ALEXIS Biochemicals: Salubrinal

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ALX-250-001

Revised 05-Sep-06

4-Aminophenylphosphate . sodium salt
PRODUCT LINE	Signal Transduction
PRODUCT CATEGORY	Phosphatases Other Products

Ordering Information

Product Numbers:	Format:	Size:	Unit Price:	Quantity:	Add To Cart
ALX-250-001-M010		10 mg	30.00 USD
ALX-250-001-M050		50 mg	120.00 USD
ALX-250-001-M100		100 mg	195.00 USD

Product Specification

FORMULA:	188.1 . 23.0 . 72.1
MW:	C₆H₇NO₄P . Na . 4.0H₂O
PURITY:	≥97% (HPLC)
APPEARANCE:	Off-white to light gray crystalline solid.
SOLUBILITY:	Soluble in methanol.
SHIPPING:	AMBIENT
LONG TERM STORAGE:	-20°C

Product Description

Substrate for the electrochemical measurement of alkaline phosphatase.

ALX-804-570

Revised 29-Nov-04

Monoclonal Antibody to PPM1 (mouse) (4A4)
SYNONYMS	anti-Protein Phosphatase Methyltransferase 1 (mouse) MAb (4A4) anti-LCMT1 (mouse) MAb (4A4) anti-Leucine Carboxyl Methyltransferase 1 (mouse) MAb (4A4)
PRODUCT LINE	Signal Transduction
PRODUCT CATEGORY	Phosphatases Other Products

Ordering Information

Product Numbers:	Format:	Size:	Unit Price:	Quantity:	Add To Cart
ALX-804-570-C100		100 µg	330.00 USD

Product Specification

SPECIES CROSSREACTIVITY:	Mouse
CLONE:	4A4
ISOTYPE:	Mouse IgG1
CONCENTRATION:	0.5mg/ml
FORMULATION:	Liquid. Protein G purified antibody in PBS, containing 0.02% sodium azide, PEG and sucrose.
IMMUNOGEN:	Recombinant mouse PPM1 (protein phosphatase methyltransferase 1).
SPECIFICITY:	Recognizes mouse PPM1.
APPLICATION:	Western Blot (1:1'000-1:10'000) Optimal conditions must be determined individually for each application.
SHIPPING:	SHIPPED ON BLUE ICE
SHORT TERM STORAGE:	+4°C
LONG TERM STORAGE:	-20°C
HANDLING:	Avoid freeze/thaw cycles.

Product Images

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Further Categories Containing This Product:

Monoclonal Antibodies

ALX-210-575

Revised 10-Apr-08

Polyclonal Antibody to DUSP27
SYNONYMS	anti-Dual Specificity Phosphatase 27 PAb anti-DUPD1 PAb
PRODUCT LINE	Signal Transduction
PRODUCT CATEGORY	Phosphatases Other Products

Ordering Information

Product Numbers:	Format:	Size:	Unit Price:	Quantity:	Add To Cart
ALX-210-575-R100		100 µl	270.00 USD

Product Specification

SPECIES CROSSREACTIVITY:	Human Mouse
SOURCE/HOST:	From rabbit.
FORMULATION:	Liquid. Contains sodium azide.
IMMUNOGEN:	Synthetic peptide corresponding to human DUSP27 (dual specificity phosphatase 27).
SPECIFICITY:	Recognizes human and mouse DUSP27.
APPLICATION:	Western Blot (1:1’000) Optimal conditions must be determined individually for each application.
SHIPPING:	SHIPPED ON BLUE ICE
SHORT TERM STORAGE:	+4°C
LONG TERM STORAGE:	-20°C
HANDLING:	Avoid freeze/thaw cycles.

Product Specific Literature References

Identification and characterization of DUSP27, a novel dual-specific protein phosphatase: I. Friedberg; et al.; FEBS Lett. 581, 2527 (2007) Abstract

General Information

DUSP27 is a cytosolic enzyme, expressed in skeletal muscle, liver and adipose tissue, suggesting its possible role in energy metabolism.

Further Categories Containing This Product:

Polyclonal Antibodies

ALX-270-428

Revised 25-Feb-08

Salubrinal
PRODUCT LINE	Signal Transduction
PRODUCT CATEGORY	Phosphatases Other Products

Ordering Information

Product Numbers:	Format:	Size:	Unit Price:	Quantity:	Add To Cart
ALX-270-428-M001		1 mg	30.00 USD
ALX-270-428-M005		5 mg	110.00 USD

Product Specification

FORMULA:	C₂₁H₂₀Cl₃N₄OS
MW:	479.8
CAS NUMBER:	405060-95-9
PURITY:	≥98%
APPEARANCE:	White to off-white powder.
SOLUBILITY:	Soluble in DMSO (10mg/ml).
SHIPPING:	AMBIENT
LONG TERM STORAGE:	-20°C
USE/STABILITY:	Product may darken when exposed to air. Stock solutions are stable for up to 3 months when stored at -20°C.
HANDLING:	Protect from light. Keep under inert gas.

Product Description

Cell permeable and selective inhibitor of the phosphatase complexes that dephosphorylate eukaryotic translation initiation factor 2 subunit α (eIF-2α). Protects ER stress-induced apoptosis (EC₅₀~15µM in PC12 cells stimulated with 750ng/ml of tunicamycin (Prod. No. ALX-380-047)).

Product Specific Literature References

A selective inhibitor of eIF2alpha dephosphorylation protects cells from ER stress: M. Boyce, et al.; Science 307, 935 (2005) Abstract
A pharmacoproteomic approach implicates eukaryotic elongation factor 2 kinase in ER stress-induced cell death: M. Boyce, et al.; Cell Death Differ. 15, 589 (2008) Abstract