• Home
  • Sitemap
  • Help
  • Technical Support
  • Contact
Signal Transduction
You are here: Product Lines > Signal Transduction
 
Toolbar - View Selection
 
 Items 100-120 of 2920 Page 6 of 146 Select Page: << 1 2 3 4 5 6 7 8 9 10  >>  
ALX-350-326 Revised 29-May-07
Agelongine
Add to Clipboard
PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Natural Products for Neurological Research
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-350-326-M001   1 mg 160.00 USD Add To Cart
Product Specification
FORMULA: C13H11BrN2O4
MW: 339.1
CAS NUMBER: 163564-84-9
SOURCE/HOST: Isolated from the sponge Agelas longissima.
PURITY: ≥97% (HPLC)
APPEARANCE: Yellow to brown solid.
SOLUBILITY: Soluble in DMSO or 100% ethanol.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
HANDLING: Protect from light.
IDENTITY: Identity determined by 1H-NMR, 13C-NMR and MS.

Product Description
Alkaloid exhibiting antagonistic activity on serotonin receptors.
Product Specific Literature References
A novel bromopyrrole alkaloid from the sponge agelas longissima with antiserotonergic activity: F. Cafieri, et al.; Bioorg. Med. Chem. Lett. 5, 799 (1995)
Inhibition of cyclin-dependent kinases, GSK-3beta and CK1 by hymenialdisine, a marine sponge constituent: L. Meijer, et al.; Chem. Biol. 7, 51 (2000) Abstract
Further Categories Containing This Product:
Alkaloids • Serotonergics & Serotonin Receptors / Related Products
 
 
ALX-550-001 Revised 20-Jun-07
Agmatine . sulfate
Add to Clipboard
SYNONYMS 1-Amino-4-guanidinobutane . sulfate
4-(Aminobutyl)guanidine . sulfate
PRODUCT LINE Neurobiology
PRODUCT CATEGORY Imidazoline Binding Site Ligands
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-550-001-M100   100 mg 22.00 USD Add To Cart
ALX-550-001-M500   500 mg 44.00 USD Add To Cart
Product Specification
FORMULA: C5H14N4 . H2SO4
MW: 130.2 . 98.1
CAS NUMBER: 2482-00-0
MERCK INDEX: 14: 188
PURITY: ≥97%
APPEARANCE: White to off-white powder.
SOLUBILITY: Soluble in water.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C

Product Description
Decarboxylation product of L-arginine. Endogenous clonidine-displacing substance in the brain. Putative endogenous neurotransmitter at imidazoline receptors. Antagonist of NMDA receptor. Endogenous inhibitor of nitric oxide synthase (NOS). Antiproliferative by its suppresive effect on polyamine.
Product Specific Literature References
Agmatine: an endogenous clonidine-displacing substance in the brain: G. Li, et al.; Science 263, 966 (1994) Abstract
Selective inhibition of inducible nitric oxide synthase by agmatine: M. Auguet, et al.; Jpn. J. Pharmacol. 69, 285 (1995) Abstract
Inhibition of mammalian nitric oxide synthases by agmatine, an endogenous polyamine formed by decarboxylation of arginine: E. Galea, et al.; Biochem. J. 316, 247 (1996) Abstract; Full Text
An emerging role for agmatine: J. Satriano, et al.; Kidney Int. 56, 1252 (1999), (Review) Abstract
Is agmatine a novel neurotransmitter in brain?: D.J. Reis & S. Regunathan; Trends Pharmacol. Sci. 21, 187 (2000) Abstract
Agmatine suppresses nitric oxide production in microglia: K. Abe, et al.; Brain Res. 872, 141 (2000) Abstract
Agmatine enhances the NADPH oxidase activity of neuronal NO synthase and leads to oxidative inactivation of the enzyme: D.R. Demady, et al.; Mol. Pharmacol. 59, 24 (2001) Abstract; Full Text
Regulation of inducible nitric oxide synthase and agmatine synthesis in macrophages and astrocytes: S. Regunathan & J.E. Piletz; Ann. N. Y. Acad. Sci. 1009, 20 (2003) Abstract
Agmatine: at the crossroads of the arginine pathways: J. Satriano; Ann. N. Y. Acad. Sci. 1009, 34 (2003), (Review) Abstract
Agmatine signaling: odds and threads: R. Berkels, et al.; Cardiovasc. Drug Rev. 22, 7 (2004), (Review) Abstract
Further Categories Containing This Product:
NOS Inhibitors (NOS Induction & Enzyme Activity) • NMDA Receptors / Related Products
 
 
ALX-550-101 Revised 16-Apr-05
AIDA
Add to Clipboard
SYNONYMS (±)-1-Aminoindane-1,5-dicarboxylic acid
UPF 523
PRODUCT LINE Neurobiology
PRODUCT CATEGORY Glutamate Receptors (Metabotropic) / Related Products
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-550-101-M005   5 mg 35.00 USD Add To Cart
ALX-550-101-M025   25 mg 140.00 USD Add To Cart
Product Specification
FORMULA: C11H11NO4
MW: 221.2
CAS NUMBER: 168560-79-0
PURITY: ≥96%
SOLUBILITY: Soluble in water.
SHIPPING: AMBIENT
LONG TERM STORAGE: +4°C

Product Description
Potent and selective ligand for group I mGluRs. Shows no effect on group II or group III mGluRs. Has no effect on ionotropic glutamate receptors.
Product Specific Literature References
1-Aminoindan-1,5-dicarboxylic acid: a novel antagonist at phospholipase C-linked metabotropic glutamate receptors: R. Pellicciari, et al.; J. Med. Chem. 38, 3717 (1995) Abstract
mGluR modulation of post-traumatic neuronal death: role of NMDA receptors: A.G. Mukhin, et al.; Neuroreport 8, 2561 (1997) Abstract
Class I mGlu receptor antagonist 1-aminoindan-1,5-dicarboxylic acid blocks contextual but not cue conditioning in rats: K.S. Nielsen, et al.; Eur. J. Pharmacol. 326, 105 (1997) Abstract
Pharmacological characterization of 1-aminoindan-1,5-dicarboxylic acid, a potent mGluR1 antagonist: F. Moroni, et al.; J. Pharmacol. Exp. Ther. 281, 721 (1997) Abstract
Induction of LTD by activation of group l mGluR in the denate gyrus in vitro: N. Camodeca, et al.; Neuropharmacology 38, 1597 (1999) Abstract
Metabotropic G-protein-coupled glutamate receptors as therapeutic targets: R. Pellicciari & G. Costantino; Curr. Opin. Chem. Biol. 3, 433 (1999), (Review) Abstract
1-Aminoindan-1,5-dicarboxylic acid and (S)-(+)-2-(3'- carboxybicyclo[1.1.1] pentyl)-glycine, two mGlu1 receptor-preferring antagonists, reduce neuronal death in in vitro and in vivo models of cerebral ischaemia: D.E. Pellegrini-Giampietro, et al.; Eur. J. Neurosci. 11, 3637 (1999) Abstract
Evaluation of agonists and antagonists acting at Group I metabotropic glutamate receptors in the thalamus in vivo: T.E. Salt, et al.; Neuropharmacology 38, 1505 (1999) Abstract
Pharmacological agents acting at subtypes of metabotropic glutamate receptors: D.D. Schoepp, et al.; Neuropharmacology 38, 1431 (1999), (Review) Abstract
Further Categories Containing This Product:
Acetylcholine Receptors (Muscarinic) / Related Products
 
 
ALX-380-046 Revised 08-Apr-08
Alamethicin
Add to Clipboard
SYNONYMS U-22324
PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Antibiotics - Ionophores
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-380-046-M001   1 mg 40.00 USD Add To Cart
ALX-380-046-M005   5 mg 90.00 USD Add To Cart
Product Specification
SEQUENCE: Main component: Ac-Aib-Pro-Aib-Ala-Aib-Ala-Gln-Aib-Val-Aib-Gly-Leu-Aib-Pro-Val-Aib-Aib-Glu-Gln-Phl
FORMULA: C92H150N22O25
MW: 1964.3
CAS NUMBER: 27061-78-5, 59588-86-2
SOURCE/HOST: Isolated from Trichoderma viride.
PURITY: ≥50% (remainder homologs)
APPEARANCE: Off-white to brown solid.
SOLUBILITY: Soluble in DMSO, 100% ethanol or methanol.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
USE/STABILITY: Solutions are stable for up to 3 months when stored at -20°C.
HAZARD: TOXIC.
Product Description
Membrane permeabilizing antibiotic.
Product Specific Literature References
The primary structure of alamethicin: J.W. Payne, et al.; Biochem. J. 117, 757 (1970) Abstract
Alamethicin-mediated fusion of lecithin vesicles: A.L.Y. Lau and S.I. Chan; PNAS 72, 2170 (1975) Abstract
The use of ionophores and channel formers in the study of the function of biological membranes: A. Gomez-Puyou & C. Gomez-Lojero; Curr. Top. Bioener. 6, 221 (1977)
The production of alamethicins by Trichoderma spp: D. Brewer, et al.; Can. J. Microbiol. 33, 619 (1987) Abstract
Model ion channels: gramicidin and alamethicin: G. A. Woolley & B. A. Wallace; J. Membr. Biol. 129, 109 (1992), Review Abstract
Ligand-induced extramembrane conformation switch controlling alamethicin assembly and the channel current: S. Futaki & K. Asami; Chem. Biodivers. 4, 1313 (2007), Review Abstract
Channel-forming activity of alamethicin: effects of covalent tethering: G.A. Woolley; Chem. Biodivers. 4, 1323 (2007), Review Abstract
 
 
ALX-460-036 Revised 17-Jan-05
Alfacalcidol
Add to Clipboard
SYNONYMS Hydroxyvitamin D3
1-Hydroxycholecalciferol
(1α,3β,5Z,7E)-9,10-Secocholesta-5,7,10(19)-triene-1,3-diol
PRODUCT LINE Bone Metabolism
PRODUCT CATEGORY Vitamin D3 & Vitamin D3 Receptor / Related Products
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-460-036-M001   1 mg 75.00 USD Add To Cart
Product Specification
FORMULA: C27H44O2
MW: 400.6
CAS NUMBER: 41294-56-8
RTECS: VS2851000
PURITY: ≥97%
APPEARANCE: White to off white crystals.
SOLUBILITY: Soluble in ethanol.
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: -20°C
HANDLING: Protect from light. Keep under inert gas.

Product Description
Converts to active calcitriol (1α,25-dihydroxyvitamin D3; Prod. No. ALX-460-032) in vivo. Inhibits bone resorption.
Further Categories Containing This Product:
Vitamins
 
 
ALX-270-448 Revised 24-Jul-06
ALK5 Inhibitor I
Add to Clipboard
SYNONYMS TGF-β RI Kinase Inhibitor I
3-(Pyridin-2-yl)-4-(4-quinonyl)]-1H-pyrazole
PRODUCT LINE Chemokines & Cytokines
PRODUCT CATEGORY Transforming Growth Factor beta [TGFbeta] & Receptors / Related Products
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-270-448-M001   1 mg 30.00 USD Add To Cart
ALX-270-448-M005   5 mg 90.00 USD Add To Cart
Product Specification
FORMULA: C17H12N4
MW: 272.3
PURITY: ≥97% (1H-NMR)
APPEARANCE: Yellow to brown solid.
SOLUBILITY: Soluble in DMSO or methanol.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
USE/STABILITY: Stable for 2 years after receipt when stored at -20°C. Stock solutions are stable for up to 3 months when stored at -20°C.
HANDLING: Protect from light.
HAZARD: MAY BE CARCINOGENIC. HARMFUL.

Product Description

Cell permeable, potent, selective and ATP-competitive inhibitor of TGF-β RI kinase (IC50=51nM). Displays ~15-fold greater selectivity over p38α MAPK (IC50=740nM). Inhibits TGF-β-dependent cellular growth (IC50=89nM in NIH 3T3 mouse fibroblasts) and transcription activation (IC50=47nM in mink lung cells).
Product Specific Literature References
Synthesis and activity of new aryl- and heteroaryl-substituted pyrazole inhibitors of the transforming growth factor-beta type I receptor kinase domain: J.S. Sawyer, et al.; J. Med. Chem. 46, 3953 (2003) Abstract
Successful shape-based virtual screening: the discovery of a potent inhibitor of the type I TGFbeta receptor kinase (TbetaRI): J. Singh, et al.; Bioorg. Med. Chem. Lett. 13, 4355 (2003) Abstract
Further Categories Containing This Product:
MAPK Pathway Inhibitors
 
 
ALX-270-445 Revised 20-Jul-06
ALK5 Inhibitor II
Add to Clipboard
SYNONYMS TGF-β RI Kinase Inhibitor II
2-(3-(6-Methylpyridin-2-yl)-1H-pyrazol-4-yl)-1,5-naphthyridine
PRODUCT LINE Chemokines & Cytokines
PRODUCT CATEGORY Transforming Growth Factor beta [TGFbeta] & Receptors / Related Products
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-270-445-M001   1 mg 60.00 USD Add To Cart
ALX-270-445-M005   5 mg 240.00 USD Add To Cart
Product Specification
FORMULA: C17H13N5
MW: 287.3
PURITY: ≥97% (1H-NMR)
APPEARANCE: Yellow solid.
SOLUBILITY: 5mg/ml soluble in DMSO or methanol.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
USE/STABILITY: Stable for 2 years after receipt when stored at -20°C. Stock solutions are stable for up to 6 months when stored at -20°C.
HANDLING: Protect from light.

Product Description
Cell permeable, potent, selective and ATP-competitive inhibitor of TGF-β RI kinase (IC50=23nM, 4nM and 18nM for binding, auto-phosphorylation and cellular assay in HepG2 cells of TGF-β RI kinase, respectively). Minimally affects a panel of 9 closely related kinases including p38 MAPK (IC50>16µM).
Product Specific Literature References
Identification of 1,5-naphthyridine derivatives as a novel series of potent and selective TGF-beta type I receptor inhibitors: F. Gellibert, et al.; J. Med. Chem. 47, 4494 (2004) Abstract
Further Categories Containing This Product:
MAPK Pathway Inhibitors
 
 
ALX-430-031 Revised 11-Jan-07
Allethrin
Add to Clipboard
SYNONYMS (R,S)-3-Allyl-2-methyl-4-oxocyclopent-2-enyl-(1R,S)-cis,trans-chrysanthemate
Allylcinerin
PRODUCT LINE Signal Transduction
PRODUCT CATEGORY PP2B [Calcineurin] / Related Products
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-430-031-M010   10 mg 30.00 USD Add To Cart
ALX-430-031-M025   25 mg 60.00 USD Add To Cart
Product Specification
FORMULA: C19H26O3
MW: 302.4
CAS NUMBER: 584-79-2
MERCK INDEX: 14: 260
RTECS: GZ1925000
PURITY: ≥95% (HPLC)
APPEARANCE: Clear or whitish film.
SOLUBILITY: Soluble in DMSO or 100% ethanol; insoluble in water.
SHIPPING: AMBIENT
LONG TERM STORAGE: +4°C
HANDLING: Protect from light. Avoid alkalis.
HAZARD: HARMFUL.

Product Description
Type I pyrethroid, useful as a very weakly active "negative" control for inhibition of calcineurin (protein phosphatase 2B) by type II pyrethroids.
Product Specific Literature References
Specific inhibition of calcineurin by type II synthetic pyrethroid insecticides: E. Enan & F. Matsumura; Biochem. Pharmacol 43, 1777 (1992) Abstract
Nerve membrane Na+ channels as targets of insecticides: T. Narahashi; TIPS 13, 236 (1992), (Review) Abstract
Further Categories Containing This Product:
Pyrethroids
 
 
ALX-350-329 Revised 21-May-08
Allicin
Add to Clipboard
SYNONYMS 2-Propene-1-sulfinothioic acid S-2-propenyl ester
Diallyl thiosulfinate
PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Natural Products - Antioxidants
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-350-329-M001   1 mg 200.00 USD Add To Cart
ALX-350-329-M005   5 mg 690.00 USD Add To Cart
Product Specification
FORMULA: C6H10OS2
MW: 162.3
CAS NUMBER: 539-86-6
MERCK INDEX: 14: 261
SOURCE/HOST: Synthetic.
PURITY: ≥98%
APPEARANCE: Clear to slightly yellow liquid.
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: -20°C

Product Description
Active metabolite of garlic. Exhibits antimicrobial, antioxidant, antiproliferative, chemopreventive, antihyperlipidaemic and antihypertensive effects. Inhibits telomerase activity. Induces apoptosis. Also inhibits inducible nitric oxide synthase (iNOS; NOS II) expression.
Product Specific Literature References
Allicin from garlic strongly inhibits cysteine proteinases and cytopathic effects of Entamoeba histolytica: S. Ankri, et al.; Antimicrob. Agents Chemother. 41, 2286 (1997) Abstract
Effect of allicin and ajoene, two compounds of garlic, on inducible nitric oxide synthase: V.M. Dirsch, et al.; Atherosclerosis 139, 333 (1998) Abstract
Antimicrobial properties of allicin from garlic: S. Ankri & D. Mirelman; Microbes Infect. 1, 125 (1999), Review Abstract
Effect of purified allicin, the major ingredient of freshly crushed garlic, on cancer cell proliferation: K. Hirsch, et al.; Nutr. Cancer 38, 245 (2000) Abstract
The effects of allicin and enalapril in fructose-induced hyperinsulinemic hyperlipidemic hypertensive rats: A. Elkayam, et al.; Am. J. Hypertens. 14, 377 (2001) Abstract
Effects of allicin on both telomerase activity and apoptosis in gastric cancer SGC-7901 cells: L. Sun & X. Wang; World J. Gastroenterol. 9, 1930 (2003) Abstract
Allicin (from garlic) induces caspase-mediated apoptosis in cancer cells: S. Oommen, et al.; Eur. J. Pharmacol. 485, 97 (2004) Abstract
Antibacterial activity of a new, stable, aqueous extract of allicin against methicillin-resistant Staphylococcus aureus: R.R. Cutler & P. Wilson; Br. J. Biomed. Sci. 61, 71 (2004) Abstract
The pungency of garlic: activation of TRPA1 and TRPV1 in response to allicin: L.J. Macpherson, et al.; Curr. Biol. 15, 929 (2005) Abstract
An overview of the antifungal properties of allicin and its breakdown products--the possibility of a safe and effective antifungal prophylactic: S.R. Davis; Mycoses 48, 95 (2005), Review Abstract
Thiolsulfinate allicin from garlic: inspiration for a new antimicrobial agent: R. Hunter, et al.; Ann. N.Y. Acad. Sci. 1056, 234 (2005), Review Abstract
The antioxidant properties of garlic compounds: allyl cysteine, alliin, allicin, and allyl disulfide: L.Y. Chung; J. Med. Food 9, 205 (2006) Abstract
Effect of raw garlic vs commercial garlic supplements on plasma lipid concentrations in adults with moderate hypercholesterolemia: a randomized clinical trial: C.D. Gardner, et al.; Arch. Intern. Med. 167, 346 (2007) Abstract
Further Categories Containing This Product:
Active Substances from Fruit and Vegetables • NOS Inhibitors (NOS Induction & Enzyme Activity) • Natural Products - Nitric Oxide Pathway Modulators • Natural Products - Apoptosis Inducers & Inhibitors • Antitumor Agents (Anti-proliferative) • Natural Products with Antibiotic Activity • Natural Products - Chemopreventive Agents • TRPV1 Agonists and Antagonists / Related Products
 
 
ALX-270-386 Revised 24-Feb-05
Aloisine