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G-Protein Coupled Receptor Signalling
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ALX-301-004 Revised 09-Dec-04
Lyso-PAF (C18)
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SYNONYMS 1-O-Octadecyl-sn-glycero-3-phosphocholine
PRODUCT LINE Inflammation
PRODUCT CATEGORY Platelet Activating Factors [PAF] & Receptors / Related Products
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-301-004-M001   1 mg 15.00 USD Add To Cart
ALX-301-004-M005   5 mg 45.00 USD Add To Cart
ALX-301-004-M025   25 mg 135.00 USD Add To Cart
Product Specification
FORMULA: C26H56NO6P
MW: 509.7
CAS NUMBER: 74430-89-0
SOURCE/HOST: Sythetic.
PURITY: ≥98%
SOLUBILITY: Soluble in chloroform, methanol or 100% ethanol. Soluble in water after sonification for 1 minute at 40°C.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
HANDLING: Slightly hygroscopic.

Further Categories Containing This Product:
Phospholipids / Related Products
 
 
ALX-350-241 Revised 07-Dec-07
Manumycin A
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PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Antibiotics - Other Signal Transduction Pathway Modulators
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Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-350-241-M001   1 mg 58.00 USD Add To Cart
ALX-350-241-M005   5 mg 170.00 USD Add To Cart
ALX-350-241-M010   10 mg 260.00 USD Add To Cart
Product Specification
FORMULA: C31H38N2O7
MW: 550.7
CAS NUMBER: 52665-74-4
SOURCE/HOST: Isolated from Streptomyces parvulus.
PURITY: ≥96% (HPLC)
APPEARANCE: Yellow to brown powder.
SOLUBILITY: Soluble in methanol or DMSO; insoluble in water.
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: -20°C
HANDLING: Protect from light.
IDENTITY: Determined by 1H-NMR.

Product Description
Potent, selective and competitive inhibitor of Ras farnesyltransferase. Does not affect geranylgeranyltransferase. Inhibition is competitive with respect to farnesyl pyrophosphate and non-competitive with respect to Ras. Inhibits neutral sphingomyelinase.
Product Specific Literature References
Inhibitors of Ras farnesyltransferases: F. Tamanoi; TIBS 18, 349 (1993), (Review) Abstract
Farnesyltransferase inhibitors: Ras research yields a potential cancer therapeutic: J.B. Gibbs, et al.; Cell 77, 175 (1994) Abstract
Manumycin inhibits ras signal transduction pathway and induces apoptosis in COLO320-DM human colon tumour cells: A. Di Paolo, et al.; Br. J. Cancer 82, 905 (2000) Abstract
Manumycin A and its analogues are irreversible inhibitors of neutral sphingomyelinase: C. Arenz, et al.; ChemBioChem 2, 141 (2001) Abstract
Enhancement of manumycin A-induced apoptosis by methoxyamine in myeloid leukemia cells: M. She, et al.; Leukemia 19, 595 (2005) Abstract
Binding of manumycin A inhibits IkappaB kinase beta activity: M. Bernier, et al.; J. Biol. Chem. 281, 2551 (2006) Abstract
Further Categories Containing This Product:
Ceramides / Cerebrosides / Sphingolipids / Related Products • Farnesylation / Isoprenylation Reagents • Antibiotics - Apoptosis Inducers & Inhibitors
 
 
ALX-550-118 Revised 28-Jan-05
MAP4
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SYNONYMS (S)-2-Amino-2-methyl-4-phosphonobutanoic acid
α-Methyl-AP4
PRODUCT LINE Neurobiology
PRODUCT CATEGORY Glutamate Receptors (Metabotropic) / Related Products
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ALX-550-118-M005   5 mg 75.00 USD Add To Cart
Product Specification
FORMULA: C5H12NO5P
MW: 197.1
CAS NUMBER: 157381-42-5
PURITY: ≥96%
APPEARANCE: White powder.
SOLUBILITY: Soluble in dilute aqueous base.
SHIPPING: AMBIENT
LONG TERM STORAGE: +4°C

Product Description
Selective agonist for group III mGluRs.
Product Specific Literature References
Actions of two new antagonists showing selectivity for different sub-types of metabotropic glutamate receptor in the neonatal rat spinal cord: D.E. Jane, et al.; Br. J. Pharmacol. 112, 809 (1994) Abstract
Phenylglycine derivatives as antagonists of metabotropic glutamate receptors: J. Watkins and G. Collingridge; TIPS 15, 333 (1994), (Review) Abstract
Antagonism of the synaptic depressant actions of L-AP4 in the lateral perforant path by MAP4: T.J. Bushell, et al.; Neuropharmacology 34, 239 (1995) Abstract
Pharmacological characterization of MCCG and MAP4 at the mGluR1b, mGluR2 and mGluR4a human metabotropic glutamate receptor subtypes: T. Knöpfel, et al.; Neuropharmacology 34, 1099 (1995) Abstract
Distinct presynaptic metabotropic receptors for L-AP4 and CCG1 on GABAergic terminals: pharmacological evidence using novel alpha-methyl derivative mGluR antagonists, MAP4 and MCCG, in the rat thalamu: T.E. Salt & S.A. Eaton; Neuroscience 65, 5 (1995) Abstract
Coupling of metabotropic glutamate receptors 2 and 4 to G alpha 15, G alpha 16, and chimeric G alpha q/i proteins: characterization of new antagonists: J. Gomeza, et al.; Mol. Pharmacol. 50, 923 (1996) Abstract
Agonists of cyclic AMP-coupled metabotropic glutamate receptors in adult rat cortical slices: M.C. Kemp, et al.; Eur. J. Pharmacol. 309, 79 (1996) Abstract
Structure-activity relationships of new agonists and antagonists of different metabotropic glutamate receptor subtypes: N. Sekiyama, et al.; Br. J. Pharmacol. 117, 1493 (1996) Abstract
Neuroprotective effects of group III mGluR in traumatic neuronal injury: A.I. Faden, et al.; J. Neurotrauma 14, 885 (1997) Abstract
 
 
ALX-162-001 Revised 09-Oct-08
Mastoparan
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PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Neurotoxins
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ALX-162-001-M001   1 mg 50.00 USD Add To Cart
ALX-162-001-M005   5 mg 200.00 USD Add To Cart
Product Specification
SEQUENCE: H-Ile-Asn-Leu-Lys-Ala-Leu-Ala-Ala-Leu-Ala-Lys-Lys-Ile-Leu-NH2
FORMULA: C70H131N19O15
MW: 1478.9
CAS NUMBER: 72093-21-1
SOURCE/HOST: Synthetic. Originally isolated from wasp venom.
PURITY: ≥98%
APPEARANCE: Lyophilized.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
Product Description

Mast cell degranulating peptide. Stimulates glycogenolysis. Stimulates phospholipase D2 (PLD2) activity. Alters G-proteins in brain membranes.
Product Specific Literature References
A new mast cell degranulating peptide "mastoparan" in the venom of Vespula lewisii: Y. Hirai, et al.; Chem. Pharm. Bull. 27, 1942 (1979) Abstract
Mastoparan, a peptide toxin from wasp venom, mimics receptors by activating GTP-binding regulatory proteins (G proteins): T. Higashijima, et al.; J. Biol. Chem. 263, 6491 (1988) Abstract; Full Text
Mastoparan, a peptide toxin from wasp venom, stimulates glycogenolysis mediated by an increase of the cytosolic free Ca2+ concentration but not by an increase of cAMP in rat hepatocytes: M. Tohkin, et al.; FEBS Lett. 260, 179 (1990) Abstract
Interaction of wasp venom mastoparan with biomembranes: T. Katsu, et al.; Biochim. Biophys. Acta 1027, 185 (1990) Abstract
Effects of the wasp venom peptide, mastoparan, on GTP hydrolysis in rat brain membranes: Y. Odagaki, et al.; Br. J. Pharmacol. 121, 1406 (1997) Abstract
Mastoparan selectively activates phospholipase D2 in cell membranes: A. Chahdi, et al.; J. Biol. Chem. 278, 12039 (2003) Abstract
Mastoparan, a G protein agonist peptide, differentially modulates TLR4- and TLR2-mediated signaling in human endothelial cells and murine macrophages: A. Lentschat, et al.; J. Immunol. 174, 4252 (2005) Abstract
Biological applications of the receptor mimetic peptide mastoparan: S. Jones & J. Howl; Curr. Protein Pept. Sci. 7, 501 (2006), Review Abstract
Further Categories Containing This Product:
G-proteins & GTPases Other Products • Peptides
 
 
ALX-550-075 Revised 10-Feb-05
(S)-MCPG
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SYNONYMS (S)-α-Methyl-4-carboxyphenylglycine
PRODUCT LINE Neurobiology
PRODUCT CATEGORY Glutamate Receptors (Metabotropic) / Related Products
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ALX-550-075-M005   5 mg 80.00 USD Add To Cart
ALX-550-075-M025   25 mg 320.00 USD Add To Cart
Product Specification
FORMULA: C10H11NO4
MW: 209.2
CAS NUMBER: 150145-89-4
PURITY: ≥97%
APPEARANCE: White solid.
SOLUBILITY: Soluble in dilute aqueous base.
SHIPPING: AMBIENT
LONG TERM STORAGE: +20°C
HANDLING: Protect from light.

Product Description
Active isomer of (RS)-MCPG (Prod. No. ALX-550-054). Non selective group I/group II mGluR antagonist.
Product Specific Literature References
Stereospecific antagonism by (+)-alpha-methyl-4-carboxyphenylglycine (MCPG) of (1S,3R)-ACPD-induced effects in neonatal rat motoneurones and rat thalamic neurones: D.E. Jane, et al.; Neuropharmacology 32, 725 (1993) Abstract
Antagonism of presynaptically mediated depressant responses and cyclic AMP-coupled metabotropic glutamate receptors: M. Kemp, et al.; Eur. J. Pharmacol. 266, 187 (1994) Abstract
Phenylglycine derivatives as antagonists of metabotropic glutamate receptors: J. Watkins & G. Collingridge; TIPS 15, 333 (1994), (Review) Abstract
Pharmacological analysis of 4-carboxyphenylglycine derivatives: comparison of effects on mGluR1 alpha and mGluR5a subtypes: A.E. Kingston, et al.; Neuropharmacology 34, 887 (1995) Abstract
Agonists and antagonists for metabotropic glutamate receptors: P.L. Ornstein, et al.; Curr. Pharm. Design 1, 355 (1995), (Review)
Effects of the metabotropic glutamate receptor antagonist MCPG on spatial and context-specific learning: F. Bordi, et al.; Neuropharmacology 35, 1557 (1996) Abstract
Stereoselective Synthesis of (S)-(+)-alpha-M4CPG, a Selective Antagonist of Metabotropic Glutamate Receptors: M. Dawei & T. Hongqi; Tetrahydron Assym. 7, 1567 (1996)
Structure-activity relationships of new agonists and antagonists of different metabotropic glutamate receptor subtypes: N. Sekiyama, et al.; Br. J. Pharmacol. 117, 1493 (1996) Abstract
(R,S)-alpha-methyl-4-carboxyphenylglycine (MCPG) fails to block long-term potentiation under urethane anaesthesia in vivo: S.J. Martin & R.G. Morris; Neuropharmacology 36, 1339 (1997) Abstract
Absolute configuration of (+)-alpha-methyl-4-carboxyphenylglycine (MCPG), a metabotropic glutamate receptor antagonist: C. Wilson, et al.; Acta. Crystallogr. C 53 ( Pt 7), 909 (1997) Abstract
Inhibition of group I metabotropic glutamate receptors blocks spatial learning in rats: D. Balschun & W. Wetzel; Neurosci. Lett. 249, 41 (1998) Abstract
(+)-MCPG blocks induction of LTP in CA1 of rat hippocampus via agonist action at an mGluR group II receptor: N.A. Breakwell, et al.; J. Neurophysiol. 79, 1270 (1998) Abstract
The metabotropic glutamate receptor antagonist (RS)-MCPG produces hyperlocomotion in amphetamine pre-exposed rats: J.H. Kim & P. Vezina; Neuropharmacology 37, 189 (1998) Abstract
Pharmacological agents acting at subtypes of metabotropic glutamate receptors: D.D. Schoepp, et al.; Neuropharmacology 38, 1431 (1999), (Review) Abstract
 
 
ALX-550-054 Revised 28-Jan-05
(RS)-MCPG
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SYNONYMS (RS)-α-Methyl-4-carboxyphenylglycine
PRODUCT LINE Neurobiology
PRODUCT CATEGORY Glutamate Receptors (Metabotropic) / Related Products
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ALX-550-054-M005   5 mg 80.00 USD Add To Cart
Product Specification
FORMULA: C10H11NO4
MW: 209.2
CAS NUMBER: 146669-29-6
PURITY: ≥97%
APPEARANCE: White solid.
SOLUBILITY: Soluble in dilute aqueous base. Insoluble in water, ethanol, DMSO.
SHIPPING: AMBIENT
LONG TERM STORAGE: +20°C
HANDLING: Protect from light.

Product Specific Literature References
Induction of LTP in the hippocampus needs synaptic activation of glutamate metabotropic receptors: Z.I. Bashir, et al.; Nature 363, 347 (1993) Abstract
Competitive antagonism at metabotropic glutamate receptors by (S)-4-carboxyphenylglycine and (RS)-alpha-methyl-4-carboxyphenylglycine: S.A. Eaton, et al.; Eur. J. Pharmacol. 244, 195 (1993) Abstract
Phenylglycine derivatives as antagonists of metabotropic glutamate receptors: J. Watkins & G. Collingridge; TIPS 15, 333 (1994), (Review) Abstract
Long-lasting enhancement of NMDA receptor-mediated synaptic transmission by metabotropic glutamate receptor activation: J.J. O'Connor, et al.; Nature 367, 557 (1994) Abstract
Molecular, functional, and pharmacological characterization of the metabotropic glutamate receptor type 5 splice variants: comparison with mGluR1: C. Joly, et al.; J. Neurosci. 15, 3970 (1995) Abstract
Agonists and antagonists for metabotropic glutamate receptors: P.L. Ornstein, et al.; Curr. Pharm. Design 1, 355 (1995), (Review)
(R,S)-alpha-methyl-4-carboxyphenylglycine (MCPG) fails to block long-term potentiation under urethane anaesthesia in vivo: S.J. Martin & R.G. Morris; Neuropharmacology 36, 1339 (1997) Abstract
Absolute configuration of (+)-alpha-methyl-4-carboxyphenylglycine (MCPG), a metabotropic glutamate receptor antagonist: C. Wilson, et al.; Acta. Crystallogr. C 53 ( Pt 7), 909 (1997) Abstract
The metabotropic glutamate receptor antagonist (RS)-MCPG produces hyperlocomotion in amphetamine pre-exposed rats: J.H. Kim & P. Vezina; Neuropharmacology 37, 189 (1998) Abstract
Inhibition of group I metabotropic glutamate receptors blocks spatial learning in rats: D. Balschun & W. Wetzel; Neurosci. Lett. 249, 41 (1998) Abstract
(+)-MCPG blocks induction of LTP in CA1 of rat hippocampus via agonist action at an mGluR group II receptor: N.A. Breakwell, et al.; J. Neurophysiol. 79, 1270 (1998) Abstract
Pharmacological agents acting at subtypes of metabotropic glutamate receptors: D.D. Schoepp, et al.; Neuropharmacology 38, 1431 (1999), (Review) Abstract
 
 
ALX-300-151 Revised 08-Jul-08
Mead acid ethanolamide
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SYNONYMS (Z,Z,Z)-5,8,11-Eicosatrienoic acid, N-(2-hydroxyethyl)-
PRODUCT LINE Neurobiology
PRODUCT CATEGORY Cannabinoid Receptor Agonists & Antagonists / Related Products
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ALX-300-151-M001   1 mg 108.00 USD Add To Cart
Product Specification
FORMULA: C22H39NO2
MW: 349.6
CAS NUMBER: 169232-04-6
PURITY: ≥98%
FORMULATION: Liquid. Solution in ethanol.
SOLUBILITY: Soluble in DMSO (10mg/ml) or dimethyl formamide (30mg/ml).
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: -20°C
USE/STABILITY: Stable for at least 1 year after receipt when stored at -20°C.
HANDLING: Protect from light and oxygen.

Product Description
CB1 (Ki=0.75µM) and CB2 (Ki=1.8µM) receptor agonist. Equipotent with anandamide.
Product Specific Literature References
Mead ethanolamide, a novel eicosanoid, is an agonist for the central (CB1) and peripheral (CB2) cannabinoid receptors: J. Priller, et al.; Mol. Pharmacol. 48, 288 (1995) Abstract
Comparison of the pharmacology and signal transduction of the human cannabinoid CB1 and CB2 receptors: C.C. Felder, et al.; Mol. Pharmacol. 48, 443 (1995) Abstract
General Information
BACKGROUND/TECHNICAL INFORMATION To change the solvent, evaporate the ethanol under a gentle stream of nitrogen and immediately add the solvent of choice.
 
 
ALX-550-071 Revised 07-Mar-08
Melatonin
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SYNONYMS N-Acetyl-5-methoxytryptamine
PRODUCT LINE Neurobiology
PRODUCT CATEGORY Melatonin Receptors / Related Products
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-550-071-G001   1 g 35.00 USD Add To Cart
ALX-550-071-G005   5 g 105.00 USD Add To Cart
Product Specification
FORMULA: C13H16N2O2
MW: 232.3
CAS NUMBER: 73-31-4
MERCK INDEX: 14: 5816
RTECS: AC5955000
PURITY: ≥99%
APPEARANCE: White to off-white powder.
SOLUBILITY: Soluble in dilute aqueous acid or 100% ethanol.
SHIPPING: AMBIENT
LONG TERM STORAGE: +4°C
HANDLING: Protect from light.

Product Specific Literature References
Physiological concentrations of melatonin inhibit nitric oxide synthase in rat cerebellum: D. Pozo, et al.; Life Sci. 55, PL455 (1994) Abstract
Melatonin receptors: are there multiple subtypes?: M.L. Dubocovich; TIPS 16, 50 (1995), (Review) Abstract
Melatonin comes of age?: R.M. Hagan & N.R. Oakley; TIPS 16, 81 (1995), (Review) Abstract
Melatonin receptors step into the light: cloning and classification of subtypes: S.M. Reppert, et al.; TIPS 17, 100 (1996), (Review) Abstract
Melatonin madness: S.M. Reppert & D.R. Weaver; Cell 83, 1059 (1995), (Minireview) Abstract
Melatonin is a scavenger of peroxynitrite: E. Gilad, et al.; Life Sci. 60, PL169 (1997) Abstract
Inhibition of cerebellar nitric oxide synthase and cyclic GMP production by melatonin via complex formation with calmodulin: D. Pozo, et al.; J. Cell Biochem. 65, 430 (1997) Abstract
Melatonin inhibits expression of the inducible isoform of nitric oxide synthase in murine macrophages: role of inhibition of NFkappaB activation: E. Gilad, et al.; FASEB J. 12, 685 (1998) Abstract; Full Text
Oxidative damage in the central nervous system: protection by melatonin: R.J. Reiter; Prog. Neurobiol. 56, 359 (1998) Abstract
The oxidant/antioxidant network: role of melatonin: R.J. Reiter, et al.; Biol. Signals Recept. 8, 56 (1999), (Review) Abstract
Interactions between melatonin, reactive oxygen species, and nitric oxide: D.K. Lahiri & C. Ghosh; Ann. N. Y. Acad. Sci. 893, 325 (1999) Abstract
Nitrosation of melatonin by nitric oxide and peroxynitrite: B. Blanchard, et al.; J. Pineal. Res. 29, 184 (2000) Abstract
Melatonin suppresses NO-induced apoptosis via induction of Bcl-2 expression in PGT-beta immortalized pineal cells: Y.M. Yoo, et al.; J. Pineal. Res. 33, 146 (2002) Abstract
Mitochondrial regulation by melatonin and its metabolites: D. Acuna-Castroviejo, et al.; Adv. Exp. Med. Biol. 527, 549 (2003), (Review) Abstract
Melatonin suppresses macrophage cyclooxygenase-2 and inducible nitric oxide synthase expression by inhibiting p52 acetylation and binding: W.G. Deng, et al.; Blood 108, 518 (2006) Abstract
Melatonin and nitric oxide: S. Aydogan, et al.; J. Endocrinol. Invest. 29, 281 (2006), (Review) Abstract
Melatonin inhibits endothelial nitric oxide production in vitro: E.K. Tamura, et al.; J. Pineal. Res. 41, 267 (2006) Abstract
Further Categories Containing This Product:
Chemopreventive Agents Other Products • Apoptosis Inducers & Inhibitors Other Products • Nitric Oxide Pathway Other Products
 
 
ALX-550-363 Revised 28-Jan-05
Memantine . hydrochloride
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SYNONYMS 1-Amino-3,5-dimethyladamantane . HCl
3,5-Dimethyl-1-aminoadamantane . HCl
PRODUCT LINE Neurobiology
PRODUCT CATEGORY NMDA Receptors / Related Products
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Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-550-363-M010   10 mg 20.00 USD Add To Cart
ALX-550-363-M050   50 mg 60.00 USD Add To Cart
Product Specification
FORMULA: C12H21N . HCl
MW: 179.3 . 36.5
CAS NUMBER: 41100-52-1
MERCK INDEX: 14: 5829
PURITY: ≥99%
APPEARANCE: White powder.
SHIPPING: AMBIENT
LONG TERM STORAGE: +4°C
HANDLING: Protect from light.

Product Description
Low-affinity NMDA receptor antagonist. Stimulates dopamine release.
Product Specific Literature References
Open-channel block of N-methyl-D-aspartate (NMDA) responses by memantine: therapeutic advantage against NMDA receptor-mediated neurotoxicity: H.S. Chen, et al.; J. Neurosci. 12, 4427 (1992) Abstract
Memantine stimulates inositol phosphates production in neurones and nullifies N-methyl-D-aspartate-induced destruction of retinal neurones: N.N. Osborne & G. Quack; Neurochem. Int. 21, 329 (1992) Abstract
Effects of memantine and MK-801 on NMDA-induced currents in cultured neurones and on synaptic transmission and LTP in area CA1 of rat hippocampal slices: T. Frankiewicz, et al.; Br. J. Pharmacol. 117, 689 (1996) Abstract
Trapping channel block of NMDA-activated responses by amantadine and memantine: T.A. Blanpied, et al.; J. Neurophysiol. 77, 309 (1997)