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ALX-157-020
Revised 03-Mar-05
Galanin Like Peptide [GALP] (1-60) (pig)
PRODUCT LINE
Obesity & Adipokines
PRODUCT CATEGORY
Galanin & Galanin Receptor / Related Products
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ALX-157-020-MC01
0.1 mg
490.00 USD
Product Specification
SEQUENCE:
H-Ala-Pro-Val-His-Arg-Gly-Arg-Gly-Gly-Trp-Thr-Leu-Asn-Ser-Ala-Gly-Tyr-Leu-Leu-Gly-Pro-Val-Leu-His-Pro-Pro-Ser-Arg-Ala-Glu-Gly-Gly-Gly-Lys-Gly-Lys-Thr-Ala-Leu-Gly-Ile-Leu-Asp-Leu-Trp-Lys-Ala-Ile-Asp-Gly-Leu-Pro-Tyr-Pro-Gln-Ser-Gln-Leu-Ala-Ser-OH
FORMULA:
C
281
H
443
N
81
O
78
MW:
6204.1
CAS NUMBER:
245114-96-9
SOURCE/HOST:
Isolated from pig hypothalamus.
PURITY:
≥95%
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
Product Description
GALP is a 60 amino acid peptide that, unlike galanin, has a non-amidated C-terminus. GALP (aa 9-21) is identical to the biologically active N-terminal (aa 1-13) portion of galanin. Receptor binding studies revealed that GALP has a high affinity for the galanin receptor 2 (IC
50
=0.24nM) and a lower affinity for the galanin receptor 1 (IC
50
=0.48nM). GALP is therefore an endogenous ligand that preferentially binds to galanin receptor 2, whereas galanin is relatively non-selective.
Product Specific Literature References
Isolation and cDNA cloning of a novel galanin-like peptide (GALP) from porcine hypothalamus
:
T. Ohtaki, et al.; J. Biol. Chem.
274
, 37041 (1999)
Abstract
;
Full Text
Galanin-like peptide (GALP) is a target for regulation by leptin in the hypothalamus of the rat
:
A. Jureus, et al.; Endocrinology
141
, 2703 (2000)
Abstract
;
Full Text
Galanin-like peptide (GALP) mRNA expression is restricted to arcuate nucleus of hypothalamus in adult male rat brain
:
J.A. Larm & A.L. Gundlach; Neuroendocrinology
72
, 67 (2000)
Abstract
Further Categories Containing This Product:
Peptides
ALX-290-006
Revised 25-Jun-08
Geranylgeranylpyrophosphate . triammonium salt
SYNONYMS
3,7,11,15-Tetramethyl-2,6,10,14-hexadecatetraenyl pyrophosphate . 3NH
3
GGPP . 3NH
3
PRODUCT LINE
Signal Transduction
PRODUCT CATEGORY
Geranyl-related Reagents
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ALX-290-006-C200
200 µg
60.00 USD
Product Specification
FORMULA:
C
20
H
36
O
7
P
2
. 3NH
3
MW:
450.5 . 51.1
CAS NUMBER:
6699-20-3
CONCENTRATION:
1mg/ml
PURITY:
≥98%
FORMULATION:
Liquid. In 70% ethanol in 0.25M NH
4
HCO
3
.
SOLUBILITY:
Soluble in water; also soluble in methanol or 100% ethanol.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
HAZARD:
HARMFUL. FLAMMABLE
Product Description
Geranylgeranyl donor utilized by geranylgeranyltransferase for isoprenylation of target proteins.
Product Specific Literature References
Effects of tautomycin, a protein phosphatase inhibitor, on recycling of mammalian cell surface molecules:
T. Kurisaki, et al.; J. Antibiot.
45
, 252 (1992)
Abstract
Steady-state kinetic mechanism of Ras farnesyl:protein transferase:
D.L. Pompliano, et al.; Biochemistry
31
, 3800 (1992)
Abstract
Divalent cation and prenyl pyrophosphate specificities of the protein farnesyltransferase from rat brain, a zinc metalloenzyme:
Y. Reiss, et al.; J. Biol. Chem.
267
, 6403 (1992)
Abstract
;
Full Text
Rab geranylgeranyl transferase. A multisubunit enzyme that prenylates GTP-binding proteins terminating in Cys-X-Cys or Cys-Cys:
M.C. Seabra, et al.; J. Biol. Chem
267
, 14497 (1992)
Abstract
;
Full Text
ALX-550-185
Revised 17-Dec-04
GR-135,531
SYNONYMS
5-Methoxy-carbonylamino-N-acetyl-tryptamine
5-MCA-NAT
PRODUCT LINE
Neurobiology
PRODUCT CATEGORY
Melatonin Receptors / Related Products
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ALX-550-185-M001
1 mg
30.00 USD
Product Specification
FORMULA:
C
14
H
17
N
3
O
3
MW:
275.3
PURITY:
≥97%
APPEARANCE:
Off-white solid.
SOLUBILITY:
Soluble in 100% ethanol.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
+4°C
Product Description
High affinity ligand for the MT
3
melatonin receptor subtype.
Product Specific Literature References
Melatonin receptors: are there multiple subtypes?:
M.L. Dubocovich; TIPS
16
, 50 (1995), (Review)
Abstract
Investigation into the contractile response of melatonin in the guinea-pig isolated proximal colon: the role of 5-HT4 and melatonin receptors:
A. Lucchelli, et al.; Br. J. Pharmacol.
121
, 1775 (1997)
Abstract
Characterization of a melatonin binding site in Siberian hamster brown adipose tissue:
S. Le Gouic, et al.; Eur. J. Pharmacol.
339
, 271 (1997)
Abstract
ALX-301-009
Revised 09-Dec-04
1-O-Hexadecyl-2-acetyl-sn-glycero-3-phospho-(N,N,N-trimethyl)-hexanolamine
PRODUCT LINE
Inflammation
PRODUCT CATEGORY
Platelet Activating Factors [PAF] & Receptors / Related Products
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ALX-301-009-M005
5 mg
45.00 USD
ALX-301-009-M025
25 mg
180.00 USD
Product Specification
FORMULA:
C
30
H
62
NO
7
P
MW:
579.8
CAS NUMBER:
99103-16-9
PURITY:
≥98%
APPEARANCE:
White solid.
SOLUBILITY:
Soluble in chloroform, 100% ethanol or methanol. Soluble in water after sonification for 1 minute at 40°C.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
HANDLING:
Slightly hygroscopic.
Product Description
PAF antagonist. Shows inhibitory behavior on platelet aggregation, secretion and phospholipid turnover.
Product Specific Literature References
Structural analogs of alkylacetylglycerophosphocholine inhibitory behavior on platelet activation:
A. Tokumura, et al.; J. Biol. Chem.
260
, 12710 (1985)
Abstract
;
Full Text
Platelet activating factor is a potent stimulant of the production of active oxygen species by human monocyte-derived macrophages:
M. Rouis, et al.; BBRC
156
, 1293 (1988)
Abstract
Further Categories Containing This Product:
Phospholipids / Related Products
•
Antithrombotic Agents / Platelet Aggregation Inhibitors / Related Products
ALX-550-061
Revised 18-Mar-08
(+)-Himbacine
SYNONYMS
(3S,3aR,4R,4aS,8aR,9aS)-4-[(1
E
)-2-[(2R,6S)-1,6-Dimethyl-2-piperdinyl]ethenyl]decahydro-3-methyl-naphtho[2,3-
c
]furan-1(3
H
)-one
PRODUCT LINE
Natural Products / Antibiotics
PRODUCT CATEGORY
Natural Products for Neurological Research
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ALX-550-061-M001
1 mg
40.00 USD
ALX-550-061-M005
5 mg
160.00 USD
ALX-550-061-M025
25 mg
520.00 USD
Product Specification
FORMULA:
C
22
H
35
NO
2
MW:
345.5
CAS NUMBER:
6879-74-9
RTECS:
QL0843500
SOURCE/HOST:
Isolated from the Australian pine
Galbulimima baccata
.
PURITY:
≥98%
APPEARANCE:
White to off-white powder.
SOLUBILITY:
Soluble in methanol, 100% ethanol or methylene chloride; insoluble in water.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
+20°C
HANDLING:
Hygroscopic.
Product Description
Potent muscarinic antagonist that displays selectivity for the M2 or M4 receptors.
Product Specific Literature References
Binding and functional selectivity of himbacine for cloned and neuronal muscarinic receptors:
J.H. Miller, et al.; Pharmacol. Exp. Ther.
263
, 663 (1992)
Abstract
Structural basis of the subtype selectivity of muscarinic antagonists: a study with chimeric m2/m5 muscarinic receptors:
J. Wess, et al.; Mol. Pharmacol.
41
, 369 (1992)
Abstract
Simplified analogs of himbacine displaying potent binding affinity for muscarinic receptors
:
M.J. Malaska, et al.; Bioorg. Med. Chem. Lett.
3
, 1247 (1993)
Chemical modification of ring C of himbacine: discovery of a pharmacophoric element for M
2
-selectivity
:
M.J. Malaska, et al.; Bioorg. Med. Chem. Lett.
5
, 61 (1995)
Total Syntheses of (+)-Himbacine and (+)-Himbeline:
D.J. Hart, et al.; JACS
117
, 9369 (1995)
Design, synthesis, and structure-activity relationship studies of himbacine derived muscarinic receptor antagonists:
D. Doller, et al.; Bioorg. Med. Chem. Lett.
9
, 901 (1999)
Abstract
Himbacine analogs as muscarinic receptor antagonists--effects of tether and heterocyclic variations:
S. Chackalamannil, et al.; Bioorg. Med. Chem. Lett.
14
, 3967 (2004)
Abstract
Further Categories Containing This Product:
Acetylcholine Receptors (Muscarinic) / Related Products
•
Alkaloids
ALX-550-132
Revised 24-Jun-08
Histamine . dihydrochloride
SYNONYMS
1
H
-Imidazole-4-ethanamine . 2HCl
PRODUCT LINE
Neurobiology
PRODUCT CATEGORY
Histaminergics & Histamine Receptors / Related Products
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ALX-550-132-G005
5 g
40.00 USD
Product Specification
FORMULA:
C
5
H
9
N
3
. 2HCl
MW:
111.1 . 73.0
CAS NUMBER:
56-92-8
MERCK INDEX:
14:
4719
RTECS:
MS1575000
PURITY:
≥98%
APPEARANCE:
White to off-white solid.
SOLUBILITY:
Soluble in water (50mg/ml).
SHIPPING:
AMBIENT
LONG TERM STORAGE:
+4°C
HAZARD:
HARMFUL.
IDENTITY:
Identity determined by IR.
Further Categories Containing This Product:
Nitric Oxide Pathway Other Products
ALX-550-048
Revised 11-Jan-07
7-Hydroxy-DPAT . hydrobromide
SYNONYMS
(±)-7-Hydroxy-2-dipropylaminotetralin . HBr
7-OH-DPAT . HBr
PRODUCT LINE
Neurobiology
PRODUCT CATEGORY
Dopaminergics & Dopamine Receptors / Related Products
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ALX-550-048-M010
10 mg
50.00 USD
Product Specification
FORMULA:
C
16
H
25
NO . HBr
MW:
247.4 . 80.9
CAS NUMBER:
74938-11-7
PURITY:
≥98% (HPLC)
APPEARANCE:
White to off-white solid.
SOLUBILITY:
Soluble in water or 100% ethanol.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
+4°C
HANDLING:
Protect from light.
Product Description
Selective D
3
dopamine receptor agonist.
Product Specific Literature References
Identification, characterization, and localization of the dopamine D3 receptor in rat brain using 7-[3H]hydroxy-N,N-di-n-propyl-2- aminotetralin:
D. Levesque, et al.; PNAS
89
, 8155 (1992)
Abstract
Behavioural effects of the putative D-3 dopamine receptor agonist 7-OH- DPAT in relation to other "D-2-like" agonists:
S.A. Daly & J.L. Waddington; Neuropharmacology
32
, 509 (1993)
Abstract
Expression and pharmacological characterization of the human D3 dopamine receptor:
S.B. Freedman, et al.; J. Pharmacol. Exp. Ther.
268
, 417 (1994)
Abstract
ALX-550-195
Revised 09-Dec-04
8-Hydroxy-DPAT . hydrobromide
SYNONYMS
(±)-8-Hydroxy-2-dipropylaminotetralin . HBr
8-OH-DPAT . HBr
PRODUCT LINE
Neurobiology
PRODUCT CATEGORY
Serotonergics & Serotonin Receptors / Related Products
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ALX-550-195-M005
5 mg
20.00 USD
ALX-550-195-M025
25 mg
80.00 USD
Product Specification
FORMULA:
C
16
H
25
NO . HBr
MW:
247.4 . 80.9
CAS NUMBER:
78950-78-4
PURITY:
≥99%
APPEARANCE:
White solid.
SOLUBILITY:
Soluble in water or 100% ethanol.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
+20°C
HANDLING:
Protect from light.
Product Description
Standard selective 5-HT
1A
serotonin receptor agonist.
Product Specific Literature References
8-Hydroxy-2-(di-n-propylamino)-tetralin discriminates between subtypes of the 5-HT1 recognition site:
D.N. Middlemiss & J.R. Fozard; Eur. J. Pharmacol.
90
, 151 (1983)
Abstract
Anticonflict effect of the putative serotonin receptor agonist 8- hydroxy-2-(di-n-propylamino)tetralin (8-OH-DPAT):
J.A. Engel, et al.; Eur. J. Pharmacol.
105
, 365 (1984)
Abstract
ALX-290-009
Revised 02-Apr-04
α-Hydroxyfarnesylphosphonic acid
PRODUCT LINE
Signal Transduction
PRODUCT CATEGORY
Farnesylation / Isoprenylation Reagents
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ALX-290-009-M001
1 mg
160.00 USD
Product Specification
FORMULA:
C
15
H
27
O
4
P
MW:
302.4
PURITY:
≥96%
FORMULATION:
Liquid. 1mg dissolved in 500µl ethanol.
SOLUBILITY:
Soluble in DMSO or 100% ethanol.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
USE/STABILITY:
Product decomposes rapidly when not in solution. Do not evaporate to dryness.
Product Description
Potent inhibitor of farnesyltransferase in cell-free enzyme preparations (IC
50
=30nM) and in whole cells. Selectively inhibits farnesyltransferase over geranylgeranyltransferases I and II (IC
50
=35.8µM and IC
50
=67.0µM).
Product Specific Literature References
Steady-state kinetic mechanism of Ras farnesyl:protein transferase:
D.L. Pompliano, et al.; Biochemistry
31
, 3800 (1992)
Abstract
Selective inhibition of farnesyl-protein transferase blocks ras processing in vivo:
J.B. Gibbs, et al.; J. Biol. Chem.
268
, 7617 (1993)
Abstract
;
Full Text
Inhibitors of Ras farnesyltransferases:
F. Tamanoi; TIBS
18
, 349 (1993), (Review)
Abstract
ALX-106-023
Revised 13-Dec-02
5-Hydroxy-L-tryptophan
PRODUCT LINE
Neurobiology
PRODUCT CATEGORY
Serotonergics & Serotonin Receptors / Related Products
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ALX-106-023-M500
500 mg
20.00 USD
Product Specification
FORMULA:
C
11
H
12
N
2
O
3
MW:
220.2
CAS NUMBER:
56-69-9
APPEARANCE:
White solid.
SOLUBILITY:
Soluble in water.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
HANDLING:
Protect from light.
Product Description
Serotonin precursor.
Further Categories Containing This Product:
Special Amino Acids
•
Glutamate Receptors (Metabotropic) / Related Products
ALX-350-291
Revised 19-Oct-07
Hymenidin
SYNONYMS
2-Debromooroidin
PRODUCT LINE
Natural Products / Antibiotics
PRODUCT CATEGORY
Natural Products for Cell Cycle Research
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ALX-350-291-M001
1 mg
230.00 USD
Product Specification
FORMULA:
C
11
H
12
BrN
5
O
MW:
310.2
CAS NUMBER:
107019-95-4
SOURCE/HOST:
Isolated from
Hymeniacidon sp
.
PURITY:
≥95%
APPEARANCE:
Amorphous solid.
SOLUBILITY:
Soluble in DMSO or 100 % ethanol.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
HANDLING:
Protect from light.
HAZARD:
TOXIC. CYTOTOXIC.
Product Description
