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ALX-153-064 Revised 31-Aug-07
Caveolin-1 Scaffolding Domain Peptide
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SYNONYMS Cavtratin
AP-Cav
Pen-C1-SD
PRODUCT LINE Protein Synthesis, Modification & Degradation
PRODUCT CATEGORY Caveolae / Related Products
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ALX-153-064-M001   1 mg 140.00 USD Add To Cart
ALX-153-064-M005   5 mg 560.00 USD Add To Cart
Product Specification
SEQUENCE: H-Arg-Gln-Ile-Lys-Ile-Trp-Phe-Gln-Asn-Arg-Arg-Met-Lys-Trp-Lys-Lys-Asp-Gly-Ile-Trp-Lys-Ala-Ser-Phe-Thr-Thr-Phe-Thr-Val-Thr-Lys-Tyr-Trp-Phe-Tyr-Arg-OH
FORMULA: C228H335N61O49S
MW: 4746.6
APPEARANCE: ≥97% (HPLC)
SOLUBILITY: Soluble in DMSO or acentonitrile:water (50:50).
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
USE/STABILITY: Stock solutions are stable for up to 3 months when stored at -20°C.
HANDLING: Hygroscopic. Protect from light.
HAZARD: MAY BE CARCINOGENIC. HARMFUL.
Product Description
Cell permeable peptide that blocks eNOS (NOS III) activity and cellular nitric oxide (NO) release in vitro and reduces inflammation and tumorigenesis in vivo. Caveolin-1 interacts with several lipid-modified signalling ligands, such as EGFR, eNOS, G-protein α-subunits, PKCα, H-Ras, and Src, via the C1-SD82-101 sequence.
Product Specific Literature References
Caveolins, a family of scaffolding proteins for organizing "preassembled signaling complexes" at the plasma membrane: T. Okamoto, et al.; J. Biol. Chem. 273, 4519 (1998) Abstract; Full Text
In vivo delivery of the caveolin-1 scaffolding domain inhibits nitric oxide synthesis and reduces inflammation: M. Bucci, et al.; Nat. Med. 6, 1362 (2000) Abstract; Full Text
Selective inhibition of tumor microvascular permeability by cavtratin blocks tumor progression in mice: J.P. Gratton, et al.; Cancer Cell 4, 31 (2003) Abstract; Full Text
Caveolin-1 gene disruption promotes mammary tumorigenesis and dramatically enhances lung metastasis in vivo. Role of Cav-1 in cell invasiveness and matrix metalloproteinase (MMP-2/9) secretion: T.M. Williams, et al.; J. Biol. Chem. 279, 51630 (2004) Abstract; Full Text
Dissecting the molecular control of endothelial NO synthase by caveolin-1 using cell-permeable peptides: P.N. Bernatchez, et al.; PNAS 102, 761 (2005) Abstract; Full Text
Further Categories Containing This Product:
Peptides • NOS Inhibitors (NOS Induction & Enzyme Activity) • NOS Regulation • Cancer Other Products
 
 
ALX-201-246 Revised 24-Apr-08
Matriptase (human) (recombinant)
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SYNONYMS MT-SP1 (human) (recombinant)
Membrane-type Serine Protease 1 (human) (recombinant)
ST14 (human) (recombinant)
Suppression of Tumorigenicity Protein 14 (human) (recombinant)
TADG-15 (human) (recombinant)
Tumor-associated Differentially Expressed Gene 15 Protein (human) (recombinant)
SNC19 (human) (recombinant)
PRODUCT LINE Signal Transduction
PRODUCT CATEGORY Proteases Other Products
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ALX-201-246-U125   125 U 360.00 USD Add To Cart
Product Specification
MW: ~25kDa
SOURCE/HOST: Recombinant human matriptase (aa 596-855) fused at the N-terminus to a His-tag.
CONCENTRATION: 100nM
PURITY: ≥98% (SDS-PAGE)
FORMULATION: Liquid. In 100mM TRIS, pH 9.0, containing 200mM sodium chloride, 1mM β-mercaptoethanol and 10% glycerol.
ACTIVITY: Trypsin-like serine protease.
SPECIFIC ACTIVITY: ~2.5U/µl. One unit is defined as the amount of enzyme that releases 1nmol of AMC per min. at 37°C in the presence of 50µM of Boc-Gln-Ala-Arg-AMC.
SHIPPING: SHIPPED ON DRY ICE
SHORT TERM STORAGE: -20°C
LONG TERM STORAGE: -80°C
USE/STABILITY: Stable for at least 6 months when stored at -20°C. Do not store diluted solutions.
HANDLING: Avoid freeze/thaw cycles.
Product Specific Literature References
Reverse biochemistry: use of macromolecular protease inhibitors to dissect complex biological processes and identify a membrane-type serine protease in epithelial cancer and normal tissue: T. Takeuchi, et al.; PNAS 96, 11054 (1999) Abstract; Full Text
Inhibition of human matriptase by eglin c variants: A. Désilets, et al.; FEBS Lett. 580, 2227 (2006) Abstract
General Information
BACKGROUND/TECHNICAL INFORMATION Recommended Assay Buffer:
100mM TRIS, pH 9.5, containing 5mg/ml BSA.
Further Categories Containing This Product:
Recombinant Proteins / Fusion Proteins • Cancer Other Products • Cytoskeleton & Extracellular Matrix Other Products
 
 
ALX-201-259 Revised 26-Feb-07
Recoverin (human) (recombinant)
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SYNONYMS CAR (human) (recombinant)
Cancer-associated Retinopathy Protein (human) (recombinant)
PRODUCT LINE Signal Transduction
PRODUCT CATEGORY Calcium Signalling (Intracellular) Other Products
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ALX-201-259-C100   100 µg 430.00 USD Add To Cart
Product Specification
MW: ~23kDa
SOURCE/HOST: Produced in E. coli.
CONCENTRATION: 1mg/ml
PURITY: ≥95% (SDS-PAGE)
FORMULATION: Liquid. In 20mM TRIS, pH 8.0, containing 1mM EDTA, 2mM MgCl2 and 10% glycerol.
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: -20°C
HANDLING: Avoid freeze/thaw cycles.
Product Specific Literature References
Cloning, expression, and crystallization of recoverin, a calcium sensor in vision: S. Ray, et al.; PNAS 89, 5705 (1992) Abstract; Full Text
The effect of recombinant recoverin on the photoresponse of truncated rod photoreceptors: M.A. Erickson, et al.; PNAS 95, 6474 (1998) Abstract; Full Text
Cerebrospinal fluid (vascular endothelial growth factor) and serologic (recoverin) tumor markers for malignant glioma: P. Sampath, et al.; Cancer Control 11, 174 (2004) Abstract; Full Text
Further Categories Containing This Product:
Vision Research • Recombinant Proteins / Fusion Proteins • Cancer Other Products
 
 
ALX-210-248 Revised 23-Apr-08
Polyclonal Antibody to PAR-4
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SYNONYMS anti-Prostate Apoptosis Response Protein-4 PAb
PRODUCT LINE Cell Death / Apoptosis / Autophagy
PRODUCT CATEGORY Cell Death / Apoptosis / Autophagy Other Products
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ALX-210-248-C200   200 µg 379.00 USD Add To Cart
Product Specification
SPECIES CROSSREACTIVITY:
Human
Rat
SOURCE/HOST: From rabbit.
CONCENTRATION: 1mg/ml.
FORMULATION: Liquid. Epitope-affinity purified IgG in PBS containing 1mg/ml BSA and 0.05% sodium azide.
IMMUNOGEN: Synthetic peptide corresponding to aa 324-342 (CE324QLKQENKT
LLKVVGQLTR342) of human PAR-4 (prostate apoptosis response protein-4).
SPECIFICITY: Recognizes human and rat PAR-4. Detects a band of ~40kDa by Western blot.
APPLICATION: Western Blot (2µg/ml)
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: -20°C
HANDLING: Avoid freeze/thaw cycles.
BLOCKING PEPTIDE: For Blocking Peptide see Prod. No. ALX-165-044.
General Information
Prostate apotosis response-4 (PAR-4) is a leucine zipper domain protein that is widely expressed in diverse normal and cancerous cell types and tissues. It is known as a tumor-suppressor protein that induces apoptosis in cancer cells, but not in normal/immortalized cells. The cancer-specific proapoptotic fuction of PAR-4 is localized in its central core SAC domain. Y. Zhao, et al. characterized a novel mouse model with ubiquitous expression of the SAC domain. Their findings provided genetic evidence that the SAC domain of PAR-4 confers cancer resistance in transgenic mice without compromising normal viability or aging, and may have therapeutic significance. PAR-4 has also been observed at ~18 times higher concentration in human brain tissue from Alzheimer patients when compared to unaffected brain tissue.
General Literature References
Expression and function of the leucine zipper protein Par-4 in apoptosis: S.F. Sells, et al.; Mol. Cell Biol. 17, 3823 (1997) Abstract; Full Text
Cancer resistance in transgenic mice expressing the SAC module of Par-4: Y. Zhao, et al.; Cancer Res. 67, 9276 (2007) Abstract
Further Categories Containing This Product:
Cancer Other Products • Polyclonal Antibodies
 
 
ALX-210-536 Revised 31-Oct-06
Polyclonal Antibody to p130Cas
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SYNONYMS anti-CRK-associated Substrate PAb
anti-CRKAS PAb
anti-Breast Cancer anti-estrogen Resistance 1 Protein PAb
anti-BCAR1 PAb
PRODUCT LINE Signal Transduction
PRODUCT CATEGORY Adaptor Proteins & Interaction Domains Other Products
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ALX-210-536-R100   100 µl 220.00 USD Add To Cart
Product Specification
SPECIES CROSSREACTIVITY:
Human
Mouse
SOURCE/HOST: From rabbit.
PURITY: Liquid. Neat serum containing 0.05% sodium azide.
IMMUNOGEN: Recombinant mouse p130Cas (CRK-associated substrate; BCAR1) C-terminal portion (aa 675-874).
SPECIFICITY: Recognizes human and mouse p130Cas.
APPLICATION: ELISA
Immunoprecipitation
Note: Does not work for Western Blot.
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: -20°C
HANDLING: Avoid freeze/thaw cycles.
Further Categories Containing This Product:
Tyrosine Kinases Other Products • Cancer Other Products • Polyclonal Antibodies
 
 
ALX-210-948 Revised 18-Jun-08
Polyclonal Antibody to ILEI (AT123)
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SYNONYMS anti-Interleukin-like EMT Inducer PAb (AT123)
anti-FAM3C PAb (AT123)
PRODUCT LINE Chemokines & Cytokines
PRODUCT CATEGORY Chemokines & Cytokines Other Products
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ALX-210-948-C100   100 µg 350.00 USD Add To Cart
Product Specification
SPECIES CROSSREACTIVITY:
Human
Mouse
SOURCE/HOST: From rabbit.
CONCENTRATION: 1mg/ml
PURITY DETAIL: Protein A-affinity purified.
FORMULATION: Liquid. In PBS containing 0.02% sodium azide.
IMMUNOGEN: Recombinant mouse ILEI (aa 25-227) (Prod. No. ALX-522-119).
SPECIFICITY: Recognizes human and mouse ILEI.
APPLICATION: Immunoprecipitation (1:200)
Western Blot (1:1’000)
SHIPPING: SHIPPED ON BLUE ICE
SHORT TERM STORAGE: +4°C
LONG TERM STORAGE: -20°C
USE/STABILITY: Stable for at least 1 year after receipt when stored at -20°C.
HANDLING: After reconstitution, prepare aliquots and store at -20°C. Avoid freeze/thaw cycles.
General Information
In 2006, T. Waerner, et al. characterized ILEI as a key player in both epithelial to mesenchymal transition and late-stage carcinoma progression. EMT is a process that involves changes in gene expression, cytoskeleton organization, cell adhesion, and extracellular matrix composition. This process is important during tissue formation and organogenesis, but also during cancer progression, metastasis and chronic inflammation. ILEI is overexpressed and/or altered in intracellular localization in multiple human tumors, an event strongly correlated to invasion/EMT, metastasis formation, and survival in human colon and breast cancer.
MANUFACTURER Manufactured by Apotech Corporation.
General Literature References
Cloning, expression, and initial characterization of a novel cytokine-like gene family: Y. Zhu; Genomics 80, 144 (2002) Abstract
ILEI: a cytokine essential for EMT, tumor formation, and late events in metastasis in epithelial cells: T. Waerner, et al.; Cancer Cell 10, 227 (2006) Abstract
Further Categories Containing This Product:
Transforming Growth Factor beta [TGFbeta] & Receptors / Related Products • Cancer Other Products • Polyclonal Antibodies
 
 
ALX-215-049 Revised 21-Aug-08
Polyclonal Antibody to HERG1 (CT) (pan)
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SYNONYMS anti-Erg1 (CT) (pan) PAb
anti-Ether-a-go-go Related Protein 1 (CT) (pan) PAb
anti-KCNH2 (CT) (pan) PAb
anti-Voltage-gated Potassium Channel Subfamily H Member 2 (CT) (pan) PAb
anti-Voltage-gated Potassium Channel Kv11.1 (CT) (pan) PAb
PRODUCT LINE Signal Transduction
PRODUCT CATEGORY K+ Channel Antibodies
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ALX-215-049-R100   100 µl 270.00 USD Add To Cart
Product Specification
SPECIES CROSSREACTIVITY:
Human
Mouse
SOURCE/HOST: From rabbit.
FORMULATION: Liquid. Neat serum.
IMMUNOGEN: Recombinant HERG1 (human ether-a-go-go related protein 1) (aa 1106-1158).
SPECIFICITY: Recognizes C-terminal epitope of HERG1 and mouse Erg1. Recognizes both isoforms HERG1A and HERG1B.
APPLICATION: Flow Cytometry (1:1'000)
Immunocytochemistry (1:100-1:200)
Immunohistochemistry (frozen sections, paraffin sections) (1:100-1:400)
Western Blot (1:1'000)
SHIPPING: SHIPPED ON BLUE ICE
SHORT TERM STORAGE: +4°C
LONG TERM STORAGE: -20°C
HANDLING: Avoid freeze/thaw cycles.
Product Specific Literature References
herg1 gene and HERG1 protein are overexpressed in colorectal cancers and regulate cell invasion of tumor cells: E. Lastraioli, et al.; Cancer Res. 64, 606 (2004) Abstract; Full Text
Human ether-a-go-go-related gene 1 channels are physically linked to beta1 integrins and modulate adhesion-dependent signaling: A. Cherubini, et al.; Mol. Biol. Cell 16, 2972 (2005) Abstract; Full Text
Expression pattern of the ether-a-go-go-related (ERG) family proteins in the adult mouse central nervous system: evidence for coassembly of different subunits: L. Guasti, et al.; J. Comp. Neurol. 491, 157 (2005) Abstract
hERG1 channels are overexpressed in glioblastoma multiforme and modulate VEGF secretion in glioblastoma cell lines: A. Masi, et al.; Br. J. Cancer 93, 781 (2005) Abstract
Identification of a post-translational mechanism for the regulation of hERG1 K+ channels expression and hERG1 current density in tumor cells: L. Guasti, et al.; Mol. Cell. Biol. 28, 5043 (2008) Abstract
General Information

The ether-a-go-go related gene family of K+ channels (HERG/Erg) comprises three members, HERG1/Erg1, HERG2/Erg2, HERG3/Erg3. HERG channel activity is relevant to tumor cell biology. It controls cell proliferation, especially in leukaemias. HERG channels are thus considered novel diagnostic and prognostic factors in human cancers, as well as targets for anti-neoplastic therapies.
Further Categories Containing This Product:
Cancer Other Products • Polyclonal Antibodies
 
 
ALX-215-050 Revised 22-Feb-07
Polyclonal Antibody to HERG1A (NT)
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SYNONYMS anti-Erg1A (NT) PAb
anti-Ether-a-go-go Related Protein 1A (NT) PAb
anti-KCNH2 (Isoform A) (NT) PAb
anti-Voltage-gated Potassium Channel Subfamily H Member 2 (Isoform A) (NT) PAb
anti-Voltage-gated Potassium Channel Kv11.1 (Isoform A) (NT) PAb
PRODUCT LINE Signal Transduction
PRODUCT CATEGORY K+ Channel Antibodies
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ALX-215-050-R100   100 µl 270.00 USD Add To Cart
Product Specification
SPECIES CROSSREACTIVITY:
Human
Mouse
SOURCE/HOST: From rabbit.
FORMULATION: Liquid. Neat serum.
IMMUNOGEN: Recombinant HERG1 (human ether-a-go-go related protein 1) (aa 1-135).
SPECIFICITY: Recognizes N-terminal epitope of HERG1A and mouse Erg1A isoform.
APPLICATION: Immunocytochemistry (1:50-1:200)
Immunohistochemistry (frozen sections, paraffin sections) (1:100-1:400)
Immunoprecipitation (5µl/1.5mg protein)
SHIPPING: SHIPPED ON BLUE ICE
SHORT TERM STORAGE: +4°C
LONG TERM STORAGE: -20°C
HANDLING: Avoid freeze/thaw cycles.
Product Specific Literature References
HERG potassium channels are more frequently expressed in human endometrial cancer as compared to non-cancerous endometrium: A. Cherubini, et al.; Br. J. Cancer 83, 1722 (2000) Abstract
Cell cycle-dependent expression of HERG1 and HERG1B isoforms in tumor cells: O. Crociani, et al.; J. Biol. Chem. 278, 2947 (2003) Abstract; Full Text
Human ether-a-go-go-related gene 1 channels are physically linked to beta1 integrins and modulate adhesion-dependent signaling: A. Cherubini, et al.; Mol. Biol. Cell 16, 2972 (2005) Abstract; Full Text
Expression pattern of the ether-a-go-go-related (ERG) family proteins in the adult mouse central nervous system: evidence for coassembly of different subunits: L. Guasti, et al.; J. Comp. Neurol. 491, 157 (2005) Abstract
Interneurons transiently express the ERG K+ channels during development of mouse spinal networks in vitro: F. Furlan, et al.; Neuroscience 135, 1179 (2005) Abstract
General Information
The ether-a-go-go related gene family of K+ channels (HERG/Erg) comprises three members, HERG1/Erg1, HERG2/Erg2, HERG3/Erg3. HERG channel activity is relevant to tumor cell biology. It controls cell proliferation, especially in leukaemias. HERG channels are thus considered novel diagnostic and prognostic factors in human cancers, as well as targets for anti-neoplastic therapies.
Further Categories Containing This Product:
Cancer Other Products • Cancer Other Products • Polyclonal Antibodies
 
 
ALX-215-051 Revised 24-Jun-08
Polyclonal Antibody to HERG1B
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SYNONYMS anti-Erg1B PAb
anti-Ether-a-go-go Related Protein 1B PAb
anti-KCNH2 (Isoform B) PAb
anti-Voltage-gated Potassium Channel Subfamily H Member 2 (Isoform B) PAb
anti-Voltage-gated Potassium Channel Kv11.1 (Isoform B) PAb
PRODUCT LINE Signal Transduction
PRODUCT CATEGORY K+ Channel Antibodies
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ALX-215-051-R100   100 µl 270.00 USD Add To Cart
Product Specification
SPECIES CROSSREACTIVITY:
Human
Mouse
SOURCE/HOST: From rabbit.
PURITY DETAIL: Affinity purified.
FORMULATION: Liquid. In 100mM TRIS containing 100mM glycine.
IMMUNOGEN: Synthetic peptide corresponding to aa 15-28 (R15PRAQKGRVRRAVR28) of HERG1B (human ether-a-go-go related protein 1B).
SPECIFICITY: Recognizes HERG1B and mouse Erg1B isoform.
APPLICATION: Immunocytochemistry (1:50-1:200)
Immunohistochemistry (frozen sections) (1:100)
Western Blot (1:1'000)
SHIPPING: SHIPPED ON BLUE ICE
SHORT TERM STORAGE: -20°C
LONG TERM STORAGE: -80°C
HANDLING: Avoid freeze/thaw cycles. After opening, prepare aliquots and store at -80°C.
Product Specific Literature References
Human ether-a-go-go-related gene 1 channels are physically linked to beta1 integrins and modulate adhesion-dependent signaling: A. Cherubini, et al.; Mol. Biol. Cell 16, 2972 (2005) Abstract; Full Text
Interneurons transiently express the ERG K+ channels during development of mouse spinal networks in vitro: F. Furlan, et al.; Neuroscience 135, 1179 (2005) Abstract
Expression pattern of the ether-a-go-go-related (ERG) family proteins in the adult mouse central nervous system: evidence for coassembly of different subunits: L. Guasti, et al.; J. Comp. Neurol. 491, 157 (2005) Abstract
Identification of a post-translational mechanism for the regulation of hERG1 K+ channels expression and hERG1 current density in tumor cells: L. Guasti, et al.; Mol. Cell. Biol. Epub ahead of print, (2008) Abstract
General Information
The ether-a-go-go related gene family of K+ channels (HERG/Erg) comprises three members, HERG1/Erg1, HERG2/Erg2, HERG3/Erg3. HERG channel activity is relevant to tumor cell biology. It controls cell proliferation, especially in leukaemias. HERG channels are thus considered novel diagnostic and prognostic factors in human cancers, as well as targets for anti-neoplastic therapies.
Further Categories Containing This Product:
Cancer Other Products • Polyclonal Antibodies
 
 
ALX-215-052 Revised 01-Jun-07
Polyclonal Antibody to HERG2
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SYNONYMS anti-Erg2 PAb
anti-Ether-a-go-go Related Protein 2 PAb
anti-KCNH6 PAb
anti-Voltage-gated Potassium Channel Subfamily H Member 6 PAb
anti-Voltage-gated Potassium Channel Kv11.2 PAb
PRODUCT LINE Signal Transduction
PRODUCT CATEGORY K+ Channel Antibodies
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ALX-215-052-R100   100 µl 270.00 USD Add To Cart
Product Specification
SPECIES CROSSREACTIVITY:
Human
Mouse
SOURCE/HOST: From rabbit.
PURITY DETAIL: Protein A-affinity purified.
FORMULATION: Liquid. In 100mM TRIS containing 100mM glycine.
IMMUNOGEN: Recombinant human HERG2 (ether-a-go-go related protein 2) (aa 907-986).
SPECIFICITY: Recognizes HERG2 and mouse Erg2.
APPLICATION: Immunocytochemistry (1:50-1:200)
Immunohistochemistry (frozen sections, paraffin sections) (1:100-1:400)
SHIPPING: SHIPPED ON BLUE ICE
SHORT TERM STORAGE: -20°C
LONG TERM STORAGE: -80°C
HANDLING: Avoid freeze/thaw cycles. After opening, prepare aliquots and store at -80°C.
Product Specific Literature References
Interneurons transiently express the ERG K+ channels during development of mouse spinal networks in vitro: F. Furlan, et al.; Neuroscience 135, 1179 (2005) Abstract
Expression pattern of the ether-a-go-go-related (ERG) family proteins in the adult mouse central nervous system: evidence for coassembly of different subunits: L. Guasti, et al.; J. Comp. Neurol. 491, 157 (2005) Abstract
General Information