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ALX-300-075
Revised 19-May-03
1,2-O,O-Ditetradecyl-rac-glycerol
PRODUCT LINE
Signal Transduction
PRODUCT CATEGORY
Mono- & Diacylglycerols
Ordering Information
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ALX-300-075-M250
250 mg
60.00 USD
ALX-300-075-G001
1 g
180.00 USD
Product Specification
FORMULA:
C
31
H
64
O
3
MW:
484.9
PURITY:
≥98%
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
ALX-700-002
Revised 16-Feb-05
DMTAP . mesylate
SYNONYMS
N-(1,2-Dimyristoyl-dihydroxypropyl)-N,N,N-trimethylammonium . mesylate
1,2-Dimyristoyl-3-trimethylammonium-propane mesylate
PRODUCT LINE
Signal Transduction
PRODUCT CATEGORY
Lipid Signalling Pathways Other Products
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Format:
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ALX-700-002-M005
5 mg
20.00 USD
ALX-700-002-M025
25 mg
80.00 USD
Product Specification
FORMULA:
C
34
H
78
NO
4
. CH
3
O
3
S
MW:
554.9 . 95.1
PURITY:
≥98%
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
ALX-300-071
Revised 03-Jan-08
1-O-Dodecyl-rac-glycerol
SYNONYMS
1-O-Lauryl-
rac
-glycerol
PRODUCT LINE
Signal Transduction
PRODUCT CATEGORY
Mono- & Diacylglycerols
Ordering Information
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ALX-300-071-G001
1 g
60.00 USD
Product Specification
FORMULA:
C
15
H
32
O
3
MW:
260.4
CAS NUMBER:
1561-07-5
SOURCE/HOST:
Synthetic.
PURITY:
≥99%
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
Product Description
This lipid was shown to exhibit excellent bacteriostatic effects. Moreover, it is a mild nonionic surfactant qualitatively similar to monoglyceride surfactants that are frequently used as food emulsifiers. Its use as a potential food additive and its metabolism and nutritional effects in mice have been described.
Product Specific Literature References
Dodecylglycerol. A new type of antibacterial agent which stimulates autolysin activity in Streptococcus faecium ATCC 9790:
H.S. Ved, et al.; J. Biol. Chem.
259
, 8115 (1984)
Abstract
;
Full Text
The involvement of the proteinase of Streptococcus faecium ATCC 9790 in the stimulation of its autolysin activity by dodecylglycerol:
H.S. Ved, et al.; J. Biol. Chem.
259
, 8122 (1984)
Abstract
;
Full Text
Metabolism of orally administered rac-1-O-[1'-14C]dodecylglycerol and nutritional effects of dietary rac-1-O-dodecylglycerol in mice:
N. Weber; J. Lipid Res.
26
, 1412 (1985), and references cited therein.
Abstract
;
Full Text
Activation of mouse peritoneal macrophages by lysophospholipids and ether derivatives of neutral lipids and phospholipids:
N. Yamamoto & B. Z. Ngwenya; Cancer Res
47
, 2008 (1987)
Abstract
Participation of serum proteins in the inflammation-primed activation of macrophages:
N. Yamamoto, et al.; Inflammation
18
, 311 (1994)
Abstract
Inhibition of phorbol ester-stimulated arachidonic acid release by alkylglycerols:
M. Robinson, et al.; Biochim. Biophys. Acta
1254
, 361 (1995)
Abstract
Further Categories Containing This Product:
Antibiotics Other Products
ALX-300-069
Revised 09-Dec-04
1-O-Dodecyl-sn-glycerol
SYNONYMS
1-O-Lauryl-
sn
-glycerol
PRODUCT LINE
Signal Transduction
PRODUCT CATEGORY
Mono- & Diacylglycerols
Ordering Information
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Format:
Size:
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ALX-300-069-M250
250 mg
70.00 USD
Product Specification
FORMULA:
C
15
H
32
O
3
MW:
260.4
PURITY:
≥99%
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
ALX-300-070
Revised 19-May-03
3-O-Dodecyl-sn-glycerol
SYNONYMS
3-O-Lauryl-
sn
-glycerol
PRODUCT LINE
Signal Transduction
PRODUCT CATEGORY
Mono- & Diacylglycerols
Ordering Information
Product Numbers:
Format:
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ALX-300-070-M250
250 mg
60.00 USD
ALX-300-070-G001
1 g
180.00 USD
Product Specification
FORMULA:
C
15
H
32
O
3
MW:
260.4
PURITY:
≥98%
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
ALX-300-128
Revised 16-Feb-05
Dodecyl-phospho-rac-glycerol . sodium salt
PRODUCT LINE
Signal Transduction
PRODUCT CATEGORY
Phospholipids / Related Products
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ALX-300-128-M250
250 mg
70.00 USD
ALX-300-128-G001
1 g
210.00 USD
Product Specification
FORMULA:
C
15
H
32
O
6
P . Na
MW:
339.4 . 23.0
PURITY:
≥98%
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
ALX-700-001
Revised 13-May-08
DOTAP . mesylate
SYNONYMS
N-(1-(2,3-Dioleoyloxy)propyl)-N.N.N-trimethylammonium . mesylate
N-(1,2-Dioleyl-dihydroxypropyl)-N.N.N-trimethylammonium . mesylate
1,2-Dioleoyl-3-trimethylammonium-propane mesylate
PRODUCT LINE
Signal Transduction
PRODUCT CATEGORY
Lipid Signalling Pathways Other Products
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ALX-700-001-M005
5 mg
20.00 USD
ALX-700-001-M025
25 mg
80.00 USD
Product Specification
FORMULA:
C
42
H
80
NO
4
. SO
3
CH
3
MW:
663.1 . 95.1
CAS NUMBER:
252769-92-9; 144189-73-1
SOURCE/HOST:
Synthetic.
PURITY:
≥98%
APPEARANCE:
White to off-white solid.
SOLUBILITY:
Soluble in methanol, 100% ethanol, methylene chloride, tetrahydrofuran or isopropanol; insoluble in DMSO or water.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
HANDLING:
Packaged under inert gas.
Product Description
Cationic lipid used for transfection of DNA, RNA and other negatively charged molecules into eukaryotic cells.
Product Specific Literature References
Interactions of mammalian cells with lipid dispersions containing novel metabolizable cationic amphiphiles:
R. Leventis & J.R. Silvius; Biochim. Biophys. Acta
1023
, 124 (1990)
Abstract
Further Categories Containing This Product:
Buffers / Detergents / Solutions
ALX-270-097
Revised 07-Sep-06
Ebselen
SYNONYMS
2-Phenyl-1,2-benzisoselenazol-3-(2
H
)-one
PRODUCT LINE
Oxidative Stress
PRODUCT CATEGORY
Peroxynitrite / Scavengers / Detection
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ALX-270-097-M001
1 mg
12.00 USD
ALX-270-097-M005
5 mg
20.00 USD
ALX-270-097-M025
25 mg
60.00 USD
Product Specification
FORMULA:
C
13
H
9
NOSe
MW:
274.2
CAS NUMBER:
60940-34-3
PURITY:
≥98% (NMR)
APPEARANCE:
White to off-white crystalline solid.
SOLUBILITY:
Soluble in DMSO.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
HANDLING:
Protect from light.
Product Description
Selenium-based inhibitor of protein kinase C, NADPH, 5-lipoxygenase, cyclooxygenase (COX) and NADPH oxidase. Anti-inflammatory antioxidant. Mimics glutathione peroxidase. Inhibits oxidative modifications of low density lipoproteins (LDL).
Product Specific Literature References
A novel biologically active seleno-organic compound--III. Effects of PZ 51 (Ebselen) on glutathione peroxidase and secretory activities of mouse macrophages
:
M.J. Parnham & S. Kindt; Biochem. Pharmacol.
33
, 3247 (1984)
Abstract
Seleno-organic compounds and the therapy of hydroperoxide-linked pathological conditions
:
M.J. Parnham & E. Graf; Biochem. Pharmacol.
36
, 3095 (1987)
Abstract
Kinetic mechanism and substrate specificity of glutathione peroxidase activity of ebselen (PZ51)
:
M. Maiorino, et al.; Biochem. Pharmacol.
37
, 2267 (1988)
Abstract
Studies on the anti-inflammatory activity of ebselen. Ebselen interferes with granulocyte oxidative burst by dual inhibition of NADPH oxidase and protein kinase C?:
I.A. Cotgreave, et al.; Biochem. Pharmacol.
38
, 649 (1989)
Abstract
T. Nikawa, et al.; Biochem. Pharmacol.
47
, 1007 (1994)
Abstract
Effects of ebselen and probucol on oxidative modifications of lipid and protein of low density lipoprotein induced by free radicals:
N. Noguchi, et al.; Biochim. Biophys. Acta
1213
, 176 (1994)
Abstract
Strong inhibition of mammalian lipoxygenases by the antiinflammatory seleno-organic compound ebselen in the absence of glutathione:
C. Schewe, et al.; Biochem. Pharmacol.
48
, 65 (1994)
Abstract
Ebselen: a glutathione peroxidase mimic
:
H. Sies; Meth. Enzymol.
234
, 476 (1994)
Abstract
Molecular actions of ebselen-an antiinflammatory antioxidant
:
T. Schewe; Gen. Pharmacol.
26
, 1153 (1995)
Abstract
Ebselen
:
H. Sies; Meth. Enzymol.
252
, 341 (1995)
Abstract
Ebselen as a glutathione peroxidase mimic and as a scavenger of peroxynitrite
:
H. Sies & H. Masumoto; Adv. Pharmacol.
38
, 229 (1997)
Abstract
Free radical generation by selenium compounds and their prooxidant toxicity
:
J.E. Spallholz; Biomed. Environ. Sci.
10
, 260 (1997)
Abstract
Protection against peroxynitrite by selenoproteins
:
H. Sies, et al.; Z. Naturforsch. [C]
53
, 228 (1998)
Abstract
Ebselen protects mice against T cell-dependent, TNF-mediated apoptotic liver injury
:
G. Tiegs, et al.; J. Pharmacol. Exp. Ther.
287
, 1098 (1998)
Abstract
;
Full Text
Further Categories Containing This Product:
Antioxidants, Flavonoids & Free Radical Scavengers Other Products
•
PKC Inhibitors
•
Malaria / Related Products
•
Lipoxygenases / Related Products
•
Anti-inflammatory Agents Other Products
•
COX Inhibitors
ALX-300-152
Revised 09-Feb-05
1-Elaidylphosphocholine (C18:1, trans)
PRODUCT LINE
Signal Transduction
PRODUCT CATEGORY
Phospholipids / Related Products
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ALX-300-152-M250
250 mg
80.00 USD
ALX-300-152-G001
1 g
240.00 USD
Product Specification
FORMULA:
C
23
H
48
NO
4
P
MW:
433.6
PURITY:
≥98%
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
HANDLING:
Hygroscopic.
Product Description
Cytotoxic alkylphosphocholine for a variey of tumor cells and protozoal diseases (leishmaniasis).
General Literature References
Hexadecylphosphocholine: a new and selective antitumor drug
:
H. Eibl & C. Unger; Cancer Treat. Rev.
17
, 233 (1990), (Review)
Abstract
Induction of tumor cell differentiation by alkylphosphocholines: a new approach for in vitro screening
:
H.R. Maurer & P. Hilgard; Prog. Exp. Tumor Res.
34
, 90 (1992), (Review)
Abstract
Alkylphosphocholines: a new class of membrane-active anticancer agents
:
P. Hilgard, et al.; Cancer Chemother. Pharmacol.
32
, 90 (1993), (Review)
Abstract
Current concepts of treatment in medical oncology: new anticancer drugs
:
C. Unger; J. Cancer Res. Clin. Oncol.
122
, 189 (1996), (Review)
Abstract
Further Categories Containing This Product:
Antitumor Reagents Other Products
ALX-270-341
Revised 28-Sep-07
Epoxyquinone G109 (racemic)
PRODUCT LINE
Neurobiology
PRODUCT CATEGORY
Ceramides / Cerebrosides / Sphingolipids / Related Products
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ALX-270-341-M002
2 mg
190.00 USD
Product Specification
FORMULA:
C
18
H
27
NO
4
MW:
321.4
CAS NUMBER:
163972-12-1 ((+)-enantiomer)
PURITY:
≥98%
APPEARANCE:
Pale yellow powder.
SOLUBILITY:
Soluble in DMSO or methanol.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
HANDLING:
Protect from light.
HAZARD:
TOXIC.
Product Description
Potent and selective irreversible inhibitor of neutral sphingomyelinase (N-SMase).
Product Specific Literature References
Manumycin A and its analogues are irreversible inhibitors of neutral sphingomyelinase
:
C. Arenz, et al.; ChemBioChem
2
, 141 (2001)
Abstract
Endothelial apoptosis induced by inhibition of integrins αvβ3 and αvβ5 involves ceramide metabolic pathways:
A. Erdreich-Epstein, et al.; Blood
105
, 4353 (2005)
Abstract
Further Categories Containing This Product:
Other Toxins
ALX-270-099
Revised 02-Dec-04
Ethyl 3,4-dihydroxybenzylidenecyanoacetate
PRODUCT LINE
Inflammation
PRODUCT CATEGORY
Lipoxygenases / Related Products
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ALX-270-099-M025
25 mg
63.00 USD
Product Specification
FORMULA:
C
12
H
11
NO
4
MW:
233.2
CAS NUMBER:
132464-92-7
PURITY:
≥96%
SOLUBILITY:
Soluble in DMSO and methanol.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
+4°C
Product Description
12- and 15-lipoxygenase inhibitor.
Product Specific Literature References
Novel caffeic acid derivatives: extremely potent inhibitors of 12- lipoxygenase:
H. Cho, et al.; J. Med. Chem.
34
, 1503 (1991)
Abstract
ALX-300-065
Revised 02-Dec-04
1-O-Ethyl-rac-glycerol
PRODUCT LINE
Signal Transduction
PRODUCT CATEGORY
Mono- & Diacylglycerols
Ordering Information
Product Numbers:
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ALX-300-065-G001
1 g
60.00 USD
Product Specification
FORMULA:
C
5
H
12
O
3
MW:
120.2
PURITY:
≥98%
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
