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Protein Kinase C [PKC] / Related Products
You are here: Product Lines > Signal Transduction > Protein Kinase C [PKC] / Related Products
 
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ALX-162-016 Revised 04-Jul-07
[Pyr4]-Myelin Basic Protein (4-14) (bovine)
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SYNONYMS [Pyr4]-MBP (4-14) (bovine)
PRODUCT LINE Neurobiology
PRODUCT CATEGORY Myelin Basic Protein / Related Products
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ALX-162-016-M001   1 mg 95.00 USD Add To Cart
ALX-162-016-M005   5 mg 380.00 USD Add To Cart
Product Specification
SEQUENCE: Pyr-Lys-Arg-Pro-Ser-Gln-Arg-Ser-Lys-Tyr-Leu-OH
FORMULA: C60H100N20O17
MW: 1373.6
CAS NUMBER: 136132-68-8
PURITY: ≥96%
APPEARANCE: White lyophilized powder.
SOLUBILITY: Soluble in water.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
Product Description
Very selective substrate for protein kinase C (PKC).
Product Specific Literature References
A synthetic peptide substrate for selective assay of protein kinase C: I. Yasuda, et al.; BBRC 166, 1220 (1990) Abstract
Peptide fragments of myelin basic protein as substrates of protein kinase C: M. Eller, et al.; Biochem. Int. 27, 625 (1992) Abstract
Further Categories Containing This Product:
PKC Substrates • Peptides
 
 
ALX-162-010 Revised 28-Jul-08
Myelin Basic Protein (104-118) (bovine)
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SYNONYMS MBP (104-118) (bovine)
PRODUCT LINE Neurobiology
PRODUCT CATEGORY Myelin Basic Protein / Related Products
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ALX-162-010-M001   1 mg 95.00 USD Add To Cart
ALX-162-010-M005   5 mg 380.00 USD Add To Cart
Product Specification
SEQUENCE: H-Gly-Lys-Gly-Arg-Gly-Leu-Ser-Leu-Ser-Arg-Phe-Ser-Trp-Gly-Ala-OH
FORMULA: C70H111N23O19
MW: 1578.8
PURITY: ≥97%
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
Product Description
Substrate for protein kinase C (PKC).
Product Specific Literature References
Substrate specificity of phospholipid/Ca2+-dependent protein kinase as probed with synthetic peptide fragments of the bovine myelin basic protein: R.S. Turner, et al.; J. Biol. Chem. 260, 11503 (1985) Abstract; Full Text
Synthetic myelin basic protein peptide analogs are specific inhibitors of phospholipid/calcium-dependent protein kinase (protein kinase C): H. Su, et al.; BBRC 134, 78 (1986) Abstract
Further Categories Containing This Product:
PKC Substrates • Peptides
 
 
ALX-162-017 Revised 08-Jan-03
N-Myristoyl-Lys-Arg-Thr-Leu-Arg-OH
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PRODUCT LINE Signal Transduction
PRODUCT CATEGORY PKC Inhibitors
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ALX-162-017-M001   1 mg 70.00 USD Add To Cart
ALX-162-017-M005   5 mg 280.00 USD Add To Cart
Product Specification
FORMULA: C42H82N12O8
MW: 883.2
PURITY: ≥96%
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
Product Description
Effective inhibitor of protein kinase C (PKC)-catalyzed histone phosphorylation.
Product Specific Literature References
Inhibition of IL-2 receptor induction and IL-2 production in the human leukemic cell line Jurkat by a novel peptide inhibitor of protein kinase C: C.G. Ioannides, et al.; Cell. Immunol. 131, 242 (1990) Abstract
N-myristyl-Lys-Arg-Thr-Leu-Arg: a novel protein kinase C inhibitor: C.A. O'Brian, et al.; Biochem. Pharmacol. 39, 49 (1990) Abstract
Further Categories Containing This Product:
Histones / Related Products • Peptides
 
 
ALX-162-018 Revised 04-Jul-03
N-Myristoyl-Phe-Ala-Arg-Lys-Gly-Ala-Leu-Arg-Gln-OH
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PRODUCT LINE Signal Transduction
PRODUCT CATEGORY PKC Inhibitors
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ALX-162-018-M001   1 mg 120.00 USD Add To Cart
ALX-162-018-M005   5 mg 480.00 USD Add To Cart
Product Specification
FORMULA: C60H105N17O12
MW: 1256.6
PURITY: ≥97%
APPEARANCE: White lyophilized powder.
SOLUBILITY: Soluble in water.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
Product Description
Selective and cell permeable inhibitor of protein kinase C (PKC). The peptide corresponds to the pseudosubstrate domain of PKCα and PKCβ subtypes.
Product Specific Literature References
A myristoylated pseudosubstrate peptide, a novel protein kinase C inhibitor: T. Eichholtz, et al.; J. Biol. Chem. 268, 1982 (1993) Abstract; Full Text
Further Categories Containing This Product:
Peptides
 
 
ALX-163-004 Revised 06-Jun-03
Neurogranin (28-43)
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PRODUCT LINE Signal Transduction
PRODUCT CATEGORY PKC Substrates
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ALX-163-004-M001   1 mg 120.00 USD Add To Cart
Product Specification
SEQUENCE: H-Ala-Ala-Lys-Ile-Gln-Ala-Ser-Phe-Arg-Gly-His-Met-Ala-Arg-Lys-Lys-OH
FORMULA: C78H134N28O19S
MW: 1800.2
PURITY: ≥97%
APPEARANCE: White lyophilized powder.
SOLUBILITY: Soluble in water.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
Product Description
Peptide derived from the neurogranin phosphorylation domain. Highly selective substrate for protein kinase C (PKC), but very poor substrate for Ca2+/calmodulin-dependent kinase II and cAMP-dependent kinase (PKA).
Product Specific Literature References
Studies with synthetic peptide substrates derived from the neuronal protein neurogranin reveal structural determinants of potency and selectivity for protein kinase C: S.-J. Chen, et al.; Biochemistry 32, 1032 (1993) Abstract
Further Categories Containing This Product:
Peptides
 
 
ALX-270-104 Revised 21-Mar-07
NPC-15437 . dihydrochloride
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SYNONYMS (S)-2,6-diamino-N-{[1'-(1''-oxotridecyl)-2'-piperidinyl]methyl}hexanamide . 2HCl
PRODUCT LINE Signal Transduction
PRODUCT CATEGORY PKC Inhibitors
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ALX-270-104-M001   1 mg 90.00 USD Add To Cart
ALX-270-104-M005   5 mg 350.00 USD Add To Cart
Product Specification
FORMULA: C25H50N4O2 . 2 HCl
MW: 438.7 . 73.0
CAS NUMBER: 136449-85-9; 141774-20-1
APPEARANCE: White to off-white solid.
SOLUBILITY: Soluble in water, DMSO or methanol.
SHIPPING: AMBIENT
LONG TERM STORAGE: +4°C
HANDLING: Hygroscopic.

Product Description
Selective inhibitor of protein kinase C (PKC).
Product Specific Literature References
NPC 15437 interacts with the C1 domain of protein kinase C. An analysis using mutant PKC constructs: J.P. Sullivan, et al.; FEBS Lett. 285, 120 (1991) Abstract
2,6-Diamino-N-([1-oxotridecyl)-2-piperidinyl]methyl)hexanamide (NPC 15437): a selective inhibitor of protein kinase C: J.P. Sullivan, et al.; Agents Actions 34, 142 (1991) Abstract
2,6-Diamino-N-([1-(1-oxotridecyl)-2-piperidinyl] methyl)hexanamide (NPC 15437): a novel inhibitor of protein kinase C interacting at the regulatory domain: J.P. Sullivan, et al.; Mol. Pharmacol. 41, 38 (1992) Abstract
 
 
ALX-300-006 Revised 03-Jul-06
1-O-Octadecyl-2-O-methyl-rac-glycero-3-phosphocholine
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SYNONYMS rac-ET-18-OCH3
Edelfosine
PRODUCT LINE Signal Transduction
PRODUCT CATEGORY Phospholipids / Related Products
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ALX-300-006-M050   50 mg 45.00 USD Add To Cart
ALX-300-006-M250   250 mg 180.00 USD Add To Cart
Product Specification
FORMULA: C27H58NO6P
MW: 523.7
CAS NUMBER: 70641-51-9
RTECS: YK0718000
PURITY: ≥99%
APPEARANCE: White to off-white amorphous solid.
SOLUBILITY: Soluble in chloroform (50mg/ml), 100% ethanol (5mg/ml) or water.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
HANDLING: Hygroscopic.
HAZARD: MAY BE MUTAGENIC. HARMFUL.
Product Description
Produces strong antitumor and antimetastatic activities. Inhibits phosphatidylinositol specific phospholipase C and protein kinase C (PKC). Induces apoptosis.
Product Specific Literature References
Antiinvasive effect of racemic 1-O-octadecyl-2-O-methylglycero-3- phosphocholine on MO4 mouse fibrosarcoma cells in vitro: G.A. Storme, et al.; Cancer Res. 45, 351 (1985) Abstract
Cytotoxic ether phospholipids. Different affinities to lysophosphocholine acyltransferases in sensitive and resistant cells: D.B.J. Herrmann & H.A. Neumann; J. Biol. Chem. 261, 7742 (1986) Abstract; Full Text
Inhibition of Na,K-ATPase and sodium pump by anticancer ether lipids and protein kinase C inhibitors ET-18-OCH3 and BM 41.440: K. Oishi, et al.; BBRC 157, 1000 (1988) Abstract
Solubilization of the NADPH-oxidase from bone marrow derived macrophages by dialkylphospholipid and purification by HPLC-anion exchange chromatography: J. Storch & E. Ferber; Biol. Chem. Hoppe-Seyler 369, 403 (1988) Abstract
Molecular dynamics of antitumor ether-linked phospholipids in model membranes: a spin-label study: C.-S. Lai, et al.; BBRC 160, 1189 (1989) Abstract
The ether lipid 1-octadecyl-2-methyl-rac-glycero-3-phosphocholine induces expression of fos and jun proto-oncogenes and activates AP-1 transcription factor in human leukaemic cells: F. Mollinedo, et al.; Biochem. J. 302, 325 (1994) Abstract
Ether lipids enhance the cytotoxic effect of teniposide and paclitaxel in liposomes against leukaemic cells in culture: B.B. Lundberg; Anticancer Drug Des. 12, 503 (1997) Abstract
Selective induction of apoptosis in cancer cells by the ether lipid ET- 18-OCH3 (Edelfosine): molecular structure requirements, cellular uptake, and protection by Bcl-2 and Bcl-X(L): F. Mollinedo, et al.; Cancer Res. 57, 1320 (1997) Abstract
The inhibition of cell signaling pathways by antitumor ether lipids: G. Arthur & R. Bittman; Biochim. Biophys. Acta. 1390, 85 (1998) Abstract
Cytotoxic etherphospholipid analogues: D. Berkovic; Gen Pharmacol. 31, 511 (1998) Abstract
Involvement of c-Jun NH2-terminal kinase activation and c-Jun in the induction of apoptosis by the ether phospholipid 1-O-octadecyl-2-O- methyl-rac-glycero-3-phosphocholine: C. Gajate, et al.; Mol. Pharmacol. 53, 602 (1998) Abstract
The anticancer drug edelfosine is a potent inhibitor of neovascularization in vivo: W.R. Vogler, et al.; Cancer Invest. 16, 549 (1998) Abstract
Liposomal ET-18-OCH(3) induces cytochrome c-mediated apoptosis independently of CD95 (APO-1/Fas) signaling: O. Cuvillier, et al.; Blood 94, 3583 (1999) Abstract
Induction of apoptosis in human mitogen-activated peripheral blood T- lymphocytes by the ether phospholipid ET-18-OCH3: involvement of the Fas receptor/ligand system: C. Cabaner, et al.; Br. J. Pharmacol. 127, 813 (1999) Abstract
Alkyl-lysophospholipids activate the SAPK/JNK pathway and enhance radiation-induced apoptosis: G.A. Ruiter, et al.; Cancer Res. 59, 2457 (1999) Abstract
Intracellular triggering of Fas, independently of FasL, as a new mechanism of antitumor ether lipid-induced apoptosis: C. Gajate, et al.; Int. J. Cancer 85, 674 (2000) Abstract
Involvement of mitochondria and caspase-3 in ET-18-OCH(3)-induced apoptosis of human leukemic cells: C. Gajate, et al.; Int. J. Cancer 86, 208 (2000) Abstract
Further Categories Containing This Product:
Phospholipase C / Related Products • Antitumor Agents (Enzyme Inhibitors) • PKC Inhibitors • Antitumor Agents (Apoptosis Inducers)
 
 
ALX-300-004 Revised 13-Mar-08
1-O-Octadecyl-2-O-methyl-sn-glycero-3-phosphocholine
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SYNONYMS 2-O-Methyl-PAF-C-18
sn-ET-18-OCH3
Edelfosine
PRODUCT LINE Signal Transduction
PRODUCT CATEGORY Phospholipids / Related Products
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ALX-300-004-M050   50 mg 40.00 USD Add To Cart
ALX-300-004-M250   250 mg 160.00 USD Add To Cart
ALX-300-004-G001   1 g 480.00 USD Add To Cart
Product Specification
FORMULA: C27H58NO6P
MW: 523.7
CAS NUMBER: 77286-66-9
PURITY: ≥98%
APPEARANCE: White amorphous powder.
SOLUBILITY: Soluble in 100% ethanol, DMSO or dimethyl formamide.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
HANDLING: Hygroscopic.

Product Description
Produces strong antitumor and antimetastatic activities. Inhibits phosphatidylinositol specific phospholipase C and protein kinase C from various leukemic cells. Antineoplastic activity.
Product Specific Literature References
Selective destruction of human leukemic cells by alkyl- lysophospholipids: R. Andreesen, et al.; Cancer Res. 38, 3894 (1978) Abstract
Disturbance of phospholipid metabolism during the selective destruction of tumor cells induced by alkyl-lysophospholipids: M. Modolell, et al.; Cancer Res. 39, 4681 (1979) Abstract
Phospholipid-sensitive Ca2+-dependent protein phosphorylation system in various types of leukemic cells from human patients and in human leukemic cell lines HL60 and K562, and its inhibition by alkyl- lysophospholipid: D.M. Helfman, et al.; Cancer Res. 43, 2955 (1983) Abstract
Purging leukemic cells from simulated human remission marrow with alkyl- lysophospholipid: S. Okamoto, et al.; Blood 69, 1381 (1987) Abstract
HL-60 cells become resistant towards antitumor ether-linked phospholipids following differentiation into a granulocytic form: D.S. Vallari, et al.; BBRC 156, 1 (1988) Abstract
The ether lipid 1-octadecyl-2-methyl-rac-glycero-3-phosphocholine induces expression of fos and jun proto-oncogenes and activates AP-1 transcription factor in human leukaemic cells: F. Mollinedo, et al.; Biochem. J. 302, 325 (1994) Abstract
Ether lipids enhance the cytotoxic effect of teniposide and paclitaxel in liposomes against leukaemic cells in culture: B.B. Lundberg; Anticancer Drug Des. 12, 503 (1997) Abstract
Selective induction of apoptosis in cancer cells by the ether lipid ET- 18-OCH3 (Edelfosine): molecular structure requirements, cellular uptake, and protection by Bcl-2 and Bcl-X(L): F. Mollinedo, et al.; Cancer Res. 57, 1320 (1997) Abstract
The inhibition of cell signaling pathways by antitumor ether lipids: G. Arthur & R. Bittman; Biochim. Biophys. Acta. 1390, 85 (1998) Abstract
Cytotoxic etherphospholipid analogues: D. Berkovic; Gen Pharmacol. 31, 511 (1998) Abstract
Involvement of c-Jun NH2-terminal kinase activation and c-Jun in the induction of apoptosis by the ether phospholipid 1-O-octadecyl-2-O- methyl-rac-glycero-3-phosphocholine: C. Gajate, et al.; Mol. Pharmacol. 53, 602 (1998) Abstract
The anticancer drug edelfosine is a potent inhibitor of neovascularization in vivo: W.R. Vogler, et al.; Cancer Invest. 16, 549 (1998) Abstract
Liposomal ET-18-OCH(3) induces cytochrome c-mediated apoptosis independently of CD95 (APO-1/Fas) signaling: O. Cuvillier, et al.; Blood 94, 3583 (1999) Abstract
Alkyl-lysophospholipids activate the SAPK/JNK pathway and enhance radiation-induced apoptosis: G.A. Ruiter, et al.; Cancer Res. 59, 2457 (1999) Abstract
Induction of apoptosis in human mitogen-activated peripheral blood T- lymphocytes by the ether phospholipid ET-18-OCH3: involvement of the Fas receptor/ligand system: C. Cabaner, et al.; Br. J. Pharmacol. 127, 813 (1999) Abstract
Intracellular triggering of Fas, independently of FasL, as a new mechanism of antitumor ether lipid-induced apoptosis: C. Gajate, et al.; Int. J. Cancer 85, 674 (2000) Abstract
Involvement of mitochondria and caspase-3 in ET-18-OCH(3)-induced apoptosis of human leukemic cells: C. Gajate, et al.; Int. J. Cancer 86, 208 (2000) Abstract
Further Categories Containing This Product:
Phospholipase C / Related Products • Antitumor Agents (Enzyme Inhibitors) • PKC Inhibitors
 
 
ALX-300-138 Revised 28-Jan-05
Oleic acid (high purity)
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SYNONYMS cis-9-Octadecenoic acid 18:1
PRODUCT LINE Obesity & Adipokines
PRODUCT CATEGORY Fatty Acids
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ALX-300-138-G001   1 g 25.00 USD Add To Cart
Product Specification
FORMULA: C18H34O2
MW: 282.5
CAS NUMBER: 112-80-1
MERCK INDEX: 14: 6828
PURITY: ≥99%
APPEARANCE: Colorless liquid.
SOLUBILITY: Soluble in chloroform or 100% ethanol.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
HANDLING: Keep under inert gas. Protect from light and oxygen.
HAZARD: IRRITANT.

Product Description
Unsaturated fatty acid that has been shown to activate protein kinase C (PKC) in hepatocytes. Inhibitor of glucose production and food intake. Upregulates the expression of uncoupling protein-3 (UCP-3) in L6 myotubes.
Product Specific Literature References
Oleic acid promotes changes in the subcellular distribution of protein kinase C in isolated hepatocytes: M.J. Diaz-Guerra; J. Biol. Chem. 266, 23568 (1991) Abstract; Full Text
Spinal cord of the rat contains more lipoprotein lipase than other brain regions: D.H. Bessesen, et al.; J. Lipid Res. 34, 229 (1993) Abstract
Free fatty acid-induced alterations in the steroid-binding properties of rat androgen-binding protein: F. Felden, et al.; BBRC 190, 602 (1993) Abstract
Chronic feline leukemia virus infection alters arachidonic acid proportions in vivo and in vitro: L.L. Williams, et al.; Proc. Soc. Exp. Biol. Med. 202, 239 (1993) Abstract
Central administration of oleic acid inhibits glucose production and food intake: S. Obici, et al.; Diabetes 51, 271 (2002) Abstract; Full Text
Effects of rosiglitazone and oleic acid on UCP-3 expression in L6 myotubes: A. Costello, et al.; Diabetes Obes. Metab. 5, 136 (2003) Abstract
Further Categories Containing This Product:
Obesity & Diabetes Other Products • PKC Activators
 
 
ALX-300-300 Revised 08-Jul-08
1-Oleoyl-2-acetyl-sn-glycerol
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SYNONYMS OAG
PRODUCT LINE Signal Transduction
PRODUCT CATEGORY Mono- & Diacylglycerols
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ALX-300-300-M005   5 mg 62.00 USD Add To Cart
ALX-300-300-M025   25 mg