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Signal Transduction
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 Items 350-400 of 2920 Page 8 of 59 Select Page: << 1 2 3 4 5 6 7 8 9 10  >>  
ALX-550-315 Revised 22-Aug-02
2-Bromomelatonin
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PRODUCT LINE Neurobiology
PRODUCT CATEGORY Melatonin Receptors/Related Products
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ALX-550-315-M001   1 mg 60.00 USD Add To Cart
Product Specification
FORMULA: C13H16N2O2Br
MW: 312.2
PURITY: ≥95%
APPEARANCE: Yellow solid.
SOLUBILITY: Soluble in ethyl acetate.
SHIPPING: AMBIENT
LONG TERM STORAGE: +4°C

Product Description
Melatonin agonist with high affinity for chicken brain membrane melatonin receptors.
Product Specific Literature References
2-Bromomelatonin: synthesis and characterization of a potent melatonin agonist: E. Duranti, et al.; Life Sci. 51, 479 (1992) Abstract
2-Substituted 5-methoxy-N-acyltryptamines: synthesis, binding affinity for the melatonin receptor, and evaluation of the biological activity: G. Spadoni, et al.; J. Med. Chem. 36, 4069 (1993) Abstract
 
 
ALX-550-524 Revised 19-Jul-07
1,3-bis(4-Bromophenyl)-5-phenyl-2,4-imidazolidinedione
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SYNONYMS Compound 25
CB1 Cannabinoid Receptor Inverse Agonist
PRODUCT LINE Neurobiology
PRODUCT CATEGORY Cannabinoid Receptor Agonists & Antagonists/Related Products
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ALX-550-524-M005   5 mg 25.00 USD Add To Cart
Product Specification
FORMULA: C21H14Br2N2O2
MW: 486.2
CAS NUMBER: 878533-35-8
PURITY: ≥98%
APPEARANCE: White to off-white solid.
SOLUBILITY: Soluble in DMSO or dimethyl formamide; sparingly soluble in aqueous buffers.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
USE/STABILITY: Stable for at least 2 years after receipt when stored at -20°C.

Product Description
Potent and selective inverse agonist of CB1 receptor (Ki=243nM and EC50=195nM).
Product Specific Literature References
Synthesis and activity of 1,3,5-triphenylimidazolidine-2,4-diones and 1,3,5-triphenyl-2-thioxoimidazolidin-4-ones: characterization of new CB1 cannabinoid receptor inverse agonists/antagonists: G.G. Muccioli, et al.; J. Med. Chem. 49, 872 (2006) Abstract
 
 
ALX-430-025 Revised 13-May-03
(-)-p-Bromotetramisole . oxalate
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SYNONYMS (-)-(S)-6-(4-Bromophenyl)-2,3,5,6-tetrahydroimidazo[2,1-b]thiazole . oxalate
PRODUCT LINE Signal Transduction
PRODUCT CATEGORY Protein Tyrosine Phosphatases Other Products
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ALX-430-025-M005   5 mg 90.00 USD Add To Cart
Product Specification
FORMULA: C11H11BrN2S . C2H2O4
MW: 283.2 . 90.0
PURITY: ≥98%
APPEARANCE: White powder.
SOLUBILITY: Soluble in water, methanol, DMF or DMSO.
SHIPPING: AMBIENT
LONG TERM STORAGE: +4°C

Product Description
Potent alkaline phosphatase inhibitor.
 
 
ALX-350-005 Revised 02-Oct-07
Bryostatin 1
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PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Natural Products - Other Signal Transduction Pathway Modulators
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ALX-350-005-C010   10 µg 85.00 USD Add To Cart
Product Specification
FORMULA: C47H68O17
MW: 905.0
CAS NUMBER: 83314-01-6
MERCK INDEX: 14: 1457
PURITY: ≥97%
APPEARANCE: Colorless oil.
SOLUBILITY: 25mg/ml soluble in 100% ethanol or DMSO.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
HANDLING: Store tightly sealed. Binds to glass and plastic surfaces in aqueous solutions.

Product Description
Binds to and activates protein kinase C (PKC). Antineoplastic.
Product Specific Literature References
Isolation and structure of Bryostatin 1: G.R. Pettit, et al.; J. Am. Chem. Soc. 104, 6846 (1982)
Bryostatin 1: differentiating agent from the depths: R.M. Stone; Leuk. Res. 21, 399 (1997) Abstract
Chemistry and clinical biology of the bryostatins: R. Mutter & M. Wills; Bioorg. Med. Chem. 8, 1841 (2000), (Review) Abstract
The clinical development of the bryostatins: A. Clamp and G.C. Jayson; Anticancer Drugs 13, 673 (2002) Abstract
The chemistry and biology of the bryostatin antitumour macrolides: K.J. Hale, et al.; Nat. Prod. Rep. 19, 413 (2002), Review Abstract
Bryostatin-1: pharmacology and therapeutic potential as a CNS drug: M.K. Sun & D.L. Alkon; CNS Drug Rev. 12, 1 (2006), Review Abstract
Further Categories Containing This Product:
Antitumor Agents (Enzyme Activators & Inducers) • PKC Activators • Natural Products - Antitumor Reagents • Natural Products - Immunomodulators
 
 
ALX-350-281 Revised 11-Jun-07
Bufalin
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SYNONYMS (3β,5β)-3,14-Dihydroxybufa-20,22-dienolide
PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Natural Products - ATPase Inhibitors
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ALX-350-281-M005   5 mg 160.00 USD Add To Cart
Product Specification
FORMULA: C24H34O4
MW: 386.5
CAS NUMBER: 465-21-4
MERCK INDEX: 14: 1471
SOURCE/HOST: Isolated from Bufonis venom.
PURITY: ≥98%
APPEARANCE: White powder.
SOLUBILITY: Soluble in chloroform.
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: +4°C
HAZARD: TOXIC.

Product Description
Cardiotonic steroid specific Na+/K+-ATPase inhibitor. More potent than ouabain (Prod. No. ALX-350-066). Induces cell differentiation and apoptosis.
Product Specific Literature References
Actions of bufalin and cinobufotalin, two bufadienolides respectively more active and less active than ouabain, on ouabain binding and 86Rb uptake by human erythrocytes: A.A. Brownlee, et al.; Clin. Sci. (Lond.) 78, 169 (1990) Abstract
Neutralization of cardiac toxins oleandrin, oleandrigenin, bufalin, and cinobufotalin by digibind: monitoring the effect by measuring free digitoxin concentrations: A. Dasgupta & L. Emerson; Life Sci. 63, 781 (1998) Abstract
Bufadienolides from animal and plant sources: L. Krenn & B. Kopp; Phytochemistry 48, 1 (1998), (Review) Abstract
The T-cell suppressive effect of bufadienolides: structural requirements for their immunoregulatory activity: P. Terness, et al.; Int. Immunopharmacol. 1, 19 (2001) Abstract
Simultaneous determination of four bufadienolides in human liver by high-performance liquid chromatography: Z. Wang, et al.; Biomed. Chromatogr. 18, 318 (2004) Abstract
Cardiotonic steroids differentially affect intracellular Na+ and [Na+]i/[K+]i-independent signaling in C7-MDCK cells: O.A. Akimova, et al.; J. Biol. Chem. 280, 832 (2005) Abstract
Further Categories Containing This Product:
Na+/K+-ATPase/Related Products • Natural Products - Apoptosis Inducers & Inhibitors • Natural Products - Immunomodulators
 
 
ALX-350-282 Revised 16-Jun-06
Bufotalin
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SYNONYMS (3β,5β,16β)-16-(Acetyloxy)-3-,14-dihydroxybufa-20,22-dienolide
3β,14,16β-Trihydroxy-5β bufa-20,22-dienolide 16-acetate
PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Natural Products - ATPase Inhibitors
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ALX-350-282-M005   5 mg 85.00 USD Add To Cart
Product Specification
FORMULA: C26H36O6
MW: 444.6
CAS NUMBER: 471-95-4
MERCK INDEX: 14: 1477
SOURCE/HOST: Isolated from Bufonis venom.
PURITY: ≥98% (HPLC)
APPEARANCE: White to off-white solid.
SOLUBILITY: Soluble in 100% ethanol or chloroform.
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: +4°C
HAZARD: TOXIC.

Product Description
Less potent Na+/K+-ATPase inhibitor than other bufadienolides. Potent immunosuppressor.
Product Specific Literature References
Bufadienolides from animal and plant sources: L. Krenn & B. Kopp; Phytochemistry 48, 1 (1999), (Review) Abstract
The T-cell suppressive effect of bufadienolides: structural requirements for their immunoregulatory activity: P. Terness, et al.; Int. Immunopharmacol. 1, 119 (2001) Abstract
Further Categories Containing This Product:
Na+/K+-ATPase/Related Products • Natural Products - Immunomodulators
 
 
ALX-550-238 Revised 03-Feb-05
Bumetanide
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SYNONYMS Ro 10-6338
3-(Aminosulfonyl)-5-(butylamino)-4-phenoxybenzoic acid
PRODUCT LINE Signal Transduction
PRODUCT CATEGORY Na+ Channels
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ALX-550-238-M500   500 mg 40.00 USD Add To Cart
ALX-550-238-G001   1 g 60.00 USD Add To Cart
Product Specification
FORMULA: C17H20N2O5S
MW: 364.4
CAS NUMBER: 28395-03-1
MERCK INDEX: 14: 1484
PURITY: ≥99%
APPEARANCE: White solid.
SOLUBILITY: Soluble in ethanol or DMSO.
SHIPPING: AMBIENT
LONG TERM STORAGE: +20°C
HAZARD: TOXIC.

Product Description
Specific inhibitor of Na+/K+/2Cl- cotransport and is used clinically as a diuretic. Shows high affinity and specific binding to membranes of many cell types.
Product Specific Literature References
Characteristics and functions of Na-K-Cl cotransport in epithelial tissues: S.M. O'Grady, et al.; Am. J. Physiol. 253, C177 (1987) Abstract
Effect of bradykinin on Na-K-2Cl cotransport and bumetanide binding in aortic endothelial cells: J.D. Klein & W.C. O'Neill; J. Biol. Chem. 265, 22238 (1990) Abstract; Full Text
The regulation of Na/K/2Cl cotransport and bumetanide binding in avian erythrocytes by protein phosphorylation and dephosphorylation. Effects of kinase inhibitors and okadaic acid: E.B. Pewitt, et al.; J. Biol. Chem. 265, 20747 (1990) Abstract; Full Text
Pharmacokinetics and pharmacodynamics of the diuretic bumetanide in the elderly: R. Oberbauer, et al.; Clin. Pharmacol. Ther. 57, 42 (1995) Abstract
 
 
ALX-630-075 Revised 31-Oct-07
α-Bungarotoxin
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SYNONYMS α-BuTx
PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Neurotoxins
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ALX-630-075-M001   1 mg 65.00 USD Add To Cart
Product Specification
SEQUENCE: H-Ile-Val-Cys-His-Thr-Thr-Ala-Thr-Ser-Pro-Ile-Ser-Ala-Val-Thr-Cys-Pro-Pro-Gly-Glu-Asn-Leu-Cys-Tyr-Arg-Lys-Met-Trp-Cys-Asp-Ala-Phe-Cys-Ser-Ser-Arg-Gly-Lys-Val-Val-Glu-Leu-Gly-Cys-Ala-Ala-Thr-Cys-Pro-Ser-Lys-Lys-Pro-Tyr-Glu-Glu-Val-Thr-Cys-Cys-Ser-Thr-Asp-Lys-Cys-Asn-Pro-His-Pro-Lys-Gln-Arg-Pro-Gly-OH
(Disulfide bonds between Cys3-Cys23, Cys16-Cys44, Cys29-Cys33, Cys48-Cys59 and Cys60-Cys65)
MW: 7984.2
CAS NUMBER: 11032-79-4
MERCK INDEX: 14: 1488
SOURCE/HOST: Isolated from Bungarus multicinctus.
PURITY: ≥98%
APPEARANCE: Lyophilized powder.
SOLUBILITY: Soluble in water or aqueous buffers.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
HAZARD: POTENT NEUROTOXIN.
Product Description
Post-synaptic neurotoxin that binds irreversibly to acetylcholine receptor sites, producing neuromuscular blockade and skeletal muscle paralysis. Prevents opening of nicotinic receptor-associated ion channels.
Product Specific Literature References
Use of a snake venom toxin to characterize the cholinergic receptor protein: J.P. Changeux, et al.; PNAS 67, 1241 (1970) Abstract
Amino acid sequence of alpha-bungarotoxin from the venom of Bungarus multicinctus: D. Mebs, et al.; BBRC 44, 711 (1971) Abstract
Elapid neurotoxins. Purification, characterization, and immunochemical studies of alpha-bungarotoxin: D.G. Clark, et al.; Biochemistry 11, 1663 (1972) Abstract
Purification, properties and amino acid sequence of alpha-bungarotoxin from the venom of Bungarus multicinctus: D. Mebs, et al.; Hoppe Seylers Z. Physiol. Chem. 353, 243 (1972) Abstract
alpha-Bungarotoxin binding sites in the CNS: B.J. Morley, et al.; Life Sci. 24, 859 (1979) Abstract
Alpha-bungarotoxin binding and central nervous system nicotinic acetylcholine receptors: R.E. Oswald & J.A. Freeman; Neuroscience 6, 1 (1981) Abstract
Determination of the primary amino acid sequence specifying the alpha-bungarotoxin binding site on the alpha subunit of the acetylcholine receptor from Torpedo californica: P.T. Wilson, et al.; PNAS 82, 8790 (1985) Abstract
The crystal structure of alpha-bungarotoxin at 2.5 A resolution: relation to solution structure and binding to acetylcholine receptor: R.A. Love & R.M. Stroud; Protein Eng. 1, 37 (1986) Abstract
Neuronal nicotinic alpha-bungarotoxin sites: M. Quik & S. Geertsen; Can. J. Physiol. Pharmacol. 66, 971 (1988) Abstract
The fall and rise of neuronal alpha-bungarotoxin binding proteins: P.B. Clarke; TIPS 13, 407 (1992), (Review) Abstract
Three subtypes of alpha-bungarotoxin-sensitive nicotinic acetylcholine receptors are expressed in chick retina: K.T. Keyser, et al.; J. Neurosci. 13, 442 (1993) Abstract
Neuronal acetylcholine receptors that bind alpha-bungarotoxin mediate neurite retraction in a calcium-dependent manner: P.C. Pugh and D.K. Berg; J. Neurosci. 14, 889 (1994) Abstract
The alpha-bungarotoxin binding site on the nicotinic acetylcholine receptor: analysis using a phage-epitope library: M. Balass, et al.; PNAS 94, 6054 (1997) Abstract
Nicotine blocks TNF-alpha-mediated neuroprotection to NMDA by an alpha-bungarotoxin-sensitive pathway: N.G. Carlson, et al.; J. Neurobiol. 35, 29 (1998) Abstract
Alpha-Bungarotoxin binding to human muscle acetylcholine receptor measurement of affinity, delineation of AChR subunit residues crucial to binding, and protection of AChR function by synthetic peptide: A. Vincent, et al.; Neurochem. Int. 32, 427 (1998) Abstract
Alpha-bungarotoxin binding to acetylcholine receptor membranes studied by low angle X-ray diffraction: H.S. Young, et al.; Biophys. J. 83, 943 (2003) Abstract
Imaging of receptor trafficking by using alpha-bungarotoxin-binding-site-tagged receptors: Y. Sekine-Aizawa & R. L. Huganir; PNAS 101, 17114 (2004) Abstract
The cholinergic antagonist alpha-bungarotoxin also binds and blocks a subset of GABA receptors: C.M. McCann, et al.; PNAS 103, 5149 (2006) Abstract
MD and NMR studies of alpha-bungarotoxin surface accessibility: V. Venditti, et al.; Biochem. Biophys. Res. Commun . 356, 114 (2007) Abstract
Further Categories Containing This Product:
Acetylcholine Receptors (Nicotinic)/Related Products
 
 
ALX-630-050 Revised 31-Oct-07
β-Bungarotoxin
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SYNONYMS β-BuTx
PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Neurotoxins
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ALX-630-050-M001   1 mg 60.00 USD Add To Cart
Product Specification
MW: 6979.0
CAS NUMBER: 12778-32-4
MERCK INDEX: 14: 1488
SOURCE/HOST: Isolated from Bungarus multicinctus.
PURITY: ≥98%
APPEARANCE: Lyophilized powder.
SOLUBILITY: Soluble in water or aqueous buffers.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
HAZARD: POTENT NEUROTOXIN.
Product Description
Presynaptic, neurotoxic phospholipase A2 activity.
Product Specific Literature References
Use of a snake venom toxin to characterize the cholinergic receptor protein: J.P. Changeux, et al.; PNAS 67, 1241 (1970) Abstract
Amino acid sequence of alpha-bungarotoxin from the venom of Bungarus multicinctus: D. Mebs, et al; BBRC 44, 711 (1971) Abstract
Alpha-bungarotoxin binding and central nervous system nicotinic acetylcholine receptors: R.E. Oswald; Neuroscience 6, 1 (1981) Abstract
Amino acid sequence of beta 2-bungarotoxin from Bungarus multicinctus venom. The amino acid substitutions in the B chains: K. Kondo, et al.; J. Biochem. 91, 1519 (1982) Abstract
Amino acid sequences of three beta-bungarotoxins (beta 3-, beta 4-, and beta 5- bungarotoxins) from Bungarus multicinctus venom. Amino acid substitutions in the A chains: K. Kondo; J. Biochem. 91, 1531 (1982) Abstract
Biochemical and electrophysiological demonstrations of the actions of beta-bungarotoxin on synapses in brain: J.V. Halliwell; J. Neurochem. 39, 543 (1982) Abstract
Solubilization and characterization of the beta-bungarotoxin-binding protein of chick brain membranes: H. Rehm & H. Betz; J. Biol. Chem. 259, 6865 (1984) Abstract; Full Text
Beta-bungarotoxin inhibits a non-inactivating potassium current in guinea pig dorsal root ganglion neurones: M. Petersen, et al.; Neurosci. Lett. 68, 141 (1986) Abstract
Cross-linking of beta-bungarotoxin to chick brain membranes. Identification of subunits of a putative voltage-gated K+ channel: R.R. Schmidt & H. Betz; Biochemistry 28, 8346 (1989) Abstract
Nucleotide sequence encoding beta-bungarotoxin A2-chain from the venom glands of Bungarus multicinctus: J.M. Danse, et al.; Nucl. Acids Res. 18, 4609 (1990) Abstract
Potassium channel toxins: P.N. Strong; Pharmacol. Ther. 46, 137 (1990), (Review) Abstract
Mechanism of action of beta-bungarotoxin, a presynaptically acting phospholipase A2 neurotoxin: its effect on protein phosphorylation in rat brain synaptosomes: E. Ueno & P. Rosenberg; Toxicon 34, 1219 (1996) Abstract
What does beta-bungarotoxin do at the neuromuscular junction?: E.G. Rowan; Toxicon 39, 107 (2001), (Review) Abstract
Induction by beta-bungarotoxin of apoptosis in cultured hippocampal neurons is mediated by Ca(2+)-dependent formation of reactive oxygen species: O. Shakhman, et al.; J. Neurochem. 87, 598 (2003) Abstract
Phospholipase A(2) activity of beta-bungarotoxin is essential for induction of cytotoxicity on cerebellar granule neurons: Y.J. Chen; J. Neurobiol. 64, 213 (2005) Abstract
Mechanism of beta-bungarotoxin in facilitating spontaneous transmitter release at neuromuscular synapse: J.C. Liou, et al.; Neuropharmacology 51, 671 (2006) Abstract
Further Categories Containing This Product:
K+ Channel Blockers & Inhibitors • PLA2
 
 
ALX-550-144 Revised 09-Dec-04
Buspirone . hydrochloride
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SYNONYMS 8-[4-[4-(2-Pyrimidinyl)-1-piperazinyl]butyl]-8-azaspiro[4,5]decane-7,9-dione . HCl
PRODUCT LINE Neurobiology
PRODUCT CATEGORY Serotonergics & Serotonin Receptors/Related Products
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ALX-550-144-G001   1 g 48.00 USD Add To Cart
Product Specification
FORMULA: C21H31N5O2 . HCl
MW: 385.5 . 36.5
CAS NUMBER: 33386-08-2
MERCK INDEX: </