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ALX-151-026
Revised 20-Jun-08
N-Acetyl-Asp-Tyr(2-malonyl)-Val-Pro-Met-Leu-NH2
PRODUCT LINE
Signal Transduction
PRODUCT CATEGORY
Tyrosine Kinase Inhibitors
Ordering Information
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ALX-151-026-M001
1 mg
90.00 USD
Product Specification
FORMULA:
C
39
H
57
N
7
O
14
S
MW:
880.0
PURITY:
≥96% (HPLC)
APPEARANCE:
White to off-white powder.
SOLUBILITY:
Soluble in water (1mg/ml).
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
USE/STABILITY:
Peptide is very unstable.
Product Description
Peptide containing a phosphotyrosyl mimetic. Effective protein tyrosine kinase inhibitor. Inhibits the phosphoinositide 3-kinase (PI(3)K) C-terminal p85 SH2 domain.
Product Specific Literature References
L-O-(2-malonyl)tyrosine: a new phosphotyrosyl mimetic for the preparation of Src homology 2 domain inhibitory peptides:
B. Ye, et al.; J. Med. Chem.
38
, 4270 (1995)
Abstract
Further Categories Containing This Product:
Phosphoinositide 3-kinase [PI(3)K]/Related Products
•
Peptides
ALX-151-027
Revised 17-Jan-05
N-Acetyl-Asp-Tyr(PO3H2)-Val-Pro-Met-Leu-NH2
PRODUCT LINE
Signal Transduction
PRODUCT CATEGORY
Tyrosine Kinase Inhibitors
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ALX-151-027-M001
1 mg
90.00 USD
Product Specification
FORMULA:
C
36
H
57
N
7
O
13
SP
MW:
858.9
PURITY:
≥96%
SOLUBILITY:
Soluble in water.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
Product Description
Phosphotyrosine containing peptide. Effective protein tyrosine kinase inhibitor. Inhibits the phosphoinositide 3-kinase (PI(3)K) C-terminal p85 SH2 domain.
Product Specific Literature References
L-O-(2-malonyl)tyrosine: a new phosphotyrosyl mimetic for the preparation of Src homology 2 domain inhibitory peptides:
B. Ye, et al.; J. Med. Chem.
38
, 4270 (1995)
Abstract
Further Categories Containing This Product:
Phosphoinositide 3-kinase [PI(3)K]/Related Products
•
Peptides
ALX-201-006
Revised 04-Dec-04
N-Acetyl-eglin C (recombinant)
PRODUCT LINE
Cancer
PRODUCT CATEGORY
Cathepsin Inhibitors
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
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ALX-201-006-MC01
0.1 mg
95.00 USD
ALX-201-006-MC05
0.5 mg
380.00 USD
ALX-201-006-M001
1 mg
670.00 USD
Product Specification
SEQUENCE:
Ac-Thr-Glu-Phe-Gly-Ser-Glu-Leu-Lys-Ser-Phe-Pro-Glu-Val-Val-Gly-Lys-Thr-Val-Asp-Gln-Ala-Arg-Glu-Tyr-Phe-Thr-Leu-His-Tyr-Pro-Gln-Tyr-Asn-Val-Tyr-Phe-Leu-Pro-Glu-Gly-Ser-Pro-Val-Thr-Leu-Asp-Leu-Arg-Tyr-Asp-Arg-Val-Arg-Val-Phe-Tyr-Asn-Pro-Gly-Thr-Asn-Val-Val-Asn-His-Val-Pro-His-Val-Gly-OH
MW:
8090.1
CAS NUMBER:
96380-69-7
SOURCE/HOST:
Produced in
E. coli
.
PURITY:
≥97% (HPLC)
APPEARANCE:
Lyophilized powder.
SHIPPING:
SHIPPED ON BLUE ICE
LONG TERM STORAGE:
-20°C
Product Description
Eglin C was originally isolated from the leech
Hirudo medicinalis
[1]. Recombinant N-acetyl-eglin C is a 70 amino acid peptide with identical biological activity to native eglin C. An effective inhibitor of chymotrypsin and subtilisin as well as of leukocyte elastase and cathepsin G.
Product Specific Literature References
[1]
Structure of the elastase-cathepsin G inhibitor of the leech Hirudo medicinalis:
U. Seemüller, et al.; Hoppe-Seyler's Z. Physiol. Chem.
361
, 1841 (1980)
Abstract
[2]
A large fragment approach to DNA synthesis: total synthesis of a gene for the protease inhibitor eglin c from the leech Hirudo medicinalis and its expression in E. coli:
H. Rink, et al.; Nucl. Acids Res.
12
, 6369 (1984)
Abstract
General Information
BACKGROUND/TECHNICAL INFORMATION
Swiss-Prot link P01051:
Eglin C (Hirudo medicinalis)
Further Categories Containing This Product:
Proteases Other Products
•
Recombinant Proteins/Fusion Proteins
ALX-290-001
Revised 29-Nov-04
N-Acetyl-S-farnesyl-L-cysteine
SYNONYMS
AFC
PRODUCT LINE
Signal Transduction
PRODUCT CATEGORY
Farnesylation/Isoprenylation Reagents
Ordering Information
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ALX-290-001-M005
5 mg
50.00 USD
ALX-290-001-M025
25 mg
150.00 USD
Product Specification
FORMULA:
C
20
H
33
NO
3
S
MW:
367.6
CAS NUMBER:
135304-07-3
PURITY:
≥97%
APPEARANCE:
Clear oil.
SOLUBILITY:
Soluble in DMSO, methanol or ethanol.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
Product Description
Specific inhibitor of S-farnesylcysteine methyl transferase.
Related Products
ALX-290-007
N-Acetyl-S-geranyl-L-cysteine
ALX-290-010
Revised 20-Apr-07
N-Acetyl-S-farnesyl-L-cysteine-methyl ester
SYNONYMS
AFCME
PRODUCT LINE
Signal Transduction
PRODUCT CATEGORY
Farnesylation/Isoprenylation Reagents
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ALX-290-010-M010
10 mg
40.00 USD
Product Specification
FORMULA:
C
21
H
35
NO
3
S
MW:
381.6
CAS NUMBER:
135304-08-4
PURITY:
≥95%
APPEARANCE:
White to slightly yellow powder.
SOLUBILITY:
Soluble in methanol.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
HANDLING:
Hygroscopic.
Product Description
Substrate for studying the reversibility of carboxyl methylation in signal-transducing G-proteins.
Product Specific Literature References
Methylation and demethylation reactions of guanine nucleotide-binding proteins of retinal rod outer segments:
D. Pérez-Sala, et al.; PNAS
88
, 3043 (1991)
Abstract
Identifying the recognition unit for G protein methylation:
E.W. Tan, et al.; J. Biol. Chem.
266
, 10719 (1991)
Abstract
;
Full Text
ALX-290-007
Revised 02-Jun-08
N-Acetyl-S-geranyl-L-cysteine
SYNONYMS
AGC
PRODUCT LINE
Signal Transduction
PRODUCT CATEGORY
Geranyl-related Reagents
Ordering Information
Product Numbers:
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ALX-290-007-M005
5 mg
90.00 USD
Product Specification
FORMULA:
C
15
H
25
NO
3
S
MW:
299.4
PURITY:
≥98% (TLC)
APPEARANCE:
Clear to pale yellow viscous oil.
SOLUBILITY:
> 25mg/ml soluble in DMSO or 100% ethanol.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
USE/STABILITY:
Solutions may be stored at -20 °C for up to 3 months. Product is not sterile.
Product Description
Negative control for AFC (Prod. No.
ALX-290-001
)
and AGGC (Prod. No.
ALX-290-008
)
. Has a closely similar structure to these two compounds but lacks their biological activity.
Related Products
ALX-290-001
N-Acetyl-S-farnesyl-L-cysteine
ALX-290-008
N-Acetyl-S-geranylgeranyl-L-cysteine
ALX-290-008
Revised 13-Jul-06
N-Acetyl-S-geranylgeranyl-L-cysteine
SYNONYMS
AGGC
PRODUCT LINE
Signal Transduction
PRODUCT CATEGORY
Geranyl-related Reagents
Ordering Information
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ALX-290-008-M005
5 mg
140.00 USD
Product Specification
FORMULA:
C
25
H
41
NO
3
S
MW:
435.7
CAS NUMBER:
139332-94-8
PURITY:
≥98%
APPEARANCE:
Viscous yellow oil.
SOLUBILITY:
Soluble in 100% ethanol or DMSO.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
Product Description
Specifically blocks methyl esterification of geranylgeranylated proteins such as Rab proteins. Blocks receptor-mediated signal transduction in human neutrophils (IC
50
=4µM). Induces insulin release from HIT-T15 cells by mimicking the action of Rab3A. Inhibits β2-integrin-induced actin polymerization (IC
50
~45nM) in neutrophils.
Related Products
ALX-290-007
N-Acetyl-S-geranyl-L-cysteine
ALX-550-208
Revised 17-Dec-04
N-Acetyl-5-hydroxytryptamine
SYNONYMS
N-Acetylserotonin
PRODUCT LINE
Neurobiology
PRODUCT CATEGORY
Melatonin Receptors/Related Products
Ordering Information
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ALX-550-208-M010
10 mg
10.00 USD
ALX-550-208-M050
50 mg
25.00 USD
ALX-550-208-M500
500 mg
125.00 USD
Product Specification
FORMULA:
C
12
H
14
N
2
O
2
MW:
218.3
CAS NUMBER:
1210-83-9; 17994-17-1
PURITY:
≥99%
APPEARANCE:
Off-white powder.
SOLUBILITY:
Soluble in ethanol.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
+4°C
HANDLING:
Protect from light.
Product Description
Metabolite of serotonin (Prod. No.
ALX-550-328
). Precursor of melatonin (Prod. No.
ALX-550-071
). Inhibitor of hydroxyindole-O-methyltransferase.
Product Specific Literature References
The metabolism of serotonin (5-hydroxytryptamine)
:
W.M. McIsaac and I.H. Page; J. Biol. Chem.
234
, 858 (1959)
Full Text
Hydroxyindole-O-methyltransferase. I. Substrate binding:
B.T. Ho, et al.; J. Pharm. Sci.
58
, 130 (1969)
Abstract
Hydroxyindole-O-methyltransferase. II. Inhibitory activities of some N- acyltryptamines:
B.T. Ho, et al.; J. Pharm. Sci.
57
, 1998 (1968)
Abstract
Further Categories Containing This Product:
Serotonergics & Serotonin Receptors/Related Products
ALX-350-310
Revised 03-Apr-08
3-O-Acetyl-11-keto-β-boswellic acid
SYNONYMS
AKβBA
PRODUCT LINE
Natural Products / Antibiotics
PRODUCT CATEGORY
Natural Products - Antitumor Reagents
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ALX-350-310-M005
5 mg
130.00 USD
Product Specification
FORMULA:
C
32
H
48
O
5
MW:
512.7
CAS NUMBER:
67416-61-9
SOURCE/HOST:
Isolated from
Boswellia serrata.
PURITY:
≥99% (HPLC, NMR)
APPEARANCE:
White to off-white solid.
SOLUBILITY:
Soluble in acetone, dichloromethane, diethyl ether or DMSO.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
USE/STABILITY:
Stock solutions are stable for up to 3 months when stored at -20°C.
HANDLING:
Protect from light.
HAZARD:
MAY BE CARCINOGENIC. HARMFUL.
Product Description
Shows antitumor and anti-inflammatory activities. Potent non-redox, noncompetitive 5-lipoxygenase and topoisomerase I and IIa inhibitor leading to apoptosis. 10-times more potent than 3-O-acetyl-β-boswellic acid (Prod. No.
ALX-350-308
). Exhibits
in vivo
efficacy in tumor growth and inhibition.
Product Specific Literature References
Acetyl-11-keto-beta-boswellic acid induces apoptosis in HL-60 and CCRF-CEM cells and inhibits topoisomerase I:
R.F. Hoernlein, et al.; J. Pharmacol. Exp. Ther.
288
, 613 (1999)
Abstract
;
Full Text
Boswellic acids activate p42(MAPK) and p38 MAPK and stimulate Ca(2+) mobilization:
A. Altmann, et al.; BBRC
290
, 185 (2002)
Abstract
Coupling of boswellic acid-induced Ca2+ mobilisation and MAPK activation to lipid metabolism and peroxide formation in human leucocytes:
A. Altmann, et al.; Br. J. Pharmacol.
141
, 223 (2004)
Abstract
;
Full Text
Inhibition of IkappaB kinase activity by acetyl-boswellic acids promotes apoptosis in androgen-independent PC-3 prostate cancer cells in vitro and in vivo:
T. Syrovets, et al.; J. Biol. Chem.
280
, 6170 (2005)
Abstract
;
Full Text
Boswellic acids: biological actions and molecular targets:
D. Poeckel & O. Werz; Curr. Med. Chem.
13
, 3359 (2006), Review
Abstract
Mechanisms underlying the anti-inflammatory actions of boswellic acid derivatives in experimental colitis:
C. Anthoni, et al.; Am. J. Physiol. Gastrointest. Liver Physiol.
290
, G1131 (2006)
Abstract
Potentiation of antinociceptive effect of NSAIDs by a specific lipooxygenase inhibitor, acetyl 11-keto-beta boswellic acid:
M. Bishnoi, et al.; Indian J. Exp. Biol.
44
, 128 (2006)
Abstract
Related Products
ALX-350-308
3-O-Acetyl-β-boswellic acid
Further Categories Containing This Product:
NF-kB Pathway Inhibitors
•
Natural Products - NF-kB Pathway Inhibitors
•
Antitumor Agents (Apoptosis Inducers)
•
Natural Products - Protein Kinase Inhibitors
•
Natural Products - Topoisomerase Inhibitors
•
Lipoxygenases/Related Products
•
Natural Products - Anti-inflammatory Agents
•
Natural Products - Apoptosis Inducers & Inhibitors
ALX-550-200
Revised 09-Aug-02
N-Acetyltryptamine
PRODUCT LINE
Neurobiology
PRODUCT CATEGORY
Melatonin Receptors/Related Products
Ordering Information
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ALX-550-200-M005
5 mg
50.00 USD
ALX-550-200-M025
25 mg
190.00 USD
Product Specification
FORMULA:
C
12
H
14
N
2
O
MW:
202.3
CAS NUMBER:
1016-47-3
PURITY:
≥97%
SOLUBILITY:
Soluble in methanol.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
+4°C
Product Description
Partial agonist for melatonin receptors.
Product Specific Literature References
Characterization of a retinal melatonin receptor:
M.L. Dubocovich; J. Pharmacol. Exp. Ther.
234
, 395 (1985)
Abstract
Luzindole (N-0774): a novel melatonin receptor antagonist:
M.L. Dubocovich; J. Pharmacol. Exp. Ther.
246
, 902 (1988)
Abstract
ALX-550-232
Revised 13-May-08
Aconitine
SYNONYMS
(1α,3α,6α,14α,15α,16β)-20-Ethyl-1,6,16-trimethoxy-4-(methoxymethyl)aconitane-3,8,13,14,15-pentol 8-acetate 14-benzoate
PRODUCT LINE
Natural Products / Antibiotics
PRODUCT CATEGORY
Neurotoxins
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ALX-550-232-M025
25 mg
45.00 USD
Product Specification
FORMULA:
C
34
H
47
NO
11
MW:
645.7
CAS NUMBER:
302-27-2
M
