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Signal Transduction Other Products
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ALX-280-001 Revised 25-Jul-08
DTT
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SYNONYMS 1,4-Dithio-DL-threitol
DL-Dithiothreitol
Cleland's Reagent
PRODUCT LINE Signal Transduction
PRODUCT CATEGORY Signal Transduction Other Products
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-280-001-G005   5 g 70.00 USD Add To Cart
ALX-280-001-G010   10 g 120.00 USD Add To Cart
ALX-280-001-G025   25 g 220.00 USD Add To Cart
ALX-280-001-G050   50 g 350.00 USD Add To Cart
Product Specification
FORMULA: C4H10O2S2
MW: 154.2
CAS NUMBER: 3483-12-3
MERCK INDEX: 14: 3376
RTECS: EK1610000
PURITY: ≥98%
APPEARANCE: White to off-white solid.
SOLUBILITY: Soluble in water, 100% ethanol, acetone or ethyl acetate.
SHIPPING: AMBIENT
LONG TERM STORAGE: +4°C
HAZARD: HARMFUL.

Product Description
Cell permeable protective agent for SH groups, maintaining monothiols completely in the reduced state and of reducing disulfides quantitatively.
Product Specific Literature References
Dithiothreitol, A New Protective Reagent For SH Groups: W.W. Cleland; Biochemistry 3, 480 (1964)
Enzyme activity and sulfhydryl status in rat renal cortex following mercuric chloride and dithiothreitol administration: D.R. Klonne & D.R. Johnson; Toxicol. Lett. 42, 199 (1988) Abstract
Molecular mechanism for prevention of N-acetyl-p-benzoquinoneimine cytotoxicity by the permeable thiol drugs diethyldithiocarbamate and dithiothreitol: V.V.M. Lauriault & P.J. O'Brien; Mol. Pharmacol. 40, 125 (1991) Abstract
Cleland's reagents block lethal and hypnotic effects of pentobarbital: L. Gailis; Eur. J. Pharmacol. 292, 39 (1994) Abstract
 
 
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