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Protein Kinase C [PKC] / Related Products
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ALX-270-261 Revised 14-May-03
(2S,5S)-8-Decylbenzolactam V
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PRODUCT LINE Signal Transduction
PRODUCT CATEGORY PKC Activators
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ALX-270-261-C500   500 µg 125.00 USD Add To Cart
Product Specification
FORMULA: C25H42N2O2
MW: 402.6
PURITY: ≥95%
APPEARANCE: Oil.
SOLUBILITY: Soluble in ethanol.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C

Product Description
Activator of protein kinase C (PKC) with improved selectivity for the α, β and γ isoforms.
Product Specific Literature References
Modeling, chemistry, and biology of the benzolactam analogues of indolactam V (ILV). 2. Identification of the binding site of the benzolactams in the CRD2 activator-binding domain of PKCdelta: A.P. Kozikowski, et al.; J. Med. Chem. 40, 1316 (1997) Abstract
Restoration of TEA-induced calcium responses in fibroblasts from Alzheimer's disease patients by a PKC activator: S. Bhagavan, et al.; Neurobiol. Dis. 5, 177 (1998) Abstract
 
 
ALX-445-049 Revised 24-Oct-07
12-Deoxyphorbol 13-phenylacetate
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PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Phorbols / Phorbol Esters
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ALX-445-049-M005   5 mg 220.00 USD Add To Cart
Product Specification
FORMULA: C28H34O6
MW: 466.6
CAS NUMBER: 58821-98-0
PURITY: ≥98%
SOLUBILITY: Soluble in DMSO and ethanol.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
HAZARD: POTENTIAL TUMOR PROMOTER. IRRITANT.

Product Description
Metabolite of 12-deoxyphorbol 13-phenylacetate 20-acetate. Potent activator of protein kinase C (PKC). Induces the expression of HIV-1 in latently infected T cells.
Product Specific Literature References
Role of protein kinase C isozymes in activation of human immunodeficiency virus type 1 in chronically infected promonocytic cells: evidence against a role of PKC beta 1: C.H. Kim, et al.; Biochem. Biophys. Res. Commun. 199, 292 (1994) Abstract
Differential regulation by anti-tumor-promoting 12-deoxyphorbol-13-phenylacetate reveals distinct roles of the classical and novel protein kinase C isozymes in biological responses of primary mouse keratinocytes: Z. Szallasi, et al.; Mol. Pharmacol. 47, 258 (1995) Abstract
Activation of latent HIV-1 expression by the potent anti-tumor promoter 12-deoxyphorbol 13-phenylacetate: S. Bocklandt, et al.; Antiviral Res. 59, 89 (2003) Abstract
Further Categories Containing This Product:
PKC Activators
 
 
ALX-430-027 Revised 05-Dec-04
Diacylglycerol Kinase Inhibitor I (R59 022)
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SYNONYMS 6-[2-(4-[(4-Fluorophenyl)phenylmethylene]-1-piperidinyl)ethyl]-7-methyl-5H-thiazolo-[3,2-a]pyrimidine-5-one
PRODUCT LINE Signal Transduction
PRODUCT CATEGORY Diacylglycerol Kinases / Related Products
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ALX-430-027-M005   5 mg 115.00 USD Add To Cart
Product Specification
FORMULA: C27H26FN3OS
MW: 459.6
CAS NUMBER: 93076-89-2
PURITY: ≥99%
APPEARANCE: Yellow powder.
SOLUBILITY: Soluble in DMSO, THF or DMF. Insoluble in water.
SHIPPING: AMBIENT
LONG TERM STORAGE: +4°C

Product Description
Potentiates the activity of protein kinase C (PKC) by inhibiting the diacylglycerol metabolism. Inhibits diacylglycerol kinase without affecting phosphodiesterase or phosphatidyl inositol kinase.
Product Specific Literature References
R 59 022, a diacylglycerol kinase inhibitor. Its effect on diacylglycerol and thrombin-induced C kinase activation in the intact platelet: D. de Chaffoy de Courcelles, et al.; J. Biol. Chem. 260, 15762 (1985) Abstract; Full Text
Further Categories Containing This Product:
PKC Activators
 
 
ALX-300-052 Revised 16-Apr-05
1,2-Dioctanoyl-sn-glycerol
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SYNONYMS DOG
PRODUCT LINE Signal Transduction
PRODUCT CATEGORY Mono- & Diacylglycerols
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ALX-300-052-M010   10 mg 30.00 USD Add To Cart
ALX-300-052-M050   50 mg 90.00 USD Add To Cart
ALX-300-052-M100   100 mg 150.00 USD Add To Cart
Product Specification
FORMULA: C19H36O5
MW: 344.5
CAS NUMBER: 60514-48-9
PURITY: ≥98%
APPEARANCE: Clear colorless liquid.
SOLUBILITY: Soluble in DMSO or chloroform.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
HANDLING: At room temperature DOG is an oil. Due to its instability, keep it cool and dry.

Product Description
Potent activator of protein kinase C (PKC).
Product Specific Literature References
Diacylglycerols release LH: structure-activity relations reveal a role for protein kinase C: P.M. Conn, et al.; BBRC 126, 532 (1985) Abstract
sn-1,2-Dioctanoylglycerol. A cell-permeable diacylglycerol that mimics phorbol diester action on the epidermal growth factor receptor and mitogenesis: R.J. Davis, et al.; J. Biol. Chem. 260, 1562 (1985) Abstract; Full Text
Diacylglycerols mimic phorbol diester induction of leukemic cell differentiation: J.G. Ebeling, et al.; PNAS 82, 815 (1985) Abstract
Activation of protein kinase C by Triton X-100 mixed micelles containing diacylglycerol and phosphatidylserine: Y.A. Hannun, et al.; J. Biol. Chem. 260, 10039 (1985) Abstract; Full Text
Exogenous sn-1,2-diacylglycerols containing saturated fatty acids function as bioregulators of protein kinase C in human platelets: E.G. Lapetina, et al.; J. Biol. Chem. 260, 1358 (1985) Abstract; Full Text
Further Categories Containing This Product:
PKC Activators
 
 
ALX-270-097 Revised 07-Sep-06
Ebselen
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SYNONYMS 2-Phenyl-1,2-benzisoselenazol-3-(2H)-one
PRODUCT LINE Oxidative Stress
PRODUCT CATEGORY Peroxynitrite / Scavengers / Detection
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ALX-270-097-M001   1 mg 12.00 USD Add To Cart
ALX-270-097-M005   5 mg 20.00 USD Add To Cart
ALX-270-097-M025   25 mg 60.00 USD Add To Cart
Product Specification
FORMULA: C13H9NOSe
MW: 274.2
CAS NUMBER: 60940-34-3
PURITY: ≥98% (NMR)
APPEARANCE: White to off-white crystalline solid.
SOLUBILITY: Soluble in DMSO.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
HANDLING: Protect from light.

Product Description
Selenium-based inhibitor of protein kinase C, NADPH, 5-lipoxygenase, cyclooxygenase (COX) and NADPH oxidase. Anti-inflammatory antioxidant. Mimics glutathione peroxidase. Inhibits oxidative modifications of low density lipoproteins (LDL).
Product Specific Literature References
A novel biologically active seleno-organic compound--III. Effects of PZ 51 (Ebselen) on glutathione peroxidase and secretory activities of mouse macrophages: M.J. Parnham & S. Kindt; Biochem. Pharmacol. 33, 3247 (1984) Abstract
Seleno-organic compounds and the therapy of hydroperoxide-linked pathological conditions: M.J. Parnham & E. Graf; Biochem. Pharmacol. 36, 3095 (1987) Abstract
Kinetic mechanism and substrate specificity of glutathione peroxidase activity of ebselen (PZ51): M. Maiorino, et al.; Biochem. Pharmacol. 37, 2267 (1988) Abstract
Studies on the anti-inflammatory activity of ebselen. Ebselen interferes with granulocyte oxidative burst by dual inhibition of NADPH oxidase and protein kinase C?: I.A. Cotgreave, et al.; Biochem. Pharmacol. 38, 649 (1989) Abstract
T. Nikawa, et al.; Biochem. Pharmacol. 47, 1007 (1994) Abstract
Effects of ebselen and probucol on oxidative modifications of lipid and protein of low density lipoprotein induced by free radicals: N. Noguchi, et al.; Biochim. Biophys. Acta 1213, 176 (1994) Abstract
Strong inhibition of mammalian lipoxygenases by the antiinflammatory seleno-organic compound ebselen in the absence of glutathione: C. Schewe, et al.; Biochem. Pharmacol. 48, 65 (1994) Abstract
Ebselen: a glutathione peroxidase mimic: H. Sies; Meth. Enzymol. 234, 476 (1994) Abstract
Molecular actions of ebselen-an antiinflammatory antioxidant: T. Schewe; Gen. Pharmacol. 26, 1153 (1995) Abstract
Ebselen: H. Sies; Meth. Enzymol. 252, 341 (1995) Abstract
Ebselen as a glutathione peroxidase mimic and as a scavenger of peroxynitrite: H. Sies & H. Masumoto; Adv. Pharmacol. 38, 229 (1997) Abstract
Free radical generation by selenium compounds and their prooxidant toxicity: J.E. Spallholz; Biomed. Environ. Sci. 10, 260 (1997) Abstract
Protection against peroxynitrite by selenoproteins: H. Sies, et al.; Z. Naturforsch. [C] 53, 228 (1998) Abstract
Ebselen protects mice against T cell-dependent, TNF-mediated apoptotic liver injury: G. Tiegs, et al.; J. Pharmacol. Exp. Ther. 287, 1098 (1998) Abstract; Full Text
 
 
ALX-155-021 Revised 29-Jun-05
EGF Receptor (human) (651-658)
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SYNONYMS Epidermal Growth Factor Receptor (human) (651-658)
EGFR (human) (651-658)
HER-1 (human) (651-658)
PRODUCT LINE Signal Transduction
PRODUCT CATEGORY EGF / EGF Receptor [EGFR] Kinase Other Products
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ALX-155-021-M001   1 mg 50.00 USD Add To Cart
ALX-155-021-M005   5 mg 200.00 USD Add To Cart
Product Specification
SEQUENCE: H-Arg-Lys-Arg-Thr-Leu-Arg-Arg-Leu-OH
FORMULA: C46H91N21O10
MW: 1098.4
PURITY: ≥97%
APPEARANCE: White lyophilized powder.
SOLUBILITY: Soluble in water.
LONG TERM STORAGE: -20°C
Product Description
Substrate for protein kinase C (PKC).
Product Specific Literature References
A novel N-myristylated synthetic octapeptide inhibits protein kinase C activity and partially reverses murine fibrosarcoma cell resistance to adriamycin: C.A. O'Brian, et al.; Invest. New Drugs 9, 169 (1991) Abstract
Further Categories Containing This Product:
PeptidesPKC Substrates
 
 
ALX-155-022 Revised 29-Jun-05
EGF Receptor (human) (651-658) (N-Myristoylated)
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SYNONYMS Epidermal Growth Factor Receptor (human) (651-658) (N-Myristoylated)
EGFR (human) (651-658) (N-Myristoylated)
HER-1 (human) (651-658) (N-Myristoylated)
PRODUCT LINE Signal Transduction
PRODUCT CATEGORY EGF / EGF Receptor [EGFR] Kinase Other Products
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ALX-155-022-M001   1 mg 60.00 USD Add To Cart
ALX-155-022-M005   5 mg 240.00 USD Add To Cart
Product Specification
SEQUENCE: Myr-Arg-Lys-Arg-Thr-Leu-Arg-Arg-Leu-OH
FORMULA: C60H117N21O11
MW: 1308.7
PURITY: ≥97%
APPEARANCE: White lyophilized powder.
SOLUBILITY: Soluble in water.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
Product Description
Potent, cell permeable and possibly selective inhibitor of protein kinase C (PKC). This product is the N-terminal myristoylated form of Prod. No. ALX-155-021.
Product Specific Literature References
A novel N-myristylated synthetic octapeptide inhibits protein kinase C activity and partially reverses murine fibrosarcoma cell resistance to adriamycin: C.A. O'Brian, et al.; Invest. New Drugs 9, 169 (1991) Abstract
Cyanobacteria secondary metabolites-the cyanotoxins: W.W. Carmichael; J. Appl. Bacteriol. 72, 445 (1992) Abstract
Inhibition of protein kinase C by N-myristoylated peptide substrate analogs: N.G. Ward & C.A. O'Brian; Biochemistry 32, 11903 (1993) Abstract
Further Categories Containing This Product:
PeptidesPKC Inhibitors
 
 
ALX-155-023 Revised 29-Jun-05
EGF Receptor (human) (652-657)
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SYNONYMS Epidermal Growth Factor Receptor (human) (652-657)
EGFR (human) (652-657)
HER-1 (human) (652-657)
PRODUCT LINE Signal Transduction
PRODUCT CATEGORY EGF / EGF Receptor [EGFR] Kinase Other Products
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ALX-155-023-M001   1 mg 45.00 USD Add To Cart
ALX-155-023-M005   5 mg 180.00 USD Add To Cart
Product Specification
SEQUENCE: H-Lys-Arg-Thr-Leu-Arg-Arg-OH
FORMULA: C34H68N16O8
MW: 829.0
PURITY: ≥97%
APPEARANCE: White lyophilized powder.
SOLUBILITY: Soluble in water.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
Product Description
Specific substrate (aa 652-657 of mature EGF receptor, without signal peptide (aa 1-24)) for protein kinase C (PKC).
Product Specific Literature References
Regulation of protein kinase C by nerve growth factor, epidermal growth factor, and phorbol esters in PC12 pheochromocytoma cells: L. Heasley & G.L. Johnson; J. Biol. Chem. 264, 8646 (1989) Abstract; Full Text
Further Categories Containing This Product:
PeptidesPKC Substrates
 
 
ALX-270-263 Revised 03-Apr-08
(-)-Epigallocatechin gallate
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SYNONYMS EGCG
(2R,3R)-2-(3,4,5-Trihydroxyphenyl)-3,4-dihydro-1[2H]-benzopyran-3,5,7-triol 3-(3,4,5-trihydroxybenzoate)
PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Natural Products - Antioxidants
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ALX-270-263-M010   10 mg 20.00 USD Add To Cart
ALX-270-263-M050   50 mg 60.00 USD Add To Cart
Product Specification
FORMULA: C22H18O11
MW: 458.4
CAS NUMBER: 989-51-5
MERCK INDEX: 14: 3526
SOURCE/HOST: Isolated from green tea.
PURITY: ≥98% (HPLC)
APPEARANCE: Off-white to yellow powder.
SOLUBILITY: Soluble in 100% ethanol, dimethyl formamide or DMSO; slightly soluble in water.
SHIPPING: AMBIENT
LONG TERM STORAGE: +4°C
USE/STABILITY: Stock solutions in DMSO are stable for up to 3 months when stored at -20°C.
HANDLING: After reconstitution, prepare aliquots and store at -20°C. Keep under inert gas. Protect from light.

Product Description
Antitumor reagent. Antioxidant. Protects cells from lipid peroxidation and DNA damage induced by reactive free radicals. Inhibits inducible nitric oxide synthase (iNOS; NOS II). Chemopreventive anticancer agent. Induces apoptosis in human cancer cell lines. Inhibits MAP kinase mediated signalling pathways. Inhibits angiogenesis. Inhibits telomerase and DNA methyltransferase. Anti-inflammatory agent.
Product Specific Literature References
Inhibitory effect of topical application of a green tea polyphenol fraction on tumor initiation and promotion in mouse skin: M.T. Huang, et al.; Carcinogenesis 13, 947 (1992) Abstract
Inhibition of 12-O-tetradecanoylphorbol-13-acetate and other skin tumor-promoter-caused induction of epidermal interleukin-1 alpha mRNA and protein expression in SENCAR mice by green tea polyphenols: S.K. Katiyar, et al.; J. Invest. Dermatol. 105, 394 (1995) Abstract
Growth inhibition and regression of human prostate and breast tumors in athymic mice by tea epigallocatechin gallate: S. Liao, et al.; Cancer Lett. 96, 239 (1995) Abstract
Inhibition of N-methyl-N'-nitro-N-nitrosoguanidine-induced carcinogenesis by (-)-epigallocatechin gallate in the rat glandular stomach: T. Yamane, et al.; Cancer Res. 55, 2081 (1995) Abstract
(-)-Epigallocatechin gallate, a polyphenolic tea antioxidant, inhibits peroxynitrite-mediated formation of 8-oxodeoxyguanosine and 3-nitrotyrosine: E.S. Fiala, et al.; Experientia 52, 922 (1996) Abstract
Green tea constituent epigallocatechin-3-gallate and induction of apoptosis and cell cycle arrest in human carcinoma cells: N. Ahmad, et al.; J. Natl. Cancer Inst. 89, 1881 (1997) Abstract
Inhibition of inducible nitric oxide synthase gene expression and enzyme activity by epigallocatechin gallate, a natural product from green tea: M.M. Chan, et al.; Biochem. Pharmacol. 54, 1281 (1997) Abstract
(-)-Epigallocatechin-3-gallate blocks the induction of nitric oxide synthase by down-regulating lipopolysaccharide-induced activity of transcription factor nuclear factor-kappaB: Y.L. Lin & J.K. Lin; Mol. Pharmacol. 52, 465 (1997) Abstract
Telomerase inhibition, telomere shortening, and senescence of cancer cells by tea catechins: I. Naasani, et al.; BBRC 249, 391 (1998) Abstract
Epigallocatechin suppression of proliferation of vascular smooth muscle cells: correlation with c-jun and JNK: L.H. Lu, et al.; Br. J. Pharmacol. 124, 1227 (1998) Abstract
ESR study on the structure-antioxidant activity relationship of tea catechins and their epimers: Q. Guo, et al.; Biochim. Biophys. Acta 1427, 13 (1999) Abstract
Pharmacokinetics of the green tea derivative, EGCG, by the topical route of administration in mouse and human skin: K. Dvorakova, et al.; Cancer Chemother. Pharmacol. 43, 331 (1999) Abstract
Polyphenolic antioxidant (-)-epigallocatechin-3-gallate from green tea reduces UVB-induced inflammatory responses and infiltration of leukocytes in human skin: S.K. Katiyar, et al.; Photochem. Photobiol. 69, 148 (1999) Abstract
Antioxidant chemistry of green tea catechins. Identification of products of the reaction of (-)-epigallocatechin gallate with peroxyl radicals: S. Valcic, et al.; Chem. Res. Toxicol. 12, 382 (1999) Abstract
Antimutagenic and anticarcinogenic activity of tea polyphenols: Y. Kuroda & Y. Hara; Mutat. Res. 436, 69 (1999) Abstract
Inhibitory effect of green and black tea on tumor growth: A.H. Conney, et al.; Proc. Soc. Exp. Biol. Med. 220, 229 (1999) Abstract
Green tea epigallocatechin gallate: a natural inhibitor of fatty-acid synthase: X. Wang & W. Tian; BBRC 288, 1200 (2001) Abstract
Epigallocatechin gallate, a constituent of green tea, represses hepatic glucose production: M.E. Waltner-Law, et al.; J. Biol. Chem. 277, 34933 (2002) Abstract; Full Text
The specificities of protein kinase inhibitors: an update:: J. Bain, et al.; Biochem. J. 371, 199 (2003) Abstract; Full Text
Selective inhibition of ADAMTS-1, -4 and -5 by catechin gallate esters: M.N. Vankemmelbeke, et al.; Eur. J. Biochem. 270, 2394 (2003) Abstract
Epigallocatechin-3-gallate, constituent of green tea, suppresses the LPS-induced phenotypic and functional maturation of murine dendritic cells through inhibition of mitogen-activated protein kinases and NF-kappaB: S.C. Ahn, et al.; BBRC 313, 148 (2004) Abstract
Epigallocatechin-3-gallate inhibits epidermal growth factor receptor signaling pathway. Evidence for direct inhibition of ERK1/2 and AKT kinases: J.F. Sah, et al.; J. Biol. Chem. 279, 12755 (2004) Abstract
Inhibition of c-Jun NH2-terminal kinase activity improves ischemia/reperfusion injury in rat lungs: M. Ishii, et al.; J. Immunol. 172, 2569 (2004) Abstract
A constituent of green tea, epigallocatechin-3-gallate, activates endothelial nitric oxide synthase by a phosphatidylinositol-3-OH-kinase-, cAMP-dependent protein kinase-, and Akt-dependent pathway and leads to endothelial-dependent vasorelaxation: M. Lorenz, et al.; J. Biol. Chem. 279, 6190 (2004) Abstract; Full Text
Green tea polyphenols prevent toxin-induced hepatotoxicity in mice by down-regulating inducible nitric oxide-derived prooxidants: J.H. Chen, et al.; Am. J. Clin. Nutr. 80, 742 (2004) Abstract; Full Text
Neuroprotective effects of (-)-epigallocatechin gallate following hypoxia-ischemia-induced brain damage: novel mechanisms of action: B.A. Sutherland, et al.; FASEB J. 19, 258 (2005) Abstract; Full Text
Tea flavanols inhibit angiotensin-converting enzyme activity and increase nitric oxide production in human endothelial cells: I.A. Persson, et al.; J. Pharm. Pharmacol. 58, 1139 (2006) Abstract
General Literature References
Anticarcinogenic effects of (-)-epigallocatechin gallate: H. Fujiki, et al.; Prev. Med. 21, 503 (1992), (Review) Abstract
Absorption, metabolism and antioxidative effects of tea catechin in humans: T. Miyazawa; Biofactors 13, 55 (2000), (Review) Abstract
Inhibition of tumour invasion and angiogenesis by epigallocatechin gallate (EGCG), a major component of green tea: Y.D. Jung and L.M. Ellis; Int. J. Exp. Pathol