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Ligand-gated Ion Channels
You are here: Product Lines > Signal Transduction > Receptors > Ligand-gated Ion Channels
 
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ALX-550-520 Revised 02-Jun-08
Sazetidine-A
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PRODUCT LINE Neurobiology
PRODUCT CATEGORY Acetylcholine Receptors (Nicotinic) / Related Products
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Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-550-520-M001   1 mg 180.00 USD Add To Cart
Product Specification
FORMULA: C15H20N2O2 . 2HCl
MW: 260.3 . 73.0
CAS NUMBER: 820231-95-6
PURITY: ≥95% (HPLC)
APPEARANCE: White to off-white solid.
SOLUBILITY: Soluble in DMSO, methanol or water.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C

Product Description
Novel ligand of nicotinic acetylcholine receptors (nAChRs). Potent agonist of native and recombinant
α4β2 nACHRs showing differential efficacy on α4β2 nAChRs subtypes.
Product Specific Literature References
Sazetidine-A, a novel ligand that desensitizes alpha4beta2 nicotinic acetylcholine receptors without activating them: Y. Xiao, et al.; Mol. Pharmacol. 70, 1454 (2006) Abstract; Full Text
Sazetidine-A is a potent and selective agonist at native and recombinant alpha4beta2 nicotinic acetylcholine receptors: R. Zwart, et al.; Mol. Pharmacol. 73, 1838 (2008) Abstract
 
 
ALX-550-004 Revised 18-Nov-08
Spermidine . trihydrochloride
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SYNONYMS N-[3-Aminopropyl]-1,4-butanediamine . 3HCl
PRODUCT LINE Neurobiology
PRODUCT CATEGORY NMDA Receptors / Related Products
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ALX-550-004-G001   1 g 38.00 USD Add To Cart
ALX-550-004-G005   5 g 90.00 USD Add To Cart
Product Specification
FORMULA: C7H19N3 . 3HCl
MW: 145.2 . 109.4
CAS NUMBER: 334-50-9
MERCK INDEX: 14: 8742
PURITY: ≥98%
APPEARANCE: White crystalline solid.
SOLUBILITY: Soluble in water.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
HANDLING: Keep under inert gas. Strong odor, keep tightly sealed.

Product Description
Spermidine is a precursor of spermine. It binds to the polyamine modulatory site of the NMDA receptor and has shown to potentiate NMDA-induced currents in a concentration-dependent manner.
Product Specific Literature References
Interactions of polyamines with neuronal ion channels: R.H. Scott, et al.; TINS 16, 153 (1993), (Review) Abstract
Further Categories Containing This Product:
Nitric Oxide Pathway Other Products
 
 
ALX-550-003 Revised 13-Oct-05
Spermine . tetrahydrochloride
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SYNONYMS N,N'-bis[3-Aminopropyl]-1,4-butanediamine . 4HCl
PRODUCT LINE Neurobiology
PRODUCT CATEGORY NMDA Receptors / Related Products
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ALX-550-003-G001   1 g 40.00 USD Add To Cart
ALX-550-003-G005   5 g 160.00 USD Add To Cart
Product Specification
FORMULA: C10H26N4 . 4HCl
MW: 202.4 . 145.8
CAS NUMBER: 306-67-2
MERCK INDEX: 14: 8743
PURITY: ≥98%
APPEARANCE: White to off-white powder.
SOLUBILITY: Soluble in water.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
HANDLING: Strong odor, keep tightly sealed. Keep under inert gas.
HAZARD: IRRITANT.

Product Specific Literature References
Interactions of polyamines with neuronal ion channels: R.H. Scott, et al.; TINS 16, 153 (1993), (Review) Abstract
Further Categories Containing This Product:
Nitric Oxide Pathway Other Products
 
 
ALX-430-022 Revised 11-Jun-08
Suramin . hexasodium salt
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SYNONYMS Suramin . 6Na
PRODUCT LINE Neurobiology
PRODUCT CATEGORY P2X Purinergic Receptors / Related Products
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ALX-430-022-M050   50 mg 33.00 USD Add To Cart
ALX-430-022-M250   250 mg 132.00 USD Add To Cart
ALX-430-022-G001   1 g 310.00 USD Add To Cart
Product Specification
FORMULA: C51H34N6O23S6 . 6Na
MW: 1291.2 . 137.9
CAS NUMBER: 129-46-4
MERCK INDEX: 14: 9006
RTECS: QM7000000
PURITY: ≥98%
APPEARANCE: White to off-white solid.
SOLUBILITY: Soluble in water or physiological saline; sparingly soluble in 95% ethanol; insoluble in benzene, ether or chloroform.
SHIPPING: AMBIENT
LONG TERM STORAGE: +4°C

Product Description
P2x and P2y purinergic receptor antagonist. Antitumor and antiparasitic compound.
Product Specific Literature References
PPADS and suramin as antagonists at cloned P2Y- and P2U-purinoceptors: S.J. Charlton, et al.; Br. J. Pharmacol. 118, 704 (1996) Abstract
Further Categories Containing This Product:
P2Y Purinergic Receptors / Related Products • Antitumor Agents (Enzyme Inhibitors)
 
 
ALX-550-193 Revised 13-Jun-03
Synthalin . sulfate
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SYNONYMS N,N'-1,10-Decanediylbis(guanidine) . H2SO4
PRODUCT LINE Neurobiology
PRODUCT CATEGORY NMDA Receptors / Related Products
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ALX-550-193-M005   5 mg 55.00 USD Add To Cart
Product Specification
FORMULA: C12H28N6 . H2SO4
MW: 256.4 . 98.1
CAS NUMBER: 301-15-5
PURITY: ≥99%
SOLUBILITY: Soluble in water.
SHIPPING: AMBIENT
LONG TERM STORAGE: +4°C

Product Description
Effective non-competitive NMDA receptor antagonist, which binds preferably to the polyamine site.
Product Specific Literature References
1,10-bis(guanidino)decane inhibits N-methyl-D-aspartate responses in vitro and in vivo: I.J. Reynolds, et al.; J. Pharmacol. Exp. Ther. 259, 626 (1991) Abstract
Interactions between zinc and spermidine on the N-methyl-D-aspartate receptor complex: clues to the mechanism of action of 1,10- bis(guanidino)decane and pentamidine: I.J. Reynolds; J. Pharmacol. Exp. Ther. 263, 632 (1992) Abstract
 
 
ALX-550-300 Revised 07-Feb-05
TMB-8 . hydrochloride
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SYNONYMS 8-(Diethylamino)octyl-3,4,5-trimethoxybenzoate . HCl
PRODUCT LINE Inflammation
PRODUCT CATEGORY Platelet Activating Factors [PAF] & Receptors / Related Products
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ALX-550-300-M025   25 mg 50.00 USD Add To Cart
Product Specification
FORMULA: C22H37NO5 . HCl
MW: 395.5 . 36.5
CAS NUMBER: 53464-72-5
PURITY: ≥98%
APPEARANCE: White solid.
SOLUBILITY: Soluble in water or ethanol.
SHIPPING: AMBIENT
LONG TERM STORAGE: +4°C
HANDLING: Protect from light and moisture.

Product Description
Intracellular Ca2+ antagonist of serum-stimulated Na+ influx in human fibroblasts. Inhibits platelet-activating factor (PAF) and PMA-stimulated prostaglandin production in Kupffer cells.
Product Specific Literature References
Inhibition of protein kinase C activation by 8-(N,N-diethylamino)-octyl- 3, 4, 5-trimethoxybenzoate (TMB-8), an intracellular Ca2+ antagonist: M. Sawamura; J. Med. Sci. 31, 221 (1985) Abstract
Platelet-activating factor-mediated synthesis of prostaglandins in rat Kupffer cells: C.R. Gandhi, et al.; Biochim. Biophys. Acta 1136, 68 (1992) Abstract
Calcium-independent effects of TMB-8. Modification of phospholipid metabolism in neuroblastoma cells by inhibition of choline uptake: F.B. Palmer, et al.; Biochem. J. 286, 505 (1992) Abstract
Further Categories Containing This Product:
Ca2+ Modulators • Acetylcholine Receptors (Muscarinic) / Related Products • Prostaglandins Other Products • Acetylcholine Receptors Other Products • Acetylcholine Receptors (Nicotinic) / Related Products
 
 
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