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Receptors
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ALX-550-269 Revised 27-Oct-06
8-Cyclopentyl-1,3-dipropylxanthine
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SYNONYMS DPCPX
PD 116,948
1,3-Dipropyl-8-cyclopentylxanthine
PRODUCT LINE Neurobiology
PRODUCT CATEGORY Adenosine Receptors / Related Products
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ALX-550-269-M010   10 mg 35.00 USD Add To Cart
Product Specification
FORMULA: C16H24N4O2
MW: 304.4
CAS NUMBER: 102146-07-6
PURITY: ≥98% (HPLC)
APPEARANCE: White to light yellow.
SOLUBILITY: Soluble in 100% ethanol or DMSO; insoluble in water.
SHIPPING: AMBIENT
LONG TERM STORAGE: +20°C
HAZARD: IRRITANT.

Product Description
Potent and very selective A1 adenosine receptor antagonist, both in vitro and in vivo.
Product Specific Literature References
1,3-Dipropyl-8-cyclopentylxanthine (DPCPX) inhibition of [3H]N- ethylcarboxamidoadenosine (NECA) binding allows the visualization of putative non-A1 adenosine receptors: K.S. Lee & M. Reddington; Brain Res. 368, 394 (1986) Abstract
Binding of the A1-selective adenosine antagonist 8-cyclopentyl-1,3- dipropylxanthine to rat brain membranes: R.F. Bruns, et al.; Naunyn-Schmiedeberg's Arch. Pharmacol. 335, 59 (1987) Abstract
PD 116,948, a highly selective A1 adenosine receptor antagonist: S.J. Haleen, et al.; Life Sci. 40, 555 (1987) Abstract
Effects of 1,3-dipropyl-8-cyclopentylxanthine (DPCPX), a highly selective adenosine receptor antagonist, on force of contraction in guinea-pig atrial and ventricular cardiac preparations: H. von der Leyen, et al.; Naunyn-Schmiedeberg's Arch. Pharmacol. 340, 204 (1989) Abstract
Characterization of the adenosine receptors mediating hypothermia in the conscious mouse: Anderson, et al.; Br. J. Pharmacol. 113, 1386 (1994) Abstract
 
 
ALX-106-028 Revised 03-Apr-08
D-Cycloserine
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SYNONYMS R(+)-4-Amino-3-isoxazolidinone
PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Natural Products for Neurological Research
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ALX-106-028-M050   50 mg 20.00 USD Add To Cart
ALX-106-028-M250   250 mg 80.00 USD Add To Cart
Product Specification
FORMULA: C3H6N2O2
MW: 102.1
CAS NUMBER: 68-41-7
RTECS: NY2975000
SOURCE/HOST: Synthetic.
PURITY: ≥97%
APPEARANCE: White to off-white solid.
SOLUBILITY: Soluble in water.
SHIPPING: AMBIENT
LONG TERM STORAGE: +4°C
HANDLING: Hygroscopic.

Product Description
Excitatory amino acid. Partial agonist at the glycine modulatory site of the NMDA receptor.
Further Categories Containing This Product:
Excitatory Amino Acids • Special Amino Acids • NMDA Receptors / Related Products
 
 
ALX-106-037 Revised 09-Oct-07
L-Cycloserine
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SYNONYMS S(-)-4-Amino-3-isoxazolidinone
PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Natural Products for Neurological Research
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ALX-106-037-M025   25 mg 50.00 USD Add To Cart
ALX-106-037-M100   100 mg 150.00 USD Add To Cart
Product Specification
FORMULA: C3H6N2O2
MW: 102.1
CAS NUMBER: 339-72-0; 4834-58-6
MERCK INDEX: 14: 2751
RTECS: NY2976000
PURITY: ≥98%
APPEARANCE: White to off-white powder.
SOLUBILITY: Soluble in water.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
HANDLING: Hygroscopic.

Product Description
Excitatory amino acid. Inhibitor of ketosphinganine synthase (serine-palmitoyl-CoA transferase, EC 2.3.1.50), leading to blockade of sphingosine biosynthesis. Partial agonist at the glycine modulatory site of the NMDA receptor.
Product Specific Literature References
Inhibition of sphingolipid synthesis by cycloserine in vitro and in vivo: K.S. Sundaram & M. Lev; J. Neurochem. 42, 577 (1984) Abstract
Inhibition of serine palmitoyltransferase activity in rabbit aorta by L-cycloserine: R.D. Williams, et al.; J. Lipid Res. 28, 1478 (1987) Abstract; Full Text
D-cycloserine acts as a partial agonist at the glycine modulatory site of the NMDA receptor expressed in Xenopus oocytes: G.B. Watson, et al.; Brain Res. 510, 158 (1990) Abstract
D-cycloserine, a putative cognitive enhancer, facilitates activation of the N-methyl-D-aspartate receptor-ionophore complex in Alzheimer brain: I.P. Chessell, et al.; Brain Res. 565, 345 (1991) Abstract
Rapid kidney changes resulting from glycosphingolipid depletion by treatment with a glucosyltransferase inhibitor: G.S. Shukla, et al.; Biochim. Biophys. Acta 1083, 101 (1991) Abstract
Further Categories Containing This Product:
Special Amino Acids • Excitatory Amino Acids • NMDA Receptors / Related Products
 
 
ALX-550-338 Revised 31-May-07
Cyclothiazide
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SYNONYMS 3-Bicyclo[2.2.1]hept-5-en-2-yl-6-chloro-3,4-dihydro-2H-1,2,4-benzothiadiazine-7-sulfonamide 1,1-dioxide
6-Chloro-3,4-dihydro-3[2-norbornen-5-yl]-2H-1,2,4-benzothiadiazine-7-sulfonamide 1,1-dioxide
PRODUCT LINE Neurobiology
PRODUCT CATEGORY AMPA Receptors / Related Products
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ALX-550-338-M010   10 mg 40.00 USD Add To Cart
ALX-550-338-M050   50 mg 160.00 USD Add To Cart
Product Specification
FORMULA: C14H16ClN3O4S2
MW: 389.9
CAS NUMBER: 2259-96-3
MERCK INDEX: 14: 2754
PURITY: ≥98% (HPLC)
APPEARANCE: White to off-white solid.
SOLUBILITY: Soluble in DMSO, methanol (36mg/ml) or dilute aqueous base (36mg/ml); insoluble in water.
SHIPPING: AMBIENT
LONG TERM STORAGE: +4°C
MELTINGPOINT: 228-230°C

Product Description
Potently inhibits the desensitization of AMPA receptors. Antihypertensive.
Product Specific Literature References
Desensitization of AMPA receptors upon multiquantal neurotransmitter release: L.O. Trussell, et al.; Neuron 10, 1185 (1993) Abstract
Differential modulation by cyclothiazide and concanavalin A of desensitization at native alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid- and kainate-preferring glutamate receptors: L.A. Wong & M.L. Mayer; Mol. Pharmacol. 44, 504 (1993) Abstract
Cyclothiazide potentiates agonist responses at human AMPA/kainate receptors expressed in oocytes: R.L. Sharp, et al.; Eur. J. Pharmacol. 266, R1 (1994) Abstract
Modulation of AMPA/kainate receptors by cyclothiazide increases cytoplasmic free Ca2+ and 45Ca2+ uptake in brain neurons: G. Cebers & S. Liljequist; Eur. J. Pharmacol. 290, 105 (1995) Abstract
Cyclothiazide acts at a site on the alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid receptor complex that does not recognize competitive or noncompetitive AMPA receptor antagonists: M.A. Desai, et al.; J. Pharmacol. Exp. Ther. 272, 38 (1995) Abstract
Inhibition by cyclothiazide of neuronal nicotinic responses in bovine chromaffin cells: J.M. Nooney & A. Feltz; Br. J. Pharmacol. 114, 648 (1995) Abstract
 
 
ALX-350-373 Revised 10-Jul-08 New product
Cytisine
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PRODUCT LINE Neurobiology
PRODUCT CATEGORY Acetylcholine Receptors (Nicotinic) / Related Products
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ALX-350-373-M005   5 mg 35.00 USD Add To Cart
ALX-350-373-M025   25 mg 120.00 USD Add To Cart
Product Specification
FORMULA: C11H14N2O
MW: 190.2
CAS NUMBER: 485-35-8
MERCK INDEX: 14:2789
RTECS: HA4025000
SOURCE/HOST: Isolated from seeds of Laburnum anagyroides
PURITY: ≥95% (HPLC)
APPEARANCE: Light to dark yellow powder.
SOLUBILITY: Soluble in benzene, acetone, ethyl acetate or 100% ethanol; sparingly soluble in water or methanol.
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: -20°C
HAZARD: TOXIC.
IDENTITY: Identity determined by 1H-NMR.

Product Description
Pyridine-like alkaloid. Nicotine agonist. Potent ligand for many nAChR subtypes. Potent agonist at α3β4 and α7 nicotinic acetylcholine receptors and partial agonist at α4β2 nicotinic acetylcholine receptors. Shows analgesic, antihypertensive and inotropic activities.
Product Specific Literature References
Some studies on cytisine and its methylated derivatives: R.B. Barlow & L.J. McLeod; Br. J. Pharmacol. 35, 161 (1969) Abstract; Full Text
Release of [3H]-noradrenaline from rat hippocampal synaptosomes by nicotine: mediation by different nicotinic receptor subtypes from striatal [3H]-dopamine release: P.B. Clarke & M. Reuben; Br. J. Pharmacol. 117, 595 (1996) Abstract; Full Text
Evaluation of anti-nociceptive effects of neuronal nicotinic acetylcholine receptor (NAChR) ligands in the rat tail-flick assay: T.S. Rao, et al.; Neuropharmacology 35, 393 (1996) Abstract
Somatic and prejunctional nicotinic receptors in cultured rat sympathetic neurones show different agonist profiles: D. Kristufek, et al.; J. Physiol. 516, 739 (1999) Abstract; Full Text
Inherited, selective hypoanalgesic response to cytisine in the tail-flick test in CF-1 mice: T.W. Seale, et al.; Neuroreport 9, 201 (1998) Abstract
Effects of cytisine on hydroxyl radicals in vitro and MPTP-induced dopamine depletion in vivo: B. Ferger, et al.; Eur. J. Pharmacol. 360, 155 (1998) Abstract
Cytisine derivatives as ligands for neuronal nicotine receptors and with various pharmacological activities: C.C. Boido, et al.; Farmaco 58, 265 (2003) Abstract
Pharmacological characterization of recombinant bovine alpha3beta4 neuronal nicotinic receptors stably expressed in HEK 293 cells: R.B. Free, et al.; Neurosci. Lett. 343, 180 (2003) Abstract
Nitrogen substitution modifies the activity of cytisine on neuronal nicotinic receptor subtypes: E. Carbonnelle, et al.; Eur. J. Pharmacol. 471, 85 (2003) Abstract
Cytisine binds with similar affinity to nicotinic alpha4beta2 receptors on the cell surface and in homogenates: J. Zhang & J.H. Steinbach; Brain Res. 959, 98 (2003) Abstract
Pharmacological characterization of recombinant bovine alpha3beta4 neuronal nicotinic receptors stably expressed in HEK 293 cells: R.B. Free, et al.; Neurosci. Lett. 343, 180 (2003) Abstract
Cytisine, a partial agonist of high-affinity nicotinic acetylcholine receptors, has antidepressant-like properties in male C57BL/6J mice: Y.S. Mineur, et al.; Neuropharmacology 52, 1256 (2007) Abstract; Full Text
Ligands selective for alpha4beta2 but not alpha3beta4 or alpha7 nicotinic receptors generalise to the nicotine discriminative stimulus in the rat: J.W. Smith, et al.; Psychopharmacology (Berl) 190, 157 (2007) Abstract
 
 
ALX-550-046 Revised 14-May-03
4-DAMP methiodide
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SYNONYMS 4-Diphenylacetoxy-N-methylpiperidine methiodide
PRODUCT LINE Neurobiology
PRODUCT CATEGORY Acetylcholine Receptors (Muscarinic) / Related Products
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ALX-550-046-M005   5 mg 20.00 USD Add To Cart
ALX-550-046-M025   25 mg 60.00 USD Add To Cart
Product Specification
FORMULA: C21H26NO2I
MW: 451.4
CAS NUMBER: 1952-15-4
PURITY: ≥99.5%
APPEARANCE: White powder.
SOLUBILITY: Soluble in water.
SHIPPING: AMBIENT
LONG TERM STORAGE: +20°C
HANDLING: Protect from light.

Product Description
M3 muscarinic receptor antagonist.
Product Specific Literature References
A further search for selective antagonists at M2-muscarinic receptors: R.B. Barlow & M.K. Shepherd; Br. J. Pharmacol. 89, 837 (1986) Abstract
 
 
ALX-620-064 Revised 17-Dec-04
Dansyl-NECA
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SYNONYMS 1-Deoxy-1-[6-[[6-[[[5-(dimethylamino)-1-naphthalenyl]sulfonyl]amino]hexyl]amino]-9H-purin-9-yl]-N-ethyl-β-D-ribofuranuronamide
PRODUCT LINE Neurobiology
PRODUCT CATEGORY Adenosine Receptors / Related Products
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ALX-620-064-MC05   0.5 mg 80.00 USD Add To Cart
Product Specification
FORMULA: C30H40N8O6S
MW: 640.8
CAS NUMBER: 219982-12-4
PURITY: ≥98%
APPEARANCE: Yellow solid.
SOLUBILITY: Soluble in DMSO or methanol.
SHIPPING: AMBIENT
LONG TERM STORAGE: +4°C
HANDLING: Protect from light.

Product Description
Fluorescent ligand for adenosine receptors with a marked selectivity for the A1 receptor subtype. Has been successfully applied in fluorescence microscopy assays.
Product Specific Literature References
Fluorescent probes for adenosine receptors: synthesis and biology of N6-dansylaminoalkyl-substituted NECA derivatives: M. Macchia, et al.; Bioorg. Med. Chem. Lett. 8, 3223 (1998) Abstract
Further Categories Containing This Product:
Dyes / Stains / Fluorescent Probes / Fluorescent Labels
 
 
ALX-270-281 Revised 28-Sep-06
Daphnetin
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SYNONYMS 7,8-Dihydroxycoumarin
PRODUCT LINE Signal Transduction
PRODUCT CATEGORY EGFR Kinase Inhibitors
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ALX-270-281-M005   5 mg 25.00 USD Add To Cart
ALX-270-281-M025   25 mg 95.00 USD Add To Cart
Product Specification
FORMULA: C9H6O4
MW: 178.1
CAS NUMBER: 486-35-1
RTECS: GN6382600
PURITY: ≥97%
APPEARANCE: White to rose powder.
SOLUBILITY: Soluble in 100% ethanol, methanol or dimethyl formamide.
SHIPPING: AMBIENT
LONG TERM STORAGE: +20°C

Product Description
Inhibitor of protein kinases. EGF receptor tyrosine kinase (IC50=7.87µM), PKA (IC50=9.33µM), PKC (IC50=25.01µM). Antioxidant. Antimalarial agent.
Product Specific Literature References
Daphnetin: a novel antimalarial agent with in vitro and in vivo activity: Y.Z. Yang, et al.; Am. J. Trop. Med. Hyg. 46, 15 (1992) Abstract
Daphnetin, one of coumarin derivatives, is a protein kinase inhibitor: E.B. Yang, et al.; BBRC 260, 682 (1999) Abstract
Further Categories Containing This Product:
Antioxidants, Flavonoids & Free Radical Scavengers Other Products • PKA Inhibitors • Malaria / Related Products • Tyrosine Kinase Inhibitors
 
 
ALX-550-334 Revised 28-Jan-05
DCG IV
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SYNONYMS (2S,2'R,3'R)-2-(2',3'-Dicarboxycyclopropyl)glycine
PRODUCT LINE Neurobiology
PRODUCT CATEGORY Glutamate Receptors (Metabotropic) / Related Products
Ordering Information
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ALX-550-334-M001   1 mg 50.00 USD Add To Cart
ALX-550-334-M005   5 mg 150.00 USD Add To Cart
ALX-550-334-M010   10 mg 280.00 USD Add To Cart
Product Specification
FORMULA: C7H9NO6
MW: 203.2
CAS NUMBER: 147782-19-2
PURITY: ≥96%
SOLUBILITY: Soluble in water.
SHIPPING: AMBIENT
LONG TERM STORAGE: +4°C
HANDLING: Protect from light.

Product Description
Highly potent group II mGluR agonist. Presynaptic depressant.
Product Specific Literature References
A potent metabotropic glutamate receptor agonist: electrophysiological actions of a conformationally restricted glutamate analogue in the rat spinal cord and Xenopus oocytes: M. Ishida, et al.; Brain Res. 537, 311 (1990) Abstract
Agonist analysis of 2-(carboxycyclopropyl)glycine isomers for cloned metabotropic glutamate receptor subtypes expressed in Chinese hamster ovary cells: Y. Hayashi, et al.; Br. J. Pharmacol. 107, 539 (1992) Abstract
A new metabotropic glutamate receptor agonist: developmental change of its sensitivity to receptors in the newborn rat spinal cord: M. Ishida, et al.; Neurosci. Lett. 160, 156 (1993) Abstract
A novel metabotropic glutamate receptor agonist: marked depression of monosynaptic excitation in the newborn rat isolated spinal cord: M. Ishida, et al.; Br. J. Pharmacol. 109, 1169 (1993) Abstract
Synthesis of L-2-(2,3-dicarboxycyclopropyl)-glycines. Novel conformationally restricted glutamate analogues: Y. Ohfune, et al.; Bioorg. Med. Chem. Lett. 3, 15 (1993)
Metabotropic glutamate receptor agonist DCG-IV as NMDA receptor agonist in immature rat hippocampal neurons: V.W. Wilsch, et al.; Eur. J. Pharmacol. 262, 287 (1994) Abstract
DCG-IV inhibits synaptic transmission by activation of NMDA receptors in area CA1 of rat hippocampus: N.A. Breakwell, et al.; Eur. J. Pharmacol. 322, 173 (1997) Abstract
Anticonvulsive and neuroprotective actions of a potent agonist (DCG-IV) for group II metabotropic glutamate receptors against intraventricular kainate in the rat: M. Miyamoto, et al.; Neuroscience 77, 131 (1997) Abstract
DCG-IV, a potent metabotropic glutamate receptor agonist, as an NMDA receptor agonist in the rat cortical slice: Y. Uyama, et al.; Brain Res. 752, 327 (1997) Abstract
Anticonvulsant and glutamate release-inhibiting properties of the highly potent metabotropic glutamate receptor agonist (2S,2'R, 3'R)-2-(2',3'-dicarboxycyclopropyl)glycine (DCG-IV): P.J. Attwell, et al.; Brain Res. 805, 138 (1998) Abstract
Comparative effect of L-CCG-I, DCG-IV and gamma-carboxy-L-glutamate on all cloned metabotropic glutamate receptor subtypes: I. Brabet, et al.; Neuropharmacology 37, 1043 (1998) Abstract
Presynaptic inhibitory action of the group II metabotropic glutamate receptor agonists, LY354740 and DCG-IV: J. Kilbride, et al.; Eur. J. Pharmacol. 356, 149 (1998) Abstract
Regulation of phosphoinositide turnover in neonatal rat cerebral cortex by group I- and II- selective metabotropic glutamate receptor agonists: R. Mistry, et al.; Br. J. Pharmacol. 123, 581 (1998) Abstract
Pharmacological agents acting at subtypes of metabotropic glutamate receptors: D.D. Schoepp, et al.; Neuropharmacology 38, 1431 (1999), (Review) Abstract
 
 
ALX-522-055 Revised 24-Mar-05
DcR3 (human):Fc (human) (recombinant)
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