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Calcium Signalling (Intracellular)
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ALX-630-062 Revised 19-Jun-08
Ryanodine (high purity)
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PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Neurotoxins
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ALX-630-062-M001   1 mg 130.00 USD Add To Cart
ALX-630-062-M005   5 mg 520.00 USD Add To Cart
Product Specification
FORMULA: C25H35NO9
MW: 493.6
CAS NUMBER: 15662-33-6
MERCK INDEX: 14: 8307
RTECS: VM4025000
SOURCE/HOST: Isolated from Ryania speciosa, Flacourtiaceae.
PURITY: ≥99% (HPLC)
APPEARANCE: White to off-white solid.
SOLUBILITY: Soluble in methanol or DMSO (>29mg/ml), in 100% ethanol (16mg/ml); slightly soluble in water (warm).
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
HANDLING: Protect from light.
HAZARD: HARMFUL.
IDENTITY: Identity determined by MS and 1H-NMR.

Product Description
Potent neurotoxin. Blocks the release of Ca2+ from the sarcoplasmic reticulum. Has many complex effects on Ca2+ transport and action in the muscle.
Product Specific Literature References
The pharmacology of ryanodine: D.J. Jenden & A.S. Fairhurst; Pharmacol. Rev. 21, 1 (1969), (Review) Abstract
Ryanodine modification of cardiac muscle responses to potassium-free solutions. Evidence for inhibition of sarcoplasmic reticulum calcium release: J.L. Sutko & J.L. Kenyon; J. Gen. Physiol. 82, 385 (1983) Abstract
Mechanism of action of ryanodine on cardiac sarcoplasmic reticulum: J.J. Feher & G.B. Lipford; Biochim. Biophys. Acta 813, 77 (1985) Abstract
The calcium-ryanodine receptor complex of skeletal and cardiac muscle: I.N. Pessah, et al.; BBRC 128, 449 (1985) Abstract
Ryanodine: a modifier of sarcoplasmic reticulum calcium release in striated muscle: J.L. Sutko, et al.; Fed. Prod. 44, 2984 (1985) Abstract
Structural aspects of ryanodine action and selectivity: A.L. Waterhouse, et al.; J. Med. Chem. 30, 710 (1987) Abstract
Ryanodine as a functional probe of the skeletal muscle sarcoplasmic reticulum Ca2+ release channel: G. Meissner & A. el-Hashem; Mol. Cell. Biochem. 114, 119 (1992) Abstract
The pharmacology of ryanodine and related compounds: J. L. Sutko, et al.; Pharmacol. Rev. 49, 53 (1997) Abstract
The interaction of ryanoids with individual ryanodine receptor channels: A. J. Williams and B. Tanna; Biol. Res. 37, 527 (2004) Abstract
Further Categories Containing This Product:
Ryanodine / Related Products • Natural Products - Other Signal Transduction Pathway Modulators • Alkaloids
 
 
ALX-350-234 Revised 08-Apr-08
12-epi-Scalaradial
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PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Natural Products - Other Signal Transduction Pathway Modulators
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ALX-350-234-M001   1 mg 190.00 USD Add To Cart
Product Specification
FORMULA: C27H40O4
MW: 428.6
CAS NUMBER: 53527-28-9
SOURCE/HOST: Isolated from Cacospongia sp.
PURITY: ≥98%
APPEARANCE: Waxy solid.
SOLUBILITY: Soluble in acetic acid, 100% ethanol or DMSO.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C

Product Description
Inhibitor of bee venom phospholipase A2 (PLA2). Inhibits Ca2+ mobilization induced by leukotriene B4 (LTB4) and platelet activating factor. Inhibits Ca2+-dependent arachidonic acid release in human neutrophils. Inhibits epidermal growth factor (EGF)-stimulated Akt (protein kinase B; PKB) phosphorylation.
Product Specific Literature References
Two-step inactivation of bee venom phospholipase A2 by scalaradial: M.S. De Carvalho & R.S. Jacobs; Biochem. Pharmacol. 42, 1621 (1991) Abstract
Evidence for different mechanisms involved in the formation of lyso platelet-activating factor and the calcium-dependent release of arachidonic acid from human neutrophils: J.D. Winkler, et al.; Biochem. Pharmacol. 44, 2055 (1992) Abstract
Effects of scalaradial, a type II phospholipase A2 inhibitor, on human neutrophil arachidonic acid mobilization and lipid mediator formation: L.A. Marshall, et al.; J. Pharmacol. Exp. Ther. 268, 709 (1994) Abstract
Scalaradial inhibition of epidermal growth factor receptor-mediated Akt phosphorylation is independent of secretory phospholipase A2: Y. Xie, et al.; J. Pharmacol. Exp. Ther. 314, 1210 (2005) Abstract
Scalaradial, a dialdehyde-containing marine metabolite that causes an unexpected noncovalent PLA2 Inactivation: M.C. Monti, et al.; Chembiochem 8, 1585 (2007) Abstract
Further Categories Containing This Product:
PLA2 Inhibitors • Akt [PKB] / Related Products • Calcium Signalling (Intracellular) Other Products
 
 
ALX-550-297 Revised 22-Sep-08
SKF-96365 . hydrochloride
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SYNONYMS 1-[β-[3-(4-Methoxyphenyl)propoxy]-4-methoxyphenethyl]-1H-imidazole . HCl
PRODUCT LINE Signal Transduction
PRODUCT CATEGORY Ca2+ Modulators
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ALX-550-297-M001   1 mg 37.00 USD Add To Cart
ALX-550-297-M005   5 mg 88.00 USD Add To Cart
Product Specification
FORMULA: C22H26N2O3 . HCl
MW: 366.5 . 36.5
CAS NUMBER: 130495-35-1
PURITY: ≥98% (TLC)
APPEARANCE: White to off-white solid.
SOLUBILITY: Soluble in water (30mg/ml) or DMSO.
SHIPPING: AMBIENT
LONG TERM STORAGE: +20°C
USE/STABILITY: Stock solutions are stable for up to 3 months at -20°C.

Product Description
Inhibits voltage-gated Ca2+ channels. Inhibits the histamine-induced formation of nitric oxide in human endothelial cells.
Product Specific Literature References
SKF 96365, a novel inhibitor of receptor-mediated calcium entry: J.E. Merritt, et al.; Biochem. J. 271, 515 (1990) Abstract
Inhibition of a receptor-operated calcium channel in pig aortic microsomes by cyclic GMP-dependent protein kinase: L.M. Blayney, et al.; Biochem. J. 273, 803 (1991) Abstract
SKF 96365 inhibits histamine-induced formation of endothelium-derived relaxing factor in human endothelial cells: W.F. Graier, et al.; BBRC 186, 1539 (1992) Abstract
Vectorial Ca2+ flux from the extracellular space to the endoplasmic reticulum via a restricted cytoplasmic compartment regulates inositol 1,4,5-trisphosphate-stimulated Ca2+ release from internal stores in vascular endothelial cells: O.A. Cabello & W.P. Schilling; Biochem. J. 295, 357 (1993) Abstract
General Information
BACKGROUND/TECHNICAL INFORMATION Product is not sterile.
Further Categories Containing This Product:
Nitric Oxide Pathway Other Products
 
 
ALX-350-311 Revised 07-Feb-05
Stellettamide A . trifluoroacetate
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PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Natural Products - Other Signal Transduction Pathway Modulators
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ALX-350-311-C100   100 µg 460.00 USD Add To Cart
Product Specification
FORMULA: C26H45N2O . CF3CO2
MW: 401.7 . 113.0
CAS NUMBER: 129744-24-7
SOURCE/HOST: Isolated from the marine sponge Stellata sp.
PURITY: ≥95%
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: -20°C
HAZARD: TOXIC.

Product Description
Inhibits intrinsic tyrosine fluorescence in a concentration-dependent manner. Binds to calmodulin and inhibits Ca2+/calmodulin-dependent enzyme activities.
Product Specific Literature References
Stellettamide-A, a novel inhibitor of calmodulin, isolated from a marine sponge: Y. Abe, et al.; Br. J. Pharmacol. 121, 1309 (1997) Abstract
Further Categories Containing This Product:
Calmodulin Inhibitors • Alkaloids • Marine Natural Products
 
 
ALX-270-477 Revised 19-Aug-08
STO-609
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SYNONYMS 7-Oxo-7H-benzimidazo[2,1-a]benz[de]isoquinoline-3-carboxylic acid acetic acid
PRODUCT LINE Signal Transduction
PRODUCT CATEGORY CAM Kinase Inhibitors
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ALX-270-477-M001   1 mg 45.00 USD Add To Cart
Product Specification
FORMULA: C19H10N2O3 · CH3COOH
MW: 314.3 . 60.1
CAS NUMBER: 52029-86-4
PURITY: ≥95% (HPLC)
APPEARANCE: Yellow to orange solid.
SOLUBILITY: Soluble in DMSO (10mg/ml; warm) or 100mM sodium hydroxide (20mg/ml).
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
USE/STABILITY: Stock solutions are stable for up to 6 months when stored at -20°C.
HANDLING: Protect from light. Hygroscopic.
IDENTITY: Identity determined by 1H-NMR.

Product Description
Cell permeable, highly selective, potent and ATP-competitive inhibitor of CaM-KK (Ca2+/calmodulin-dependent protein kinase kinase) (IC50=120ng/ml and 40ng/ml for CaM-KKα and CaM-KKβ isoforms, respectively). Inhibits autophosphorylation through binding to the catalytic domain of CaM-KK.
Product Specific Literature References
STO-609, a specific inhibitor of the Ca(2+)/calmodulin-dependent protein kinase kinase: H. Tokumitsu, et al.; J. Biol. Chem. 277, 15813 (2002) Abstract; Full Text
A single amino acid difference between alpha and beta Ca2+/calmodulin-dependent protein kinase kinase dictates sensitivity to the specific inhibitor, STO-609: H. Tokumitsu, et al.; J. Biol. Chem. 278, 10908 (2003) Abstract; Full Text
Calmodulin-dependent kinase kinase/calmodulin kinase I activity gates extracellular-regulated kinase-dependent long-term potentiation: J.M. Schmitt, et al.; J. Neurosci. 25, 1281 (2005) Abstract; Full Text
The Ca2+/calmodulin-dependent protein kinase kinases are AMP-activated protein kinase kinases: R.L. Hurley, et al.; J. Biol. Chem 280, 29060 (2005) Abstract; Full Text
AMP-activated protein kinase mediates VEGF-stimulated endothelial NO production: J.A. Reihill, et al.; BBRC 354, 1084 (2007) Abstract; Full Text
Ca2+/calmodulin-dependent protein kinase kinase-alpha regulates skeletal muscle glucose uptake independent of AMP-activated protein kinase and Akt activation: C.A. Witczak, et al.; Diabetes 56, 1403 (2007) Abstract
Phosphatidylinositol ether lipid analogues induce AMP-activated protein kinase-dependent death in LKB1-mutant non small cell lung cancer cells: R.M. Memmott, et al.; Cancer Res. 68, 580 (2008) Abstract
Small molecule antagonizes autoinhibition and activates AMP-activated protein kinase in cells: T. Pang, et al.; J. Biol. Chem. 283, 16051 (2008) Abstract; Full Text
 
 
ALX-167-007 Revised 12-Jun-03
Syntide 2
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PRODUCT LINE Signal Transduction
PRODUCT CATEGORY CAM Kinase Substrates
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ALX-167-007-M001   1 mg 70.00 USD Add To Cart
ALX-167-007-M005   5 mg 280.00 USD Add To Cart
Product Specification
SEQUENCE: H-Pro-Leu-Ala-Arg-Thr-Leu-Ser-Val-Ala-Gly-Leu-Pro-Gly-Lys-Lys-OH
FORMULA: C68H122N20O18
MW: 1507.8
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
Product Description
Substrate for Ca2+/calmodulin-dependent protein kinase II and protein kinase C (PKC). The peptide sequence is homologous to the phosphorylation site 2 in glycogen synthase.
Product Specific Literature References
Calcium . calmodulin-dependent protein kinase II and calcium . phospholipid-dependent protein kinase activities in rat tissues assayed with a synthetic peptide: Y. Hashimoto & T.R. Soderling; Arch. Biochem. Biophys. 252, 418 (1987) Abstract
Further Categories Containing This Product:
Peptides • PKC Substrates
 
 
ALX-480-061 Revised 15-Mar-06
Theobromine
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SYNONYMS 3,7-Dimethylxanthine
PRODUCT LINE Neurobiology
PRODUCT CATEGORY Adenosine Receptors / Related Products
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ALX-480-061-G005   5 g 10.00 USD Add To Cart
ALX-480-061-G025   25 g 45.00 USD Add To Cart
Product Specification
FORMULA: C7H8N4O2
MW: 180.2
CAS NUMBER: 83-67-0
MERCK INDEX: 14: 9282
PURITY: ≥98%
APPEARANCE: White solid.
SOLUBILITY: Soluble in 0.5M sodium hydroxide; insoluble in 100% ethanol or water.
SHIPPING: AMBIENT
LONG TERM STORAGE: +20°C
HAZARD: TOXIC.

Product Description
Weak phosphodiesterase inhibitor and adenosine receptor blocker. Diuretic and smooth-muscle relaxant.
Product Specific Literature References
Subclasses of adenosine receptors in the central nervous system: interaction with caffeine and related methylxanthines: J.W. Daly, et al.; Cell Mol. Neurobiol. 3, 69 (1983) Abstract
Characterization of the A2 adenosine receptor labeled by [3H]NECA in rat striatal membranes: R.F. Bruns, et al.; Mol. Pharmacol. 29, 331 (1986) Abstract
Further Categories Containing This Product:
Natural Products for Neurological Research • Active Substances from Fruit and Vegetables • Alkaloids • Phosphodiesterases / Related Products
 
 
ALX-480-062 Revised 24-Oct-07
Theophylline
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SYNONYMS 1,3-Dimethylxanthine
PRODUCT LINE Neurobiology
PRODUCT CATEGORY Adenosine Receptors / Related Products
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ALX-480-062-G005   5 g 5.00 USD Add To Cart
ALX-480-062-G025   25 g 15.00 USD Add To Cart
Product Specification
FORMULA: C7H8N4O2
MW: 180.2
CAS NUMBER: 58-55-9
MERCK INDEX: 14: 9285
PURITY: ≥98%
APPEARANCE: White solid.
SOLUBILITY: Soluble in dilute aqueous acid, dilute aqueous base or 100% ethanol; insoluble in water.
SHIPPING: AMBIENT
LONG TERM STORAGE: +20°C
HAZARD: TOXIC.

Product Description
Cyclic phosphodiesterase inhibitor. Weakly inhibits alkaline phosphodiesterases and 5’-nucleotidase. Muscle relaxant, cardiac stimulant and diuretic. Used for the treatment of asthma.
Product Specific Literature References
1,3-Dialkyl-8-(p-sulfophenyl)xanthines: potent water-soluble antagonists for A1- and A2-adenosine receptors: J.W. Daly, et al.; J. Med. Chem. 28, 487 (1985) Abstract
Characterization of the A2 adenosine receptor labeled by [3H]NECA in rat striatal membranes: R.F. Bruns, et al.; Mol. Pharmacol. 29, 331 (1986) Abstract
Theophylline: new perspectives for an old drug: P.J. Barnes; Am. J. Respir. Crit. Care Med. 167, 813 (2003), (Review) Abstract
Further Categories Containing This Product:
Natural Products - Chemopreventive Agents • Active Substances from Fruit and Vegetables • Alkaloids • Phosphodiesterases / Related Products
 
 
ALX-480-067 Revised 16-May-03
Theophylline, 7-(β-Hydroxyethyl)-
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SYNONYMS 7-(β-Hydroxyethyl)theophylline
Etofylline
1,3-Dimethyl-7-(β-hydroxyethyl)xanthine
PRODUCT LINE Signal Transduction
PRODUCT CATEGORY Phosphodiesterases / Related Products
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ALX-480-067-G005   5 g 15.00 USD Add To Cart
Product Specification
FORMULA: C9H12N4O3
MW: 224.2
CAS NUMBER: 519-37-9
MERCK INDEX: 14: 3878
PURITY: ≥98%
APPEARANCE: White solid.
SOLUBILITY: Soluble in water or 100% ethanol.
SHIPPING: AMBIENT
LONG TERM STORAGE: +20°C
HAZARD: TOXIC.

Product Description
Weak phosphodiesterase inhibitor resembling theophylline (Prod. No. ALX-480-062) in its pharmacological profile. Used as an intermediate in the preparation of 7-substituted xanthines.
Product Specific Literature References
Adenosine antagonism by purines, pteridines and benzopteridines in human fibroblasts: R.F. Bruns; Biochem. Pharmacol. 30, 325 (1981) Abstract
Xanthine derivatives as antagonists at A1 and A2 adenosine receptors: U. Schwabe, et al.; Naunyn Schmiedebergs Arch. Pharmacol. 330, 212 (1985) Abstract
Analogues of caffeine and theophylline: effect of structural alterations on affinity at adenosine receptors: J.W. Daly, et al.; J. Med. Chem. 29, 1305 (1986) Abstract
Further Categories Containing This Product:
Natural Products - Other Signal Transduction Pathway Modulators • Active Substances from Fruit and Vegetables • Alkaloids
 
 
ALX-550-299 Revised 09-Oct-06
Thioridazine . hydrochloride
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SYNONYMS 10-[2-(1-Methyl-2-piperidinyl)ethyl]-2-(methylthio)-phenothiazine . HCl
PRODUCT LINE Signal Transduction
PRODUCT CATEGORY Ca2+ Modulators
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ALX-550-299-G001   1 g 20.00 USD Add To Cart
Product Specification
FORMULA: C21H26N2S2 . HCl
MW: 370.6 . 36.5
CAS NUMBER: 130-61-0
MERCK INDEX: 14: 9359
RTECS: SP2275000
PURITY: ≥99% (TLC)