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ALX-210-151
Revised 19-Mar-08
Polyclonal Antibody to Androgen Receptor
PRODUCT LINE
DNA Regulation / Transcription
PRODUCT CATEGORY
Androgens & Androgen Receptors / Related Products
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-210-151-R200
200 µl
379.00 USD
Product Specification
SPECIES CROSSREACTIVITY:
Human
Mouse
Rat
Monkey
SOURCE/HOST:
From rabbit.
FORMULATION:
Liquid. Antiserum diluted in PBS containing 0.05% sodium azide.
IMMUNOGEN:
Recombinant human androgen receptor (aa 331-572).
SPECIFICITY:
Recognizes human, mouse, rat and monkey androgen receptor. Detects a band of ~110kDa by Western blot.
APPLICATION:
Immunocytochemistry
Immunohistochemistry (paraffin sections, frozen sections) (1:100)
Immunoprecipitation
Western Blot (1:500)
SHIPPING:
SHIPPED ON BLUE ICE
LONG TERM STORAGE:
-20°C
HANDLING:
Avoid freeze/thaw cycles.
Further Categories Containing This Product:
Tumor Markers
•
Polyclonal Antibodies
ALX-210-152/1
Revised 28-Feb-08
Polyclonal Antibody to Androgen Receptor
PRODUCT LINE
DNA Regulation / Transcription
PRODUCT CATEGORY
Androgens & Androgen Receptors / Related Products
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-210-152/1-C100
100 µg
379.00 USD
Product Specification
SPECIES CROSSREACTIVITY:
Human
SOURCE/HOST:
From rabbit.
CONCENTRATION:
1mg/ml.
PURITY DETAIL:
Epitope affinity-purified IgG.
FORMULATION:
Liquid. In PBS containing 1mg/ml BSA and 0.05% sodium azide.
IMMUNOGEN:
Synthetic peptide corresponding to N-terminal aa 1-21 (M
1
EVQLGLGRVYPRPPSKTYRG
21
C) of human, mouse and rat androgen receptor.
SPECIFICITY:
Recognizes human androgen receptor. Detects a band of ~110kDa by Western blot. Does not cross-react with estrogen, progesterone, or glucocorticoid receptors.
APPLICATION:
Western Blot (2µg/ml)
SHIPPING:
SHIPPED ON BLUE ICE
LONG TERM STORAGE:
-20°C
HANDLING:
Avoid freeze/thaw cycles.
BLOCKING PEPTIDE:
For Blocking Peptide see Prod. No.
ALX-151-033
.
Product Specific Literature References
Immunocytochemical analysis of androgen receptor along the ducts of the separate rat prostate lobes after androgen withdrawal and replacement:
G.S. Prins, et al.; Endocrinology
132
, 169 (1993)
Abstract
Androgen receptor localization in different cell types of the adult rat prostate:
G.S. Prins, et al.; Endocrinology
129
, 3187 (1991)
Abstract
Related Products
ALX-151-033
Blocking Peptide for PAb to Androgen Receptor (Prod. No.
ALX-210-152/1
)
Further Categories Containing This Product:
Tumor Markers
•
Polyclonal Antibodies
ALX-210-571
Revised 10-Apr-08
Polyclonal Antibody to ARAP1 (human)
PRODUCT LINE
Signal Transduction
PRODUCT CATEGORY
GTPase-activating Proteins [GAPs]
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-210-571-C100
100 µg
380.00 USD
Product Specification
SPECIES CROSSREACTIVITY:
Human
SOURCE/HOST:
From rabbit.
CONCENTRATION:
1mg/ml.
PURITY:
Liquid. In PBS.
IMMUNOGEN:
Recombinant C-terminal part of mouse ARAP1 (aa 1084-1371).
SPECIFICITY:
Recognizes human ARAP1.
APPLICATION:
Western Blot (1µg/ml)
Optimal conditions must be determined individually for each application.
SHIPPING:
SHIPPED ON BLUE ICE
LONG TERM STORAGE:
-20°C
HANDLING:
Avoid freeze/thaw cycles.
Product Images
Please click on thumbnails to enlarge.
General Information
The adaptor protein ARAP1 is a PIP3-dependent Arf GAP that regulates Arf-, Rho-, and Cdc42-dependent cell activities. ARAP1 plays an important role in the regulation of blood pressure and renal function via activation of the intrarenal renin-angiotensin system. It was shown that ARAP1 might affect the efficacy of TRAIL-induced apoptosis due to its cell-specific trafficking of TRAIL-R1 (DR4).
General Literature References
ARAP1: a point of convergence for Arf and Rho signaling:
K. Miura, et al.; Mol. Cell
9
, 109 (2002)
Abstract
Development of hypertension and kidney hypertrophy in transgenic mice overexpressing ARAP1 gene in the kidney:
D.F. Guo, et al.; Hypertension
48
, 453 (2006)
Abstract
;
Full Text
Arf and Rho GAP adapter protein ARAP1 participates in the mobilization of TRAIL-R1/DR4 to the plasma membrane:
S. Simova, et al.; Apoptosis
13
, 423 (2008)
Abstract
Further Categories Containing This Product:
Renin-Angiotensin-Aldosterone System [RAAS] Other Products
•
Polyclonal Antibodies
ALX-210-507A
Revised 17-Jun-08
Polyclonal Antibody to Endothelin A Receptor
SYNONYMS
anti-ET
A
-Receptor PAb
PRODUCT LINE
Signal Transduction
PRODUCT CATEGORY
Endothelins [ETs] & Endothelin Receptors / Related Products
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-210-507A-C250
250 µg
330.00 USD
Product Specification
SPECIES CROSSREACTIVITY:
Human
Mouse
Rat
SOURCE/HOST:
From sheep.
CONCENTRATION:
1mg/ml
PURITY DETAIL:
Epitope-affinity purified.
FORMULATION:
Liquid. In TRIS-citrate-phosphate, pH 7-8, containing 0.1% sodium azide.
IMMUNOGEN:
Synthetic peptide corresponding to aa 410-422 (Q
410
EQNHNTERSSHK
422
) of C-terminal rat ET
A
-receptor (endothelin A receptor).
SPECIFICITY:
Recognizes an epitope on the cytoplasmic side of human, mouse and rat ET
A
-receptor. Detects bands of 34-52kDa. Does not block the binding of endothelins to the receptor.
APPLICATION:
Immunohistochemistry (paraffin sections (4µg/ml))
Western Blot (10-20µg/ml using ECL)
SHIPPING:
SHIPPED ON BLUE ICE
SHORT TERM STORAGE:
+4°C
LONG TERM STORAGE:
-20°C
HANDLING:
Avoid freeze/thaw cycles. After opening, prepare aliquots and store at -20°C.
Product Images
Please click on thumbnails to enlarge.
Product Specific Literature References
Endothelin-1-, endothelin-A-, and endothelin-B-receptor expression is correlated with vascular endothelial growth factor expression and angiogenesis in breast cancer:
P. Wulfing, et al.; Clin. Cancer Res.
10
, 2393 (2004)
Abstract
General Information
Endothelins are a family of peptides that are potent vasoconstrictors produced by mammalian vascular endothelial cells. The receptors for the endothelins are found on various tissues including, but not restricted to, lung and intestine.
BACKGROUND/TECHNICAL INFORMATION
Note:
As this antibody is generated against the cytosolic portion of endothelin A receptor, permeabilization is required for immunochemical analysis.
Further Categories Containing This Product:
Polyclonal Antibodies
ALX-210-506A
Revised 17-Jun-08
Polyclonal Antibody to Endothelin B Receptor
SYNONYMS
anti-ET
B
-Receptor PAb
PRODUCT LINE
Signal Transduction
PRODUCT CATEGORY
Endothelins [ETs] & Endothelin Receptors / Related Products
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-210-506A-C250
250 µg
330.00 USD
Product Specification
SPECIES CROSSREACTIVITY:
Human
Mouse
Rat
Sheep
SOURCE/HOST:
From sheep.
CONCENTRATION:
1mg/ml
PURITY DETAIL:
Epitope-affinity purified and sterile filtered.
FORMULATION:
Liquid. In TRIS-citrate-phosphate buffer, pH 7-8, containing 0.1% sodium azide.
IMMUNOGEN:
Synthetic peptide corresponding to aa 424-437 (K
424
ANDHGYDN
FRSSNN
437
) of C-terminal rat ET
B
-receptor (endothelin B receptor).
SPECIFICITY:
Recognizes the cytoplasmic side of human, mouse, rat and sheep ET
B
-receptor. Detects isoforms A and C in human. Detects bands of 34-52kDa. Does not block the binding of endothelins to the receptor.
APPLICATION:
Immunohistochemistry (paraffin sections (2.5µg/ml); frozen sections (10µg/ml))
Western Blot
SHIPPING:
SHIPPED ON BLUE ICE
SHORT TERM STORAGE:
+4°C
LONG TERM STORAGE:
-20°C
Product Images
Please click on thumbnails to enlarge.
Product Specific Literature References
Endothelin-1-, endothelin-A-, and endothelin-B-receptor expression is correlated with vascular endothelial growth factor expression and angiogenesis in breast cancer
:
P. Wulfing, et al.; Clin. Cancer Res.
10
, 2393 (2004)
Abstract
General Information
Endothelins are a family of peptides that are potent vasoconstrictors produced by mammalian vascular endothelial cells. The receptors for the endothelins are found on various tissues including, but not restricted to, lung and intestine.
BACKGROUND/TECHNICAL INFORMATION
Note:
This PAb was generated against the cytoplasmic portion of ET
B
-receptor, permeabilization is required for immunochemical analysis.
Further Categories Containing This Product:
Polyclonal Antibodies
ALX-210-201
Revised 22-May-06
Polyclonal Antibody to Estrogen Receptor α
SYNONYMS
anti-ERα PAb
PRODUCT LINE
DNA Regulation / Transcription
PRODUCT CATEGORY
Estrogen & Estrogen Receptors / Related Products
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-210-201-C050
50 µg
379.00 USD
Product Specification
SPECIES CROSSREACTIVITY:
Human
Rat
SOURCE/HOST:
From rabbit.
CONCENTRATION:
1mg/ml
PURITY DETAIL:
Epitope-affinity purified IgG.
FORMULATION:
Liquid. In PBS containing 1mg/ml BSA and 0.05% sodium azide.
IMMUNOGEN:
Synthetic peptide corresponding to aa 1-21 (M
1
TMTLHTKASGMALLHQIQGN
21
) of N-terminal human ERα (estrogen receptor α). This sequence is completely conserved in rat and mouse ERα and is highly conserved in sheep, pig, dog, bovine and chicken ERα.
SPECIFICITY:
Recognizes human and rat endogenous ERα . Detects a band of ~64kDa by Western blot. Does not cross-react with ERβ.
APPLICATION:
Immunocytochemistry
Immunohistochemistry (frozen sections, paraffin sections (1-5µg/ml))
Western Blot (1µg/ml).
SHIPPING:
SHIPPED ON BLUE ICE
LONG TERM STORAGE:
-20°C
HANDLING:
Avoid freeze/thaw cycles.
BLOCKING PEPTIDE:
For Blocking Peptide see Prod. No.
ALX-155-031
.
Product Images
Please click on thumbnails to enlarge.
Product Specific Literature References
Differential Regulation of Estrogen Receptor Subtypes alpha and beta in Human Aortic Smooth Muscle Cells by Oligonucleotides and Estradiol:
F. Barchiesi, et al.; J. Clin. Endocrinol. Metab.
89
, 2373 (2004)
Abstract
Cytochromes 1A1/1B1- and catechol-O-methyltransferase-derived metabolites mediate estradiol-induced antimitogenesis in human cardiac fibroblast:
R.K. Dubey, et al.; J. Clin. Endocrinol. Metab.
90
, 247 (2005)
Abstract
;
Full Text
Related Products
ALX-155-031
Blocking Peptide for PAb to Estrogen Receptor α (Prod. No.
ALX-210-201
)
Further Categories Containing This Product:
Polyclonal Antibodies
ALX-210-202
Revised 20-Dec-07
Polyclonal Antibody to Estrogen Receptor α
SYNONYMS
anti-ERα PAb
PRODUCT LINE
DNA Regulation / Transcription
PRODUCT CATEGORY
Estrogen & Estrogen Receptors / Related Products
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-210-202-C050
50 µg
379.00 USD
Product Specification
SPECIES CROSSREACTIVITY:
Human
Rat
Pig
SOURCE/HOST:
From rabbit.
CONCENTRATION:
1mg/ml.
FORMULATION:
Liquid. Epitope-affinity purified IgG in PBS containing 1mg/ml BSA and 0.05% sodium azide.
IMMUNOGEN:
Synthetic peptide corresponding to aa 21-32 (N
21
ELEPLNRPQLK
32
) of N-terminal human ERα (estrogen receptor α). This sequence is completely conserved in mouse, rat, rabbit, sheep, pig and bovine ERα.
SPECIFICITY:
Recognizes human, rat and pig endogenous ERα. Detects a band of ~64kDa by Western blot. Does not cross-react with ERβ.
APPLICATION:
Immunocytochemistry (0.5µg/ml)
Immunohistochemistry (frozen sections, paraffin sections (1-5µg/ml))
Western Blot (1µg/ml)
SHIPPING:
SHIPPED ON BLUE ICE
LONG TERM STORAGE:
-20°C
HANDLING:
Avoid freeze/thaw cycles.
BLOCKING PEPTIDE:
For Blocking Peptide see Prod. No.
ALX-155-032
.
Product Images
Please click on thumbnails to enlarge.
Related Products
ALX-155-032
Blocking Peptide for PAb to Estrogen Receptor α (Prod. No.
ALX-210-202
)
Further Categories Containing This Product:
Polyclonal Antibodies
ALX-210-132
Revised 07-Jan-08
Polyclonal Antibody to Estrogen Receptor β
SYNONYMS
anti-ERβ PAb
PRODUCT LINE
DNA Regulation / Transcription
PRODUCT CATEGORY
Estrogen & Estrogen Receptors / Related Products
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-210-132-C100
100 µg
379.00 USD
Product Specification
SPECIES CROSSREACTIVITY:
Human
Mouse
Rat
SOURCE/HOST:
From rabbit.
CONCENTRATION:
1mg/ml.
PURITY DETAIL:
Epitope-affinity purified.
FORMULATION:
Liquid. In PBS containing 1mg/ml BSA and 0.05% sodium azide.
IMMUNOGEN:
Synthetic peptide corresponding to aa 512-530 (C
512
SSTEDSKN KESSQNLQSQ
530
) of C-terminal rat ERβ (estrogen receptor β
).
SPECIFICITY:
Recognizes human, mouse and rat ERβ.
Detects a band of ~55kDa by Western blot. Does not
cross-react with ERα.
APPLICATION:
Immunocytochemistry (1µg/ml)
Immunohistochemistry ((paraffin sections, frozen sections (1:50))
Western Blot (1µg/ml)
SHIPPING:
SHIPPED ON BLUE ICE
LONG TERM STORAGE:
-20°C
HANDLING:
Avoid freeze/thaw cycles.
BLOCKING PEPTIDE:
For Blocking Peptide see Prod. No.
ALX-155-025
.
Product Images
Please click on thumbnails to enlarge.
Product Specific Literature References
Transcription and translation of estrogen receptor-beta in the male reproductive tract of estrogen receptor-alpha knock-out and wild-type mice:
C.S. Rosenfeld, et al.; Endocrinology
139
, 2982 (1998)
Abstract
Generation and reproductive phenotypes of mice lacking estrogen receptor beta:
J.H. Krege, et al.; PNAS
95
, 15677 (1998)
Abstract
;
Full Text
Distribution of estrogen-beta-like immunoreactivity in rat forebrain:
X. Li, et al.; Neuroendocrinology
66
, 63 (1997)
Abstract
Related Products
ALX-155-025
Blocking Peptide for PAb to Estrogen Receptor β (Prod. No.
ALX-210-132
)
Further Categories Containing This Product:
Polyclonal Antibodies
ALX-210-135
Revised 21-May-08
Polyclonal Antibody to Estrogen Receptor β
SYNONYMS
anti-ERβ PAb
PRODUCT LINE
DNA Regulation / Transcription
PRODUCT CATEGORY
Estrogen & Estrogen Receptors / Related Products
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-210-135-C050
50 µg
379.00 USD
Product Specification
SPECIES CROSSREACTIVITY:
Human
Mouse
Rat
Sheep
Others
SOURCE/HOST:
From rabbit.
CONCENTRATION:
1mg/ml
PURITY DETAIL:
Epitope-affinity purified IgG.
FORMULATION:
Liquid. In PBS containing 1mg/ml BSA and 0.05% sodium azide.
IMMUNOGEN:
Synthetic peptide corresponding to aa 100-115 (A
100
EPQKSPWCEARSLEH
115
) of human, mouse and rat ERβ (estrogen receptor β).
SPECIFICITY:
Recognizes human, mouse, rat, sheep and monkey ERβ. Detects a band of ~55kDa by Western blot. Does not cross-react with ERα.
APPLICATION:
Gel Shift Assay (1-5µg/ml)
Immunocytochemistry (2-4µg/ml))
Immunohistochemistry ((frozen sections, paraffin sections (1-2µg/ml))
Western Blot (1-2µg/ml)
SHIPPING:
SHIPPED ON BLUE ICE
LONG TERM STORAGE:
-20°C
HANDLING:
Avoid freeze/thaw cycles.
BLOCKING PEPTIDE:
For Blocking Peptide see Prod. No.
ALX-155-027
.
Product Images
Please click on thumbnails to enlarge.
Product Specific Literature References
Cloning of a novel receptor expressed in rat prostate and ovary:
G.G.J.H. Kuiper, et al.; PNAS
93
, 5925 (1996)
Abstract
ER beta: identification and characterization of a novel human estrogen receptor:
S. Mosselman, et al.; FEBS Lett.
392
, 49 (1996)
Abstract
Transcription and translation of estrogen receptor b in the male reproductive tract of estrogen receptor a-knock-out and wild-type mice:
C.S. Rosenfeld, et al.; Endocrinology
139
, 2982 (1998)
Abstract
Differing roles found for estrogen's two receptors:
E. Pennisi; Science
277
, 1439 (1997), (Research News)
Abstract
Cloning, chromosomal localization, and functional analysis of the murine estrogen receptor beta:
G.B. Tremblay, et al.; Mol. Endocrinol.
11
, 353 (1997)
Abstract
Comparison of the ligand binding specificity and transcript tissue distribution of estrogen receptors alpha and beta:
G.G.J.H. Kuiper, et al.; Endocrinology
138
, 863 (1997)
Abstract
Distribution of estrogen receptor-beta-like immunoreactivity in rat forebrain:
X. Li, et al.; Neuroendocrinology
66
, 63 (1997)
Abstract
A new actor in the estrogen receptor drama--enter ER-beta:
B.S. Katzenellenbogen & K.S. Korach; Endocrinology
138
, 861 (1997), (Editorial)
Abstract
Related Products
ALX-155-027
Blocking Peptide for PAb to Estrogen Receptor β (Prod. No.
ALX-210-135
)
Further Categories Containing This Product:
Polyclonal Antibodies
ALX-210-178
Revised 11-Nov-05
Polyclonal Antibody to Estrogen Receptor β
SYNONYMS
anti-ERβ PAb
PRODUCT LINE
DNA Regulation / Transcription
PRODUCT CATEGORY
Estrogen & Estrogen Receptors / Related Products
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-210-178-C050
50 µg
379.00 USD
Product Specification
SPECIES CROSSREACTIVITY:
Human
Rat
SOURCE/HOST:
