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MAPK Pathway Substrates
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ALX-155-024 Revised 04-Feb-05
ERT Protein Kinase Substrate
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PRODUCT LINE Signal Transduction
PRODUCT CATEGORY MAPK Pathway Substrates
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Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-155-024-M001   1 mg 90.00 USD Add To Cart
ALX-155-024-M005   5 mg 360.00 USD Add To Cart
Product Specification
SEQUENCE: H-Lys-Arg-Glu-Leu-Val-Glu-Pro-Leu-Thr-Pro-Ser-Gly-Glu-Ala-Pro-Asn-Gln-Ala-Leu-Leu-Arg-OH
FORMULA: C101H172N30O32
MW: 2318.7
PURITY: ≥97%
APPEARANCE: White lyophilized powder.
SOLUBILITY: Soluble in water.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
Product Description
Substrate for the growth factor-stimulated (MAP2-related) protein kinase (ERT protein kinase). The peptide covers the ERT protein kinase phosphorylation site aa 689-705 of human precursor epidermal growth factor (EGF) receptor at Thr669 (mouse Thr671) .
Product Specific Literature References
Pro-Leu-Ser/Thr-Pro is a consensus primary sequence for substrate protein phosphorylation. Characterization of the phosphorylation of c- myc and c-jun proteins by an epidermal growth factor receptor threonine 669 protein kinase: E. Alvarez, et al.; J. Biol. Chem. 266, 15277 (1991) Abstract; Full Text
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Peptides
 
 
ALX-155-026 Revised 04-Jul-03
ERT Protein Kinase Substrate Amide
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PRODUCT LINE Signal Transduction
PRODUCT CATEGORY MAPK Pathway Substrates
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ALX-155-026-M001   1 mg 80.00 USD Add To Cart
ALX-155-026-M005   5 mg 280.00 USD Add To Cart
Product Specification
SEQUENCE: H-Lys-Arg-Glu-Leu-Val-Glu-Pro-Leu-Thr-Pro-Ser-Gly-Glu-Ala-Pro-Asn-Gln-Ala-Leu-Leu-Arg-NH2
FORMULA: C101H173N31O31
MW: 2317.7
PURITY: ≥97%
APPEARANCE: White lyophilized powder.
SOLUBILITY: Soluble in water.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
Product Description
Substrate for the growth factor-stimulated (MAP2-related) protein kinase (ERT protein kinase). The peptide covers the ERT protein kinase phosphorylation site aa 689-705 of human precursor epidermal growth factor receptor (EGFR) at Thr669 (mouse Thr671).
Product Specific Literature References
Pro-Leu-Ser/Thr-Pro is a consensus primary sequence for substrate protein phosphorylation. Characterization of the phosphorylation of c- myc and c-jun proteins by an epidermal growth factor receptor threonine 669 protein kinase: E. Alvarez, et al.; J. Biol. Chem. 266, 15277 (1991) Abstract; Full Text
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Peptides
 
 
ALX-202-076 Revised 04-Jul-07
Myelin Basic Protein (bovine) (high purity)
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SYNONYMS MBP (bovine) (high purity)
PRODUCT LINE Neurobiology
PRODUCT CATEGORY Myelin Basic Protein / Related Products
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ALX-202-076-M001   1 mg 30.00 USD Add To Cart
ALX-202-076-M005   5 mg 120.00 USD Add To Cart
ALX-202-076B-M001 Biotin 1 mg 180.00 USD Add To Cart
Product Specification
SOURCE/HOST: Purified from bovine central nervous system tissue by method of Määttä et al. [1].
PURITY: ≥95% (SDS-PAGE; immunoblot)
FORMULATION: Lyophilized. Essentially salt-free.
RECONSTITUTION: Reconstitute with distilled water.
SHIPPING: SHIPPED ON BLUE ICE
SHORT TERM STORAGE: +4°C
LONG TERM STORAGE: -20°C
USE/STABILITY: Stable for at least 1 year when stored at +4°C. Reconstituted protein is stable for at least 6 months at -20°C and for at least 24 hours at +37°C in aqueous solution.
Product Specific Literature References
[1] Detection of myelin basic protein isoforms by organic concentration: J.A. Määttä, et al.; BBRC 238, 498 (1997) Abstract
General Information
MBP is a peripheral membrane protein, and its interaction with lipids is generally believed to be critical for the formation and stability of the multilamellar myelin sheath. It has been identified as a Ca2+-calmodulin regulated agent for actin polymerization, tropomyosin and actomyosin function, tubulin stabilization, and clathrin assembley.
MBP is generally considered to be the antigen responsible for autoimmunity in multiple sclerosis (MS) and it has the capability to induce experimental allergic encephalomyelitis (EAE). MBP is also an endogenous inhibitor of the high-affinity cannabinoid binding site in the brain and a substrate for numerous protein kinases (MAPK, serine/threonine kinase, protein kinase C). MBP is also suggested to be involved in intracellular signalling and as cytoskeletal components.
Further Categories Containing This Product:
CAM Kinase Substrates • MAPK Pathway Substrates • Natural Proteins
 
 
ALX-200-606 Revised 08-May-08
Myelin Basic Protein (human) (high purity)
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SYNONYMS MBP (human) (high purity)
PRODUCT LINE Neurobiology
PRODUCT CATEGORY Myelin Basic Protein / Related Products
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ALX-200-606-M001   1 mg 350.00 USD Add To Cart
Product Specification
SOURCE/HOST: Purified from human brain by method of Määttä et al. [1].
CONCENTRATION: 1mg/ml after reconstitution.
PURITY: ≥95% (SDS-PAGE; Immunoblot)
APPEARANCE: White to off-white powder.
FORMULATION: Lyophilized. Essentially salt-free.
RECONSTITUTION: Reconstitute with distilled water.
SHIPPING: SHIPPED ON BLUE ICE
SHORT TERM STORAGE: +4°C
LONG TERM STORAGE: -20°C
USE/STABILITY: Stable for at least 1 year when stored at +4°C. Reconstituted protein is stable for at least six months at -20°C and for at least 24 hours at +37°C in aqueous solution.
Product Specific Literature References
[1] Detection of myelin basic protein isoforms by organic concentration: J.A. Määttä, et al.; BBRC 238, 498 (1997) Abstract
Interaction between the C-terminal region of human myelin basic protein and calmodulin: analysis of complex formation and solution structure: V. Majava, et al.; BMC Struct. Biol. 8, 10 (2008) Abstract; Full Text
General Information
MBP is a peripheral membrane protein, and its interaction with lipids is generally believed to be critical for the formation and stability of the multilamellar myelin sheath. It has been identified as a Ca2+-calmodulin regulated agent for actin polymerization, tropomyosin and actomyosin function, tubulin stabilization, and clathrin assembley. MBP is generally considered to be the antigen responsible for autoimmunity in multiple sclerosis (MS) and it has the capability to induce experimental allergic encephalomyelitis (EAE). MBP is also an endogenous inhibitor of the high-affinity cannabinoid binding site in the brain and a substrate for numerous protein kinases (MAPK, serine/threonine kinase, protein kinase C). MBP is also suggested to be involved in intracellular signalling and as cytoskeletal components.
Further Categories Containing This Product:
Natural Proteins • MAPK Pathway Substrates • CAM Kinase Substrates
 
 
ALX-202-075 Revised 20-Sep-06
Myelin Basic Protein (mouse) (high purity)
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SYNONYMS MBP (mouse) (high purity)
PRODUCT LINE Neurobiology
PRODUCT CATEGORY Myelin Basic Protein / Related Products
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Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-202-075-M001   1 mg 120.00 USD Add To Cart
Product Specification
SOURCE/HOST: Purified from mouse central nervous system tissue by method of Määttä et al. [1].
PURITY: ≥95% (SDS-PAGE; immunoblot)
FORMULATION: Lyophilized. Essentially salt-free.
RECONSTITUTION: Reconstitute with distilled water.
SHIPPING: SHIPPED ON BLUE ICE
SHORT TERM STORAGE: +4°C
LONG TERM STORAGE: -20°C
USE/STABILITY: Stable for at least 1 year when stored at +4°C. Reconstituted protein is stable for at least six months at -20°C and for at least 24h at +37°C in aqueous solution.
Product Specific Literature References
[1] Detection of myelin basic protein isoforms by organic concentration: J.A. Määttä, et al.; BBRC 238, 498 (1997) Abstract
General Information
MBP is a peripheral membrane protein, and its interaction with lipids is generally believed to be critical for the formation and stability of the multilamellar myelin sheath. It has been identified as a Ca2+-calmodulin regulated agent for actin polymerization, tropomyosin and actomyosin function, tubulin stabilization, and clathrin assembley.
MBP is generally considered to be the antigen responsible for autoimmunity in multiple sclerosis (MS) and it has the capability to induce experimental allergic encephalomyelitis (EAE). MBP is also an endogenous inhibitor of the high-affinity cannabinoid binding site in the brain and a substrate for numerous protein kinases (MAPK, serine/threonine kinase, protein kinase C). MBP is also suggested to be involved in intracellular signalling and as cytoskeletal components.
Further Categories Containing This Product:
CAM Kinase Substrates • MAPK Pathway Substrates • Natural Proteins
 
 
ALX-202-077 Revised 22-Aug-06
Myelin Basic Protein (porcine) (high purity)
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SYNONYMS MBP (porcine) (high purity)
PRODUCT LINE Neurobiology
PRODUCT CATEGORY Myelin Basic Protein / Related Products
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-202-077-M001   1 mg 35.00 USD Add To Cart
ALX-202-077-M005   5 mg 140.00 USD Add To Cart
Product Specification
SOURCE/HOST: Purified from porcine brain by method of Määttä et al. [1].
PURITY: ≥95% (SDS-PAGE; immunoblot)
FORMULATION: Lyophilized. Essentially salt-free.
RECONSTITUTION: Reconstitute with distilled water.
SHIPPING: SHIPPED ON BLUE ICE
SHORT TERM STORAGE: +4°C
LONG TERM STORAGE: -20°C
USE/STABILITY: Stable for at least 3 years when stored at +4°C. Reconstituted protein is stable for at least six months at -20°C and for at least 24 hours at +37°C in aqueous solution.
Product Description
Passes activity test as a protein kinase substrate according to Courtney et al. [2].
Product Specific Literature References
[1] Detection of myelin basic protein isoforms by organic concentration: J.A. Määttä, et al.; BBRC 238, 498 (1997) Abstract
[2] Neurotrophins protect cultured cerebellar granule neurons against the early phase of cell death by a two-component mechanism: M.J. Courtney, et al.; J. Neurosci. 17, 4201 (1997) Abstract
General Information
MBP is a peripheral membrane protein, and its interaction with lipids is generally believed to be critical for the formation and stability of the multilamellar myelin sheath. It has been identified as a Ca2+-calmodulin regulated agent for actin polymerization, tropomyosin and actomyosin function, tubulin stabilization, and clathrin assembley.
MBP is generally considered to be the antigen responsible for autoimmunity in multiple sclerosis (MS) and it has the capability to induce experimental allergic encephalomyelitis (EAE). MBP is also an endogenous inhibitor of the high-affinity cannabinoid binding site in the brain and a substrate for numerous protein kinases (MAPK, serine/threonine kinase, protein kinase C). MBP is also suggested to be involved in intracellular signalling and as cytoskeletal components.
Further Categories Containing This Product:
CAM Kinase Substrates • MAPK Pathway Substrates • Natural Proteins
 
 
ALX-168-005 Revised 04-Mar-05
Tyrosine Hydroxylase (24-33) (rat)
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PRODUCT LINE Signal Transduction
PRODUCT CATEGORY MAPK Pathway Substrates
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ALX-168-005-M001   1 mg 85.00 USD Add To Cart
Product Specification
SEQUENCE: H-Lys-Gln-Ala-Glu-Ala-Val-Thr-Ser-Pro-Arg-OH
FORMULA: C45H79N15O16
MW: 1086.2
PURITY: ≥98%
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
Product Description
Represents consensus site for MAP kinase (MAPK/ERK) phosphorylation. Includes the Ser31 phosphorylation site.
Product Specific Literature References
ERK1 and ERK2, two microtubule-associated protein 2 kinases, mediate the phosphorylation of tyrosine hydroxylase at serine-31 in situ: J.W. Haycock, et al.; PNAS 89, 2365 (1992) Abstract
Further Categories Containing This Product:
Peptides
 
 
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