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ALX-101-010
Revised 11-Sep-07
L-Aspartic acid
SYNONYMS
H-L-Asp-OH
PRODUCT LINE
Combinatorial Chemistry
PRODUCT CATEGORY
L-Amino Acids
Ordering Information
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ALX-101-010-G001
1 g
12.00 USD
Product Specification
FORMULA:
C
4
H
7
NO
4
MW:
133.1
CAS NUMBER:
56-84-8
MERCK INDEX:
14:
840
RTECS:
CI9098500
PURITY:
≥99.5%
APPEARANCE:
White powder.
SOLUBILITY:
Soluble in water.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
+20°C
Further Categories Containing This Product:
Excitatory Amino Acids
•
NMDA Receptors/Related Products
ALX-101-011
Revised 22-Nov-06
D-Aspartic acid
SYNONYMS
H-D-Asp-OH
PRODUCT LINE
Combinatorial Chemistry
PRODUCT CATEGORY
D-Amino Acids
Ordering Information
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ALX-101-011-G001
1 g
12.00 USD
Product Specification
FORMULA:
C
4
H
7
NO
4
MW:
133.1
CAS NUMBER:
1783-96-6
MERCK INDEX:
14:
840
RTECS:
CI9097500
PURITY:
≥99%
APPEARANCE:
White powder.
SOLUBILITY:
Soluble in water.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
+20°C
Further Categories Containing This Product:
Excitatory Amino Acids
•
NMDA Receptors/Related Products
ALX-105-009
Revised 06-Jun-06
N-Methyl-D-aspartic acid
SYNONYMS
NMDA
PRODUCT LINE
Nitric Oxide Pathway
PRODUCT CATEGORY
NOS Inhibitors (NOS Induction & Enzyme Activity)
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ALX-105-009-M010
10 mg
23.00 USD
ALX-105-009-M050
50 mg
60.00 USD
Product Specification
FORMULA:
C
5
H
9
NO
4
MW:
147.1
CAS NUMBER:
6384-92-5
MERCK INDEX:
14:
6662
RTECS:
CI9457000
PURITY:
≥98%
APPEARANCE:
White crystalline powder.
SOLUBILITY:
Soluble in dilute aqueous base; slightly soluble in water or 100% ethanol.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
+20°C
HANDLING:
Protect from light.
Product Description
Selective ionotropic NMDA receptor agonist.
Product Specific Literature References
Excitatory amino acid transmitters:
J.C. Watkins & R.H. Evans; Ann. Rev. Pharmacol. Toxicol.
21
, 165 (1981), (Review)
Abstract
NMDA receptors and ligands in the vertebrate CNS:
T.W. Stone & N.R. Burton; Progr. Neurobiol.
30
, 333 (1988), (Review)
Abstract
Further Categories Containing This Product:
Special Amino Acids
•
NMDA Receptors/Related Products
ALX-106-024
Revised 06-Jun-06
O-Phospho-L-serine
SYNONYMS
L-Phosphoserine
L-Serine-O-phosphate
PRODUCT LINE
Neurobiology
PRODUCT CATEGORY
NMDA Receptors/Related Products
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ALX-106-024-G001
1 g
10.00 USD
Product Specification
FORMULA:
C
3
H
8
NO
6
P
MW:
185.1
CAS NUMBER:
407-41-0
PURITY:
≥97%
APPEARANCE:
White to off-white solid.
SOLUBILITY:
Soluble in water.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
+4°C
HANDLING:
Store tightly sealed. Use fresh solutions.
Product Description
L-AP4 agonist. Competitive NMDA antagonist. Has affinity for type IV, but not type I, metabotropic glutamate receptor.
Product Specific Literature References
L-phosphoserine, a metabolite elevated in Alzheimer's disease, interacts with specific L-glutamate receptor subtypes:
W.E. Klunk, et al.; J. Neurochem.
56
, 1997 (1991)
Abstract
Serine-O-phosphate has affinity for type IV, but not type I, metabotropic glutamate receptor:
C. Thomsen & P.D. Suzdak; Neuroreport
4
, 1099 (1993)
Abstract
Agonists and antagonists for metabotropic glutamate receptors:
P.L. Ornstein, et al.; Curr. Pharm. Design
1
, 355 (1995), (Review)
Decreased expression of the metabotropic glutamate receptor-4 gene is associated with neuronal apoptosis:
K. Borodezt & S.R. D'Mello; J. Neurosci. Res.
53
, 531 (1998)
Abstract
Further Categories Containing This Product:
Special Amino Acids
•
Glutamate Receptors (Metabotropic)/Related Products
ALX-106-028
Revised 03-Apr-08
D-Cycloserine
SYNONYMS
R(+)-4-Amino-3-isoxazolidinone
PRODUCT LINE
Natural Products / Antibiotics
PRODUCT CATEGORY
Natural Products for Neurological Research
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ALX-106-028-M050
50 mg
20.00 USD
ALX-106-028-M250
250 mg
80.00 USD
Product Specification
FORMULA:
C
3
H
6
N
2
O
2
MW:
102.1
CAS NUMBER:
68-41-7
RTECS:
NY2975000
SOURCE/HOST:
Synthetic.
PURITY:
≥97%
APPEARANCE:
White to off-white solid.
SOLUBILITY:
Soluble in water.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
+4°C
HANDLING:
Hygroscopic.
Product Description
Excitatory amino acid. Partial agonist at the glycine modulatory site of the NMDA receptor.
Further Categories Containing This Product:
Excitatory Amino Acids
•
Special Amino Acids
•
NMDA Receptors/Related Products
ALX-106-037
Revised 09-Oct-07
L-Cycloserine
SYNONYMS
S(-)-4-Amino-3-isoxazolidinone
PRODUCT LINE
Natural Products / Antibiotics
PRODUCT CATEGORY
Natural Products for Neurological Research
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ALX-106-037-M025
25 mg
50.00 USD
ALX-106-037-M100
100 mg
150.00 USD
Product Specification
FORMULA:
C
3
H
6
N
2
O
2
MW:
102.1
CAS NUMBER:
339-72-0; 4834-58-6
MERCK INDEX:
14:
2751
RTECS:
NY2976000
PURITY:
≥98%
APPEARANCE:
White to off-white powder.
SOLUBILITY:
Soluble in water.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
HANDLING:
Hygroscopic.
Product Description
Excitatory amino acid. Inhibitor of ketosphinganine synthase (serine-palmitoyl-CoA transferase, EC 2.3.1.50), leading to blockade of sphingosine biosynthesis. Partial agonist at the glycine modulatory site of the NMDA receptor.
Product Specific Literature References
Inhibition of sphingolipid synthesis by cycloserine in vitro and in vivo:
K.S. Sundaram & M. Lev; J. Neurochem.
42
, 577 (1984)
Abstract
Inhibition of serine palmitoyltransferase activity in rabbit aorta by L-cycloserine
:
R.D. Williams, et al.; J. Lipid Res.
28
, 1478 (1987)
Abstract
;
Full Text
D-cycloserine acts as a partial agonist at the glycine modulatory site of the NMDA receptor expressed in Xenopus oocytes:
G.B. Watson, et al.; Brain Res.
510
, 158 (1990)
Abstract
D-cycloserine, a putative cognitive enhancer, facilitates activation of the N-methyl-D-aspartate receptor-ionophore complex in Alzheimer brain:
I.P. Chessell, et al.; Brain Res.
565
, 345 (1991)
Abstract
Rapid kidney changes resulting from glycosphingolipid depletion by treatment with a glucosyltransferase inhibitor:
G.S. Shukla, et al.; Biochim. Biophys. Acta
1083
, 101 (1991)
Abstract
Further Categories Containing This Product:
Excitatory Amino Acids
•
NMDA Receptors/Related Products
•
Special Amino Acids
ALX-270-121
Revised 01-Dec-04
N-(3-Aminopropyl)cyclohexylamine
PRODUCT LINE
Neurobiology
PRODUCT CATEGORY
NMDA Receptors/Related Products
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ALX-270-121-G001
1 g
25.00 USD
Product Specification
FORMULA:
C
9
H
20
N
2
MW:
156.3
CAS NUMBER:
3312-60-5
PURITY:
≥97% (contains traces of water)
APPEARANCE:
Pale yellow clear liquid. d = 0.920.
SOLUBILITY:
Soluble in water.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
+4°C
Product Description
Competitive inhibitor of spermine and spermidine synthases.
Product Specific Literature References
Putrescine or spermidine binding site of aminopropyltransferases and competitive inhibitors:
A. Shirahata, et al.; Biochem. Pharmacol.
41
, 205 (1991)
Abstract
N-(3-aminopropyl)-cyclohexylamine blocks facilitation by spermidine of N-methyl-DL-aspartate-induced seizure in mice in vivo:
P.J. Chu, et al.; Eur. J. Pharmacol.
256
, 155 (1994)
Abstract
ALX-550-001
Revised 20-Jun-07
Agmatine . sulfate
SYNONYMS
1-Amino-4-guanidinobutane . sulfate
4-(Aminobutyl)guanidine . sulfate
PRODUCT LINE
Neurobiology
PRODUCT CATEGORY
Imidazoline Binding Site Ligands
Ordering Information
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ALX-550-001-M100
100 mg
22.00 USD
ALX-550-001-M500
500 mg
44.00 USD
Product Specification
FORMULA:
C
5
H
14
N
4
. H
2
SO
4
MW:
130.2 . 98.1
CAS NUMBER:
2482-00-0
MERCK INDEX:
14:
188
PURITY:
≥97%
APPEARANCE:
White to off-white powder.
SOLUBILITY:
Soluble in water.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
Product Description
Decarboxylation product of L-arginine. Endogenous clonidine-displacing substance in the brain. Putative endogenous neurotransmitter at imidazoline receptors. Antagonist of NMDA receptor. Endogenous inhibitor of nitric oxide synthase (NOS). Antiproliferative by its suppresive effect on polyamine.
Product Specific Literature References
Agmatine: an endogenous clonidine-displacing substance in the brain:
G. Li, et al.; Science
263
, 966 (1994)
Abstract
Selective inhibition of inducible nitric oxide synthase by agmatine:
M. Auguet, et al.; Jpn. J. Pharmacol.
69
, 285 (1995)
Abstract
Inhibition of mammalian nitric oxide synthases by agmatine, an endogenous polyamine formed by decarboxylation of arginine:
E. Galea, et al.; Biochem. J.
316
, 247 (1996)
Abstract
;
Full Text
An emerging role for agmatine:
J. Satriano, et al.; Kidney Int.
56
, 1252 (1999), (Review)
Abstract
Is agmatine a novel neurotransmitter in brain?
:
D.J. Reis & S. Regunathan; Trends Pharmacol. Sci.
21
, 187 (2000)
Abstract
Agmatine suppresses nitric oxide production in microglia:
K. Abe, et al.; Brain Res.
872
, 141 (2000)
Abstract
Agmatine enhances the NADPH oxidase activity of neuronal NO synthase and leads to oxidative inactivation of the enzyme:
D.R. Demady, et al.; Mol. Pharmacol.
59
, 24 (2001)
Abstract
;
Full Text
Regulation of inducible nitric oxide synthase and agmatine synthesis in macrophages and astrocytes:
S. Regunathan & J.E. Piletz; Ann. N. Y. Acad. Sci.
1009
, 20 (2003)
Abstract
Agmatine: at the crossroads of the arginine pathways:
J. Satriano; Ann. N. Y. Acad. Sci.
1009
, 34 (2003), (Review)
Abstract
Agmatine signaling: odds and threads:
R. Berkels, et al.; Cardiovasc. Drug Rev.
22
, 7 (2004), (Review)
Abstract
Further Categories Containing This Product:
NOS Inhibitors (NOS Induction & Enzyme Activity)
•
NMDA Receptors/Related Products
ALX-550-003
Revised 13-Oct-05
Spermine . tetrahydrochloride
SYNONYMS
N,N'-
bis
[3-Aminopropyl]-1,4-butanediamine . 4HCl
PRODUCT LINE
Neurobiology
PRODUCT CATEGORY
NMDA Receptors/Related Products
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ALX-550-003-G001
1 g
40.00 USD
ALX-550-003-G005
5 g
160.00 USD
Product Specification
FORMULA:
C
10
H
26
N
4
. 4HCl
MW:
202.4 . 145.8
CAS NUMBER:
306-67-2
MERCK INDEX:
14:
8743
PURITY:
≥98%
APPEARANCE:
White to off-white powder.
SOLUBILITY:
Soluble in water.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
HANDLING:
Strong odor, keep tightly sealed. Keep under inert gas.
HAZARD:
IRRITANT.
Product Specific Literature References
Interactions of polyamines with neuronal ion channels:
R.H. Scott, et al.; TINS
16
, 153 (1993), (Review)
Abstract
Further Categories Containing This Product:
Nitric Oxide Pathway Other Products
ALX-550-004
Revised 04-Mar-05
Spermidine . trihydrochloride
SYNONYMS
N-[3-Aminopropyl]-1,4-butanediamine . 3HCl
PRODUCT LINE
Neurobiology
PRODUCT CATEGORY
NMDA Receptors/Related Products
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ALX-550-004-G001
1 g
38.00 USD
ALX-550-004-G005
5 g
90.00 USD
Product Specification
FORMULA:
C
7
H
19
N
3
. 3HCl
MW:
145.2 . 109.4
CAS NUMBER:
334-50-9
MERCK INDEX:
14:
8742
PURITY:
≥98%
APPEARANCE:
White crystalline solid.
SOLUBILITY:
Soluble in water.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
HANDLING:
Keep under inert gas. Strong odor, keep tightly sealed.
Product Description
Spermidine is a precursor of spermine. It binds to the polyamine modulatory site of the NMDA receptor and has shown to potentiate NMDA-induced currents in a concentration-dependent manner.
Product Specific Literature References
Interactions of polyamines with neuronal ion channels:
R.H. Scott, et al.; TINS
16
, 153 (1993), (Review)
Abstract
Further Categories Containing This Product:
Nitric Oxide Pathway Other Products
ALX-550-013
Revised 07-May-03
1-Aminocyclobutane-cis-1,3-dicarboxylic acid
SYNONYMS
cis
-ACBD
cis
-2,4-Methanoglutamic acid
PRODUCT LINE
Neurobiology
PRODUCT CATEGORY
NMDA Receptors/Related Products
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ALX-550-013-M005
5 mg
65.00 USD
Product Specification
FORMULA:
C
6
H
9
NO
4
MW:
