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ALX-804-154
Revised 16-Jun-08
Monoclonal Antibody to Tollip (Kimmy-2)
PRODUCT LINE
Inflammation
PRODUCT CATEGORY
Toll-IL-1 Receptor Adaptors / Related Products
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-804-154-C100
100 µg
360.00 USD
ALX-804-154B-C100
Biotin
100 µg
390.00 USD
Product Specification
SPECIES CROSSREACTIVITY:
Mouse
CLONE:
Kimmy-2
ISOTYPE:
Mouse IgG1
SOURCE/HOST:
Purified from concentrated hybridoma tissue supernatant.
CONCENTRATION:
1mg/ml
PURITY:
95% (SDS-PAGE)
FORMULATION:
Liquid. In PBS containing 0.02% sodium azide.
IMMUNOGEN:
Recombinant mouse Tollip (aa 1-274).
SPECIFICITY:
Recognizes mouse and human (weak) Tollip.
APPLICATION:
Immunocytochemistry (1:100)
Immunoprecipitation
Western Blot (1µg/ml)
SHIPPING:
SHIPPED ON BLUE ICE
SHORT TERM STORAGE:
+4°C
USE/STABILITY:
Stable for at least 1 year after receipt when stored at -20°C.
HANDLING:
For long term storage keep unconjugated antibody at -20°C. Avoid freeze/thaw cycles. Keep conjugated formats at +4°C. Do not freeze. Protect from light.
Product Images
Please click on thumbnails to enlarge.
General Information
MANUFACTURER
Manufactured by Apotech Corporation.
Further Categories Containing This Product:
Monoclonal Antibodies
ALX-804-248
Revised 01-Oct-07
Monoclonal Antibody to TRAF2 (human) (33A1293)
SYNONYMS
anti-Tumor Necrosis Factor (TNF) Receptor-associated Factor 2 (human) (33A1293)
PRODUCT LINE
Inflammation
PRODUCT CATEGORY
TRAFs / Related Products
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-804-248-C100
100 µg
293.00 USD
Product Specification
SPECIES CROSSREACTIVITY:
Human
CLONE:
33A1293
ISOTYPE:
Mouse IgG1
CONCENTRATION:
0.5mg/ml
PURITY DETAIL:
Protein G-affinity purified.
FORMULATION:
Liquid. In PBS containing 0.2% gelatin and 0.05% sodium azide.
IMMUNOGEN:
Recombinant human TRAF2 (tumor necrosis factor (TNF) receptor-associated factor 2) (aa 205-222).
SPECIFICITY:
Recognizes human TRAF2. Detects a band of ~57kDa by Western blot.
APPLICATION:
Western Blot (2µg/ml)
SHIPPING:
SHIPPED ON BLUE ICE
SHORT TERM STORAGE:
+4°C
LONG TERM STORAGE:
-20°C
USE/STABILITY:
Stable for 6 months when stored at +4°C.
Product Images
Please click on thumbnails to enlarge.
Product Specific Literature References
Release of full-length 55-kDa TNF receptor 1 in exosome-like vesicles: a mechanism for generation of soluble cytokine receptors:
F.I. Hawari, et al.; PNAS
101
, 1297 (2004)
Abstract
;
Full Text
Further Categories Containing This Product:
Endoplasmatic Reticulum Stress
•
Monoclonal Antibodies
•
Autophagy Other Products
ALX-804-250
Revised 18-Aug-08
Monoclonal Antibody to TRAF5 (human) (55A219)
SYNONYMS
anti-Tumor Necrosis Factor (TNF) Receptor-associated Factor 5 (human) MAb (55A219)
PRODUCT LINE
Inflammation
PRODUCT CATEGORY
TRAFs / Related Products
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-804-250-C100
100 µg
293.00 USD
Product Specification
SPECIES CROSSREACTIVITY:
Human
CLONE:
55A219
ISOTYPE:
Mouse IgG1
CONCENTRATION:
0.5mg/ml
PURITY DETAIL:
Protein G affinity-purified.
FORMULATION:
Liquid. In PBS containing 0.2% gelatin and 0.05% sodium azide.
IMMUNOGEN:
Recombinant human TRAF5 (tumor necrosis factor (TNF) receptor-associated factor 5) (aa 77-186).
SPECIFICITY:
Recognizes human TRAF5. Detects a band of ~64kDa by Western blot.
APPLICATION:
Western Blot (2µg/ml)
SHIPPING:
SHIPPED ON BLUE ICE
SHORT TERM STORAGE:
+4°C
LONG TERM STORAGE:
-20°C
Product Images
Please click on thumbnails to enlarge.
Further Categories Containing This Product:
Monoclonal Antibodies
ALX-840-603
Revised 08-Mar-07
Positive Control (Cell Lysate) for Antibodies to NALP1 (human)
SYNONYMS
Positive Control (Cell Lysate) for Antibodies to NACHT-, LRR- and PYD-containing Protein 1 (human)
Positive Control (Cell Lysate) for Antibodies to DEFCAP (human)
Positive Control (Cell Lysate) for Antibodies to NAC (human)
Positive Control (Cell Lysate) for Antibodies to CARD7 (human)
Positive Control (Cell Lysate) for Antibodies to Caspase Recruitment Domain-containing Protein 7 (human)
PRODUCT LINE
Inflammation
PRODUCT CATEGORY
Inflammasome
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-840-603-R100
100 µl
70.00 USD
Product Specification
SOURCE/HOST:
Whole cell lysate of HEK 293T cells transfected with an expression plasmid for human NALP1 (aa 1-1429).
QUANTITY:
100µl corresponding to 2 x 10
6
cells.
FORMULATION:
Liquid. In 5x sample buffer (312.5mM TRIS, pH 6.8, containing 10% SDS, 6% glycerol, 0.075% bromophenol blue, 10% β-mercaptoethanol and 10mM DTT).
APPLICATION:
Positive control in Western blot for MAb to NALP1 (human) (Nalpy1-4) (Prod. No.
ALX-804-803
), PAb to NALP1 (human) (AL176) (Prod. No.
ALX-210-904
), PAb to NALP1 (human) (CT) (Bur 242) (Prod. No.
ALX-210-017
) and PAb to NALP1 (human) (NT) (Bur 241) (Prod. No.
ALX-210-018
).
Add 13µl sterile water and 2µl DTT (100mM) to 5µl of cell lysate.
SHIPPING:
SHIPPED ON BLUE ICE
LONG TERM STORAGE:
-20°C
HANDLING:
Avoid freeze/thaw cycles. After opening, prepare aliquots and store at -20°C.
Product Images
Please click on thumbnails to enlarge.
General Information
MANUFACTURER
Manufactured by Apotech Corporation.
Further Categories Containing This Product:
Caspase Recruitment Domain [CARD] Proteins / Related Products
ALX-165-019
Revised 24-Feb-05
PDGF Fragment (phosphorylated) (cyclic)
PRODUCT LINE
Signal Transduction
PRODUCT CATEGORY
SH2 & SH3 Domains
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-165-019-MC01
0.1 mg
50.00 USD
ALX-165-019-M001
1 mg
250.00 USD
Product Specification
SEQUENCE:
cyclo(Gly-Tyr(PO
3
H
2
)-Val-Pro-Met-Leu)
FORMULA:
C
32
H
49
N
6
O
10
PS
MW:
740.8
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
Product Description
Cyclic hexapeptide inhibitor of SH2 interactions. The peptide sequence represents the autophosphorylation region around Tyr
751
of the PDGF β-receptor.
Product Specific Literature References
Synthesis of phosphonomethyl-phenylalanine and phosphotryrosine containing cyclic peptides as inhibitors of protein kinase/SN2 interactions:
M. Nomizu, et al.; Tetrahedron
50
, 2691 (1994)
Further Categories Containing This Product:
Peptides
•
Platelet-derived Growth Factors [PDGFs] & Receptors / Related Products
ALX-165-005
Revised 16-Feb-05
PDGF β-Receptor (719-723) (phosphorylated)
PRODUCT LINE
Signal Transduction
PRODUCT CATEGORY
SH2 & SH3 Domains
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
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ALX-165-005-M001
1 mg
130.00 USD
ALX-165-005-M005
5 mg
520.00 USD
Product Specification
SEQUENCE:
H-Tyr(PO
3
H
2
)-Val-Pro-Met-Leu-OH
FORMULA:
C
30
H
48
N
5
O
10
PS
MW:
701.8
PURITY:
≥97%
APPEARANCE:
White lyophilized powder.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
Product Description
Contains the PDGF β-receptor recognition sequence which specifically interacts with the SH2 domain of PI(3)K (phosphoinositide 3-kinase). In this phosphorylated form the peptide inhibits the binding of the 85kDa subunit of PI(3)K to the PDGF β-receptor.
Product Specific Literature References
Distinct phosphotyrosines on a growth factor receptor bind to specific molecules that mediate different signaling pathways:
W.J. Fantl, et al.; Cell
69
, 413 (1992)
Abstract
Closing in on SH2 specificity:
R.B. Birge & H. Hanafusa; Science
262
, 1522 (1993)
Abstract
Further Categories Containing This Product:
Peptides
•
Platelet-derived Growth Factors [PDGFs] & Receptors / Related Products
ALX-215-025
Revised 21-Jul-06
Polyclonal Antibody to 14-3-3ε (NT)
SYNONYMS
anti-KCIP-1 PAb (NT)
anti-Protein Kinase C Inhibitor Protein 1 PAb (NT)
anti-14-3-3E PAb (NT)
PRODUCT LINE
Signal Transduction
PRODUCT CATEGORY
14-3-3 Proteins / Related Products
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-215-025-R100
100 µl
290.00 USD
Product Specification
SPECIES CROSSREACTIVITY:
Human
Mouse
Rat
Sheep
SOURCE/HOST:
From rabbit.
FORMULATION:
Liquid. Neat serum. Contains no preservatives.
IMMUNOGEN:
Synthetic peptide corresponding to aa 1-12 (M
1
DDREDLVYQAK
12
C) of 14-3-3ε.
SPECIFICITY:
Recognizes human, mouse, rat, sheep, bovine and chicken 14-3-3ε.
APPLICATION:
ELISA
Immunohistochemistry (1:400)
Western Blot (1:3000)
Optimal condition must be determined individually for each application.
SHIPPING:
SHIPPED ON BLUE ICE
LONG TERM STORAGE:
-20°C
HANDLING:
Avoid freeze/thaw cycles.
Product Specific Literature References
Antibodies against the major brain isoforms of 14-3-3 protein. An antibody specific for the N-acetylated amino-terminus of a protein:
H. Martin, et al.; FEBS Lett.
331
, 296 (1993)
Abstract
;
Full Text
Subcellular localisation of 14-3-3 isoforms in rat brain using specific antibodies:
H. Martin, et al.; J. Neurochem.
63
, 2259 (1994)
Abstract
Purification of 14-3-3 protein and analysis of isoforms in chicken brain:
Y. Patel, et al.; Biochim. Biophys. Acta
1222
, 405 (1994)
Abstract
Isoforms of 14-3-3 protein can form homo- and heterodimers in vivo and in vitro: implications for function as adapter proteins:
D.H. Jones, et al.; FEBS Lett.
368
, 55 (1995)
Abstract
;
Full Text
Expression and structural analysis of 14-3-3 proteins:
D.H. Jones, et al.; J. Mol. Biol.
245
, 375 (1995)
Abstract
Identification of 14-3-3 proteins in human platelets: effects of synthetic peptides on protein kinase C activation:
C.P. Wheeler-Jones, et al.; Biochem. J.
315
, 41 (1996)
Abstract
;
Full Text
14-3-3 inhibits the Dictyostelium myosin II heavy-chain-specific protein kinase C activity by a direct interaction: identification of the 14-3-3 binding domain:
M. Matto-Yelin, et al.; Mol. Biol. Cell
8
, 1889 (1997)
Abstract
;
Full Text
Isoform pattern of 14-3-3 proteins in the cerebrospinal fluid of patients with Creutzfeldt-Jakob disease:
J. Wiltfang, et al.; J. Neurochem.
73
, 2485 (1999)
Abstract
Functional specificity in 14-3-3 isoform interactions through dimer formation and phosphorylation. Chromosome location of mammalian isoforms and variants:
A. Aitken; Plant Mol. Biol.
50
, 993 (2002)
Abstract
Immunolocalisation of 14-3-3 isoforms in normal and scrapie-infected murine brain:
H.C. Baxter, et al.; Neuroscience
109
, 5 (2002)
Abstract
Interaction of Akt-phosphorylated ataxin-1 with 14-3-3 mediates neurodegeneration in spinocerebellar ataxia type 1:
H.K. Chen, et al.; Cell
113
, 457 (2003)
Abstract
Unchanged survival rates of 14-3-3gamma knockout mice after inoculation with pathological prion protein:
P. Steinacker, et al.; Mol. Cell. Biol.
25
, 1339 (2005)
Abstract
;
Full Text
Further Categories Containing This Product:
Polyclonal Antibodies
ALX-210-708
Revised 30-Jun-06
Polyclonal Antibody to 14-3-3 (human)
PRODUCT LINE
Signal Transduction
PRODUCT CATEGORY
14-3-3 Proteins / Related Products
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-210-708-C100
100 µg
320.00 USD
Product Specification
SPECIES CROSSREACTIVITY:
Human
SOURCE/HOST:
From rabbit.
CONCENTRATION:
0.1mg/ml
PURITY DETAIL:
Protein A-affinity purified IgG.
FORMULATION:
Liquid. In 0.05M sodium phosphate buffer containing 0.1% sodium azide and 0.2% gelatin.
IMMUNOGEN:
Synthetic peptide corresponding to aa 221-242 of 14-3-3 protein family members.
SPECIFICITY:
Recognizes human 14-3-3 protein family members.
APPLICATION:
Western Blot (2.5µg/ml)
SHIPPING:
SHIPPED ON BLUE ICE
LONG TERM STORAGE:
+4°C
HANDLING:
Do not freeze.
General Information
General Literature References
[1]
14-3-3 proteins. Hot numbers in signal transduction:
P.D. Burbelo and A. Hall; Curr. Biol.
5
, 95 (1995)
Abstract
[2]
Isoforms of 14-3-3 protein can form homo- and heterodimers in vivo and in vitro: implications for function as adapter proteins:
D.H. Jones, et al.; FEBS Lett.
368
, 55 (1995)
Abstract
[3]
14-3-3 proteins: a highly conserved, widespread family of eukaryotic proteins:
A. Aitken, et al.; TIBS
17
, 498 (1992), (Review)
Abstract
[4]
Evolutionary conservation of the 14-3-3 protein:
G.J. Martens, et al.; BBRC
184
, 1456 (1992)
Abstract
[5]
Expression and structural analysis of 14-3-3 proteins:
D.H. Jones, et al.; D.H. Jones, et al.
245
, 375 (1995)
Abstract
[6]
Subcellular localisation of 14-3-3 isoforms in rat brain using specific antibodies :
H. Martin, et al.; J. Neurochem.
63
, 2259 (1994)
Abstract
Further Categories Containing This Product:
Polyclonal Antibodies
ALX-215-028
Revised 17-Aug-06
Polyclonal Antibody to 14-3-3τ
SYNONYMS
anti-14-3-3θ PAb
anti-KCIP-1 PAb
anti-Protein Kinase C Inhibitor Protein 1 PAb
anti-HS1 Protein PAb
anti-T Cell Protein PAb
PRODUCT LINE
Signal Transduction
PRODUCT CATEGORY
14-3-3 Proteins / Related Products
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-215-028-R100
100 µl
290.00 USD
Product Specification
SPECIES CROSSREACTIVITY:
Human
Mouse
Rat
Sheep
SOURCE/HOST:
From rabbit.
FORMULATION:
Liquid. Neat serum. Contains no preservatives.
IMMUNOGEN:
Synthetic peptide corresponding to aa 1-10 (M
1
EKTELIQKA
10
C) of 14-3-3τ.
SPECIFICITY:
Recognizes human, mouse, rat, sheep, bovine and chicken 14-3-3τ.
APPLICATION:
ELISA
Immunohistochemistry (1:60)
Western Blot (1:3000)
Optimal condition must be determined individually for each application.
SHIPPING:
SHIPPED ON BLUE ICE
LONG TERM STORAGE:
-20°C
HANDLING:
Avoid freeze/thaw cycles.
Product Specific Literature References
Antibodies against the major brain isoforms of 14-3-3 protein. An antibody specific for the N-acetylated amino-terminus of a protein:
H. Martin, et al.; FEBS Lett.
331
, 296 (1993)
Abstract
;
Full Text
Subcellular localisation of 14-3-3 isoforms in rat brain using specific antibodies:
H. Martin, et al.; J. Neurochem.
63
, 2259 (1994)
Abstract
Purification of 14-3-3 protein and analysis of isoforms in chicken brain:
Y. Patel, et al.; Biochim. Biophys. Acta
1222
, 405 (1994)
Abstract
Isoforms of 14-3-3 protein can form homo- and heterodimers in vivo and in vitro: implications for function as adapter proteins:
D.H. Jones, et al.; FEBS Lett.
368
, 55 (1995)
Abstract
;
Full Text
Expression and structural analysis of 14-3-3 proteins:
D.H. Jones, et al.; J. Mol. Biol.
245
, 375 (1995)
Abstract
Identification of 14-3-3 proteins in human platelets: effects of synthetic peptides on protein kinase C activation:
C.P. Wheeler-Jones, et al.; Biochem. J.
315
, 41 (1996)
Abstract
;
Full Text
14-3-3 inhibits the Dictyostelium myosin II heavy-chain-specific protein kinase C activity by a direct interaction: identification of the 14-3-3 binding domain:
M. Matto-Yelin, et al.; Mol. Biol. Cell
8
, 1889 (1997)
Abstract
;
Full Text
Isoform pattern of 14-3-3 proteins in the cerebrospinal fluid of patients with Creutzfeldt-Jakob disease:
J. Wiltfang, et al.; J. Neurochem.
73
, 2485 (1999)
Abstract
Functional specificity in 14-3-3 isoform interactions through dimer formation and phosphorylation. Chromosome location of mammalian isoforms and variants:
A. Aitken; Plant Mol. Biol.
50
, 993 (2002)
Abstract
Immunolocalisation of 14-3-3 isoforms in normal and scrapie-infected murine brain:
H.C. Baxter, et al.; Neuroscience
109
, 5 (2002)
Abstract
Interaction of Akt-phosphorylated ataxin-1 with 14-3-3 mediates neurodegeneration in spinocerebellar ataxia type 1:
H.K. Chen, et al.; Cell
113
, 457 (2003)
Abstract
Unchanged survival rates of 14-3-3gamma knockout mice after inoculation with pathological prion protein:
P. Steinacker, et al.; Mol. Cell. Biol.
25
, 1339 (2005)
Abstract
;
Full Text
Further Categories Containing This Product:
Polyclonal Antibodies
ALX-215-029
Revised 21-Jul-06
Polyclonal Antibody to 14-3-3ζ
SYNONYMS
anti-KCIP-1 PAb
anti-Protein Kinase C Inhibitor Protein 1 PAb
anti-14-3-3δ PAb
PRODUCT LINE
Signal Transduction
PRODUCT CATEGORY
14-3-3 Proteins / Related Products
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-215-029-R100
100 µl
290.00 USD
Product Specification
SPECIES CROSSREACTIVITY:
Human
Mouse
Rat
Sheep
SOURCE/HOST:
From rabbit.
FORMULATION:
Liquid. Neat serum. Contains no preservatives.
IMMUNOGEN:
Synthetic peptide corresponding to aa 1-10 (M1DKNELVQKA10C) of 14-3-3ζ.
SPECIFICITY:
Recognizes human, mouse, rat, sheep, bovine and chicken 14-3-3ζ.
APPLICATION:
ELISA
Immunohistochemistry (1:400)
Western Blot (1:3000)
Optimal condition must be determined individually for each application.
SHIPPING:
SHIPPED ON BLUE ICE
LONG TERM STORAGE:
-20°C
HANDLING:
Avoid freeze/thaw cycles.
Product Specific Literature References
Antibodies against the major brain isoforms of 14-3-3 protein. An antibody specific for the N-acetylated amino-terminus of a protein:
H. Martin, et al.; FEBS Lett.
331
, 296 (1993)
Abstract
;
Full Text
Subcellular localisation of 14-3-3 isoforms in rat brain using specific antibodies:
H. Martin, et al.; J. Neurochem.
63
, 2259 (1994)
Abstract
Purification of 14-3-3 protein and analysis of isoform
