto, et al.; Nat. Immunol.
4
, 1144 (2003)
Abstract
;
Full Text
Further Categories Containing This Product:
Polyclonal Antibodies
ALX-215-016
Revised 10-Apr-08
Polyclonal Antibody to TRIF
SYNONYMS
anti-TICAM-1 PAb
anti-TIR-containing Adaptor Molecule-1 PAb
anti-Toll-interleukin-1 Receptor [TIR] Domain-containing Adaptor Inducing Interferon-β [IFN-β] PAb
PRODUCT LINE
Inflammation
PRODUCT CATEGORY
Toll-IL-1 Receptor Adaptors / Related Products
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-215-016-R200
200 µl
267.00 USD
Product Specification
SPECIES CROSSREACTIVITY:
Human
Mouse
SOURCE/HOST:
From rabbit.
FORMULATION:
Liquid. In PBS containing 0.05% BSA and 0.05% sodium azide.
IMMUNOGEN:
Synthetic peptide corresponding to aa 143-158 (A
143
APGGAIVSELCQALS
158
) of mouse TRIF [TICAM-1].
SPECIFICITY:
Recognizes human and mouse TRIF.
APPLICATION:
Western Blot (1:500-1:1'000)
SHIPPING:
SHIPPED ON BLUE ICE
SHORT TERM STORAGE:
+4°C
LONG TERM STORAGE:
-20°C
USE/STABILITY:
Stable for 6 months when stored at +4°C.
HANDLING:
After opening, prepare aliquots and store at -20°C. Avoid freeze/thaw cycles.
Product Images
Please click on thumbnails to enlarge.
Product Specific Literature References
Transforming growth factor-beta differentially inhibits MyD88-dependent, but not TRAM- and TRIF-dependent, lipopolysaccharide-induced TLR4 signaling:
Y. Naiki, et al.; J. Biol. Chem.
280
, 5491 (2005)
Abstract
;
Full Text
Renal collecting duct epithelial cells react to pyelonephritis-associated Escherichia coli by activating distinct TLR4-dependent and -independent inflammatory pathways:
C. Chassin, et al.; J. Immunol.
177
, 4773 (2006)
Abstract
Further Categories Containing This Product:
Antiviral Signalling / Related Products
•
Polyclonal Antibodies
ALX-210-908
Revised 14-Jan-08
Polyclonal Antibody to TRIF (human) (AL227)
SYNONYMS
anti-TICAM-1 (human) PAb (AL227)
anti-TIR-containing Adaptor Molecule-1 (human) PAb (AL227)
anti-Toll-interleukin-1 Receptor [TIR] Domain-containing Adaptor Inducing Interferon-β [IFN-β] (human) PAb (AL227)
PRODUCT LINE
Inflammation
PRODUCT CATEGORY
Toll-IL-1 Receptor Adaptors / Related Products
Ordering Information
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Format:
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Unit Price:
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ALX-210-908-C050
50 µg
190.00 USD
Product Specification
SPECIES CROSSREACTIVITY:
Human
SOURCE/HOST:
From rabbit.
CONCENTRATION:
1mg/ml
PURITY DETAIL:
Affinity purified.
FORMULATION:
Liquid. In PBS containing 0.02% sodium azide.
IMMUNOGEN:
Synthetic peptide corresponding to aa 4-31 (T
4
GPSLPSAFDIL
GAAGQDKLLYLKHKLK
31
) of N-terminal human TRIF [TICAM-1].
SPECIFICITY:
Recognizes human TRIF.
APPLICATION:
Immunoprecipitation
Western Blot
SHIPPING:
SHIPPED ON BLUE ICE
SHORT TERM STORAGE:
+4°C
LONG TERM STORAGE:
-20°C
USE/STABILITY:
Stable for at least 1 year after receipt when stored at -20°C.
HANDLING:
Avoid freeze/thaw cycles.
Product Images
Please click on thumbnails to enlarge.
Product Specific Literature References
The human adaptor SARM negatively regulates adaptor protein TRIF-dependent Toll-like receptor signaling:
M. Carty, et al.; Nat. Immunol.
7
, 1074 (2006)
Abstract
Interferon regulatory factor 3-dependent responses to lipopolysaccharide are selectively blunted in cord blood cells:
E. Aksoy, et al.; Blood
109
, 2887 (2007)
Abstract
;
Full Text
General Information
MANUFACTURER
Manufactured by Apotech Corporation.
Further Categories Containing This Product:
Antiviral Signalling / Related Products
•
Polyclonal Antibodies
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