ALEXIS Biochemicals: Cylindrospermopsin

You are here: Product Lines > Signal Transduction > Nucleotides, Nucleosides & Nucleobases / Related Products > Uridine Derivatives

Uridine Derivatives Other Products

ALX-350-149

Revised 23-Oct-07

Cylindrospermopsin
PRODUCT LINE	Natural Products / Antibiotics
PRODUCT CATEGORY	Other Toxins

Ordering Information

Product Numbers:	Format:	Size:	Unit Price:	Quantity:	Add To Cart
ALX-350-149-C025		25 µg	140.00 USD
ALX-350-149-C100		100 µg	210.00 USD

Product Specification

FORMULA:	C₁₅H₂₁N₅O₇S
MW:	415.4
CAS NUMBER:	143545-90-8
RTECS:	UV9104310
SOURCE/HOST:	Isolated from Cylindrospermopsis raciborskii.
PURITY:	≥95% (HPLC)
APPEARANCE:	Glassy solid.
SOLUBILITY:	Soluble in water, methanol or DMSO.
SHIPPING:	AMBIENT
LONG TERM STORAGE:	-20°C
HAZARD:	VERY TOXIC. HIGHLY IRRITANT.

Product Description

Tricyclic alkaloid hepatotoxin. Exhibits a completely different mechanism of toxicity than microcystins. Protein synthesis inhibitor. Might be carcinogenic. Inhibits pyrimidine nucleotide synthesis.

Product Specific Literature References

Severe hepatotoxicity caused by the tropical cyanobacterium (blue-green alga) Cylindrospermopsis raciborskii (Woloszynska) Seenaya and Subba Raju isolated from a domestic water supply reservoir: P.R. Hawkins, et al.; Appl. Environ. Microbiol. 50, 1292 (1985) Abstract; Full Text
Cylindrospermopsin, a potent hepatotoxin from the blue-green alga Cylindrospermopsis raciborskii: I. Ohtani, et al.; JACS 114, 7941 (1992) Full Text
Isolation and toxicity of Cylindrospermopsis raciborskii from an ornamental lake: P.R. Hawkins, et al.; Toxicon. 35, 341 (1997) Abstract
Cylindrospermopsin, a cyanobacterial alkaloid: evaluation of its toxicologic activity: G.R. Shaw, et al.; Ther. Drug Monit. 22, 89 (2000) Abstract
Preliminary evidence for in vivo tumour initiation by oral administration of extracts of the blue-green alga cylindrospermopsis raciborskii containing the toxin cylindrospermopsin: I.R. Falconer & A.R. Humpage; Environ. Toxicol. 16, 192 (2001) Abstract
The Palm Island mystery disease 20 years on: a review of research on the cyanotoxin cylindrospermopsin: D.J. Griffiths and M.L. Saker; Environ. Toxicol. 18, 78 (2003), Review Abstract
The cyanobacterial toxin cylindrospermopsin inhibits pyrimidine nucleotide synthesis and alters cholesterol distribution in mice: M. Reisner, et al.; Toxicol. Sci. 82, 620 (2004) Abstract

Further Categories Containing This Product:

Uridine Derivatives Other Products • Protein Synthesis Other Products • Lipid Metabolism Other Products • Alkaloids

another CS2 website

Online Product Ordering

Clipboard [0]

Your items will be kept only for the duration of your visit.