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Ion Channels & Transporters / Related Products
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 Items 240-260 of 307 Page 13 of 16 Select Page: << 1 2 3 4 5 6 7 8 9 10  >>  
ALX-210-299 Revised 16-Feb-05
Polyclonal Antibody to γ-Epithelial Cell Sodium Channel (rat)
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SYNONYMS anti-γ-ENaC (rat)  PAb
PRODUCT LINE Signal Transduction
PRODUCT CATEGORY Na+ Channels
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-210-299-C100   100 µg 379.00 USD Add To Cart
Product Specification
SPECIES CROSSREACTIVITY:
Rat
SOURCE/HOST: From rabbit.
CONCENTRATION: 1mg/ml.
FORMULATION: Liquid. Epitope-affinity purified IgG containing 1mg/ml BSA and 0.05% sodium azide in PBS.
IMMUNOGEN: Synthetic peptide corresponding to aa 630-649 (L630RLERAFSNQLTDTQMLDEL649) of human ENaCγ (epithelial cell sodium channel γ).
SPECIFICITY: Recognizes rat ENaCγ. Binds specifically to the unglycosylated, ~75kDa protein.
APPLICATION: Immunoprecipitation.
Note: Not suitable for Western blot.
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: -20°C
HANDLING: Avoid freeze/thaw cycles.
BLOCKING PEPTIDE: For Blocking Peptide see Prod. No. ALX-155-034.
Product Description
Epithelial sodium channels are amiloride-sensitive members of the degenerin/epithelial sodium channel (Deg/ENaC) superfamily of ion channels. Members of this superfamily of ion channels share organizational similarity in that they all possess two short intracellular amino and carboxyl termini, two short membrane spanning segments, and a large extracellular loop with a conserved cysteine-rich region. There are three homologous isoforms of the ENaC (α, β and γ) protein. ENaC in the kidney, lung, and colon plays an essential role in transepithelial Na+ and fluid balance. ENaC also mediates aldosterone-dependent (see Prod.No. 804-099) sodium reabsorption in the distal nephron of the kidney, thus regulating blood pressure. ENaC is thought to be regulated, in part, through association with the cystic fibrosis transmembrane conductance regulator (CFTR, see Prod.No. 804-214) chloride ion channel. Gain-of-function mutations in β- or γ-ENaC can cause sever arterial hypertension (Liddel's syndrome) and loss-of-function mutations in α- β-ENaC pseudohypoaldosteronism (PHA-1).
Further Categories Containing This Product:
Polyclonal Antibodies
 
 
ALX-210-400 Revised 30-Oct-06
Polyclonal Antibody to Gephyrin
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PRODUCT LINE Neurobiology
PRODUCT CATEGORY Glycine Receptors / Related Products
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Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-210-400-R050   50 µl 145.00 USD Add To Cart
Product Specification
SPECIES CROSSREACTIVITY:
Human
Mouse
Rat
SOURCE/HOST: From rabbit.
FORMULATION: Liquid. Neat serum containing 0.05% sodium azide.
IMMUNOGEN: Recombinant human gephyrin N-terminal domain (aa 1-175).
SPECIFICITY: Recognizes different splice forms of human, mouse and rat gephyrin in organs (brain, liver) and cell cultures.
APPLICATION: Immunoprecipitation (1:200-1:400)
Western Blot (1:4'000-1:16'000; wash with TBST)
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: -20°C
HANDLING: After opening, prepare aliquots and store at -20°C. Avoid freeze/thaw cycles.
Product Description
In 1982 F. Pfeiffer, et al. isolated gephyrin from rat spinal cord and brain. The 93kDa protein gephyrin is a tubulin binding peripheral membrane protein that is located to and anchored at postsynaptic sites of glycine receptors (GlyRs). GlyRs are ligand-gated chloride channel proteins composed of α- and β-subunits. At the neuronal surface, native GABA(A) receptor clustering and synaptic targeting require a γ2-subunit and the participation of gephyrin. Molecular cloning of gephyrin revealed similarity to proteins involved in the synthesis of a molybdenum-containing cofactor from various organisms. It has been shown in mice that gephyrin is required both for synaptic clustering of glycine receptors in spinal cord and for molybdoenzyme activity in nonneural tissues.
Product Specific Literature References
A mutation in the gene for the neurotransmitter receptor-clustering protein gephyrin causes a novel form of molybdenum cofactor deficiency: J. Reiss, et al.; Am. J. Hum. Genet. 68, 208 (2001) Abstract
General Literature References
Purification by affinity chromatography of the glycine receptor of rat spinal cord: F. Pfeiffer, et al.; J. Biol. Chem. 257, 9389 (1982) Abstract; Full Text
Further Categories Containing This Product:
Microtubule-associated Proteins / Related Products • Polyclonal Antibodies
 
 
ALX-215-049 Revised 21-Aug-08
Polyclonal Antibody to HERG1 (CT) (pan)
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SYNONYMS anti-Erg1 (CT) (pan) PAb
anti-Ether-a-go-go Related Protein 1 (CT) (pan) PAb
anti-KCNH2 (CT) (pan) PAb
anti-Voltage-gated Potassium Channel Subfamily H Member 2 (CT) (pan) PAb
anti-Voltage-gated Potassium Channel Kv11.1 (CT) (pan) PAb
PRODUCT LINE Signal Transduction
PRODUCT CATEGORY K+ Channel Antibodies
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Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-215-049-R100   100 µl 270.00 USD Add To Cart
Product Specification
SPECIES CROSSREACTIVITY:
Human
Mouse
SOURCE/HOST: From rabbit.
FORMULATION: Liquid. Neat serum.
IMMUNOGEN: Recombinant HERG1 (human ether-a-go-go related protein 1) (aa 1106-1158).
SPECIFICITY: Recognizes C-terminal epitope of HERG1 and mouse Erg1. Recognizes both isoforms HERG1A and HERG1B.
APPLICATION: Flow Cytometry (1:1'000)
Immunocytochemistry (1:100-1:200)
Immunohistochemistry (frozen sections, paraffin sections) (1:100-1:400)
Western Blot (1:1'000)
SHIPPING: SHIPPED ON BLUE ICE
SHORT TERM STORAGE: +4°C
LONG TERM STORAGE: -20°C
HANDLING: Avoid freeze/thaw cycles.
Product Specific Literature References
herg1 gene and HERG1 protein are overexpressed in colorectal cancers and regulate cell invasion of tumor cells: E. Lastraioli, et al.; Cancer Res. 64, 606 (2004) Abstract; Full Text
Human ether-a-go-go-related gene 1 channels are physically linked to beta1 integrins and modulate adhesion-dependent signaling: A. Cherubini, et al.; Mol. Biol. Cell 16, 2972 (2005) Abstract; Full Text
Expression pattern of the ether-a-go-go-related (ERG) family proteins in the adult mouse central nervous system: evidence for coassembly of different subunits: L. Guasti, et al.; J. Comp. Neurol. 491, 157 (2005) Abstract
hERG1 channels are overexpressed in glioblastoma multiforme and modulate VEGF secretion in glioblastoma cell lines: A. Masi, et al.; Br. J. Cancer 93, 781 (2005) Abstract
Identification of a post-translational mechanism for the regulation of hERG1 K+ channels expression and hERG1 current density in tumor cells: L. Guasti, et al.; Mol. Cell. Biol. 28, 5043 (2008) Abstract
General Information

The ether-a-go-go related gene family of K+ channels (HERG/Erg) comprises three members, HERG1/Erg1, HERG2/Erg2, HERG3/Erg3. HERG channel activity is relevant to tumor cell biology. It controls cell proliferation, especially in leukaemias. HERG channels are thus considered novel diagnostic and prognostic factors in human cancers, as well as targets for anti-neoplastic therapies.
Further Categories Containing This Product:
Cancer Other Products • Polyclonal Antibodies
 
 
ALX-215-050 Revised 22-Feb-07
Polyclonal Antibody to HERG1A (NT)
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SYNONYMS anti-Erg1A (NT) PAb
anti-Ether-a-go-go Related Protein 1A (NT) PAb
anti-KCNH2 (Isoform A) (NT) PAb
anti-Voltage-gated Potassium Channel Subfamily H Member 2 (Isoform A) (NT) PAb
anti-Voltage-gated Potassium Channel Kv11.1 (Isoform A) (NT) PAb
PRODUCT LINE Signal Transduction
PRODUCT CATEGORY K+ Channel Antibodies
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-215-050-R100   100 µl 270.00 USD Add To Cart
Product Specification
SPECIES CROSSREACTIVITY:
Human
Mouse
SOURCE/HOST: From rabbit.
FORMULATION: Liquid. Neat serum.
IMMUNOGEN: Recombinant HERG1 (human ether-a-go-go related protein 1) (aa 1-135).
SPECIFICITY: Recognizes N-terminal epitope of HERG1A and mouse Erg1A isoform.
APPLICATION: Immunocytochemistry (1:50-1:200)
Immunohistochemistry (frozen sections, paraffin sections) (1:100-1:400)
Immunoprecipitation (5µl/1.5mg protein)
SHIPPING: SHIPPED ON BLUE ICE
SHORT TERM STORAGE: +4°C
LONG TERM STORAGE: -20°C
HANDLING: Avoid freeze/thaw cycles.
Product Specific Literature References
HERG potassium channels are more frequently expressed in human endometrial cancer as compared to non-cancerous endometrium: A. Cherubini, et al.; Br. J. Cancer 83, 1722 (2000) Abstract
Cell cycle-dependent expression of HERG1 and HERG1B isoforms in tumor cells: O. Crociani, et al.; J. Biol. Chem. 278, 2947 (2003) Abstract; Full Text
Human ether-a-go-go-related gene 1 channels are physically linked to beta1 integrins and modulate adhesion-dependent signaling: A. Cherubini, et al.; Mol. Biol. Cell 16, 2972 (2005) Abstract; Full Text
Expression pattern of the ether-a-go-go-related (ERG) family proteins in the adult mouse central nervous system: evidence for coassembly of different subunits: L. Guasti, et al.; J. Comp. Neurol. 491, 157 (2005) Abstract
Interneurons transiently express the ERG K+ channels during development of mouse spinal networks in vitro: F. Furlan, et al.; Neuroscience 135, 1179 (2005) Abstract
General Information
The ether-a-go-go related gene family of K+ channels (HERG/Erg) comprises three members, HERG1/Erg1, HERG2/Erg2, HERG3/Erg3. HERG channel activity is relevant to tumor cell biology. It controls cell proliferation, especially in leukaemias. HERG channels are thus considered novel diagnostic and prognostic factors in human cancers, as well as targets for anti-neoplastic therapies.
Further Categories Containing This Product:
Cancer Other Products • Cancer Other Products • Polyclonal Antibodies
 
 
ALX-215-052 Revised 01-Jun-07
Polyclonal Antibody to HERG2
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SYNONYMS anti-Erg2 PAb
anti-Ether-a-go-go Related Protein 2 PAb
anti-KCNH6 PAb
anti-Voltage-gated Potassium Channel Subfamily H Member 6 PAb
anti-Voltage-gated Potassium Channel Kv11.2 PAb
PRODUCT LINE Signal Transduction
PRODUCT CATEGORY K+ Channel Antibodies
Ordering Information
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ALX-215-052-R100   100 µl 270.00 USD Add To Cart
Product Specification
SPECIES CROSSREACTIVITY:
Human
Mouse
SOURCE/HOST: From rabbit.
PURITY DETAIL: Protein A-affinity purified.
FORMULATION: Liquid. In 100mM TRIS containing 100mM glycine.
IMMUNOGEN: Recombinant human HERG2 (ether-a-go-go related protein 2) (aa 907-986).
SPECIFICITY: Recognizes HERG2 and mouse Erg2.
APPLICATION: Immunocytochemistry (1:50-1:200)
Immunohistochemistry (frozen sections, paraffin sections) (1:100-1:400)
SHIPPING: SHIPPED ON BLUE ICE
SHORT TERM STORAGE: -20°C
LONG TERM STORAGE: -80°C
HANDLING: Avoid freeze/thaw cycles. After opening, prepare aliquots and store at -80°C.
Product Specific Literature References
Interneurons transiently express the ERG K+ channels during development of mouse spinal networks in vitro: F. Furlan, et al.; Neuroscience 135, 1179 (2005) Abstract
Expression pattern of the ether-a-go-go-related (ERG) family proteins in the adult mouse central nervous system: evidence for coassembly of different subunits: L. Guasti, et al.; J. Comp. Neurol. 491, 157 (2005) Abstract
General Information

The ether-a-go-go related gene family of K+ channels (HERG/Erg) comprises three members, HERG1/Erg1, HERG2/Erg2, HERG3/Erg3. HERG channel activity is relevant to tumor cell biology. It controls cell proliferation, especially in leukaemias. HERG channels are thus considered novel diagnostic and prognostic factors in human cancers, as well as targets for anti-neoplastic therapies.
Further Categories Containing This Product:
Cancer Other Products • Polyclonal Antibodies
 
 
ALX-215-053 Revised 01-Jun-07
Polyclonal Antibody to HERG3
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SYNONYMS anti-Erg3 PAb
anti-Ether-a-go-go Related Protein 3 PAb
anti-KCNH7 PAb
anti-Voltage-gated Potassium Channel Subfamily H Member 7 PAb
anti-Voltage-gated Potassium Channel Kv11.3 PAb
PRODUCT LINE Signal Transduction
PRODUCT CATEGORY K+ Channel Antibodies
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-215-053-R100   100 µl 270.00 USD Add To Cart
Product Specification
SPECIES CROSSREACTIVITY:
Human
Mouse
SOURCE/HOST: From rabbit.
PURITY DETAIL: Protein A-affinity purified.
FORMULATION: Liquid. In 100mM TRIS containing 100mM glycine.
IMMUNOGEN: Recombinant HERG3 (human ether-a-go-go related protein 3) (aa 1115-1194).
SPECIFICITY: Recognizes HERG3 and mouse Erg3.
APPLICATION: Immunocytochemistry (1:50-1:200)
Immunohistochemistry (frozen sections, paraffin sections) (1:100-1:400)
SHIPPING: SHIPPED ON BLUE ICE
SHORT TERM STORAGE: -20°C
LONG TERM STORAGE: -80°C
HANDLING: Avoid freeze/thaw cycles. After opening, prepare aliquots and store at -80°C.
Product Specific Literature References
Interneurons transiently express the ERG K+ channels during development of mouse spinal networks in vitro: F. Furlan, et al.; Neuroscience 135, 1179 (2005) Abstract
Expression pattern of the ether-a-go-go-related (ERG) family proteins in the adult mouse central nervous system: evidence for coassembly of different subunits: L. Guasti, et al.; J. Comp. Neurol. 491, 157 (2005) Abstract
General Information
The ether-a-go-go related gene family of K+ channels (HERG/Erg) comprises three members, HERG1/Erg1, HERG2/Erg2, HERG3/Erg3. HERG channel activity is relevant to tumor cell biology. It controls cell proliferation, especially in leukaemias. HERG channels are thus considered novel diagnostic and prognostic factors in human cancers, as well as targets for anti-neoplastic therapies.
Further Categories Containing This Product:
Cancer Other Products • Polyclonal Antibodies
 
 
ALX-215-051 Revised 24-Jun-08
Polyclonal Antibody to HERG1B
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SYNONYMS anti-Erg1B PAb
anti-Ether-a-go-go Related Protein 1B PAb
anti-KCNH2 (Isoform B) PAb
anti-Voltage-gated Potassium Channel Subfamily H Member 2 (Isoform B) PAb
anti-Voltage-gated Potassium Channel Kv11.1 (Isoform B) PAb
PRODUCT LINE Signal Transduction
PRODUCT CATEGORY K+ Channel Antibodies
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-215-051-R100   100 µl 270.00 USD Add To Cart
Product Specification
SPECIES CROSSREACTIVITY:
Human
Mouse
SOURCE/HOST: From rabbit.
PURITY DETAIL: Affinity purified.
FORMULATION: Liquid. In 100mM TRIS containing 100mM glycine.
IMMUNOGEN: Synthetic peptide corresponding to aa 15-28 (R15PRAQKGRVRRAVR28) of HERG1B (human ether-a-go-go related protein 1B).
SPECIFICITY: Recognizes HERG1B and mouse Erg1B isoform.
APPLICATION: Immunocytochemistry (1:50-1:200)
Immunohistochemistry (frozen sections) (1:100)
Western Blot (1:1'000)
SHIPPING: SHIPPED ON BLUE ICE
SHORT TERM STORAGE: -20°C
LONG TERM STORAGE: -80°C
HANDLING: Avoid freeze/thaw cycles. After opening, prepare aliquots and store at -80°C.
Product Specific Literature References
Human ether-a-go-go-related gene 1 channels are physically linked to beta1 integrins and modulate adhesion-dependent signaling: A. Cherubini, et al.; Mol. Biol. Cell 16, 2972 (2005) Abstract; Full Text
Interneurons transiently express the ERG K+ channels during development of mouse spinal networks in vitro: F. Furlan, et al.; Neuroscience 135, 1179 (2005) Abstract
Expression pattern of the ether-a-go-go-related (ERG) family proteins in the adult mouse central nervous system: evidence for coassembly of different subunits: L. Guasti, et al.; J. Comp. Neurol. 491, 157 (2005) Abstract
Identification of a post-translational mechanism for the regulation of hERG1 K+ channels expression and hERG1 current density in tumor cells: L. Guasti, et al.; Mol. Cell. Biol. Epub ahead of print, (2008) Abstract
General Information
The ether-a-go-go related gene family of K+ channels (HERG/Erg) comprises three members, HERG1/Erg1, HERG2/Erg2, HERG3/Erg3. HERG channel activity is relevant to tumor cell biology. It controls cell proliferation, especially in leukaemias. HERG channels are thus considered novel diagnostic and prognostic factors in human cancers, as well as targets for anti-neoplastic therapies.
Further Categories Containing This Product:
Cancer Other Products • Polyclonal Antibodies
 
 
ALX-210-349 Revised 09-Dec-04
Polyclonal Antibody to PICK1
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SYNONYMS anti-Protein Interacting with Protein Kinase C PAb
PRODUCT LINE Neurobiology
PRODUCT CATEGORY AMPA Receptors / Related Products
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-210-349-C100   100 µg 379.00 USD Add To Cart
Product Specification
SPECIES CROSSREACTIVITY:
Mouse
Rat
SOURCE/HOST: From rabbit.
FORMULATION: Purified. Contains 0.05% sodium azide.
IMMUNOGEN: Synthetic peptide corresponding to aa 1-18 (M1FADLDYDIEEDKLGIPT18) of mouse PICK1 (protein interacting with protein kinase C).
SPECIFICITY: Recognizes mouse and rat PICK1. Detects a band of ~52kDa by Western blot.
APPLICATION: Immunocytochemistry (1.7µg/ml)
Immunoprecipitation
Western Blot (2µg/ml)
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: -20°C
BLOCKING PEPTIDE: For Blocking Peptide see Prod. No. ALX-165-051.
Further Categories Containing This Product:
PKC Other Products • Polyclonal Antibodies
 
 
ALX-210-266 Revised 22-Aug-05
Polyclonal Antibody to PSD-93 (rat)
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SYNONYMS anti-Post-synaptic Density 93kDa Protein (rat) PAb
anti-Chapsyn-110 (rat) PAb
PRODUCT LINE Neurobiology
PRODUCT CATEGORY NMDA Receptors / Related Products
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-210-266-C100   100 µg 379.00 USD Add To Cart
Product Specification
SPECIES CROSSREACTIVITY:
Rat
SOURCE/HOST: From rabbit.
CONCENTRATION: 1mg/ml.
FORMULATION: Liquid. Epitope affinity purified IgG in PBS containing 1mg/ml BSA and 0.05% sodium azide.
IMMUNOGEN: Synthetic peptide corresponding to aa 352-366 (N352KLCDKPASPR
HYSP366) of rat PSD-93 (post-synaptic density 93kDa protein).
SPECIFICITY: Recognizes rat PSD-93. Detects a band of ~110kDa by Western blot.
APPLICATION: Immunohistochemistry (frozen sections (5µg/ml))
Western Blot (3µg/ml)
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: -20°C
HANDLING: Avoid freeze/thaw cycles.
BLOCKING PEPTIDE: For Blocking Peptide see Prod. No. ALX-165-045.
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Further Categories Containing This Product:
Synaptic Proteins / Related Products • Polyclonal Antibodies
 
 
ALX-215-032 Revised 20-Oct-06
Polyclonal Antibody to Purinergic Receptor P2X1 (human)
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SYNONYMS anti-P2X Purinoceptor 1 (human) PAb
anti-P2RX1 (human) PAb
PRODUCT LINE Neurobiology
PRODUCT CATEGORY P2X Purinergic Receptors / Related Products
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-215-032-R100   100 µl 330.00 USD Add To Cart
Product Specification
SPECIES CROSSREACTIVITY:
Human
SOURCE/HOST: From rabbit.
FORMULATION: Liquid. Antiserum diluted with PBS containing 0.1% BSA and 0.02% sodium azide.
IMMUNOGEN: Vector containing the cDNA of human purinergic receptor P2X1.
SPECIFICITY: Recognizes human purinergic receptor P2X1.
APPLICATION: Flow Cytometry (1:100-1:400)
Immunocytochemistry (1:100-1:400)
Western Blot (non-reducing conditions) (1:100-1:400)
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: +4°C
General Literature References
Molecular physiology of P2X receptors: R.A. North; Physiol. Rev. 82, 1013 (2002), (Review) Abstract; Full Text
Molecular structure of P2X receptors: T.M. Egan, et al.; Curr. Top. Med. Chem. 4, 821 (2004), (Review) Abstract
Molecular properties of ATP-gated P2X receptor ion channels: C. Vial, et al.; Trends Pharmacol. Sci. 25, 487 (2004), (Review) Abstract
Further Categories Containing This Product:
Polyclonal Antibodies
 
 
ALX-215-031 Revised 20-Oct-06
Polyclonal Antibody to Purinergic Receptor P2X1 (mouse)
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