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Neuropeptides & Receptors Other Products
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ALX-152-018 Revised 20-Aug-02
Bombesin
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PRODUCT LINE Neurobiology
PRODUCT CATEGORY Neuropeptides & Receptors Other Products
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ALX-152-018-P001   1 mg* 40.00 USD Add To Cart
ALX-152-018-P005   5 mg* 160.00 USD Add To Cart
Product Specification
SEQUENCE: Pyr-Gln-Arg-Leu-Gly-Asn-Gln-Trp-Ala-Val-Gly-His-Leu-Met-NH2
FORMULA: C71H110N24O18S
MW: 1619.9
CAS NUMBER: 31362-50-2
MERCK INDEX: 14: 1329
QUANTITY: *Sold as net peptide weight.
PURITY: ≥97%
APPEARANCE: While lyophilized powder.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
Further Categories Containing This Product:
Peptides
 
 
ALX-380-264 Revised 04-Jun-08
EM574
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SYNONYMS Motilide
Idremcinal
8,9-Didehydro-N-demethyl-9-deoxo-6-deoxy-6,9-epoxy-N-(1-methylethyl)-erythromycin
PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Antibiotics - Other Signal Transduction Pathway Modulators
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ALX-380-264-M001   1 mg 280.00 USD Add To Cart
Product Specification
FORMULA: C39H69NO12
MW: 744.0
CAS NUMBER: 110480-13-2
SOURCE/HOST: Semisynthetic from erythromycin A.
PURITY: ≥95% (HPLC)
APPEARANCE: White to off-white powder.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C

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Product Description
Agonist of the motilin receptor. Shows antimicrobial and gastrointestinal motor stimulating activity in vitro and in vivo. Stimulates contractions of muscle strips in a concentration-dependent manner (10-7-10-5M) and this contractile effect is unaffected by pretreatment with atropine or tetrodotoxin (Prod. No. ALX-630-002). Binds to smooth muscle homogenates wit a Kd value of 7.8 x 10-9. Has orexigenic activity with affinity for the growth-hormone secretagogue receptor (GHS-R, Ghrelin Receptor).
Product Specific Literature References
Gastrointestinal motor-stimulating activity of macrolide antibiotics and the structure-activity relationship: S. Omura, et al.; J. Antibiot. 38, 1631 (1985) Abstract
Macrolides with gastrointestinal motor stimulating activity: S. Omura, et al.; J. Med. Chem. 30, 1941 (1987) Abstract
Motilides, macrolides with gastrointestinal motor stimulating activity. I. O-substituted and tertiary N-substituted derivatives of 8,9-anhydroerythromycin A 6,9-hemiacetal: K. Tsuzuki, et al.; Chem. Pharm. Bull. 37, 2687 (1989) Abstract
EM574, an erythromycin derivative, is a potent motilin receptor agonist in human gastric antrum: M. Satoh, et al.; J. Pharmacol. Exp. Ther. 271, 574 (1994) Abstract
Bioactive metabolites of EM574 and EM523, erythromycin derivatives having strong gastrointestinal motor stimulating activity: Y. Funabashi, et al.; J. Antibiot. 49, 794 (1996) Abstract
Vagus-dependent and vagus-independent mechanisms of action of the erythromycin derivative EM574 and motilin in dogs: N. Inatomi, et al.; Jpn. J. Pharmacol. 71, 29 (1996) Abstract
EM574, an erythromycin derivative, is a motilin receptor agonist in the rabbit: F. Sato, et al.; Eur. J. Pharmacol. 322, 63 (1997) Abstract
Effects of EM574 and cisapride on gastric contractile and emptying activity in normal and drug-induced gastroparesis in dogs: T. Tanaka, et al.; J. Pharmacol. Exp. Ther. 287, 712 (1998) Abstract
EM574, an erythromycin derivative, improves delayed gastric emptying of semi-solid meals in conscious dogs: F. Sato, et al.; Eur. J. Pharmacol. 395, 165 (2000) Abstract
General Information
MANUFACTURER Manufactured by the Kitasato Institute, Tokyo.
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Further Categories Containing This Product:
Accessory Proteins & Motor Proteins Other Products • G-Protein Coupled Receptors & Ligands Other Products • Neuropeptides & Receptors Other Products
 
 
ALX-157-003 Revised 03-Mar-05
Galanin (human)
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PRODUCT LINE Obesity & Adipokines
PRODUCT CATEGORY Galanin & Galanin Receptor / Related Products
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ALX-157-003-PC05   0.5 mg* 190.00 USD Add To Cart
ALX-157-003-P001   1 mg* 280.00 USD Add To Cart
Product Specification
SEQUENCE: H-Gly-Trp-Thr-Leu-Asn-Ser-Ala-Gly-Tyr-Leu-Leu-Gly-Pro-His-Ala-Val-Gly-Asn-His-Arg-Ser-Phe-Ser-Asp-Lys-Asn-Gly-Leu-Thr-Ser-OH
FORMULA: C139H210N42O43
MW: 3157.4
CAS NUMBER: 119418-04-1
QUANTITY: *Sold as net peptide weight.
PURITY: ≥98%
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
Product Specific Literature References
Galanin: profile of a new neuropeptide: L.W. Haynes; TIPS 7, 214 (1986), (Review)
Galanin - a newly isolated biologically active neuropeptide: A. Rökaeus; Trends Neurosci. 10, 158 (1987)
Galanin and the endocrine pancreas: B. Ahren, et al.; FEBS Lett. 229, 233 (1988) Abstract
Galanin. A selective inhibitor of insulin secretion?: J. Dupré; Pancreas 3, 119 (1988) Abstract
Co-existence of galanin and acetylcholine: is galanin involved in memory processed and dementia?: J.N. Crawley & G.L. Wenk; TINS 12, 278 (1989) Abstract
Inhibitory action of galanin on gastric acid secretion in pentobarbital-anesthetized rats: W.J. Rossowski & D.H. Coy; Life Sci. 44, 1807 (1989) Abstract
Galanin in the porcine pancreas: T. Messell, et al.; Regul. Pept. 28, 161 (1990) Abstract
Human galanin: primary structure and identification of two molecular forms: M. Bersani, et al.; FEBS Lett. 283, 189 (1991) Abstract
Isolation and primary structure of pituitary human galanin, a 30- residue nonamidated neuropeptide: W.E. Schmidt, et al.; PNAS 88, 11435 (1991) Abstract
Human galanin: molecular cloning reveals a unique structure: H.F. Evans & J. Shine; Endocrinology 129, 1682 (1991) Abstract
Further Categories Containing This Product:
Peptides • Ca2+ Modulators • Neuropeptides & Receptors Other Products
 
 
ALX-163-003 Revised 06-Jun-03
NPY (human)
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SYNONYMS Neuropeptide Y (human)
PRODUCT LINE Signal Transduction
PRODUCT CATEGORY Ca2+ Modulators
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ALX-163-003-PC05   0.5 mg* 140.00 USD Add To Cart
ALX-163-003-P001   1 mg* 250.00 USD Add To Cart
Product Specification
SEQUENCE: H-Tyr-Pro-Ser-Lys-Pro-Asp-Asn-Pro-Gly-Glu-Asp-Ala-Pro-Ala-Glu-Asp-Met-Ala-Arg-Tyr-Tyr-Ser-Ala-Leu-Arg-His-Tyr-Ile-Asn-Leu-Ile-Thr-Arg-Gln-Arg-Tyr-NH2
FORMULA: C189H285N55O57S
MW: 4271.7
CAS NUMBER: 90880-35-6
MERCK INDEX: 14: 6485
QUANTITY: *Sold as net peptide weight.
PURITY: ≥97%
APPEARANCE: White lyophilized powder.
SOLUBILITY: Soluble in water.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
Product Specific Literature References
Cloning, characterization, and DNA sequence of a human cDNA encoding neuropeptide tyrosine: C.D. Minth, et al.; PNAS 81, 4577 (1984) Abstract
Further Categories Containing This Product:
Leptin / Related Products • Peptides • Neuropeptides & Receptors Other Products
 
 
ALX-164-001 Revised 06-Jan-06
Orexin A (human, bovine, rat, mouse)
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PRODUCT LINE Obesity & Adipokines
PRODUCT CATEGORY Orexins / Related Products
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ALX-164-001-C100   100 µg 120.00 USD Add To Cart
ALX-164-001-C500   500 µg 370.00 USD Add To Cart
ALX-164-001-M001   1 mg 690.00 USD Add To Cart
Product Specification
SEQUENCE: Pyr-Pro-Leu-Pro-Asp-Cys-Cys-Arg-Gln-Lys-Thr-Cys-Ser-Cys-Arg-Leu-Tyr-Glu-Leu-Leu-His-Gly-Ala-Gly-Asn-His-Ala-Ala-Gly-Ile-Leu-Thr-Leu-NH2
(Disulfide bonds between Cys6-Cys12 and Cys7-Cys14).
FORMULA: C152H243N47O44S4
MW: 3561.2
PURITY: ≥98%
FORMULATION: Lyophilized.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
Product Description
Hypothalamic neuropeptide that stimulates food intake in rats with impressive potency. Binds specifically to the OX1 receptor.
Product Specific Literature References
Orexins and orexin receptors: a family of hypotalamic neuropeptides and G protein-coupled receptors that regulate feeding behaviour: T. Sakurai, et al.; Cell 92, 573 (1998) Abstract
Orexins and appetite: the big picture of energy homeostasis gets a little bigger: M.W. Schwartz; Nature Medicine 4, 385 (1998) Abstract
Further Categories Containing This Product:
Peptides • Neuropeptides & Receptors Other Products
 
 
ALX-164-002 Revised 06-Jan-06
Orexin B (human)
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PRODUCT LINE Obesity & Adipokines
PRODUCT CATEGORY Orexins / Related Products
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ALX-164-002-C100   100 µg 150.00 USD Add To Cart
Product Specification
SEQUENCE: H-Arg-Ser-Gly-Pro-Pro-Gly-Leu-Gln-Gly-Arg-Leu-Gln-Arg-Leu-Leu-Gln-Ala-Ser-Gly-Asn-His-Ala-Ala-Gly-Ile-Leu-Thr-Met-NH2
FORMULA: C122H212N44O34S
MW: 2871.4
PURITY: ≥95%
FORMULATION: Lyophilized.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
Product Description
Like orexin A (Prod. No. ALX-164-001), orexin B is a hypothalamatic neuropeptide stimulating food intake in rats. Stimulates food consumption in a similar manner to orexin A, but the effect did not last as long as that of orexin A. The affinity of orexin B for the OX1 receptor is significantly lower than that of orexin A. Binding affinities for the OX2 receptor are similar for orexin A and B.
Product Specific Literature References
Orexins and orexin receptors: a family of hypothalamic neuropeptides and G protein-coupled receptors that regulate feeding behavior: T. Sakurai, et al.; Cell 92, 573 (1998) Abstract
Orexins and appetite: the big picture of energy homeostasis gets a little bigger: M.W. Schwartz; Nature Medicine 4, 385 (1998) Abstract
Further Categories Containing This Product:
Peptides • Neuropeptides & Receptors Other Products
 
 
ALX-164-003 Revised 10-Jun-03
Orexin B (rat, mouse)
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PRODUCT LINE Obesity & Adipokines
PRODUCT CATEGORY Orexins / Related Products
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ALX-164-003-C100   100 µg 150.00 USD Add To Cart
Product Specification
SEQUENCE: H-Arg-Pro-Gly-Pro-Pro-Gly-Leu-Gln-Gly-Arg-Leu-Gln-Arg-Leu-Leu-Gln-Ala-Asn-Gly-Asn-His-Ala-Ala-Gly-Ile-Leu-Thr-Met-NH2
FORMULA: C125H215N45O33S
MW: 2908.5
PURITY: ≥97%
FORMULATION: Lyophilized.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
Product Specific Literature References
Orexins and orexin receptors: a family of hypothalamic neuropeptides and G protein-coupled receptors that regulate feeding behavior: T. Sakurai, et al.; Cell 92, 573 (1998) Abstract
Orexins and appetite: the big picture of energy homeostasis gets a little bigger: M.W. Schwartz; Nature Medicine 4, 385 (1998) Abstract
Further Categories Containing This Product:
Peptides • Neuropeptides & Receptors Other Products
 
 
ALX-215-061 Revised 31-Jul-08 New product
Polyclonal Antibody to SorLA (F3)
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SYNONYMS anti-LR11 PAb (F3)
anti-SorL1 PAb (F3)
anti-Sorting Protein-related Receptor Containing LDLR Class A Repeats PAb (F3)
anti-Low-density Lipoprotein Receptor Relative with 11 Ligand-binding Repeats PAb (F3)
PRODUCT LINE Neurobiology
PRODUCT CATEGORY Neuropeptides & Receptors Other Products
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ALX-215-061-1   1 Vial 250.00 USD Add To Cart
Product Specification
SPECIES CROSSREACTIVITY:
Human
Mouse
Rat
SOURCE/HOST: From rabbit.
FORMULATION: Lyophilized.
RECONSTITUTION: Reconstitute with 50μl distilled water.
IMMUNOGEN: Recombinant mouse SorLA (aa 1384-1676 representing the first 4.5 extracellular fibronectin type III domain).
SPECIFICITY: Recognizes human, mouse and rat SorLA.
APPLICATION: Immunocytochemistry (1:1’000)
Western Blot (1:3’000)
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: +4°C
HANDLING: After reconstitution, prepare aliquots and store at -20°C. Avoid freeze/thaw cycles.
Product Description
Recognizes transmembrane SorLA and also the shed ectodomain.
Product Specific Literature References
Ectodomain shedding, translocation and synthesis of SorLA are stimulated by its ligand head activator: W. Hampe, et al.; J. Cell Sci. 113, 4475 (2000) Abstract; Full Text
Characterization of the VPS10 domain of SorLA/LR11 as binding site for the neuropeptide HA: J. Lintzel, et al.; Biol. Chem. 383, 1727 (2002) Abstract
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Cholesterol & Lipid Transport / Related Products • Polyclonal Antibodies
 
 
ALX-215-060 Revised 31-Jul-08 New product
Polyclonal Antibody to SorLA (IC)
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SYNONYMS anti-LR11 PAb (IC)
anti-SorL1 PAb (IC)
anti-Sorting Protein-related Receptor Containing LDLR Class A Repeats PAb (IC)
anti-Low-density Lipoprotein Receptor Relative with 11 Ligand-binding Repeats PAb (IC)
PRODUCT LINE Neurobiology
PRODUCT CATEGORY Neuropeptides & Receptors Other Products
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ALX-215-060-1   1 Vial 250.00 USD Add To Cart
Product Specification
SPECIES CROSSREACTIVITY:
Human
Mouse
Rat
SOURCE/HOST: From rabbit.
FORMULATION: Lyophilized.
RECONSTITUTION: Reconstitute with 50μl distilled water.
IMMUNOGEN: Synthetic peptide corresponding to the 18 C-terminal aa from the intracellular tail (IC) of mouse SorLA with an added N-terminal cysteine.
SPECIFICITY: Recognizes human, mouse and rat SorLA.
APPLICATION: Immunocytochemistry (1:3’000)
Western Blot (1:3’000)
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: +4°C
HANDLING: After reconstitution, prepare aliquots and store at -20°C. Avoid freeze/thaw cycles.
BLOCKING PEPTIDE: Blocking Peptide for PAb to SorLA Prod. No. ALX-167-028
Product Description
Recognizes transmembrane SorLA, the membrane stub after ectodomain shedding and also the soluble cytoplasmic domain.
Product Specific Literature References
Ectodomain shedding, translocation and synthesis of SorLA are stimulated by its ligand head activator: W. Hampe, et al.; J. Cell Sci. 113, 4475 (2000) Abstract; Full Text
Characterization of the VPS10 domain of SorLA/LR11 as binding site for the neuropeptide HA: J. Lintzel, et al.; Biol. Chem. 383, 1727 (2002) Abstract
SorLA signaling by regulated intramembrane proteolysis: C. Böhm, et al.; J. Biol. Chem. 281, 14547 (2006) Abstract; Full Text
The neuronal sortilin-related receptor SORL1 is genetically associated with Alzheimer disease: E. Rogaeva, et al.; Nat. Genet. 39, 168 (2007) Abstract
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Further Categories Containing This Product:
Cholesterol & Lipid Transport / Related Products • Polyclonal Antibodies
 
 
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