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ALX-270-139
Revised 25-Nov-04
Tyrphostin AG 370
SYNONYMS
Tyrphostin B7
2-Amino-4-(1
H
-indol-5-yl)-1,1,3-tricyanobuta-1,3-diene
PRODUCT LINE
Signal Transduction
PRODUCT CATEGORY
Tyrphostins
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-270-139-M001
1 mg
50.00 USD
ALX-270-139-M005
5 mg
190.00 USD
Product Specification
FORMULA:
C
15
H
9
N
5
MW:
259.3
PURITY:
≥99%
APPEARANCE:
Yellow solid.
SOLUBILITY:
Soluble in DMSO.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
HANDLING:
Store tightly sealed in the dark. Protect from light.
Product Specific Literature References
Inhibition of protein-tyrosine kinases by tyrphostins:
A. Levitzki, et al.; Meth. Enzymol.
201
, 347 (1991)
Abstract
Inhibition of platelet-derived growth factor-induced mitogenesis and tyrosine kinase activity in cultured bone marrow fibroblasts by tyrphostins:
M.C. Bryckaert; Exp. Cell. Res.
199
, 255 (1992)
Abstract
ALX-270-141
Revised 07-Dec-04
Tyrphostin AG 527
SYNONYMS
Tyrphostin B44
(-)-(R)-N-(α-Methylbenzyl)-3,4-dihydroxybenzylidenecyanoacetamide
PRODUCT LINE
Signal Transduction
PRODUCT CATEGORY
Tyrphostins
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-270-141-M005
5 mg
25.00 USD
ALX-270-141-M025
25 mg
90.00 USD
Product Specification
FORMULA:
C
18
H
16
N
2
O
3
MW:
308.3
CAS NUMBER:
133550-32-0
PURITY:
≥98%
SOLUBILITY:
Soluble in DMSO or 100% ethanol.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
HANDLING:
Store tightly sealed in the dark. Protect from light.
Product Specific Literature References
Tyrphostins. 2. Heterocyclic and alpha-substituted benzylidenemalononitrile tyrphostins as potent inhibitors of EGF receptor and ErbB2/neu tyrosine kinases:
A. Gazit, et al.; J. Med. Chem.
34
, 1896 (1991)
Abstract
Further Categories Containing This Product:
EGFR Kinase Inhibitors
•
Tyrosine Kinase Inhibitors
ALX-270-142
Revised 11-Dec-04
Tyrphostin AG 555
SYNONYMS
Tyrphostin B46
N-(3-Phenylpropyl)-3,4-dihydroxy-benzylidenecyanoacetamide
α-Cyano-(3,4-dihydroxy)-N-(3-phenylpropyl)cinnamamide
PRODUCT LINE
Signal Transduction
PRODUCT CATEGORY
Tyrphostins
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-270-142-M005
5 mg
25.00 USD
ALX-270-142-M025
25 mg
90.00 USD
Product Specification
FORMULA:
C
19
H
18
N
2
O
3
MW:
322.4
PURITY:
≥98%
SOLUBILITY:
Soluble in DMSO or ethanol.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
HANDLING:
Store tightly sealed in the dark. Protect from light.
Product Specific Literature References
Tyrphostins. 2. Heterocyclic and alpha-substituted benzylidenemalononitrile tyrphostins as potent inhibitors of EGF receptor and ErbB2/neu tyrosine kinases:
A. Gazit, et al.; J. Med. Chem.
34
, 1896 (1991)
Abstract
Further Categories Containing This Product:
EGFR Kinase Inhibitors
•
Tyrosine Kinase Inhibitors
ALX-270-143
Revised 20-Feb-08
Tyrphostin AG 494
SYNONYMS
Tyrphostin B48
N-Phenyl-3,4-dihydroxybenzylidenecyanoacetamide
α-Cyano-(3,4-dihydroxy)-N-phenylcinnamamide
PRODUCT LINE
Signal Transduction
PRODUCT CATEGORY
Tyrphostins
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
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ALX-270-143-M005
5 mg
25.00 USD
ALX-270-143-M025
25 mg
90.00 USD
Product Specification
FORMULA:
C
16
H
12
N
2
O
3
MW:
280.3
CAS NUMBER:
133550-35-3
PURITY:
≥98%
APPEARANCE:
Yellow solid.
SOLUBILITY:
Soluble in DMSO or 100% ethanol.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
HANDLING:
Protect from light.
Product Description
Blocks CDK2 activation and causes cells to arrest at late G1 and during S phase.
Product Specific Literature References
Tyrphostins. 2. Heterocyclic and alpha-substituted benzylidenemalononitrile tyrphostins as potent inhibitors of EGF receptor and ErbB2/neu tyrosine kinases:
A. Gazit, et al.; J. Med. Chem.
34
, 1896 (1991)
Abstract
Tyrphostin AG 494 blocks Cdk2 activation:
N. Osherov & A. Levitzki; FEBS Lett.
410
, 187 (1997)
Abstract
Inhibition of Cdk2 activation by selected tyrphostins causes cell cycle arrest at late G1 and S phase:
N. Kleinberger-Doron, et al.; Exp. Cell Res.
241
, 340 (1998)
Abstract
Further Categories Containing This Product:
EGFR Kinase Inhibitors
•
Tyrosine Kinase Inhibitors
•
CDK & Cyclin Inhibitors
•
Cell Cycle Blockers & Inhibitors / Related Products
ALX-270-144
Revised 07-Dec-04
Tyrphostin AG 835
SYNONYMS
Tyrphostin B50
(+)-(S)-N-(α-Methylbenzyl)-3,4-dihydroxybenzylidenecyanoacetamide
PRODUCT LINE
Signal Transduction
PRODUCT CATEGORY
Tyrphostins
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-270-144-M005
5 mg
25.00 USD
ALX-270-144-M025
25 mg
90.00 USD
Product Specification
FORMULA:
C
18
H
16
N
2
O
3
MW:
308.3
CAS NUMBER:
133550-37-5
PURITY:
≥98%
APPEARANCE:
Yellow solid.
SOLUBILITY:
Soluble in DMSO or 100% ethanol.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
HANDLING:
Store tightly sealed in the dark. Protect from light.
Product Specific Literature References
Tyrphostins. 2. Heterocyclic and alpha-substituted benzylidenemalononitrile tyrphostins as potent inhibitors of EGF receptor and ErbB2/neu tyrosine kinases:
A. Gazit, et al.; J. Med. Chem.
34
, 1896 (1991)
Abstract
Further Categories Containing This Product:
EGFR Kinase Inhibitors
•
Tyrosine Kinase Inhibitors
ALX-270-145
Revised 11-Dec-04
Tyrphostin AG 698
SYNONYMS
Tyrphostin B52
N-(2-Phenylethyl)-3,4-dihydroxybenzylidenecyanoacetamide
PRODUCT LINE
Signal Transduction
PRODUCT CATEGORY
Tyrphostins
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-270-145-M005
5 mg
30.00 USD
ALX-270-145-M025
25 mg
85.00 USD
Product Specification
FORMULA:
C
18
H
16
N
2
O
3
MW:
308.3
PURITY:
≥98%
SOLUBILITY:
Soluble in DMSO or 100% ethanol.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
HANDLING:
Store tightly sealed in the dark. Protect from light.
ALX-270-146
Revised 11-Dec-04
Tyrphostin AG 556
SYNONYMS
Tyrphostin B56
N-(4-Phenylbutyl)-3,4-dihydroxybenzylidenecyanoacetamide
α-Cyano-(3,4-dihydroxy)-N-(4-phenylbutyl)cinnamamide
PRODUCT LINE
Signal Transduction
PRODUCT CATEGORY
Tyrphostins
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-270-146-M005
5 mg
25.00 USD
ALX-270-146-M025
25 mg
85.00 USD
Product Specification
FORMULA:
C
20
H
20
N
2
O
3
MW:
336.4
CAS NUMBER:
133550-41-1
PURITY:
≥98%
APPEARANCE:
Yellow solid.
SOLUBILITY:
Soluble in dimethyl formamide or DMSO.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
HANDLING:
Store tightly sealed in the dark. Protect from light.
Product Specific Literature References
Tyrphostins. 2. Heterocyclic and alpha-substituted benzylidenemalononitrile tyrphostins as potent inhibitors of EGF receptor and ErbB2/neu tyrosine kinases:
A. Gazit, et al.; J. Med. Chem.
34
, 1896 (1991)
Abstract
Further Categories Containing This Product:
EGFR Kinase Inhibitors
•
Tyrosine Kinase Inhibitors
ALX-270-147
Revised 03-Dec-04
Tyrphostin AG 528
SYNONYMS
Tyrphostin B66
N-(3',4'-Dihydroxybenzylidenecyanoacetyl)indoline
PRODUCT LINE
Signal Transduction
PRODUCT CATEGORY
Tyrphostins
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
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ALX-270-147-M005
5 mg
30.00 USD
ALX-270-147-M025
25 mg
85.00 USD
Product Specification
FORMULA:
C
18
H
14
N
2
O
3
MW:
306.3
PURITY:
≥98%
SOLUBILITY:
Soluble in DMSO.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
HANDLING:
Store tightly sealed in the dark. Protect from light.
ALX-270-148
Revised 09-Dec-04
Tyrphostin RG 13022
SYNONYMS
2-(3',4'-Dimethoxyphenyl)-1-(3''-pyridinyl)acrylonitrile
α-(3'-Pyridyl)-(3,4-dimethoxy)cinnamonitrile
PRODUCT LINE
Signal Transduction
PRODUCT CATEGORY
Tyrphostins
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-270-148-M001
1 mg
30.00 USD
ALX-270-148-M005
5 mg
85.00 USD
Product Specification
FORMULA:
C
16
H
14
N
2
O
2
MW:
266.3
CAS NUMBER:
136831-48-6
PURITY:
≥98%
SOLUBILITY:
Soluble in DMSO or 100% ethanol.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
HANDLING:
Store tightly sealed in the dark. Protect from light.
ALX-270-149
Revised 09-Dec-04
Tyrphostin RG 14620
SYNONYMS
2-(3',5'-Dichlorophenyl)-1-(3''-pyridinyl)acrylonitrile
α-(3'-Pyridyl)-3,5-dichloro)cinnamonitrile
PRODUCT LINE
Signal Transduction
PRODUCT CATEGORY
Tyrphostins
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
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ALX-270-149-M001
1 mg
30.00 USD
ALX-270-149-M005
5 mg
85.00 USD
Product Specification
FORMULA:
C
14
H
8
Cl
2
N
2
MW:
275.1
CAS NUMBER:
136831-49-7
PURITY:
≥98%
APPEARANCE:
White solid.
SOLUBILITY:
Soluble in warm DMSO.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
HANDLING:
Store tightly sealed in the dark. Protect from light.
ALX-270-150
Revised 05-Oct-06
Vinpocetine
SYNONYMS
Eburnamenine-14-carboxylic acid-ethyl ester
PRODUCT LINE
Signal Transduction
PRODUCT CATEGORY
Phosphodiesterases / Related Products
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-270-150-M005
5 mg
30.00 USD
ALX-270-150-M025
25 mg
70.00 USD
Product Specification
FORMULA:
C
22
H
26
N
2
O
2
MW:
350.5
CAS NUMBER:
42971-09-5
MERCK INDEX:
14:
9991
RTECS:
JW4792000
PURITY:
≥98%
APPEARANCE:
White to off-white solid.
SOLUBILITY:
Soluble in DMSO, 100% ethanol or acetone.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
+20°C
HAZARD:
HARMFUL.
Product Description
Selective inhibitor of Ca
2+
/calmodulin-dependent phosphodiesterase 1 (PDE1).
Product Specific Literature References
Effects of vinpocetine on cyclic nucleotide metabolism in vascular smooth muscle:
M. Hagiwara, et al.; Biochem. Pharmacol.
33
, 453 (1984)
Abstract
Effects of selective inhibitors on cyclic nucleotide phosphodiesterases of rabbit aorta:
H.S. Ahn, et al.; Biochem. Pharmacol.
38
, 3331 (1989)
Abstract
Regulation of cyclic AMP metabolism in bovine adrenal medullary cells:
P.D. Marley & K.A. Thomsom; Biochem. Pharmacol.
44
, 2105 (1992)
Abstract
Cyclic 3',5'-nucleotide diesterases in dynamics of cAMP and cGMP in rat collecting duct cells:
M. Yamaki, et al.; Am. J. Physiol.
262
, F957 (1992)
Abstract
Modulation of TNF alpha and IL-1 beta from endotoxin-stimulated monocytes by selective PDE isozyme inhibitors:
K. Molnar-Kimber, et al.; Agents Actions
39
, C77 (1993)
Abstract
ALX-270-151
Revised 10-May-05
W-5 . hydrochloride
