• Home
  • Sitemap
  • Help
  • Technical Support
  • Contact
Ion Channels & Transporters / Related Products
You are here: Product Lines > Signal Transduction > Ion Channels & Transporters / Related Products
 
Toolbar - View Selection
 
 Items 1-20 of 307 Page 1 of 16 Select Page: 1 2 3 4 5 6 7 8 9 10  >>  
ALX-550-016 Revised 08-Nov-07
(S)-AMPA
Add to Clipboard
SYNONYMS (S)-α-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid
PRODUCT LINE Neurobiology
PRODUCT CATEGORY AMPA Receptors / Related Products
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-550-016-M005   5 mg 95.00 USD Add To Cart
ALX-550-016-M025   25 mg 380.00 USD Add To Cart
Product Specification
FORMULA: C7H10N2O4
MW: 186.2
CAS NUMBER: 83643-88-3
PURITY: ≥98% (HPLC)
APPEARANCE: White to off-white powder.
SOLUBILITY: Soluble in water or dilute aqueous base.
SHIPPING: AMBIENT
LONG TERM STORAGE: +4°C
HANDLING: Hygroscopic.

Product Description
Active enantiomer of (R,S)-AMPA (Prod. No. ALX-550-023).
Product Specific Literature References
Enzymic resolution and binding to rat brain membranes of the glutamic acid agonist alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid: J.J. Hansen, et al.; J. Med. Chem. 26, 901 (1983) Abstract
Ibotenic acid analogues. Synthesis, molecular flexibility, and in vitro activity of agonists and antagonists at central glutamic acid receptors: J. Lauridsen, et al.; J. Med. Chem. 28, 668 (1985) Abstract
Pharmacological agents acting at subtypes of metabotropic glutamate receptors: D.D. Schoepp, et al.; Neuropharmacology 38, 1431 (1999), (Review) Abstract
Further Categories Containing This Product:
Special Amino Acids
 
 
ALX-550-023 Revised 04-Apr-08
(R,S)-AMPA
Add to Clipboard
SYNONYMS (R,S)-α-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid
PRODUCT LINE Neurobiology
PRODUCT CATEGORY AMPA Receptors / Related Products
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-550-023-M005   5 mg 65.00 USD Add To Cart
ALX-550-023-M025   25 mg 260.00 USD Add To Cart
Product Specification
FORMULA: C7H10N2O4
MW: 186.2
CAS NUMBER: 74341-63-2
PURITY: ≥97% (HPLC)
APPEARANCE: White powder.
SOLUBILITY: Soluble in water (10mM).
SHIPPING: AMBIENT
LONG TERM STORAGE: +4°C
IDENTITY: Identity determined by 1H-NMR and MS.

Product Description
Potent and selective quisqualate analog that interacts with the AMPA subgroup of ionotropic glutamate receptors.
Product Specific Literature References
New class of glutamate agonist structurally related to ibotenic acid: P. Krogsgaard-Larsen, et al.; Nature 284, 64 (1980) Abstract
The binding of [3H]AMPA, a structural analogue of glutamic acid, to rat brain membranes: T. Honoré, et al.; J. Neurochem. 38, 173 (1982) Abstract
Pharmacological agents acting at subtypes of metabotropic glutamate receptors: D.D. Schoepp; Neuropharmacology 38, 1431 (1999), (Review) Abstract
 
 
ALX-550-042 Revised 04-Jun-08
CNQX
Add to Clipboard
SYNONYMS 6-Cyano-7-nitroquinoxaline-2,3-dione
FG-9065
PRODUCT LINE Neurobiology
PRODUCT CATEGORY AMPA Receptors / Related Products
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-550-042-M005   5 mg 43.00 USD Add To Cart
ALX-550-042-M010   10 mg 70.00 USD Add To Cart
ALX-550-042-M025   25 mg 155.00 USD Add To Cart
ALX-550-042-M050   50 mg 280.00 USD Add To Cart
Product Specification
FORMULA: C9H4N4O4
MW: 232.2
CAS NUMBER: 115066-14-3
PURITY: ≥98% (TLC)
APPEARANCE: Off-white to yellow powder.
SOLUBILITY: Soluble in DMSO (10mg/ml) or dilute aqueous base.
SHIPPING: AMBIENT
LONG TERM STORAGE: +20°C
USE/STABILITY: Stock solutions are stable for several months when stored at -20°C.
HANDLING: Protect from light.

Product Description
Potent, competitive kainate/quisqualate (non-NMDA) receptor antagonist. For the more soluble form see CNQX . disodium salt (Prod. No. ALX-550-283).
Product Specific Literature References
Quinoxalinediones: potent competitive non-NMDA glutamate receptor antagonists: T. Honoré, et al.; Science, 241, 701 (1988) Abstract
Differential effects of the excitatory amino acid antagonists, 6-cyano- 7-nitroquinoxaline-2,3-dione (CNQX) and 3-((+-)-2-carboxypiperazin-4- yl)-propyl-1-phosphonic acid (CPP), on spinal reflex activity in mice: L. Turski, et al.; Neurosci. Lett. 113, 66 (1990) Abstract
Related Products
Further Categories Containing This Product:
Glutamate Receptors (Metabotropic) / Related Products • Kainate Receptors / Related Products
 
 
ALX-550-044 Revised 28-Jan-05
NBQX
Add to Clipboard
SYNONYMS 2,3-Dihydroxy-6-nitro-7-sulphamoylbenzo(f)-quinoxaline
6-Nitro-7-sulphamoylbenzo(f)-quinoxaline-2,3-dione
PRODUCT LINE Neurobiology
PRODUCT CATEGORY AMPA Receptors / Related Products
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-550-044-M005   5 mg 65.00 USD Add To Cart
ALX-550-044-M025   25 mg 260.00 USD Add To Cart
Product Specification
FORMULA: C12H8N4O6S
MW: 336.3
CAS NUMBER: 118876-58-7
PURITY: ≥98%
APPEARANCE: Yellow powder.
SOLUBILITY: Soluble in DMSO. A 1mM aqueous solution may be prepared by taking up in >2.5 eq. of NaOH and backtitrating to pH 8.0-8.5 with conc. HCl.
SHIPPING: AMBIENT
LONG TERM STORAGE: +4°C
HANDLING: Protect from light.

Product Description
Most potent and selective AMPA/kainate receptor antagonist. For the more soluble form see NBQX . disodium salt (Prod. No. ALX-550-272).
Product Specific Literature References
Contributions of quisqualate and NMDA receptors to the induction and expression of LTP: D. Muller, et al.; Science 242, 1694 (1988) Abstract
2,3-Dihydroxy-6-nitro-7-sulfamoyl-benzo(F)quinoxaline: a neuroprotectant for cerebral ischemia: M.J. Sheardown, et al.; Science 247, 571 (1990) Abstract
The neuroprotective actions of 2,3-dihydroxy-6-nitro-7-sulfamoyl- benzo(F)quinoxaline (NBQX) in a rat focal ischaemia model: R. Gill, et al.; Brain Res. 580, 35 (1992) Abstract
Competitive inhibition by NBQX of kainate/AMPA receptor currents and excitatory synaptic potentials: importance of 6-nitro substitution: J.C. Randle, et al.; Eur. J. Pharmacol. 215, 237 (1992) Abstract
AMPA antagonists: do they hold more promise for clinical stroke trials than NMDA antagonists?: A.M. Buchan, et al.; Stroke 24, I148 (1993) Abstract
A comparison of the actions of agonists and antagonists at non-NMDA receptors of C fibres and motoneurones of the immature rat spinal cord in vitro: P. Pook, et al.; Br. J. Pharmacol. 108, 179 (1993) Abstract
The pharmacology of AMPA receptors and their antagonists: M.J. Sheardown; Stroke 24, I146 (1993) Abstract
Antiepileptogenic and anticonvulsant effects of NBQX, a selective AMPA receptor antagonist, in the rat kindling model of epilepsy: T. Namba, et al.; Brain Res. 638, 36 (1994) Abstract
Traumatic brain damage prevented by the non-N-methyl-D-aspartate antagonist 2,3-dihydroxy-6-nitro-7-sulfamoylbenzo[f] quinoxaline: H. Bernert & L. Turski; PNAS 93, 5235 (1996) Abstract
Emerging treatments for stroke in humans: W.J. Koroshetz & M.A. Moskowitz; TIPS 17, 227 (1996), (Review) Abstract
Further Categories Containing This Product:
Glutamate Receptors (Metabotropic) / Related Products • Kainate Receptors / Related Products
 
 
ALX-550-045 Revised 29-Jan-07
DNQX
Add to Clipboard
SYNONYMS 6,7-Dinitroquinoxaline-2,3-dione
FG-9041
PRODUCT LINE Neurobiology
PRODUCT CATEGORY AMPA Receptors / Related Products
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-550-045-M005   5 mg 16.00 USD Add To Cart
ALX-550-045-M025   25 mg 45.00 USD Add To Cart
Product Specification
FORMULA: C8H4N4O6
MW: 252.1
CAS NUMBER: 2379-57-9
PURITY: ≥98%
APPEARANCE: Off-white to yellow crystalline solid.
SOLUBILITY: Soluble in DMSO, acetone or methanol.
SHIPPING: AMBIENT
LONG TERM STORAGE: +20°C
HANDLING: After reconstitution, prepare aliquots and store at -20°C.

Product Description
Potent, competitive kainate/quisqualate (non-NMDA) receptor antagonist.
Product Specific Literature References
Quinoxalinediones: potent competitive non-NMDA glutamate receptor antagonists: T. Honoré, et al.; Science 241, 701 (1988) Abstract
Contributions of quisqualate and NMDA receptors to the induction and expression of LTP: D. Müller, et al.; Science 242, 1694 (1988) Abstract
Excitatory amino acid receptors in the vertebrate central nervous system: G.L. Collingridge & R.A. Lester; Pharmacol. Rev. 41, 143 (1989), (Review) Abstract
Selectivity of quinoxalines and kynurenines as antagonists of the glycine site on N-methyl-D-aspartate receptors: N.W. Kleckner & R. Dingledine; Mol. Pharmacol. 36, 430 (1989) Abstract
Abolition of the NMDA-mediated responses by a specific glycine antagonist, 6,7-dichloroquinoxaline-2,3-dione (DCQX): Y. Yoneda & K. Ogita; BBRC 164, 841 (1989) Abstract
6,7-Dichloroquinoxaline-2,3-dione is a competitive antagonist specific to strychnine-insensitive [3H]glycine binding sites on the N-methyl-D- aspartate receptor complex: K. Ogita & Y. Yoneda; J. Neurochem. 54, 699 (1990) Abstract
Noncompetitive excitatory amino acid receptor antagonists: D. Lodge & K.M. Johnson; TIPS 11, 81 (1990), (Review) Abstract
Disulfide bonding and cysteine accessibility in the alpha-amino-3-hydroxy-5-methylisoxazole-4-propionic acid receptor subunit GluRD. Implications for redox modulation of glutamate receptors: R. Abele, et al.; J. Biol. Chem. 273, 25132 (1998) Abstract; Full Text
Stereochemistry of quinoxaline antagonist binding to a glutamate receptor investigated by Fourier transform infrared spectroscopy: D.R. Madden, et al.; J. Biol. Chem. 276, 37821 (2001) Abstract; Full Text
Further Categories Containing This Product:
Kainate Receptors / Related Products
 
 
ALX-550-052 Revised 09-Oct-08
Kynurenic acid
Add to Clipboard
SYNONYMS 4-Hydroxyquinoline-2-carboxylic acid
PRODUCT LINE Neurobiology
PRODUCT CATEGORY NMDA Receptors / Related Products
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-550-052-M250   250 mg 12.00 USD Add To Cart
ALX-550-052-G001   1 g 35.00 USD Add To Cart
Product Specification
FORMULA: C10H7NO3
MW: 189.2
CAS NUMBER: 492-27-3
MERCK INDEX: 14: 5327
PURITY: ≥98% (Titration, HPLC)
APPEARANCE: Off-white to tan powder.
SOLUBILITY: Soluble in water (~0.9% at 100°C) or 100% ethanol (warm); also soluble in 0.1N NaOH or DMSO; insoluble in ether.
SHIPPING: AMBIENT
LONG TERM STORAGE: +4°C
USE/STABILITY: Stock solutions are stable for several days when stored at +4°C.
HAZARD: IRRITANT.

Product Description
Metabolite of tryptophan. Antagonist at both the NMDA and AMPA/kainate receptors. Blocks kainic acid neurotocixity.
Product Specific Literature References
An iontophoretic investigation of the actions of convulsant kynurenines and their interaction with the endogenous excitant quinolinic acid: M.N. Perkins & T.W. Stone; Brain Res. 247, 184 (1982) Abstract
The N-methyl-D-aspartate receptor and burst firing of CA1 hippocampal pyramidal neurons: M.J. Peet, et al.; Neuroscience 22, 563 (1987) Abstract
Structural, conformational, and stereochemical requirements of central excitatory amino acid receptors: J.J. Hansen & P. Krogsgaard-Larsen; Med. Res. Rev. 10, 55 (1990) Abstract
Further Categories Containing This Product:
AMPA Receptors / Related Products • Kainate Receptors / Related Products
 
 
ALX-550-059 Revised 23-May-06
L-Quisqualic acid
Add to Clipboard
PRODUCT LINE Neurobiology
PRODUCT CATEGORY Glutamate Receptors (Metabotropic) / Related Products
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-550-059-M005   5 mg 70.00 USD Add To Cart
ALX-550-059-M025   25 mg 280.00 USD Add To Cart
Product Specification
FORMULA: C5H7N3O5
MW: 189.1
CAS NUMBER: 52809-07-1
MERCK INDEX: 14: 8085
PURITY: ≥99% (free from glutamate)
APPEARANCE: White to off-white powder.
SOLUBILITY: Soluble in dilute aqueous base.
SHIPPING: AMBIENT
LONG TERM STORAGE: +4°C

Product Description
Potent group I mGluR agonist and quis-qualate/AMPA ionotropic receptor agonist. Sensitizes neurons in hippocampus to depo-larization by L-AP6 (“quis” effect).
Product Specific Literature References
The action of natural and synthetic isomers of quisqualic acid at a well-defined glutamatergic synapse: P. Boden, et al.; Brain Res. 385, 205 (1986) Abstract
Metabotropic glutamate receptors in brain function and pathology: D.D. Schoepp and P.J. Conn; TIPS 14, 13 (1993), (Review) Abstract
Agonists and antagonists for metabotropic glutamate receptors: P.L. Ornstein, et al.; Curr. Pharm. Design 1, 355 (1995), (Review)
Pharmacological agents acting at subtypes of metabotropic glutamate receptors: D.D. Schoepp, et al.; Neuropharmacology 38, 1431 (1999), (Review) Abstract
Further Categories Containing This Product:
AMPA Receptors / Related Products
 
 
ALX-550-062 Revised 11-Jan-07
IDRA 21
Add to Clipboard
SYNONYMS 7-Chloro-3-methyl-3,4-dihydro-2H-1,2,4-benzothiadiazine-S,S-dioxide
PRODUCT LINE Neurobiology
PRODUCT CATEGORY AMPA Receptors / Related Products
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-550-062-M005   5 mg 60.00 USD Add To Cart
ALX-550-062-M025   25 mg 240.00 USD Add To Cart
Product Specification
FORMULA: C8H9ClN2O2S
MW: 232.7
CAS NUMBER: 22503-72-6
PURITY: ≥98%
APPEARANCE: White to off-white solid.
SOLUBILITY: Soluble in DMSO, 100% ethanol, methanol or dilute aqueous base.
SHIPPING: AMBIENT
LONG TERM STORAGE: +20°C

Product Description
Analog of cyclothiazide (Prod. No. ALX-550-338). Inhibits AMPA receptor desensitization. Crosses the blood-brain barrier more readily than cyclothiazide (Prod. No. ALX-550-338) and diazoxide (Prod. No. ALX-550-260) and is a more potent cognitive enhancing drug.
Product Specific Literature References
Modulation of AMPA/kainate receptors by analogues of diazoxide and cyclothiazide in thin slices of rat hippocampus: M. Bertolino, et al.; Receptors Channels 1, 267 (1993) Abstract
7-Chloro-3-methyl-3,4-dihydro-2H-1,2,4-benzothiadiazine S,S-dioxide (IDRA 21), a congener of aniracetam, potently abates pharmacologically induced cognitive impairments in patas monkeys: D.M. Thompson, et al.; PNAS 92, 7667 (1995) Abstract
7-Chloro-3-methyl-3-4-dihydro-2H-1,2,4 benzothiadiazine S,S-dioxide (IDRA 21): a benzothiadiazine derivative that enhances cognition by attenuating DL-alpha-amino-2,3-dihydro-5-methyl-3-oxo-4-isoxazol: I. Zivkovic, et al.; J. Pharmacol. Exp. Ther. 272, 300 (1995) Abstract
Effect of the AMPA receptor modulator IDRA 21 on LTP in hippocampal slices: A. Arai, et al.; Neuroreport 7, 2211 (1996) Abstract
7-Chloro-3-methyl-3,4-dihydro-2H-1,2,4-benzothiadiazine S,S-dioxide: a partial modulator of AMPA receptor desensitization devoid of neurotoxicity: F. Impagnatiello, et al.; PNAS 94, 7053 (1997) Abstract
The diazoxide derivative 7-chloro-3-methyl-3,4-dihydro-2H-1,2,4-benzothiadiazine-S,S-dioxide augments AMPA- and GABA-mediated synaptic responses in cultured hippocampal neurons: K.A. Yamada, et al.; Neurobiol. Dis. 5, 196 (1998) Abstract
The diazoxide derivative IDRA 21 enhances ischemic hippocampal neuron injury: K.A. Yamada, et al.; Ann. Neurol. 43, 664 (1998) Abstract
 
 
ALX-550-155 Revised 28-Jan-05
(RS)-4-Bromo-homo-ibotenic acid
Add to Clipboard
SYNONYMS Br-HIBO
(RS)-α-Amino-4-bromo-3-hydroxy-5-isoazolepropionic acid
PRODUCT LINE Neurobiology
PRODUCT CATEGORY Glutamate Receptors (Metabotropic) / Related Products
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-550-155-M005   5 mg 70.00 USD Add To Cart
Product Specification
FORMULA: C6H7N2O4Br
MW: 251.0
CAS NUMBER: 71366-32-0
PURITY: ≥98%
APPEARANCE: White crystalline powder.
SOLUBILITY: Soluble in dilute aqueous base.
SHIPPING: AMBIENT
LONG TERM STORAGE: +4°C
HANDLING: Protect from light.

Product Description
Potent AMPA receptor agonist. Selective but relatively non-potent group I mGluR agonist.
Product Specific Literature References
Excitatory amino acid agonists. Enzymic resolution, X-ray structure, and enantioselective activities of (R)- and (S)-bromohomoibotenic acid: J.J. Hansen, et al.; J. Med. Chem. 32, 2254 (1989) Abstract
Structure-activity relationships in the development of excitatory amino acid receptor agonists and competitive antagonists: J.C. Watkins, et al.; TIPS 11, 25 (1990) Abstract
4-Bromohomoibotenic acid selectively activates a 1-aminocyclopentane- 1S,3R-dicarboxylic acid-insensitive metabotropic glutamate receptor coupled to phosphoinositide hydrolysis in rat cortical slices: D.S. Chung, et al.; J. Neurochem. 63, 133 (1994) Abstract
Effects of bromohomoibotenate on metabotropic glutamate receptors: C. Thomsen, et al.; Neuroreport 5, 2417 (1994) Abstract
4-Methylhomoibotenic acid activates a novel metabotropic glutamate receptor coupled to phosphoinositide hydrolysis: D.S. Chung, et al.; J. Pharmacol. Exp. Ther. 283, 742 (1997) Abstract
Pharmacological agents acting at subtypes of metabotropic glutamate receptors: D.D. Schoepp, et al.; Neuropharmacology 38, 1431 (1999), (Review) Abstract
Further Categories Containing This Product:
AMPA Receptors / Related Products
 
 
ALX-550-260 Revised 29-Apr-08
Diazoxide