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ALX-210-915
Revised 25-Jan-08
Polyclonal Antibody to RAIDD (human) (AT100)
SYNONYMS
anti-CRADD (human) PAb (AT100)
anti-Caspase and RIP Adaptor with Death Domain (human) PAb (AT100)
anti-RIP-associated Protein with a Death Domain (human) PAb (AT100)
PRODUCT LINE
Cell Death / Apoptosis / Autophagy
PRODUCT CATEGORY
RAIDD / Related Products
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
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ALX-210-915-C050
50 µg
190.00 USD
Product Specification
SPECIES CROSSREACTIVITY:
Human
SOURCE/HOST:
From rabbit.
CONCENTRATION:
1mg/ml
PURITY DETAIL:
Affinity purified.
FORMULATION:
Liquid. In PBS containing 0.02% sodium azide.
IMMUNOGEN:
Recombinant human RAIDD (aa 1-199).
SPECIFICITY:
Recognizes human RAIDD.
APPLICATION:
Immunoprecipitation
Western Blot (1:1’000)
SHIPPING:
SHIPPED ON BLUE ICE
SHORT TERM STORAGE:
+4°C
LONG TERM STORAGE:
-20°C
HANDLING:
Avoid freeze/thaw cycles.
POSITIVE CONTROL:
For Positive Control (Western blot) see Prod. No.
ALX-522-085
.
Product Images
Please click on thumbnails to enlarge.
General Information
RAIDD (RIP-associated ICH-1 homologous protein with a death domain) is an adaptor molecule that mediates the action of cysteine proteases involved in apoptosis. In human cell lines, the caspase-2 adaptor RAIDD interacts selectively with caspase-2 through its caspase recruitment domain (CARD) and leads to caspase-2-dependent death. RAIDD overexpression induced caspase-2, CARD- and caspase-9-dependent apoptosis of PC12 cells and sympathetic neurons. Apoptosis correlated with the formation of discrete perinuclear aggregates. Both death and aggregates required the expression of full-length RAIDD. Recently, it has been reported that activation of caspase-2 occurs in a complex that contains the death domain–containing protein PIDD, whose expression is induced by p53, and the adaptor protein RAIDD.
MANUFACTURER
Manufactured by Apotech Corporation.
General Literature References
The PIDDosome, a protein complex implicated in activation of caspase-2 in response to genotoxic stress
:
A. Tinel and J. Tschopp; Science
304
, 843 (2004)
Abstract
RAIDD aggregation facilitates apoptotic death of PC12 cells and sympathetic neurons
:
O. Jabado, et al.; Cell Death Differ.
11
, 618 (2004)
Abstract
Further Categories Containing This Product:
Polyclonal Antibodies
ALX-210-932
Revised 28-Feb-07
Polyclonal Antibody to RIG-I (human) (AT111)
SYNONYMS
anti-RIG-1 (human) PAb (AT111)
anti-Retinoic Acid-inducible Gene 1 Protein (human) PAb (AT111)
anti-DEAD-box Protein 58 (human) PAb (AT111)
anti-Probable ATP-dependent RNA Helicase DDX58 (human) PAb (AT111)
PRODUCT LINE
DNA Regulation / Transcription
PRODUCT CATEGORY
RNA Helicases / Related Products
Ordering Information
Product Numbers:
Format:
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Unit Price:
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ALX-210-932-C100
100 µg
290.00 USD
Product Specification
SPECIES CROSSREACTIVITY:
Human
SOURCE/HOST:
From rabbit.
CONCENTRATION:
1mg/ml
PURITY DETAIL:
Protein A-affinity purified.
FORMULATION:
Liquid. In PBS containing 0.02% sodium azide.
IMMUNOGEN:
Recombinant human RIG-I (retinoic acid-inducible gene 1 protein) (aa 201-713).
SPECIFICITY:
Recognizes human RIG-I.
APPLICATION:
Immunoprecipitation (1:100)
Western blot (1:1'000)
SHIPPING:
SHIPPED ON BLUE ICE
SHORT TERM STORAGE:
+4°C
LONG TERM STORAGE:
-20°C
USE/STABILITY:
Stable for at least 1 year after receipt when stored at -20°C.
HANDLING:
Avoid freeze/thaw cycles. After opening, prepare aliquots and store at -20°C.
General Information
RIG-I (retinoic acid-inducible gene I; Ddx58), a member of the DEAD-box RNA helicases, is activated by cytoplasmic dsRNA produced during the viral replication. The protein is characterized by a N-terminal region with two caspase recruitment domains (CARD) and a C-terminal region harboring potential ATP-dependent RNA helicase activity. RIG-1 recruits the CARD adaptor inducing IFN-β (Cardif) in a CARD-CARD-dependent manner resulting in NF-κB and IRF3 activation.
MANUFACTURER
Manufactured by Apotech Corporation.
General Literature References
Virology. Sensing viral RNA amid your own:
T. Fujita; Science
314
, 935 (2006)
Abstract
5’-Triphosphate RNA is the ligand for RIG-I:
V. Hornung, et al.; Science
314
, 994 (2006)
Abstract
RIG-I-mediated antiviral responses to single-stranded RNA bearing 5’-phosphates:
A. Pichlmair, et al.; Science
314
, 997 (2006)
Abstract
Related Products
ALX-804-849
Monoclonal Antibody to RIG-I (Alme-1)
ALX-840-609
Positive Control (Cell Lysate) for Antibodies to RIG-I (human)
APO-54N-038
RIG-I (human) (IntraCellular) Detection Set [For ELISA Application]
Further Categories Containing This Product:
Caspase Recruitment Domain [CARD] Proteins / Related Products
•
NF-kB Pathway Other Products
•
Antiviral Signalling / Related Products
•
Interferons & Interferon Receptors Other Products
•
Polyclonal Antibodies
ALX-210-535
Revised 31-Oct-06
Polyclonal Antibody to Shc
SYNONYMS
anti-Shc Transforming Protein 1 PAb
anti-SH2 Domain Protein C1 PAb
anti-Shc1 PAb
PRODUCT LINE
Signal Transduction
PRODUCT CATEGORY
SH2 & SH3 Domains
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-210-535-R100
100 µl
220.00 USD
Product Specification
SPECIES CROSSREACTIVITY:
Human
Mouse
SOURCE/HOST:
From rabbit.
PURITY:
Liquid. Neat serum containing 0.05% sodium azide.
IMMUNOGEN:
Recombinant human Shc portion (aa 1180-1620).
SPECIFICITY:
Recognizes human, mouse and hamster p46shc, p52shc and p66shc isoforms of phosphorylated and unphosphorylated Shc.
APPLICATION:
ELISA
Immunoprecipitation
Western Blot
SHIPPING:
SHIPPED ON BLUE ICE
LONG TERM STORAGE:
-20°C
HANDLING:
Avoid freeze/thaw cycles.
General Information
There are 3 alternatively spliced isoforms of the Shc adapter pro-tein: p46SHC, p52SHC and p66SHC, that link activated growth factor receptors to signalling pathway. Isoform p46SHC and p52SHC, once phosphorylated, couple activated receptor tyrosine kinases to Ras via the recruitment of the GRB2/SOS com-plex and are implicated in mitogenic signalling. They function as initiators of the Ras signalling cascade in various non-neuronal systems. The isoform p66SHC does not mediate Ras activation, but is involved in signal transduction pathways that regulate the cellular response to oxidative stress and life span. It acts as a downstream target of the tumor suppressor p53 and is indispen-sable for the ability of stress-activated p53 to induce elevation of intracellular oxidants, cytochrome c release and apoptosis.
Further Categories Containing This Product:
Phospho-specific Antibodies
•
Shc & Other Ras Adaptors / Related Products
•
Polyclonal Antibodies
ALX-210-067
Revised 02-Apr-07
Polyclonal Antibody to SKAP55 (human)
PRODUCT LINE
Immunology
PRODUCT CATEGORY
Adaptor Proteins in T Cell Signal Transduction / Related Products
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
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ALX-210-067-C050
50 µg
220.00 USD
Product Specification
SPECIES CROSSREACTIVITY:
Human
SOURCE/HOST:
From rabbit.
CONCENTRATION:
~2.9mg/ml
FORMULATION:
Liquid. Protein G purified antibody in PBS containing 10% glycerol and 0.02% sodium azide.
IMMUNOGEN:
Human SKAP55 (aa 2-105).
SPECIFICITY:
Recognizes human SKAP55.
APPLICATION:
Immunoprecipitation (0.1-1µg)
Western Blot (0.2µg/ml)
SHIPPING:
SHIPPED ON BLUE ICE
LONG TERM STORAGE:
-20°C
HANDLING:
Avoid freeze/thaw cycles.
Further Categories Containing This Product:
Polyclonal Antibodies
ALX-210-566
Revised 31-Oct-06
Polyclonal Antibody to SLP-76 (human)
SYNONYMS
anti-SH2 Domain-containing Leukocyte Protein (76kDa) (human) PAb
PRODUCT LINE
Immunology
PRODUCT CATEGORY
Adaptor Proteins in T Cell Signal Transduction / Related Products
Ordering Information
Product Numbers:
Format:
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Unit Price:
Quantity:
Add To Cart
ALX-210-566-C100
100 µg
270.00 USD
Product Specification
SPECIES CROSSREACTIVITY:
Human
SOURCE/HOST:
From rabbit.
CONCENTRATION:
1mg/ml.
PURITY:
>95% (SDS-PAGE).
FORMULATION:
Liquid. In PBS, pH 7.4, containing 15mM sodium azide.
IMMUNOGEN:
Recombinant human SLP-76 (SH2 domain-containing leukocyte protein (76kDa)) (aa 216-434).
SPECIFICITY:
Recognizes human SLP-76. Other species have not been tested.
APPLICATION:
Western Blot
Optimal conditions must be determined individually for each application.
SHIPPING:
SHIPPED ON BLUE ICE
SHORT TERM STORAGE:
+4°C
LONG TERM STORAGE:
-20°C
USE/STABILITY:
Stable for at least 6 months after receipt when stored at +4°C.
HANDLING:
After opening, prepare aliquots and store at -20°C. Avoid freeze/thaw cycles.
Further Categories Containing This Product:
Autoimmunity & Self Tolerance Other Products
•
Polyclonal Antibodies
ALX-210-919
Revised 14-Jan-08
Polyclonal Antibody to SODD (human) (AL169)
SYNONYMS
anti-Silencer of Death Domain (human) PAb (AL169)
anti-BAG-4 (human) PAb (AL169)
anti-BAG-family Molecular Chaperone Regulator-4 (human) PAb (AL169)
PRODUCT LINE
Cell Death / Apoptosis / Autophagy
PRODUCT CATEGORY
Adaptor Proteins for Death Receptors Other Products
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-210-919-C050
50 µg
194.00 USD
Product Specification
SPECIES CROSSREACTIVITY:
Human
SOURCE/HOST:
From rabbit.
CONCENTRATION:
0.5mg/ml
PURITY DETAIL:
Affinity purified.
FORMULATION:
Liquid. In PBS containing 0.02% sodium azide.
IMMUNOGEN:
Synthetic peptide corresponding to C-terminal aa 350-376 (N
350
AT
SDHPNNQDQSSSLPEECVPSDEST
376
) of human SODD (Silencer of Death Domain; BAG-4; BAG-family Molecular Chaperone Regulator-4).
SPECIFICITY:
Recognizes human SODD. Detects bands of ~70kDa (full length protein) and ~60kDa (a C-terminal fragment) by Western blot.
APPLICATION:
Western Blot (1:1000)
Note:
Not recommended for immunoprecipitation.
SHIPPING:
SHIPPED ON BLUE ICE
SHORT TERM STORAGE:
+4°C
LONG TERM STORAGE:
-20°C
HANDLING:
Avoid freeze/thaw cycles.
Product Images
Please click on thumbnails to enlarge.
General Information
MANUFACTURER
Manufactured by Apotech Corporation.
General Literature References
Apoptosis: Silencing the death receptors
:
J. Tschopp, et al.; Curr. Biol.
9
, R381 (1999)
Abstract
;
Full Text
Overexpression of the 'silencer of death domain', SODD/BAG-4, modulates both TNFR1- and CD95-dependent cell death pathways
:
H. Eichholtz-Wirth, et al.; Cancer Lett.
194
, 81 (2003)
Abstract
Further Categories Containing This Product:
Stress & Heat Shock Proteins Other Products
•
Polyclonal Antibodies
ALX-210-366
Revised 23-Sep-05
Polyclonal Antibody to TIRAP (Pearl-1)
SYNONYMS
anti-Toll-interleukin 1 Receptor Domain-containing Adapter Protein PAb (Pearl-1)
anti-Mal PAb (Pearl-1)
anti-MyD88 Adapter-like Protein PAb (Pearl-1)
PRODUCT LINE
Inflammation
PRODUCT CATEGORY
Toll-IL-1 Receptor Adaptors / Related Products
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-210-366-R100
100 µl
290.00 USD
Product Specification
SPECIES CROSSREACTIVITY:
Human
Mouse
SOURCE/HOST:
From rabbit.
FORMULATION:
Liquid. Neat serum containing 0.02% sodium azide.
IMMUNOGEN:
Recombinant human TIRAP (Mal).
SPECIFICITY:
Recognizes human and mouse TIRAP (Mal). Does not cross-react with MyD88.
APPLICATION:
Western Blot (1:500)
SHIPPING:
SHIPPED ON BLUE ICE
SHORT TERM STORAGE:
+4°C
LONG TERM STORAGE:
-20°C
Product Images
Please click on thumbnails to enlarge.
General Literature References
The Toll-IL-1 receptor adaptor family grows to five members
:
L.A. O'Neill; Trends. Immunol.
24
, 286 (2003)
Further Categories Containing This Product:
Polyclonal Antibodies
ALX-210-023
Revised 29-Jun-05
Polyclonal Antibody to TRAF1 (human) (Bur 32)
SYNONYMS
anti-Tumor Necrosis Factor (TNF) Receptor-associated Factor 1 (human) PAb (Bur 32)
PRODUCT LINE
Inflammation
PRODUCT CATEGORY
TRAFs / Related Products
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-210-023-R050
50 µl
190.00 USD
Product Specification
SPECIES CROSSREACTIVITY:
Human
SOURCE/HOST:
From rabbit.
FORMULATION:
Liquid. In PBS containing 0.05% sodium azide.
IMMUNOGEN:
Synthetic peptide corresponding to aa 1-22 (M
1
ASSSGSSPRPAPDENEFPFGC
22
) of human TRAF1 (tumor necrosis factor (TNF) receptor-associated factor 1).
SPECIFICITY:
Recognizes human TRAF1. Detects endogenous protein by IHC and WB. Detects a band of ~50-53kDa by Western blot. Does not cross-react with other members of the TRAF family.
APPLICATION:
Immunohistochemistry (paraffin sections (1:1'000))
Immunoprecipitation (1:50)
Western Blot (1:1'000))
SHIPPING:
SHIPPED ON BLUE ICE
SHORT TERM STORAGE:
+4°C
LONG TERM STORAGE:
-80°C
USE/STABILITY:
Stable for at least 1 year after receipt when stored at -80°C.
HANDLING:
Avoid freeze/thaw cycles.
Product Specific Literature References
TNFR-associated factor family protein expression in normal tissues and lymphoid malignancies
:
J.M. Zapata, et al.; J. Immunol.
165
, 5084 (2000)
Abstract
;
Full Text
General Information
MANUFACTURER
Manufactured by Apotech Corporation.
Further Categories Containing This Product:
Polyclonal Antibodies
ALX-210-030
Revised 30-Oct-06
Polyclonal Antibody to TRAF1 (mouse) (AR-65)
SYNONYMS
anti-Tumor Necrosis Factor (TNF) Receptor-associated Factor 1 (mouse) PAb (AR-65)
PRODUCT LINE
Inflammation
PRODUCT CATEGORY
TRAFs / Related Products
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-210-030-R050
50 µl
190.00 USD
Product Specification
SPECIES CROSSREACTIVITY:
Mouse
SOURCE/HOST:
From rabbit.
FORMULATION:
Liquid. In PBS containing 0.05% sodium azide.
IMMUNOGEN:
Synthetic peptide corresponding to aa 51-69 (C
51
RADNLHPVSPGSPLTQEK
69
) of mouse TRAF1 (tumor necrosis factor (TNF) receptor-associated factor 1).
SPECIFICITY:
Recognizes mouse TRAF1. Detects a band of ~50-53kDa by Western blot.
APPLICATION:
Immunoprecipitation (1:50)
Western Blot (1:1'000)
SHIPPING:
SHIPPED ON BLUE ICE
SHORT TERM STORAGE:
+4°C
LONG TERM STORAGE:
-80°C
USE/STABILITY:
Stable for at least 1 year after receipt when stored at -80°C.
HANDLING:
Avoid freeze/thaw cycles.
Product Specific Literature References
TNFR-associated factor family protein expression in normal tissues and lymphoid malignancies
:
J.M. Zapata, et al.; J. Immunol.
165
, 5084 (2000)
Abstract
;
Full Text
General Information
MANUFACTURER
Manufactured by Apotech Corporation.
Further Categories Containing This Product:
Polyclonal Antibodies
ALX-210-024
Revised 29-Jun-05
Polyclonal Antibody to TRAF2 (human) (Bur 34)
SYNONYMS
anti-Tumor Necrosis Factor (TNF) Receptor-associated Factor 2 (human) PAb (Bur 34)
PRODUCT LINE
Inflammation
PRODUCT CATEGORY
TRAFs / Related Products
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-210-024-R050
50 µl
190.00 USD
Product Specification
SPECIES CROSSREACTIVITY:
Human
SOURCE/HOST:
From rabbit.
FORMULATION:
Liquid. Antiserum containing PBS and 0.05% sodium azide.
IMMUNOGEN:
Synthetic peptide corresponding to aa 6-31(V
6
TPPGSLELLQPGFSKTLLGTKLEAK
31
) of human TRAF2 (tumor necrosis factor (TNF) receptor-associated factor 2).
SPECIFICITY:
Recognizes human TRAF2. Detects endogenous protein by IHC and WB. Detects a band of ~60-64kDa by Western blot. Does not cross-react with other members of the TRAF family.
APPLICATION:
Immunohistochemistry (paraffin sections (1:2'000)
Immunoprecipitation (1:50)
Western Blot (1:1'000)
SHIPPING:
SHIPPED ON BLUE ICE
SHORT TERM STORAGE:
+4°C
LONG TERM STORAGE:
-80°C
USE/STABILITY:
Stable for at least 1 year after receipt when stored at -80°C.
HANDLING:
Avoid freeze/thaw cycles.
Product Specific Literature References
TNFR-associated factor family protein expression in normal tissues and lymphoid malignancies
:
J.M. Zapata, et al.; J. Immunol.
165
, 5084 (2000)
Abstract
;
Full Text
General Information
MANUFACTURER
Manufactured by Apotech Corporation.
Further Categories Containing This Product:
Endoplasmatic Reticulum Stress
•
Polyclonal Antibodies
•
Autophagy Other Products
ALX-210-029
Revised 01-Jun-06
Polyclonal Antibody to TRAF2 (mouse) (AR-63)
