ALEXIS Biochemicals: Caffeic acid ethyl ester

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ALX-350-298

Revised 03-Apr-08

Betulinic acid (~95%)
SYNONYMS	3β-Hydroxy-20(29)-lupaene-28-oic acid
PRODUCT LINE	Natural Products / Antibiotics
PRODUCT CATEGORY	Natural Products - Antitumor Reagents

Ordering Information

Product Numbers:	Format:	Size:	Unit Price:	Quantity:	Add To Cart
ALX-350-298-M100		100 mg	55.00 USD
ALX-350-298-M500		500 mg	180.00 USD
ALX-350-298-G001		1 g	290.00 USD

Product Specification

FORMULA:	C₃₀H₄₈O₃
MW:	456.7
CAS NUMBER:	472-15-1
SOURCE/HOST:	Isolated from Platanus acerifolia (plane tree) bark.
PURITY:	≥95% (HPLC)
APPEARANCE:	White to off-white powder.
SOLUBILITY:	Soluble in DMSO.
SHIPPING:	AMBIENT
LONG TERM STORAGE:	+4°C

Product Description

Antitumor and anti-HIV agent. Induces apoptosis by activating mitochondrial permeability transition (MPT). Inhibits NF-κB activation and NF-κB-regulated gene expression induced by carcinogens and inflammatory stimuli. Decreases expression of Bcl-2 and cyclin D1. Potent proteasome activator.

Product Specific Literature References

Anti-AIDS agents, 11. Betulinic acid and platanic acid as anti-HIV principles from Syzigium claviflorum, and the anti-HIV activity of structurally related triterpenoids: T. Fujioka, et al.; J. Nat. Prod. 57, 243 (1994) Abstract
Discovery of betulinic acid as a selective inhibitor of human melanoma that functions by induction of apoptosis: E. Pisha, et al.; Nat. Med. 1, 1046 (1995) Abstract
Betulinic acid and dihydrobetulinic acid derivatives as potent anti-HIV agents: Y. Kashiwada, et al.; J. Med. Chem. 39, 1016 (1996) Abstract
Betulinic acid triggers CD95 (APO-1/Fas)- and p53-independent apoptosis via activation of caspases in neuroectodermal tumors: S. Fulda, et al.; Cancer Res. 57, 4956 (1997) Abstract
Anti-AIDS agents--XXVII. Synthesis and anti-HIV activity of betulinic acid and dihydrobetulinic acid derivatives: F. Hashimoto, et al.; Bioorg. Med. Chem. 5, 2133 (1997) Abstract
Betulinic acid induces apoptosis in human neuroblastoma cell lines: M.L. Schmidt, et al.; Eur. J. Cancer 33, 2007 (1997) Abstract
Induction of p53 without increase in p21WAF1 in betulinic acid-mediated cell death is preferential for human metastatic melanoma: M. Rieber & M. Strasberg Rieber; DNA Cell Biol. 17, 399 (1998) Abstract
Activation of mitochondria and release of mitochondrial apoptogenic factors by betulinic acid: S. Fulda, et al.; J. Biol. Chem. 273, 33942 (1998) Abstract; Full Text
Betulinic acid inhibits aminopeptidase N activity: M.F. Melzig & H. Bormann; Planta Med. 64, 655 (1998) Abstract
Correspondence re: S. Fulda et al., Betulinic acid triggers CD95 (Apo1/Fas)- and p53-independent apoptosis via activation of caspases in neuroectodermal tumors. Cancer Res., 57: 4956, 1997: M. Rieber & M. Strasberg Rieber; Cancer. Res. 58, 5876 (1998) Abstract
Betulinic acid: a new cytotoxic agent against malignant brain-tumor cells: S. Fulda, et al.; Int. J. Cancer 82, 435 (1999) Abstract
Betulinic acid-induced apoptosis in glioma cells: A sequential requirement for new protein synthesis, formation of reactive oxygen species, and caspase processing: W. Wick, et al.; J Pharmacol. Exp. Ther. 289, 1306 (1999) Abstract; Full Text
Effects of betulinic acid alone and in combination with irradiation in human melanoma cells: E. Selzer, et al.; J. Invest. Dermatol. 114, 935 (2000) Abstract
Betulinic acid suppresses carcinogen-induced NF-kappa B activation through inhibition of I kappa B alpha kinase and p65 phosphorylation: abrogation of cyclooxygenase-2 and matrix metalloprotease-9: Y. Takada & B.B. Aggarwal; J. Immunol. 171, 3278 (2003) Abstract
Chemistry, biological activity, and chemotherapeutic potential of betulinic acid for the prevention and treatment of cancer and HIV infection: R.H. Cichewicz & S.A. Kouzi; Med. Res. Rev. 24, 90 (2004), Review Abstract
Betulinic acid-induced apoptosis in leukemia cells: H. Ehrhardt, et al.; Leukemia 18, 1406 (2004) Abstract
Betulinic acid and its derivatives: a review on their biological properties: P. Yogeeswari & D. Sriram; Curr. Med. Chem. 12, 657 (2005), Review Abstract
Betulinic acid decreases expression of bcl-2 and cyclin D1, inhibits proliferation, migration and induces apoptosis in cancer cells: W. Rzeski, et al.; Naunyn Schmiedebergs Arch. Pharmacol. 374, 11 (2006) Abstract
Activation and inhibition of the proteasome by betulinic acid and its derivatives: L. Huang, et al.; FEBS Lett. 581, 4955 (2007) Abstract

Further Categories Containing This Product:

CDK & Cyclin Inhibitors • Other Natural Products - DNA Regulation / Transcription • Natural Products - NF-kB Pathway Inhibitors • MPTP [Mitochondrial Transition Pore] / Related Products • NF-kB Pathway Inhibitors • Natural Products - Anti-inflammatory Agents • Natural Products - Antiviral / anti-HIV Agents • Ubiquitin & Proteasome Other Products • Antitumor Agents (Apoptosis Inducers) • Natural Products - Apoptosis Inducers & Inhibitors • HIV / AIDS / Related Products

ALX-350-313

Revised 11-Dec-07

3-O-Acetyl-betulinic acid
PRODUCT LINE	Natural Products / Antibiotics
PRODUCT CATEGORY	Natural Products - Antitumor Reagents

Ordering Information

Product Numbers:	Format:	Size:	Unit Price:	Quantity:	Add To Cart
ALX-350-313-M005		5 mg	35.00 USD
ALX-350-313-M025		25 mg	95.00 USD

Product Specification

FORMULA:	C₃₂H₅₀O₄
MW:	498.8
CAS NUMBER:	10376-50-8
PURITY:	≥97% (HPLC)
APPEARANCE:	White to off-white solid.
SOLUBILITY:	Soluble in DMSO; sparingly soluble in water.
SHIPPING:	AMBIENT
LONG TERM STORAGE:	-20°C

Product Description

Shows cytotoxic activity on human cancer cell lines.

Product Specific Literature References

Synthesis and cytotoxic activity of 3-O-acyl/3-hydrazine /2-bromo/20,29-dibromo betulinic acid derivatives: R. Mukherjee, et al.; Bioorg. Med. Chem. Lett. 14, 4087 (2004) Abstract
Synthesis of A-seco derivatives of betulinic acid with cytotoxic activity: M. Urban, et al.; J. Nat. Prod. 67, 1100 (2004) Abstract

ALX-460-002

Revised 13-Mar-06

D-(+)-Biotin
SYNONYMS	Vitamin H
PRODUCT LINE	Natural Products / Antibiotics
PRODUCT CATEGORY	Vitamins

Ordering Information

Product Numbers:	Format:	Size:	Unit Price:	Quantity:	Add To Cart
ALX-460-002-G001		1 g	30.00 USD
ALX-460-002-G005		5 g	140.00 USD

Product Specification

FORMULA:	C₁₀H₁₆N₂O₃S
MW:	244.3
CAS NUMBER:	58-85-5
MERCK INDEX:	14: 1231
PURITY:	≥98%
SOLUBILITY:	Soluble in hot water, diluted acids and alkaline solutions; hardly soluble in cold water.
SHIPPING:	AMBIENT
LONG TERM STORAGE:	+20°C
HAZARD:	MAY BE CARCINOGENIC.

ALX-350-287

Revised 14-May-07

Bistheonellide A
SYNONYMS	Misakinolide A
PRODUCT LINE	Natural Products / Antibiotics
PRODUCT CATEGORY	Natural Products for Cytoskeletal Research

Ordering Information

Product Numbers:	Format:	Size:	Unit Price:	Quantity:	Add To Cart
ALX-350-287-C100		100 µg	470.00 USD

Product Specification

FORMULA:	C₇₄H₁₂₈O₂₀
MW:	1337.8
CAS NUMBER:	105304-96-9
SOURCE/HOST:	Isolated from the marine sponge Theonella sp.
PURITY:	≥95%
SHIPPING:	SHIPPED ON BLUE ICE
LONG TERM STORAGE:	-20°C
HAZARD:	TOXIC.

Product Description

Inhibits actin polymerization by forming a 1:2 complex with G-actin.

Product Specific Literature References

Cellular changes of rat embryonic fibroblasts by an actin-polymerization inhibitor, bistheonellide A, from a marine sponge: S. Watabe, et al.; Cell. Struct. Func. 21, 199 (1996) Abstract
Misakinolide A is a marine macrolide that caps but does not sever filamentous actin: D.R. Terry, et al.; J. Biol. Chem. 272, 7841 (1997) Abstract
Actin-depolymerizing effect of dimeric macrolides, bistheonellide A and swinholide A: S.Y. Saito, et al.; J. Biochem. (Tokyo) 123, 571 (1998) Abstract
Use of the F-actin-binding drugs, misakinolide A and swinholide A: M.R. Bubb & I. Spector; Meth. Enzymol. 298, 26 (1998) Abstract
A novel structure involved in the formation of liver endothelial cell fenestrae revealed by using the actin inhibitor misakinolide: F. Braet, et al.; PNAS 95, 13635 (1998) Abstract
Effects of Bistheonellide A, an Actin-polymerization Inhibitor, on Chinese Hamster V79 Cells and on IL-8 Production in PMA-stimulated HL-60 Cells: T. Oda, et al.; Mar. Drugs 4, 22 (2006)

Further Categories Containing This Product:

Actin / Related Products

ALX-380-241

Revised 21-May-08

Blasticidin A
PRODUCT LINE	Natural Products / Antibiotics
PRODUCT CATEGORY	Antibiotics - Antifungal

Ordering Information

Product Numbers:	Format:	Size:	Unit Price:	Quantity:	Add To Cart
ALX-380-241-M001		1 mg	370.00 USD

Product Specification

FORMULA:	C₅₈H₁₀₇NO₂₃
MW:	1186.5 (free acid)
CAS NUMBER:	100513-53-9
RTECS:	EC4897000
SOURCE/HOST:	Isolated from Streptomyces sp. MST-AS4079.
PURITY:	≥98% (HPLC)
APPEARANCE:	Yellow tan solid.
SOLUBILITY:	Soluble in DMSO, dimethyl formamide or methanol; fairly soluble in water or 100% ethanol.
SHIPPING:	AMBIENT
LONG TERM STORAGE:	-20°C
HAZARD:	HARMFUL.

Product Description

Antibiotic. Shows broad spectrum antifungal and antibacterial activity. Specific inhibitor of aflatoxin production by Aspergillus parasiticus.

Product Specific Literature References

Blasticidin, a new anti-phytopathogenic fungal substance: K. Fukunaga, et al.; Bull. Agr. Chem. Soc. Jpn. 19, 181 (1955)
Blasticidin A as an inhibitor of aflatoxin production by Aspergillus parasiticus: S. Sakuda, et al.; J. Antibiot. 53, 1265 (2000) Abstract

Further Categories Containing This Product:

Natural Products with Antibiotic Activity • Natural Products - Antifungal Agents

ALX-380-089

Revised 29-Jul-08

Blasticidin S . hydrochloride
PRODUCT LINE	Natural Products / Antibiotics
PRODUCT CATEGORY	Antibiotics - DNA Replication Inhibitors

Ordering Information

Product Numbers:	Format:	Size:	Unit Price:	Quantity:	Add To Cart
ALX-380-089-M100		100 mg	280.00 USD

Product Specification

FORMULA:	C₁₇H₂₆N₈O₅. HCl
MW:	422.4 . 36.5
CAS NUMBER:	3513-03-9
MERCK INDEX:	14: 1316
SOURCE/HOST:	Isolated from Streptomyces griseochromogenes.
PURITY:	≥98% (HPLC)
APPEARANCE:	White to off-white powder.
SOLUBILITY:	Soluble in water; insoluble in organic solvents.
SHIPPING:	AMBIENT
LONG TERM STORAGE:	+4°C
HANDLING:	Protect from moisture.
HAZARD:	VERY TOXIC.

Product Description

Antibiotic. Inhibitor of DNA and protein synthesis.

Product Specific Literature References

Blasticidin S, a new antibiotic: S. Takeuchi, et al.; J. Antibiot. (Tokyo) 11, 1 (1958) Abstract
The blasticidin S resistance gene (bsr) selectable in a single copy state in the Bacillus subtilis chromosome: M. Itaya, et al.; J. Biochem. 107, 799 (1990) Abstract
Cloning and characterization of the gene encoding a blasticidin S acetyltransferase from Streptoverticillum sp: J.A. Perez-Gonzalez, et al.; Gene 86, 129 (1990) Abstract
Blasticidin S-resistance gene (bsr): a novel selectable marker for mammalian cells: M. Izumi, et al.; Exp. Cell Res. 197, 229 (1991) Abstract
Cloning of the blasticidin S deaminase gene (BSD) from Aspergillus terreus and its use as a selectable marker for Schizosaccharomyces pombe and Pyricularia oryzae: M. Kimura, et al.; Mol. Gen. Genet. 242, 121 (1994) Abstract
Blasticidin S deaminase gene from Aspergillus terreus (BSD): a new drug resistance gene for transfection of mammalian cells: M. Kimura, et al.; Biochim. Biophys. Acta 1219, 653 (1994) Abstract

Further Categories Containing This Product:

Reporter Gene Markers / Related Products • Translation Inhibitors • Antibiotics - Antifungal • DNA Replication Inhibitors

ALX-630-107

Revised 21-Feb-08

Bleomycin . sulfate
SYNONYMS	Blenoxane
PRODUCT LINE	Natural Products / Antibiotics
PRODUCT CATEGORY	Antitumor Antibiotics

Ordering Information

Product Numbers:	Format:	Size:	Unit Price:	Quantity:	Add To Cart
ALX-630-107-M010		10 mg	155.00 USD
ALX-630-107-M050		50 mg	595.00 USD

Product Specification

FORMULA:	C₅₅H₈₂N₁₇O₂₁S₃ . H₂SO₄
MW:	1413.6 . 98.1
CAS NUMBER:	9041-93-4
MERCK INDEX:	14: 1318
RTECS:	EC5991990
SOURCE/HOST:	A group of related glycopeptide antibiotics isolated from Streptomyces verticillus.
APPEARANCE:	White to off-white powder.
SOLUBILITY:	Soluble in water (20mg/ml) or methanol.
ACTIVITY:	1'500-2'000 IU/mg (corresponds to 1.5-2.0 bleomycin units (USP)/mg)
SHIPPING:	AMBIENT
LONG TERM STORAGE:	+4°C
USE/STABILITY:	Solutions in normal saline (~2mg/ml) are stable for 3 months when stored at +4°C in a glass container or stable for 1 month when stored at +4°C in a PVC container. Solutions in water are stable for several days only.
HAZARD:	MAY BE CARCINOGENIC. TOXIC.

Product Description

Radiomimetic DNA-cleaving agent that produces double and single DNA strand breaks through an oxygen-radical-dependent mechanism. Inhibits intracellular DNA replication. DNA alkylating agent. Antineoplastic.

Product Specific Literature References

Bleomycin and other antitumor antibiotics of high molecular weight: H. Umezawa; Antimicrobial Agents Chemother. (Bethesda) 5, 1079 (1965) Abstract
Specificity of deoxyribonucleic acid cleavage by bleomycin, phleomycin, and tallysomycin: J. Kross, et al.; Biochemistry 21, 4310 (1982) Abstract
Chromatin structure during bleomycin-induced DNA damage and repair
: B.P. Cuiffo, et al.; J. Free Radic. Biol. Med. 1, 139 (1985) Abstract
Cleavage of tRNA by Fe(II)-bleomycin: A. Huttenhofer, et al.; J. Biol. Chem. 267, 24471 (1992) Abstract
Antiangiogenic chemotherapeutic agents: characterization in comparison to their tumor growth inhibition in human renal cell carcinoma models: M. Schirner, et al.; Clin. Cancer Res. 4, 1331 (1998) Abstract
Sequence-specific changes in the metal site of ferric bleomycin induced by the binding of DNA: J.W. Sam, et al.; J. Biol. Chem. 273, 16090 (1998) Abstract
Changes in c-Jun but not Bcl-2 family proteins in p53-dependent apoptosis of mouse cerebellar granule neurons induced by DNA damaging agent bleomycin: T. Araki, et al.; Brain Res. 794, 239 (1998) Abstract
Induction of apoptosis by bleomycin in resting and cycling human lymphocytes: P. Vernole, et al.; Mutagenesis 13, 209 (1998) Abstract
Synergistic Effects of Laserthermia and Bleomycin-sulfate on Micronuclei Formation in Cytokinesis-blocked HeLa Cells: A.Sh. Monfared & H. Mozdarani; Irn. J. Med. Sci. 24, 87 (1999)
Bleomycin: new perspectives on the mechanism of action: S.M. Hecht; J. Nat. Prod. 63, 158 (2000), (Review) Abstract
Bleomycin-induced alterations in DNA replication: relationship to DNA damage: J. Dziegielewski, et al.; Biochemistry 40, 704 (2001) Abstract

Further Categories Containing This Product:

Antitumor Agents (DNA Interaction & Gene Regulation) • DNA Fragmentation & Chromatin Condensation

ALX-380-102

Revised 03-Apr-08

Borrelidin
SYNONYMS	2-(7-Cyano-8,16-dihydroxy-9,11,13,15-tetramethyl-18-oxooxacyclooctadeca-4,6-dien-2-yl)cyclopentanecarboxylic acid Treponemycin U 78548 C2989
PRODUCT LINE	Natural Products / Antibiotics
PRODUCT CATEGORY	Antibiotics for Cell Cycle Research

Ordering Information

Product Numbers:	Format:	Size:	Unit Price:	Quantity:	Add To Cart
ALX-380-102-MC05		0.5 mg	160.00 USD
ALX-380-102-M001		1 mg	240.00 USD

Product Specification

FORMULA:	C₂₈H₄₃NO₆
MW:	489.7
CAS NUMBER:	7184-60-3
RTECS:	ED8750000
SOURCE/HOST:	Isolated from Streptomyces sp.
PURITY:	≥98% (HPLC)
APPEARANCE:	White to off-white powder.
SOLUBILITY:	Soluble in DMSO or methanol.
SHIPPING:	AMBIENT
LONG TERM STORAGE:	-20°C
HAZARD:	IRRITANT.

Product Description

Antibiotic. Inhibitor of bacterial and eukaryal threonyl-tRNA synthetase (ThrRS). Inhibitor of cyclin-dependent kinase (CDK). Shows angiogenesis inhibiting and antiviral activity.

Product Specific Literature References

Isolation of a cDNA clone for human threonyl-tRNA synthetase: amplification of the structural gene in borrelidin-resistant cell lines: K.J. Kontis and S.M. Arfin; Mol. Cell. Biol. 9, 1832 (1989) Abstract
Genetic analysis of mutations causing borrelidin resistance by overproduction of threonyl-transfer ribonucleic acid synthetase: J. Frohler, et al.; J. Bacteriol. 143, 1135 (1980) Abstract; Full Text
Increased levels of threonyl-tRNA synthetase in a borrelidin-resistant Chinese hamster ovary cell line: J.S. Gantt, et al.; PNAS 78, 5367 (1981) Abstract; Full Text
Chinese hamster ovary cells resistant to borrelidin overproduce threonyl-tRNA synthetase: S.C. Gerken and S.M. Arfin; J. Biol. Chem. 259, 9202 (1984) Abstract; Full Text
Borrelidin inhibits a cyclin-dependent kinase (CDK), Cdc28/Cln2, of Saccharomyces cerevisiae: E. Tsuchiya, et al.; J. Antibiot. 54, 84 (2001) Abstract
Borrelidin induces the transcription of amino acid biosynthetic enzymes via a GCN4-dependent pathway: E.L. Eastwood and S.E. Schaus; Bioorg. Med. Chem. Lett. 13, 2235 (2003) Abstract
Isolation of vivomycin and borrelidin, two antibiotics with anti-viral activity, from a species of Streptomyces (C2989): M. Lumb, et al.; Nature 206, 263 (1965) Abstract
A unique hydrophobic cluster near the active site contributes to differences in borrelidin inhibition among threonyl-tRNA synthetases: B. Ruan, et al.; J. Biol. Chem. 280, 571 (2005) Abstract; Full Text

Further Categories Containing This Product:

CDK & Cyclin Inhibitors • tRNA / Related Products • Antibiotics - Antiviral / Anti-HIV • Antibiotics for Angiogenesis Research

ALX-350-019

Revised 17-Apr-08

(+)-Brefeldin A
SYNONYMS	BFA Ascotoxin Decumbin
PRODUCT LINE	Natural Products / Antibiotics
PRODUCT CATEGORY	Antibiotics - Apoptosis Inducers & Inhibitors

Ordering Information

Product Numbers:	Format:	Size:	Unit Price:	Quantity:	Add To Cart
ALX-350-019-M005		5 mg	80.00 USD
ALX-350-019-M010		10 mg	130.00 USD
ALX-350-019-M025		25 mg	270.00 USD
ALX-350-019-M050		50 mg	420.00 USD

Product Specification

FORMULA:	C₁₆H₂₄O₄
MW:	280.4
CAS NUMBER:	20350-15-6
MERCK INDEX:	14: 1369
SOURCE/HOST:	Isolated from Eupenicillium brefeldianum.