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ALX-850-255
Revised 12-Aug-08
Annexin V-FITC Apoptosis Detection Kit Plus
PRODUCT LINE
Cell Death / Apoptosis / Autophagy
PRODUCT CATEGORY
Annexin V / Related Products
Ordering Information
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Format:
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ALX-850-255-KI01
25 tests
203.00 USD
ALX-850-255-KI02
100 tests
413.00 USD
Product Specification
KIT/SET CONTAINS:
Annexin V-FITC, SYTOX green dye and binding buffer.
An assay protocol is included.
APPLICATION:
For the detection of apoptotic cells by flow cytometry.
SHIPPING:
SHIPPED ON BLUE ICE
LONG TERM STORAGE:
+4°C
HANDLING:
Protect from light.
Product Description
FITC-labelled recombinant human annexin V shows bright green fluorescence. SYTOX green dye is impermeant to live cells and apoptotic cells, but stains necrotic cells with intense green fluorescence (Ex(max): 488nm; Em(max): 530nm). Apoptotic cells show green fluorescence, dead cells show a higher level of green fluorescence and live cells show little or no fluorescence. By using the FL1 channel in FC, other channels are free for multiple labelling experiments.
General Information
MANUFACTURER
Manufactured by BioVision.
Further Categories Containing This Product:
Detection Kits
ALX-430-063
Revised 10-Oct-07
Anthralin
SYNONYMS
Dithranol
PRODUCT LINE
Inflammation
PRODUCT CATEGORY
Leukotrienes Other Products
Ordering Information
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ALX-430-063-G001
1 g
25.00 USD
Product Specification
FORMULA:
C
14
H
10
O
3
MW:
226.2
CAS NUMBER:
1143-38-0
MERCK INDEX:
14:
684
RTECS:
CB8927000
PURITY:
≥97% (HPLC)
APPEARANCE:
Yellow powder.
SOLUBILITY:
Soluble in acetic acid.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
HAZARD:
MAY BE MUTAGENIC. IRRITANT.
Product Description
Leukotriene biosynthesis inhibitor. Inhibits LTB
4
ω-oxidation.
Product Specific Literature References
Anthralin (1,8-dihydroxyanthrone) is a potent inhibitor of leukotriene production and LTB4-omega oxidation by human neutrophils:
J.M. Schröder; J. Invest. Dermatol.
87
, 624 (1986)
Abstract
Further Categories Containing This Product:
Carcinogens & Tumor Promoters Other Products
•
Cancer Other Products
ALX-260-093
Revised 12-Nov-08
Antipain
SYNONYMS
[(S)-1-Carboxy-2-phenylethyl]-carbamoyl-Arg-Val-arginal . 2HCl
PRODUCT LINE
Signal Transduction
PRODUCT CATEGORY
Proteases Other Products
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ALX-260-093-M005
5 mg
35.00 USD
ALX-260-093-M025
25 mg
130.00 USD
Product Specification
SEQUENCE:
[(S)-1-Carboxy-2-phenylethyl]-carbamoyl-Arg-Val-arginal
FORMULA:
C
27
H
44
N
10
O
6
. 2HCl
MW:
604.7 . 73.0
CAS NUMBER:
37682-72-7
SOURCE/HOST:
Synthetic.
PURITY:
Inhibitory Activity ≥30 U/mg (Trypsin, L-BAPA)
APPEARANCE:
White to off-white powder.
SOLUBILITY:
Soluble in water, methanol, 100 % ethanol or acetonitrile.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
HANDLING:
Protect from light.
Product Description
Inhibits papain and trypsin and to a small extent plasmin. Antipain is more specific for papain and trypsin than is leupeptin (Prod. No.
ALX-260-009
). The inhibitory potency of antipain is 100-fold higher than that of elastatinal. Acts by forming a hemiacetal adduct between its aldehyde group and the active serine of the proteinase.
Product Specific Literature References
Antipain, a new protease inhibitor isolated from actinomycetes:
H. Suda, et al.; J. Antibiot.
25
, 263 (1972)
Abstract
Structures and activities of protease inhibitors of microbial origin
:
H. Umezawa; Meth. Enzymol.
45
, 678 (1976)
Abstract
ALX-550-036
Revised 17-Jan-05
D-AP3
SYNONYMS
D(-)-2-Amino-3-phosphonopropanoic acid
PRODUCT LINE
Neurobiology
PRODUCT CATEGORY
Glutamate Receptors (Metabotropic) / Related Products
Ordering Information
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ALX-550-036-M005
5 mg
75.00 USD
Product Specification
FORMULA:
C
3
H
8
NO
5
P
MW:
169.1
CAS NUMBER:
128241-72-5
PURITY:
≥97%
APPEARANCE:
White powder.
SOLUBILITY:
Soluble in water.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
+4°C
HANDLING:
Protect from light.
Product Specific Literature References
1S,3R-ACPD stimulates and L-AP3 blocks Ca2+ mobilization in rat cerebellar neurons:
A.J. Irving, et al.; Eur. J. Pharmacol.
186
, 363 (1990)
Abstract
Stereoselectivity and mode of inhibition of phosphoinositide-coupled excitatory amino acid receptors by 2-amino-3-phosphonopropionic acid:
D.D. Schoepp, et al.; Mol. Pharmacol.
38
, 222 (1990)
Abstract
Metabotropic glutamate receptors in brain function and pathology:
D.D. Schoepp & P.J. Conn; TIPS
14
, 13 (1993), (Review)
Abstract
Pharmacological agents acting at subtypes of metabotropic glutamate receptors
:
D.D. Schoepp; Neuropharmacology
38
, 1431 (1999), (Review)
Abstract
ALX-550-038
Revised 17-Jan-05
L-AP3
SYNONYMS
L(+)-2-Amino-3-phosphonopropanoic acid
PRODUCT LINE
Neurobiology
PRODUCT CATEGORY
Glutamate Receptors (Metabotropic) / Related Products
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Format:
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ALX-550-038-M005
5 mg
55.00 USD
ALX-550-038-M025
25 mg
220.00 USD
Product Specification
FORMULA:
C
3
H
8
NO
5
P
MW:
169.1
CAS NUMBER:
23052-80-4
PURITY:
≥97%
APPEARANCE:
White hygroscopic solid.
SOLUBILITY:
Soluble in water.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
+4°C
HANDLING:
Protect from light.
Product Description
Selective antagonist of the PI-linked metabotropic glutamate response.
Product Specific Literature References
1S,3R-ACPD stimulates and L-AP3 blocks Ca2+ mobilization in rat cerebellar neurons:
A.J. Irving, et al.; Eur. J. Pharmacol.
186
, 363 (1990)
Abstract
Stereoselectivity and mode of inhibition of phosphoinositide-coupled excitatory amino acid receptors by 2-amino-3-phosphonopropionic acid:
D.D. Schoepp, et al.; Mol. Pharmacol.
38
, 222 (1990)
Abstract
Metabotropic glutamate receptors in brain function and pathology:
D.D. Schoepp & P.J. Conn; TIPS
14
, 13 (1993), (Review)
Abstract
Long-lasting enhancement of NMDA receptor-mediated synaptic transmission by metabotropic glutamate receptor activation:
J.J. O'Connor, et al.; Nature
367
, 557 (1994)
Abstract
Pharmacological agents acting at subtypes of metabotropic glutamate receptors
:
D.D. Schoepp, et al.; Neuropharmacology
38
, 1431 (1999), (Review)
Abstract
ALX-550-037
Revised 17-Jan-05
DL-AP3
SYNONYMS
DL-2-Amino-3-phosphonopropanoic acid
PRODUCT LINE
Neurobiology
PRODUCT CATEGORY
NMDA Receptors / Related Products
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ALX-550-037-M050
50 mg
30.00 USD
Product Specification
FORMULA:
C
3
H
8
NO
5
P
MW:
169.1
CAS NUMBER:
20263-06-3
PURITY:
≥97%
APPEARANCE:
White powder.
SOLUBILITY:
Soluble in water.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
+4°C
HANDLING:
Protect from light. Hygroscopic.
Product Description
NMDA receptor antagonist.
Product Specific Literature References
The effects of a series of omega-phosphonic alpha-carboxylic amino acids on electrically evoked and excitant amino acid-induced responses in isolated spinal cord preparations:
R.H. Evans, et al.; Br. J. Pharmacol.
75
, 65 (1982)
Abstract
The metabotropic glutamate receptor antagonist L-2-amino-3-phosphonopropionic acid inhibits phosphoserine phosphatase:
J.E. Hawkinson, et al.; Eur. J. Pharmacol.
307
, 219 (1996)
Abstract
Pharmacological agents acting at subtypes of metabotropic glutamate receptors
:
D.D. Schoepp; Neuropharmacology
38
, 1431 (1999), (Review)
Abstract
ALX-550-024
Revised 26-Nov-04
D-AP4
SYNONYMS
D(-)-2-Amino-4-phosphonobutanoic acid
PRODUCT LINE
Neurobiology
PRODUCT CATEGORY
Glutamate Receptors (Metabotropic) / Related Products
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ALX-550-024-M005
5 mg
70.00 USD
Product Specification
FORMULA:
C
4
H
10
NO
5
P
MW:
183.1
CAS NUMBER:
78739-01-2
PURITY:
≥97%
APPEARANCE:
White powder.
SOLUBILITY:
Soluble in dilute aqueous base.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
+4°C
HANDLING:
Protect from light.
Product Description
Broad spectrum excitatory amino acid receptor antagonist.
Product Specific Literature References
The effects of a series of omega-phosphonic alpha-carboxylic amino acids on electrically evoked and excitant amino acid-induced responses in isolated spinal cord preparations:
R.H. Evans, et al.; Br. J. Pharmacol.
75
, 65 (1982)
Abstract
Actions of D and L forms of 2-amino-5-phosphonovalerate and 2-amino-4-phosphonobutyrate in the cat spinal cord:
J. Davies and J.C. Watkins; Brain Res.
235
, 378 (1982)
Abstract
Further Categories Containing This Product:
Excitatory Amino Acids
ALX-550-026
Revised 27-Nov-04
L-AP4
SYNONYMS
L(+)-2-Amino-4-phosphonobutanoic acid
PRODUCT LINE
Neurobiology
PRODUCT CATEGORY
Glutamate Receptors (Metabotropic) / Related Products
Ordering Information
Product Numbers:
Format:
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ALX-550-026-M005
5 mg
65.00 USD
ALX-550-026-M025
25 mg
280.00 USD
Product Specification
FORMULA:
C
4
H
10
NO
5
P
MW:
183.1
CAS NUMBER:
23052-81-5
PURITY:
≥97%
APPEARANCE:
White solid.
SOLUBILITY:
Soluble in dilute aqueous base.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
+4°C
HANDLING:
Protect from light.
Product Description
Selective agonist for group III mGluRs.
Product Specific Literature References
Micromolar L-2-amino-4-phosphonobutyric acid selectively inhibits perforant path synapses from lateral entorhinal cortex:
J.F. Koerner & C.W. Cotman; Brain Res.
216
, 192 (1981)
Abstract
Actions of D and L forms of 2-amino-5-phosphonovalerate and 2-amino-4-phosphonobutyrate in the cat spinal cord:
J. Davies & J.C. Watkins; Brain Res.
235
, 378 (1982)
Abstract
The effects of a series of omega-phosphonic alpha-carboxylic amino acids on electrically evoked and excitant amino acid-induced responses in isolated spinal cord preparations:
R.H. Evans, et al.; Br. J. Pharmacol.
75
, 65 (1982)
Abstract
Structure-activity relationships in the development of excitatory amino acid receptor agonists and competitive antagonists:
J.C. Watkins, et al.; TIPS
11
, 25 (1990)
Abstract
L-2-amino-4-phosphonobutyrate (L-AP4) is an agonist at the type IV metabotropic glutamate receptor which is negatively coupled to adenylate cyclase:
C. Thomsen, et al.; Eur. J. Pharmacol.
227
, 361 (1992)
Abstract
L-AP4 inhibits calcium currents and synaptic transmission via a G-protein-coupled glutamate receptor:
P.Q. Trombley and G.L. Westbrook; J. Neurosci.
12
, 2043 (1992)
Abstract
Molecular characterization of a novel retinal metabotropic glutamate receptor mGluR6 with a high agonist selectivity for L-2-amino-4- phosphonobutyrate:
Y. Nakajima, et al.; J. Biol. Chem.
268
, 11868 (1993)
Abstract
;
Full Text
Pharmacological agents acting at subtypes of metabotropic glutamate receptors:
D.D. Schoepp, et al.; Neuropharmacology
38
, 1431 (1999), (Review)
Abstract
ALX-550-025
Revised 07-May-03
DL-AP4
SYNONYMS
DL-2-Amino-4-phosphonobutanoic acid
PRODUCT LINE
Neurobiology
PRODUCT CATEGORY
NMDA Receptors / Related Products
Ordering Information
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ALX-550-025-M050
50 mg
25.00 USD
Product Specification
FORMULA:
C
4
H
10
NO
5
P
MW:
183.1
CAS NUMBER:
20263-07-4
PURITY:
≥97%
APPEARANCE:
White powder.
SOLUBILITY:
Soluble in dilute aqueous base.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
+4°C
HANDLING:
Protect from light.
Product Description
First generation NMDA antagonist.
Product Specific Literature References
Antagonism of excitatory amino acid-induced responses and of synaptic excitation in the isolated spinal cord of the frog:
R.H. Evans, et al.; Br. J. Pharmacol.
67
, 591 (1979)
Abstract
2-amino-4-phosphonobutyric acid: a new pharmacological tool for retina research:
M.M. Slaughter and R.F. Miller; Science
211
, 182 (1981)
Abstract
The effects of a series of omega-phosphonic alpha-carboxylic amino acids on electrically evoked and excitant amino acid-induced responses in isolated spinal cord preparations:
R.H. Evans, et al.; Br. J. Pharmacol.
75
, 65 (1982)
Abstract
Anticonvulsant action of 2-amino-7-phosphonoheptanoic acid in the substantia nigra:
G. De Sarro, et al.; Eur. J. Pharmacol.
106
, 175 (1984)
Abstract
ALX-550-033
Revised 07-Aug-07
D-AP5
SYNONYMS
D(-)-2-Amino-5-phosphonopentanoic acid
PRODUCT LINE
Neurobiology
PRODUCT CATEGORY
NMDA Receptors / Related Products
Ordering Information
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ALX-550-033-M005
5 mg
65.00 USD
ALX-550-033-M025
25 mg
260.00 USD
Product Specification
FORMULA:
C
5
H
12
NO
5
P
MW:
197.1
CAS NUMBER:
79055-68-8
PURITY:
≥97%
APPEARANCE:
White to off-white powder.
SOLUBILITY:
Soluble in water (acidify for better solubility).
SHIPPING:
AMBIENT
LONG TERM STORAGE:
+4°C
HANDLING:
Protect from light.
Product Description
More active form of DL-AP5 (Prod. No.
ALX-550-034
).
Widely used competitive NMDA receptor antagonist.
Product Specific Literature References
Activity of the enantiomers of 2-amino-5-phosphono-valeric acid as stereospecific antagonists of excitatory aminoacids:
T.W. Stone, et al.; Neuroscience
6
, 2249 (1981)
Abstract
2-Amino-5-phosphonovalerate (2APV), a potent and selective antagonist of amino acid-induced and synaptic excitation:
J. Davies, et al.; Neurosci. Lett.
21
, 77 (1981)
Abstract
The effects of a series of omega-phosphonic alpha-carboxylic amino acids on electrically evoked and excitant amino acid-induced responses in isolated spinal cord preparations:
R.H. Evans, et al.; Br. J. Pharmacol.
75
, 65 (1982)
Abstract
Actions of D and L forms of 2-amino-5-phosphonovalerate and 2-amino-4- phosphonobutyrate in the cat spinal cord:
J. Davies & J.C. Watkins; Brain Res.
235
, 378 (1982)
Abstract
The NMDA receptor antagonist D-2-amino-5-phosphonopentanoate (D-AP5) impairs spatial learning and LTP in vivo at intracerebral concentrations comparable to those that block LTP in vitro:
J. Davis; J. Neurosci.
12
, 21 (1992)
Abstract
ALX-550-035
Revised 26-Nov-04
L-AP5
SYNONYMS
L(+)-2-Amino-5-phosphonopentanoic acid
PRODUCT LINE
Neurobiology
PRODUCT CATEGORY
NMDA Receptors / Related Products
Ordering Information
