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Kinases / Related Products
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ALX-270-054 Revised 07-Dec-04
Bisindolylmaleimide VI
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PRODUCT LINE Signal Transduction
PRODUCT CATEGORY PKC Inhibitors
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ALX-270-054-M001   1 mg 45.00 USD Add To Cart
ALX-270-054-M005   5 mg 150.00 USD Add To Cart
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Product Specification
FORMULA: C27H26N4O2
MW: 438.5
PURITY: ≥96% (mixture of 2 isomers)
APPEARANCE: Red solid.
SOLUBILITY: Soluble in DMSO.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
HANDLING: Protect from light.

Product Description
Selective inhibitor of protein kinase C (PKC).
 
 
ALX-270-055 Revised 07-Dec-04
Bisindolylmaleimide VII
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PRODUCT LINE Signal Transduction
PRODUCT CATEGORY PKC Inhibitors
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ALX-270-055-M001   1 mg 45.00 USD Add To Cart
ALX-270-055-M005   5 mg 150.00 USD Add To Cart
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Product Specification
FORMULA: C27H27N5O2
MW: 453.5
CAS NUMBER: 137592-47-3
PURITY: ≥96%
APPEARANCE: Orange solid.
SOLUBILITY: Soluble in DMSO.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
HANDLING: Protect from light.

Product Description
Selective inhibitor of protein kinase C (PKC).
 
 
ALX-270-056 Revised 18-Jan-08
Bisindolylmaleimide VIII . acetate
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SYNONYMS Ro 31-7549 . acetate
PRODUCT LINE Signal Transduction
PRODUCT CATEGORY PKC Inhibitors
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ALX-270-056-M001   1 mg 45.00 USD Add To Cart
ALX-270-056-M005   5 mg 150.00 USD Add To Cart
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Product Specification
FORMULA: C24H22N4O2 . CH3COOH
MW: 398.5 . 60.1
CAS NUMBER: 138516-31-1
PURITY: ≥98%
APPEARANCE: Red powder.
SOLUBILITY: Soluble in DMSO, methanol or water; slightly soluble in 100% ethanol.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
HANDLING: Protect from light.

Product Description
Selective inhibitor of protein kinase C (PKC). Enhances Fas- and TRAIL-mediated apoptosis and inhibits T cell-mediated autoimmune diseases.
Product Specific Literature References
Bisindolylmaleimide VIII facilitates Fas-mediated apoptosis and inhibits T cell-mediated autoimmune diseases: T. Zhou, et al.; Nat. Med. 5, 42 (1999) Abstract
Bisindolylmaleimide VIII enhances DR5-mediated apoptosis through the MKK4/JNK/p38 kinase and the mitochondrial pathways: T. Ohtsuka & T. Zhou; J. Biol. Chem. 277, 29294 (2002) Abstract; Full Text
Proteome-wide identification of cellular targets affected by bisindolylmaleimide-type protein kinase C inhibitors: D. Brehmer, et al.; Mol. Cell Proteomics 3, 490 (2004) Abstract; Full Text
 
 
ALX-270-020 Revised 07-Dec-04
Bisindolylmaleimide IX . methanesulfonate
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SYNONYMS Ro 31-8220 . methanesulfonate
PRODUCT LINE Signal Transduction
PRODUCT CATEGORY PKC Inhibitors
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ALX-270-020-M001   1 mg 45.00 USD Add To Cart
ALX-270-020-M005   5 mg 150.00 USD Add To Cart
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Product Specification
FORMULA: C25H23N5O2S . CH4O3S
MW: 457.6 . 96.1
CAS NUMBER: 138489-18-6
PURITY: ≥98%
APPEARANCE: Red solid.
SOLUBILITY: Soluble in DMSO.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
HANDLING: Protect from light.

Product Description
Selective inhibitor of protein kinase C (PKC).
Product Specific Literature References
Atypical isoforms of pKc and insulin secretion from pancreatic beta- cells: evidence using Go 6976 and Ro 31-8220 as Pkc inhibitors: T.E. Harris, et al.; BBRC 227, 672 (1996) Abstract
 
 
ALX-270-057 Revised 18-Jan-08
Bisindolylmaleimide X . hydrochloride
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SYNONYMS Ro 31-8425 . HCl
PRODUCT LINE Signal Transduction
PRODUCT CATEGORY PKC Inhibitors
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ALX-270-057-M001   1 mg 45.00 USD Add To Cart
ALX-270-057-M005   5 mg 150.00 USD Add To Cart
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Product Specification
FORMULA: C26H24N4O2 . HCl
MW: 424.5 . 36.5
PURITY: ≥98%
APPEARANCE: Red solid.
SOLUBILITY: Soluble in DMSO.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
HANDLING: Protect from light.

Product Description
Selective inhibitor of protein kinase C (PKC).
Product Specific Literature References
Proteome-wide identification of cellular targets affected by bisindolylmaleimide-type protein kinase C inhibitors: D. Brehmer, et al.; Mol. Cell Proteomics 3, 490 (2004) Abstract; Full Text
 
 
ALX-270-058 Revised 28-May-08
Bisindolylmaleimide XI . hydrochloride
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SYNONYMS Ro 32-0432 . HCl
PRODUCT LINE Signal Transduction
PRODUCT CATEGORY PKC Inhibitors
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ALX-270-058-M001   1 mg 45.00 USD Add To Cart
ALX-270-058-M005   5 mg 150.00 USD Add To Cart
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Product Specification
FORMULA: C28H28N4O2 . HCl
MW: 452.6 . 36.5
PURITY: ≥98% (NMR)
APPEARANCE: Orange to brown red solid.
SOLUBILITY: Soluble in DMSO or methanol.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
HANDLING: Protect from light.

Product Description
Selective inhibitor of protein kinase C (PKC).
 
 
ALX-270-487 Revised 22-Jul-08 New product
BML-259
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SYNONYMS N-(5-Isopropylthiazol-2-yl)phenylacetamide
PRODUCT LINE Cell Cycle
PRODUCT CATEGORY CDK & Cyclin Inhibitors
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ALX-270-487-M005   5 mg 70.00 USD Add To Cart
Product Specification
FORMULA: C14H16N2OS
MW: 260.4
CAS NUMBER: 267654-00-2
PURITY: ≥98% (TLC)
APPEARANCE: White to off-white solid.
SOLUBILITY: 30mg/ml soluble in DMSO or dimethyl formamide, 0.25mg/ml soluble in 100% ethanol.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
USE/STABILITY: Stock solutions are stable for up to 3 months when stored at -20°C.

Product Description
Potent inhibitor of CDK5 (IC50 = 64nM) and CDK2 / cyclin E (IC50 = 98nM).
Product Specific Literature References
Discovery and SAR of 2-aminothiazole inhibitors of cyclin-dependent kinase 5/p25 as a potential treatment for Alzheimer’s disease: C.J. Helal, et al.; Bioorg. Med. Chem. Lett. 14, 5521 (2004) Abstract
 
 
ALX-270-390 Revised 09-Jan-08
Bohemine
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SYNONYMS 6-Benzylamino-2-(3-hydroxypropylamino)-9-isopropylpurine
PRODUCT LINE Cell Cycle
PRODUCT CATEGORY CDK & Cyclin Inhibitors
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ALX-270-390-M001   1 mg 40.00 USD Add To Cart
ALX-270-390-M005   5 mg 120.00 USD Add To Cart
Product Specification
FORMULA: C18H24N6O
MW: 340.4
CAS NUMBER: 189232-42-6
PURITY: ≥97% (HPLC)
APPEARANCE: White to off-white crystalline solid.
SOLUBILITY: Soluble in DMSO, dimethyl formamide, 100% ethanol or methanol.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
HANDLING: Protect from moisture.

Product Description
Cell permeable inhibitor of CDK1 (IC50=1.1µM) and CD2 (IC50=600nM). Arrests cell cycle in the G1/S boundary and activates mature bovine oocytes.
Product Specific Literature References
Cytokinin-derived cyclin-dependent kinase inhibitors: synthesis and cdc2 inhibitory activity of olomoucine and related compounds: L. Havlicek, et al.; J. Med. Chem. 40, 408 (1997) Abstract
Treatment of Vicia faba root tip cells with specific inhibitors to cyclin-dependent kinases leads to abnormal spindle formation: P. Binarova, et al.; Plant J. 16, 697 (1998) Abstract
Activation of bovine oocytes by specific inhibition of cyclin-dependent kinases: R. Alberio, et al.; Mol. Reprod. Dev. 55, 422 (2000) Abstract
Proteomics approach in classifying the biochemical basis of the anticancer activity of the new olomoucine-derived synthetic cyclin-dependent kinase inhibitor, bohemine: H. Kovarova, et al.; Electrophoresis 21, 3757 (2000) Abstract
In vivo metabolism of 2,6,9-trisubstituted purine-derived cyclin-dependent kinase inhibitor bohemine in mice: glucosidation as the principal metabolic route: Z. Chmela, et al.; Drug. Metab. Dispos. 29, 326 (2001) Abstract; Full Text
Antiproliferative effect of plant cytokinin analogues with an inhibitory activity on cyclin-dependent kinases: K. Vermeulen, et al.; Leukemia 16, 299 (2002)
Further Categories Containing This Product:
Cell Cycle Blockers & Inhibitors / Related Products
 
 
ALX-201-204/1 Revised 06-Jun-08 New product
pro-Bone Morphogenetic Protein 2 (human) (recombinant)
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SYNONYMS proBMP-2 (human) (recombinant)
PRODUCT LINE Bone Metabolism
PRODUCT CATEGORY Bone Morphogenetic Proteins [BMPs] & Receptors / Related Products
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ALX-201-204/1-C010   10 µg 380.00 USD Add To Cart
Product Specification
MW: ~85.5kDa.
SOURCE/HOST: Produced in E. coli and renatured from inclusion body material.
CONCENTRATION: 100μg/ml after reconstitution.
PURITY: ≥98% (SDS-PAGE, UV, MS)
FORMULATION: Lyophilized from 0.1M K-HEPES, pH 7.0, containing 3% mannitol.
ENDOTOXIN CONTENT: <0.02EU/mg protein.
RECONSTITUTION: Reconstitute with 100μl distilled water at +4°C for 30 minutes.
BIOLOGICAL ACTIVITY: Administration leads to ectopic bone formation in rats.
SHIPPING: SHIPPED ON DRY ICE
LONG TERM STORAGE: -80°C
USE/STABILITY: The reconstituted solution can be diluted into other aqueous buffers and stored at +4°C for up to two weeks. Below 10μg/ml, 0.5% BSA or serum should be added.
HANDLING: Avoid freeze/thaw cycles. After reconstitution, prepare aliquots and store at -80°C.
Product Specific Literature References
Biophysical comparison of BMP-2, ProBMP-2, and the free pro-peptide reveals stabilization of the pro-peptide by the mature growth factor : F. Hillger, et al.; J. Biol. Chem. 280, 14974 (2005) Abstract; Full Text
Further Categories Containing This Product:
Recombinant Proteins / Fusion Proteins
 
 
ALX-201-205/1 Revised 17-Jun-08 New product
Bone Morphogenetic Protein 2 (human) (recombinant)
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SYNONYMS BMP-2 (human) (recombinant)
PRODUCT LINE Bone Metabolism
PRODUCT CATEGORY Bone Morphogenetic Proteins [BMPs] & Receptors / Related Products
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ALX-201-205/1-C010   10 µg 280.00 USD Add To Cart
Product Specification
MW: ~25.9kDa.
SOURCE/HOST: Produced in E. coli and renatured from inclusion body material.
CONCENTRATION: 100-500μg/ml after reconstitution. 
PURITY: ≥98% (SDS-PAGE, UV, MS)
FORMULATION: Lyophilized.
ENDOTOXIN CONTENT: <0.02EU/mg protein.
RECONSTITUTION: Reconstitute with 20-100μl 50mM sodium acetate solution, pH 4.3.
BIOLOGICAL ACTIVITY: Induces alkaline phosphatase expression at an EC50 = 14nM in C2C12 cells.
SHIPPING: SHIPPED ON DRY ICE
LONG TERM STORAGE: -80°C
USE/STABILITY:

The reconstituted solution can be further diluted in sodium acetate solution and stored at +4°C for up to two weeks. Below 10μg/ml, 0.5% BSA or serum should be added.
HANDLING: Avoid freeze/thaw cycles. After reconstitution, prepare aliquots and store at -80°C.
Product Specific Literature References
Biophysical comparison of BMP-2, ProBMP-2, and the free pro-peptide reveals stabilization of the pro-peptide by the mature growth factor: F. Hillger, et al.; J. Biol. Chem. 280, 14974 (2005) Abstract; Full Text
Further Categories Containing This Product:
Recombinant Proteins / Fusion Proteins
 
 
ALX-380-102 Revised 03-Apr-08
Borrelidin
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SYNONYMS 2-(7-Cyano-8,16-dihydroxy-9,11,13,15-tetramethyl-18-oxooxacyclooctadeca-4,6-dien-2-yl)cyclopentanecarboxylic acid
Treponemycin
U 78548
C2989
PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Antibiotics for Cell Cycle Research
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ALX-380-102-MC05   0.5 mg 160.00 USD