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ALX-300-005
Revised 09-Dec-04
3-O-Octadecyl-2-O-methyl-sn-glycero-1-phosphocholine
PRODUCT LINE
Signal Transduction
PRODUCT CATEGORY
Phospholipids / Related Products
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ALX-300-005-M050
50 mg
45.00 USD
Product Specification
FORMULA:
C
27
H
58
NO
6
P
MW:
523.7
PURITY:
≥99%
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
ALX-300-096
Revised 30-Jan-08
Octadecyl-phosphate . sodium salt
PRODUCT LINE
Signal Transduction
PRODUCT CATEGORY
Phospholipids / Related Products
Ordering Information
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ALX-300-096-G001
1 g
60.00 USD
Product Specification
FORMULA:
C
18
H
37
O
4
P . Na
MW:
348.5 . 23.0
PURITY:
≥98%
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
ALX-300-094
Revised 18-Jul-07
Octadecyl-phosphocholine
SYNONYMS
C
18:0
-PC
PRODUCT LINE
Signal Transduction
PRODUCT CATEGORY
Phospholipids / Related Products
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ALX-300-094-M250
250 mg
45.00 USD
ALX-300-094-G001
1 g
135.00 USD
Product Specification
FORMULA:
C
23
H
50
NO
4
P
MW:
435.6
PURITY:
≥99% (HPLC)
APPEARANCE:
White to off-white solid.
SOLUBILITY:
Soluble in 100% ethanol, methanol or water.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
HANDLING:
Hygroscopic.
Product Description
Potential antitumor agent.
Product Specific Literature References
H.R. Berger, et al.; Akt. Onkologie
34
, 27 (1987)
Further Categories Containing This Product:
Antitumor Reagents Other Products
ALX-300-109
Revised 09-Dec-04
Octadecyl-phospho-rac-glycerol . sodium salt
PRODUCT LINE
Signal Transduction
PRODUCT CATEGORY
Phospholipids / Related Products
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ALX-300-109-M250
250 mg
70.00 USD
ALX-300-109-G001
1 g
210.00 USD
Product Specification
FORMULA:
C
21
H
44
O
6
P . Na
MW:
423.5 . 23.0
PURITY:
≥99%
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
ALX-300-300
Revised 08-Jul-08
1-Oleoyl-2-acetyl-sn-glycerol
SYNONYMS
OAG
PRODUCT LINE
Signal Transduction
PRODUCT CATEGORY
Mono- & Diacylglycerols
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ALX-300-300-M005
5 mg
62.00 USD
ALX-300-300-M025
25 mg
276.00 USD
Product Specification
FORMULA:
C
23
H
42
O
5
MW:
398.6
CAS NUMBER:
86390-77-4
PURITY:
≥90%
FORMULATION:
Liquid. Solution in acetonitrile.
SOLUBILITY:
20mg/ml soluble in DMSO or dimethyl formamide; miscible with 100% ethanol; 1.7mg/ml soluble in 1:1 solution of ethanol:PBS (pH 7.2) (dilute the ethanol solution with PBS).
SHIPPING:
SHIPPED ON DRY ICE
LONG TERM STORAGE:
-80°C
USE/STABILITY:
Stable for at least 1 year after receipt when stored at -80°C. Stable for at least 3 months in other organic solvents when stored at -80°C. Use aqueous solutions within 12 hours.
Product Description
In vitro
potent activator of protein kinase C (PKC). Stimulator of secretion and aggregation in blood platelets.
Product Specific Literature References
Phosphatidylinositol turnover in platelet activation; calcium mobilization and protein phosphorylation:
K. Kaibuchi, et al.; Cell Calcium
3
, 323 (1982)
Abstract
Specificity of the fatty acyl moieties of diacylglycerol for the activation of calcium-activated, phospholipid-dependent protein kinase
:
T. Mori, et al.; J. Biochem. (Tokyo)
91
, 427 (1982)
Abstract
Phorbol ester and diacylglycerol induce protein phosphorylation at tyrosine:
T. Gilmore & G.S. Martin; Nature
306
, 487 (1983)
Abstract
Synergistic functions of protein phosphorylation and calcium mobilization in platelet activation:
K. Kaibuchi, et al.; J. Biol. Chem.
258
, 6701 (1983)
Abstract
;
Full Text
A possible role of protein kinase C in signal-induced lysosomal enzyme release:
N. Kajikawa, et al.; BBRC
116
, 743 (1983)
Abstract
B. Michell; TIBS
8
, 263 (1983), (Review)
Diacylglycerol and phorbol ester stimulate secretion without raising cytoplasmic free calcium in human platelets:
T.J. Rink, et al.; Nature
305
, 317 (1983)
Abstract
Opposite effects of angiotensin II and the protein kinase C activator OAG on cardiac Na+ channels:
I. Benz, et al.; J. Membr. Biol.
130
, 183 (1992)
Abstract
Ca2+ and partly GTP gamma S-dependent particulate phospholipase C hydrolyzing phosphatidylinositol 4-phosphate and phosphatidylinositol 4,5-bisphosphate is inhibited by diacyl(acyl-acetyl) glycerols:
E.W. Haeffner & U. Wittmann; J. Lipid Mediat.
5
, 237 (1992)
Abstract
New patterns of diacylglycerol metabolism in intact cells:
J. Florin-Christensen; Biochem. J.
289
, 783 (1993)
Abstract
General Information
BACKGROUND/TECHNICAL INFORMATION
To change the solvent, evaporate the acetonitrile under a gentle stream of nitrogen and immediately add the solvent of choice.
Further Categories Containing This Product:
PKC Activators
ALX-550-398
Revised 10-Jul-08
N-Oleoyldopamine
SYNONYMS
OLDA
N-[2-(3,4-Dihydroxyphenyl)ethyl]-9Z-octadecenamide
PRODUCT LINE
Neurobiology
PRODUCT CATEGORY
TRPV1 Agonists and Antagonists / Related Products
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ALX-550-398-M005
5 mg
35.00 USD
Product Specification
FORMULA:
C
26
H
43
NO
3
MW:
417.6
CAS NUMBER:
105955-11-1
CONCENTRATION:
50mg/ml
PURITY:
≥98%
FORMULATION:
Liquid. Solution in ethanol.
SOLUBILITY:
20mg/ml soluble in DMSO or dimethyl formamide; 0.5mg/ml soluble in a 1:1 solution of ethanol:PBS (pH 7.2) (dilute the ethanol solution with PBS).
SHIPPING:
SHIPPED ON BLUE ICE
LONG TERM STORAGE:
-20°C
USE/STABILITY:
Stable for at least 1 year after receipt when stored at -20°C. We do not recommend storing aqueous solutions for more than one day.
HANDLING:
Protect from light.
Product Description
Endogenous TRPV1 agonist (K
i
=36nM, EC
50
=36nM) with weak affinity for rat CB
1
receptor (K
i
=1.6µM). Potent inhibitor of 5-lipoxygenase (IC
50
=7.5nM) and of early and late events in TCR mediated T cell activation. Inhibits NF-κB dependent transcriptional activity without affecting either degradation of the cytoplasmic NF-κB inhibitory protein, IκBα, or DNA binding activity.
Product Specific Literature References
Inhibition of arachidonate 5-lipoxygenase by phenolic compounds
:
S. Iwakami, et al.; Chem. Pharm. Bull.
34
, 3960 (1986)
Abstract
Inhibition of in vitro prostaglandin and leukotriene biosyntheses by cinnamoyl-beta-phenethylamine and N-acyldopamine derivatives
:
C.F. Tseng, et al.; Chem. Pharm. Bull.
40
, 396 (1992)
Abstract
N-oleoyldopamine, a novel endogenous capsaicin-like lipid that produces hyperalgesia
:
C.J. Chu, et al.; J. Biol. Chem.
278
, 13633 (2003)
Abstract
Direct evidence for activation and desensitization of the capsaicin receptor by N-oleoyldopamine on TRPV1-transfected cell, line in gene deleted mice and in the rat
:
J. Szolcsanyi, et al.; Neurosci. Lett.
361
, 155 (2004)
Abstract
Immunosuppressive activity of endovanilloids: N-arachidonoyl-dopamine inhibits activation of the NF-kappa B, NFAT, and activator protein 1 signaling pathways
:
R. Sancho, et al.; J. Immunol.
172
, 2341 (2004)
Abstract
General Information
BACKGROUND/TECHNICAL INFORMATION
To change the solvent, evaporate the ethanol under a gentle stream of nitrogen and immediately add the solvent of choice.
Further Categories Containing This Product:
Endovanilloids
•
Lipoxygenases / Related Products
•
NF-kB Pathway Inhibitors
ALX-300-139
Revised 10-Jul-08
1-Oleoyl-sn-glycero-3-lysophosphatidic acid . sodium salt
PRODUCT LINE
Signal Transduction
PRODUCT CATEGORY
Phospholipids / Related Products
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ALX-300-139-M005
5 mg
77.00 USD
Product Specification
FORMULA:
C
21
H
40
O
7
P . Na
MW:
435.5 . 23.0
CAS NUMBER:
22556-62-3
PURITY:
≥95%
APPEARANCE:
White to off-white solid.
SOLUBILITY:
Soluble in water or PBS, pH 7.2 (8.3mg/ml); sparingly soluble in 100% ethanol, DMSO or dimethyl formamide.
SHIPPING:
SHIPPED ON BLUE ICE
LONG TERM STORAGE:
-20°C
USE/STABILITY:
Stable for at least 1 year after receipt when stored at -20°C. We do not recommend storing aqueous solutions for more than one day.
Product Description
Lysophosphatidic acids exert a wide range of biological activities that include stimulation of cell proliferation, smooth muscle contraction, platelet aggregation, neurite retraction and cell motility. Lysophosphatidic acids also induce calcium mobilization in cells via a G-protein coupled receptor. 1-Oleoyl lysophosphatidic acid is the most potent of the lysophosphatidic acids with an EC
50
of 0.2nM for calcium mobilization in A431 carcinoma cells. The product was shown to stimulate DNA synthesis in quiescent fibroblasts.
Product Specific Literature References
Mitogenic action of lysophosphatidic acid and phosphatidic acid on fibroblasts. Dependence on acyl-chain length and inhibition by suramin:
E.J. van Corven, et al.; Biochem. J.
281
, 163 (1992)
Abstract
Lysophosphatidic acid-induced Ca2+ mobilization in human A431 cells: structure-activity analysis:
K. Jalink, et al.; Biochem. J.
307
, 609 (1995)
Abstract
Further Categories Containing This Product:
Antithrombotic Agents / Platelet Aggregation Inhibitors / Related Products
ALX-300-074
Revised 20-Jul-05
1-O-Oleyl-rac-glycerol
PRODUCT LINE
Signal Transduction
PRODUCT CATEGORY
Mono- & Diacylglycerols
Ordering Information
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ALX-300-074-M250
250 mg
70.00 USD
Product Specification
FORMULA:
C
21
H
40
O
4
MW:
356.5
CAS NUMBER:
111-03-5
PURITY:
≥99%
SOLUBILITY:
Soluble in chloroform.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
ALX-300-101
Revised 09-Dec-04
1-O-Oleyl-2-O-hexadecyl-rac-glycero-3-phosphocholine
PRODUCT LINE
Signal Transduction
PRODUCT CATEGORY
Phospholipids / Related Products
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ALX-300-101-M050
50 mg
80.00 USD
ALX-300-101-M250
250 mg
320.00 USD
Product Specification
FORMULA:
C
42
H
86
NO
6
P
MW:
732.1
PURITY:
≥99%
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
Product Specific Literature References
Rapid purification of phospholipase A2 from Crotalus adamanteus venom by affinity chromatography:
C.O. Rock & F. Snyder; J. Biol. Chem.
250
, 6564 (1975)
Abstract
;
Full Text
Isolation of homogeneous phospholipase A2 from human platelets:
R.J. Apitz-Castro, et al.; BBRC
91
, 63 (1979)
Abstract
Isolation of phospholipase A2 from red cell membranes of sheep:
P. Zahler & R. Kramer; Meth. Enzymol.
71
, 690 (1981)
Abstract
Further Categories Containing This Product:
PLA2 Substrates
ALX-300-088
Revised 04-Jul-02
1-O-Oleyl-propanediol-(1,3)
PRODUCT LINE
Signal Transduction
PRODUCT CATEGORY
Lipid Signalling Pathways Other Products
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ALX-300-088-G001
1 g
80.00 USD
Product Specification
FORMULA:
C
22
H
46
O
2
MW:
342.6
PURITY:
≥98%
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
ALX-270-115
Revised 08-Dec-05
ONO-RS-082
SYNONYMS
2-(p-Amylcinnamoyl)amino-4-chlorobenzoic acid
PRODUCT LINE
Signal Transduction
PRODUCT CATEGORY
PLA2 Inhibitors
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ALX-270-115-M005
5 mg
40.00 USD
ALX-270-115-M025
25 mg
120.00 USD
Product Specification
FORMULA:
C
21
H
22
ClNO
3
MW:
371.9
CAS NUMBER:
99754-06-0
PURITY:
≥98%
APPEARANCE:
Off-white to yellow solid.
SOLUBILITY:
Soluble in DMSO or 100% ethanol.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
+20°C
USE/STABILITY:
Solutions are stable for 3 months when stored at -20°C.
HANDLING:
Do not freeze. Protect from light.
Product Description
Phospholipase A
2
inhibitor. Inhibits epinephrine-stimulated thromboxane production in human platelets. Also blocks insulin secretion in pancreatic islets in response to glucose.
Product Specific Literature References
Activation of phospholipases A and C in human platelets exposed to epinephrine: role of glycoproteins IIb/IIIa and dual role of epinephrine:
H.S. Banga, et al.; PNAS
83
, 9197 (1986)
Abstract
Inhibition of phospholipase A2 and insulin secretion in pancreatic islets:
R.J. Konrad, et al.; Biochim. Biophys. Acta
1135
, 215 (1992)
Abstract
ALX-850-202
Revised 24-Feb-05
PAF Acetylhydrolase Assay Kit
PRODUCT LINE
Inflammation
PRODUCT CATEGORY
Platelet Activating Factors [PAF] & Receptors / Related Products
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ALX-850-202-KI01
1 Kit
349.00 USD
Product Specification
SENSITIVITY:
0.02-0.2µmol/min/ml
QUANTITY:
96 wells (~80 tests).
APPLICATION:
For the measurement of platelet-activating factor acetylhydrolase (PAF-AH) activity (both cytosolic and extracellular).
SHIPPING:
SHIPPED ON BLUE ICE
LONG TERM STORAGE:
-20°C
Product Images
Please click on thumbnails to enlarge.
Product Specific Literature References
Catabolism of platelet-activating factor and its acyl analog. Differentiation of the activities of lysophospholipase
