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ALX-500-001 Revised 09-Oct-08
n-Octyl-β-D-glucopyranoside (analytical grade)
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SYNONYMS OG
PRODUCT LINE Molecular Biology
PRODUCT CATEGORY Buffers / Detergents / Solutions
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Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-500-001-G001   1 g 45.00 USD Add To Cart
ALX-500-001-G005   5 g 160.00 USD Add To Cart
ALX-500-001-G025   25 g 560.00 USD Add To Cart
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Product Specification
FORMULA: C14H28O6
MW: 292.4
CAS NUMBER: 29836-26-8
PURITY: ≥99%
APPEARANCE: White to off-white powder.
SOLUBILITY: Soluble in water (100mg/ml).
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
HANDLING: Protect from light. Keep under inert gas. Hygroscopic.
HAZARD: IRRITANT.

Product Description
Highly purified nonionic detergent that solubilizes membrane-bound proteins in their native state.
Product Specific Literature References
Widespread distribution of some minor chlorophyll-protein complexes in some green plants and algae: E.L. Camm & B.R. Green; Plant Physiol. 67, 1061 (1981)
Effects of octyl beta-glucoside on insulin binding to solubilized membrane receptors: R.J. Gould, et al.; Biochemistry 20, 6776 (1981) Abstract
Solubilization and reconstitution of the Pseudomonas aeruginosa high affinity branched-chain amino acid transport system: T. Hoshino, et al.; J. Biol. Chem. 267, 21313 (1992) Abstract; Full Text
Reconstitution of the sarcoplasmic reticulum Ca(2+)-ATPase: mechanisms of membrane protein insertion into liposomes during reconstitution procedures involving the use of detergents: D. Levy, et al.; Biochim. Biophys. Acta 1107, 283 (1992) Abstract
Purification and crystallization of the light harvesting LH1 complex from Rhodobacter sphaeroides [retracted by Nunn RS, Artymiuk PJ, Baker PJ, Rice DW, Hunter CN. In: J Mol Biol 1995 Sep 8;252(1):153]: R.S. Nunn, et al.; J. Mol. Biol. 228, 1259 (1992) Abstract
 
 
ALX-500-002 Revised 03-Jun-08
n-Octyl-oligo-oxyethylene (biochemical grade)
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SYNONYMS Octyl-POE
OPOE
PRODUCT LINE Molecular Biology
PRODUCT CATEGORY Buffers / Detergents / Solutions
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Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-500-002-L005   5 ml 55.00 USD Add To Cart
ALX-500-002-L025   25 ml 220.00 USD Add To Cart
ALX-500-002-L100   100 ml 650.00 USD Add To Cart
Product Specification
FORMULA: CH3-(CH2)7-O-(CH2-CH2-O)x-H
x = 1 to 10
CAS NUMBER: 27252-75-1
APPEARANCE: Colorless liquid.
SOLUBILITY: Soluble in water.
SHIPPING: AMBIENT
LONG TERM STORAGE: +4°C
HAZARD: IRRITANT.
Product Description
Detergent for solubilization, purification and crystallization of membrane proteins.
Product Specific Literature References
Characterization of the major envelope protein from Escherichia coli. Regular arrangement on the peptidoglycan and unusual dodecyl sulfate binding: J.P. Rosenbusch; J. Biol. Chem. 249, 8019 (1974) Abstract; Full Text
Bacterial phosphotransferase system. Solubilization and purification of the glucose-specific enzyme II from membranes of Salmonella typhimurium: B. Erni, et al.; J. Biol. Chem. 257, 13726 (1982) Abstract; Full Text
Solubilized cytochrome c oxidase from Paracoccus denitrificans is a monomer: B. Ludwig, et al.; J. Biol. Chem. 257, 5576 (1982) Abstract; Full Text
Micelle clusters of octylhydroxyoligo(oxyethylenes): M. Zulauf & J.P. Rosenbusch; J. Phys. Chem. 87, 856 (1983)
Stimulatory GTP regulatory unit Ns and the catalytic unit of adenylate cyclase are tightly associated: mechanistic consequences: H. Arad, et al.; PNAS 81, 6579 (1984) Abstract
A new procedure for the isolation of the brain myelin basic protein in a lipid-bound form: P. Riccio, et al.; FEBS Lett. 177, 236 (1984) Abstract
Topology of phage lambda receptor protein. Mapping targets of proteolytic cleavage in relation to binding sites for phage or monoclonal antibodies: S. Schenkman, et al.; J. Biol. Chem. 259, 7570 (1984) Abstract; Full Text
Porin channel triplets merge into single outlets in Escherichia coli outer membranes: A. Engel, et al.; Nature 317, 643 (1985) Abstract
Isolation and crystallization of bacterial porin: R.M. Garavito & J.P. Rosenbusch; Meth. Enzymol. 125, 309 (1986) Abstract
Topographic labelling of pore-forming proteins from the outer membrane of Escherichia coli: M.G.P. Page & J.P. Rosenbusch; Biochem. J. 235, 651 (1986) Abstract
Densely packed beta-structure at the protein-lipid interface of porin is revealed by high-resolution cryo-electron microscopy: H.J. Sass, et al.; J. Mol. Biol. 209, 171 (1989) Abstract
Critical micellar concentrations of detergents: M. Zulauf, et al.; Meth. Enzymol. 172, 528 (1989) Abstract
Membrane protein crystallization: observations and use of short chain phospholipids as amphiphiles: J.L. Eiselé, et al.; J. Cryst. Growth 110, 96 (1990)
The critical role of detergents in the crystallization of membrane proteins: J.P. Rosenbusch; J. Struct. Biol. 104, 134 (1990) Abstract
Crystallization and preliminary X-ray characterization of maltoporin from Escherichia coli: K.A. Stauffer, et al.; J. Mol. Biol. 211, 297 (1990) Abstract
Crystal structures explain functional properties of two E. coli porins: W.S. Cowman, et al.; Nature 358, 727 (1992) Abstract
Lipopolysaccharide regions involved in the activation of Escherichia coli outer membrane protease OmpT: R.A. Kramer, et al.; Eur. J. Biochem. 269, 1746 (2002) Abstract
 
 
ALX-500-003 Revised 16-Feb-07
Hecameg®
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SYNONYMS 6-O-(N-Heptylcarbamoyl)-methyl-α-D-glucopyranoside
PRODUCT LINE Molecular Biology
PRODUCT CATEGORY Buffers / Detergents / Solutions
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ALX-500-003-G001   1 g 45.00 USD Add To Cart
ALX-500-003-G005   5 g 180.00 USD Add To Cart
Product Specification
FORMULA: C15H29NO7
MW: 335.4
CAS NUMBER: 115457-83-5
PURITY: ≥99%
APPEARANCE: White to off-white crytalline solid.
SOLUBILITY: Soluble in water.
SHIPPING: AMBIENT
LONG TERM STORAGE: +4°C

Product Description
Non-ionic, glucose based detergent for membrane protein purification.
Product Specific Literature References
Synthesis and Characterization of 6-O-(N-Heptylcarbamoyl)-methyl-alpha-D-glucopyranoside, a New Surfactant for Membrane Studies: D. Plusquellec, et al.; Anal. Biochem. 179, 145 (1989) Abstract
Ultrasonic Absorption Studies of Surfactant Exchange between Micelles and Bulk Phase in Aqueous Micellar Solutions of Nonionic Surfactants with a Short Alkyl Chain. 3.Surfactants with a Sugar Head Gp: M. Frindi, et al.; J. Physiol. Chem. 96, 8137 (1992)
Purification and Characterization of Protein H, the Major Porin of Pasteurella multocida: G. Chevalier, et al.; J. Bacteriol. 175, 266 (1993) Abstract
An assessment of the biochemical applications of the non-ionic surfactant HECAMEG(R): M. Begona Ruiz, et al.; Biochim. Biophys. Acta 1193, 301 (1994) Abstract
Overexpression and Purification of the Soluble Polyhydroxyalkanoate Synthase from Alcaligenes eutrophus.: Evidence for a Required Posttranslational Modification for Catalytic Activity: T.U. Gerngross, et al.; Biochemistry 33, 9311 (1994) Abstract
In Chromaffin Cells, the Mammalian Sec1p Homologue Is a Syntaxin 1A-binding Protein Associated with Chromaffin Granules: A. Hodel, et al.; J. Biol. Chem. 269, 8623 (1994) Abstract; Full Text
Purification and Characterization of Adipocyte Heparan Sulfate Proteoglycans with Affinity for Lipoprotein Lipase: K.B. Misra, et al.; J. Biol. Chem. 269, 23838 (1994) Abstract; Full Text
Preliminary Cryocristallographic Study of the Mitochondrial Cytochrome bc1 complex: Improved Crystallization and Flash-cooling of a Large Membrane Protein: J.W. Lee, et al.; J. Mol. Biol. 252, 15 (1995) Abstract
Purification and Characterization of the Cytochrom b6f Complex from Chlamydomonas reinhardtii: Y. Pierre, et al.; J. Biol. Chem. 270, 29342 (1995) Abstract; Full Text
Dimer to monomer conversion of the cytochrome b6 f complex. Causes and consequences: C. Breyton, et al.; J. Biol. Chem. 272, 21892 (1997) Abstract; Full Text
On the presence and role of a molecule of chlorophyll a in the cytochrome b6 f complex: Y. Pierre, et al.; J. Biol. Chem. 272, 21901 (1997) Abstract; Full Text
 
 
ALX-500-007 Revised 10-Sep-08
n-Dodecyl-β-D-maltoside (high purity)
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SYNONYMS n-Dodecyl-β-D-maltopyranoside (high purity)
PRODUCT LINE Molecular Biology
PRODUCT CATEGORY Buffers / Detergents / Solutions
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Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-500-007-G001   1 g 90.00 USD Add To Cart
ALX-500-007-G005   5 g 320.00 USD Add To Cart
ALX-500-007-G025   25 g 1'250.00 USD Add To Cart
Product Specification
FORMULA: C24H46O11
MW: 510.6
CAS NUMBER: 69227-93-6
PURITY: ≥99% (free of α-isomer)
APPEARANCE: White to off-white powder.
SOLUBILITY: 100mg/ml soluble in water and 100% ethanol.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
HANDLING: Protect from light and moisture. Hygroscopic.

Product Description
Non-ionic detergent similar to n-octyl-β-D-glucopyranoside (Prod. No. ALX-500-001). However, increased alkyl chain length has been shown to increase thermal stability of lipid-free rhodopsin in solution. Applicable to membrane-protein solubilization studies.
Product Specific Literature References
Alkyl glucosides as effective solubilizing agents for bovine rhodopsin. A comparison with several commonly used detergents: G.W. Stubbs, et al.; Biochim. Biophys. Acta 426, 46 (1976) Abstract
Alkyl glycoside detergents: synthesis and applications to the study of membrane proteins: T. VanAken, et al.; Meth. Enzymol. 125, 27 (1986) Abstract
Dodecyl maltoside-sodium dodecyl sulfate two-dimensional polyacrylamide gel electrophoresis of chloroplast thylakoid membrane proteins: W.T. Bass & T.M. Bricker; Anal. Biochem. 171, 330 (1988) Abstract
Dodecyl maltoside detergent improves resolution of hepatic membrane proteins in two-dimensional gels: F. Witzmann, et al.; Electrophoresis 12, 687 (1991) Abstract
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ALX-500-009 Revised 03-Mar-08
n-Octyl-β-D-thioglucopyranoside
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PRODUCT LINE Molecular Biology
PRODUCT CATEGORY Buffers / Detergents / Solutions
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Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-500-009-G001   1 g 38.00 USD Add To Cart
ALX-500-009-G005   5 g 150.00 USD Add To Cart
Product Specification
FORMULA: C14H28O5S
MW: 308.4
CAS NUMBER: 85618-21-9
PURITY: ≥98% (HPLC)
APPEARANCE: White to off-white powder.
SOLUBILITY: Soluble in water or methanol.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
HANDLING: Hygroscopic. Protect from light.

Product Description
Nonionic detergent that may be used to isolate membrane proteins from E. coli without inactivation. Stable in aqueous solution and easily removed by dialysis.
Product Specific Literature References
Characteristics of n-octyl beta-D-thioglucopyranoside, a new non-ionic detergent useful for membrane biochemistry: S. Saito & T. Tsuchiya; Biochem. J. 222, 829 (1984) Abstract
Use of n-octyl-beta-D-thioglucoside, a new nonionic detergent, for solubilization and reconstitution of membrane proteins: T. Tsuchiya & S. Saito; J. Biochem. 96, 1593 (1984) Abstract
 
 
ALX-505-005 Revised 23-Jul-08
KillerTRAIL™ Storage and Dilution Buffer
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PRODUCT LINE Molecular Biology
PRODUCT CATEGORY Buffers / Detergents / Solutions
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ALX-505-005-R500   500 µl 60.00 USD Add To Cart
Product Specification
PURITY DETAIL: Sterile filtered.
FORMULATION: Liquid. 20mM HEPES, pH 7.4, containing 300mM NaCl, 0.01% Tween 20, 1% sucrose and 1mM DTT.
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: -20°C
Product Description
Storage and dilution buffer for use with the following products:
KillerTRAIL™, Soluble (human) (recombinant) (Prod. No. ALX-201-073)
SuperKillerTRAIL™, Soluble (human) (recombinant) (Prod. No. ALX-201-115)
SuperKillerTRAIL™, Soluble (mouse) (recombinant) (Prod. No. ALX-201-130)

Useful for prediluting the above mentioned products before preparing aliquots or performing experiments. Predilution with KillerTRAIL™ Storage and Dilution Buffer allows for easier handling of small working concentrations (sometimes only 0.1µl of the KillerTRAIL™ or SuperKillerTRAIL™ stock solution is necessary because of their high activity). Predilution with KillerTRAIL™ Storage and Dilution Buffer instead of medium or PBS prevents loss of biological activity. Can also be used as negative control.
General Information
BACKGROUND/TECHNICAL INFORMATION Prepare a 1:10 dilution of KillerTRAIL™ or SuperKillerTRAIL™ with KillerTRAIL™ Storage and Dilution Buffer. For immediate use, keep prediluted KillerTRAIL™ or SuperKillerTRAIL™ on ice until adding to cells. For storage, prepare aliquots and freeze at -80°C.
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Further Categories Containing This Product:
TRAIL [Apo-2L]
 
 
ALX-510-001 Revised 07-Feb-05
TiterMax®
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PRODUCT LINE Immunology
PRODUCT CATEGORY Antibody Production & Purification
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Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-510-001-R500   500 µl 150.00 USD Add To Cart
ALX-510-001-L001   1 ml 250.00 USD Add To Cart
ALX-510-001-L005   5 ml 1'300.00 USD Add To Cart
ALX-510-001-L010   10 ml 2'500.00 USD Add To Cart
Product Specification
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: +4°C
Product Description
TiterMax® was designed to meet the specific needs of investigators for an immunoadjuvant that was at least as effective as Freund's Complete Adjuvant, but safer and easier to use [1]. Does not contain mineral oil, proteins, polysaccharides or other microbial products, and thereby minimizes or eliminates the undesirable effects caused by Freund's Complete Adjuvant. Also available: TiterMax® Gold (Prod. No. ALX-510-002).
Product Specific Literature References
[1] A comparison of commercially available adjuvants for use in research: B. Bennett, et al.; J. Immunol. Meth. 153, 31 (1992) Abstract
Further Categories Containing This Product:
Buffers / Detergents / Solutions
 
 
ALX-510-002 Revised 07-Feb-05
TiterMax® Gold
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PRODUCT LINE Immunology
PRODUCT CATEGORY Antibody Production & Purification
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Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-510-002-L001   1 ml 145.00 USD Add To Cart
ALX-510-002-L003   3 ml 395.00 USD Add To Cart
ALX-510-002-L005   5 ml 770.00 USD Add To Cart
ALX-510-002-L010   10 ml 1'350.00 USD Add To Cart
Product Specification
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: +4°C
Product Description
TiterMax® (Prod.No. 510-001) was designed to meet the specific needs of investigators for an immunoadjuvant that was at least as effective as Freund's Complete Adjuvant, but safer and easier to use [1]. The key to success of TiterMax® Gold lies in both the immunostimulatory activity of its new block copolymer, CRL-8300, and its ability to form a stable water-oil emulsion. TiterMax® Gold can be used with a wide variety of antigens which can be entrapped in a water-in-oil emulsion. Like TiterMax®, TiterMax® Gold does not contain mineral oil, proteins, polysaccharides or other microbial products, and thereby minimizes or eliminates the undesirable effects caused by Freund's Complete Adjuvant.
Product Specific Literature References
[1] A comparison of commercially available adjuvants for use in research: B. Bennett, et al.; J. Immunol. Meth. 153, 31 (1992) Abstract
Further Categories Containing This Product:
Buffers / Detergents / Solutions
 
 
ALX-700-001 Revised 13-May-08
DOTAP . mesylate
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SYNONYMS N-(1-(2,3-Dioleoyloxy)propyl)-N.N.N-trimethylammonium . mesylate
N-(1,2-Dioleyl-dihydroxypropyl)-N.N.N-trimethylammonium . mesylate
1,2-Dioleoyl-3-trimethylammonium-propane mesylate
PRODUCT LINE Signal Transduction
PRODUCT CATEGORY Lipid Signalling Pathways Other Products
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Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-700-001-M005   5 mg 20.00 USD Add To Cart
ALX-700-001-M025   25 mg 80.00 USD Add To Cart
Product Specification
FORMULA: C42H80NO4 . SO3CH3
MW: 663.1 . 95.1
CAS NUMBER: 252769-92-9; 144189-73-1
SOURCE/HOST: Synthetic.
PURITY: ≥98%
APPEARANCE: White to off-white solid.
SOLUBILITY: Soluble in methanol, 100% ethanol, methylene chloride, tetrahydrofuran or isopropanol; insoluble in DMSO or water.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
HANDLING: Packaged under inert gas.

Product Description
Cationic lipid used for transfection of DNA, RNA and other negatively charged molecules into eukaryotic cells.
Product Specific Literature References
Interactions of mammalian cells with lipid dispersions containing novel metabolizable cationic amphiphiles: R. Leventis & J.R. Silvius; Biochim. Biophys. Acta 1023, 124 (1990) Abstract
Further Categories Containing This Product:
Buffers / Detergents / Solutions