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Hedgehog [Hh] Signalling Pathway
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ALX-270-426 Revised 17-Jul-08
SAG
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PRODUCT LINE Signal Transduction
PRODUCT CATEGORY Hedgehog [Hh] Signalling Pathway
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Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-270-426-M001   1 mg 195.00 USD Add To Cart
Product Specification
FORMULA: C28H28ClN3OS
MW: 490.1
CAS NUMBER: 364590-63-6
PURITY: ≥95%
APPEARANCE: White to off-white solid.
SOLUBILITY: Soluble in water (5mg/ml) or DMSO (10mg/ml).
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
HANDLING: Protect from light.

Product Description
Potent agonist of Hedgehog (Hh) signalling by activating the Smoothened (Smo) protein function.
Product Specific Literature References
Small molecule modulation of Smoothened activity: J.K. Chen, et al.; PNAS 99, 14071 (2002) Abstract; Full Text
Small-molecule modulators of Hedgehog signaling: identification and characterization of Smoothened agonists and antagonists: M. Frank-Kamenetsky, et al.; J. Biol. 1, 10 (2002) Abstract; Full Text
Activity-dependent internalization of smoothened mediated by beta-arrestin 2 and GRK2: W. Chen, et al.; Science 306, 2257 (2004) Abstract
Oxysterols stimulate Sonic hedgehog signal transduction and proliferation of medulloblastoma cells: R.B. Corcoran and M.P. Scott; PNAS 103, 8408 (2006) Abstract; Full Text
Smoothened Signal Transduction is Promoted by G-Protein Coupled Receptor Kinase 2: A.R. Meloni et al.; Mol Cell Biol. 26, 7550 (2006) Abstract
 
 
ALX-270-436 Revised 12-Aug-08
SANT-2
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SYNONYMS N-[3-(1H-Benzimidazol-2-yl)-4-chlorophenyl]-3,4,5-triethoxybenzamide
PRODUCT LINE Signal Transduction
PRODUCT CATEGORY Hedgehog [Hh] Signalling Pathway
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Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-270-436-M001   1 mg 165.00 USD Add To Cart
Product Specification
FORMULA: C26H26ClN3O4
MW: 480.0
CAS NUMBER: 329196-48-7
PURITY: ≥95%
APPEARANCE: White to off-white solid.
SOLUBILITY: Soluble in DMSO.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
USE/STABILITY: Stable for at least 6 months when stored at -20°C in the dark.
HANDLING: Protect from light.
IDENTITY: Identity determined by 1H-NMR, 13C-NMR and MS.

Product Description
Cell permeable antagonist of the Smoothened (Smo) protein function. Inhibitor of SAG (Prod. No. ALX-270-426) activity. Chemical tool to study the Hedgehog (Hh) signalling pathway and to explore therapeutic uses for inhibitors of Smo.
Product Specific Literature References
Small molecule modulation of Smoothened activity: J.K. Chen, et al.; PNAS 99, 14071 (2002) Abstract; Full Text
 
 
ALX-270-482 Revised 23-Apr-08 New product
GANT61
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SYNONYMS NSC 136476
2,2’-[[Dihydro-2-(4-pyridinyl)-1,3(2H,4H)-pyrimidinediyl]bis(methylene)]bis[N,N-dimethyl]-benzenamine
PRODUCT LINE Signal Transduction
PRODUCT CATEGORY Hedgehog [Hh] Signalling Pathway
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ALX-270-482-M001   1 mg 190.00 USD Add To Cart
Product Specification
FORMULA: C27H35N5
MW: 429.6
CAS NUMBER: 500579-04-4
PURITY: ≥95%
APPEARANCE: White to off-white waxy solid.
SOLUBILITY: Soluble in DMSO (5mg/ml).
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
HANDLING: Hygroscopic. Protect from light.
IDENTITY: Identity determined by 1H-NMR, 13C-NMR and MS.

Product Description
Inhibitor of Hedgehog (Hh) signalling pathway. Blocks the GLI function which constitutes the final step in the Hh pathway. Interferes with GLI1 DNA binding in living cells. Inhibits cell proliferation of tumor cells in vitro in a GLI-dependent manner. Blocks cell growth in an in vivo xenograft model using human prostate cancer cells.
Product Specific Literature References
Inhibition of GLI-mediated transcription and tumor cell growth by small-molecule antagonists: M. Lauth, et al.; PNAS 104, 8455 (2007) Abstract; Full Text
Further Categories Containing This Product:
Antitumor Reagents Other Products
 
 
ALX-350-377 Revised 12-Aug-08 New product
Tomatidine . hydrochloride
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SYNONYMS (3β,5α,22β,25S)-Spirosolan-3-ol . HCl
PRODUCT LINE Signal Transduction
PRODUCT CATEGORY Hedgehog [Hh] Signalling Pathway
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ALX-350-377-M025   25 mg 45.00 USD Add To Cart
Product Specification
FORMULA: C27H45NO2 . HCl
MW: 415.7 . 36.5
CAS NUMBER: 6192-62-7
MERCK INDEX: 14: 9544
PURITY: ≥85%
APPEARANCE: Off-white solid.
SOLUBILITY: Soluble in DMSO (2mg/ml), 100% ethanol (2.5mg/ml) or dimethyl formamide (2mg/ml). Slight warming may be required.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
USE/STABILITY: Stock solutions are stable for up to 3 months when stored at -20°C.
HANDLING: Protect from light. Hygroscopic. After reconstitution, prepare aliquots and store at -20°C.
IDENTITY: Identity determined by 1H-NMR.

Product Description
Steroidal alkaloid. Structurally similar to cyclopamine (Prod. No. ALX-430-159). Does not inhibit sonic hedgehog (shh) signalling. Negative control for jervine (Prod. No. ALX-350-378).
Product Specific Literature References
Pancreas development is promoted by cyclopamine, a hedgehog signaling inhibitor: S.K. Kim & D.A. Melton; PNAS 95, 13036 (1998) Abstract; Full Text
Teratogen-mediated inhibition of target tissue response to Shh signaling: M.K. Cooper, et al.; Science 280, 1603 (1998) Abstract
Hedgehog signalling within airway epithelial progenitors and in small-cell lung cancer: D.N. Watkins, et al.; Nature 422, 313 (2003) Abstract
Widespread requirement for Hedgehog ligand stimulation in growth of digestive tract tumours: D.M. Berman, et al.; Nature 425, 846 (2003) Abstract
Hedgehog is an early and late mediator of pancreatic cancer tumorigenesis: S.P. Thayer, et al.; Nature 425, 851 (2003) Abstract
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ALX-350-378 Revised 19-Aug-08 New product
Jervine
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SYNONYMS (3β,23β)-17,23-Epoxy-3-hydroxyveratraman-11-one
11-Ketocyclopamine
PRODUCT LINE Signal Transduction
PRODUCT CATEGORY Hedgehog [Hh] Signalling Pathway
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ALX-350-378-M001   1 mg 90.00 USD Add To Cart
ALX-350-378-M005   5 mg 360.00 USD Add To Cart
Product Specification
FORMULA: C27H39NO3
MW: 425.6
CAS NUMBER: 469-59-0
MERCK INDEX: 14: 5264
RTECS: WG9700000
PURITY: ≥98% (TLC)
APPEARANCE: White to off-white solid.
SOLUBILITY: Soluble in DMSO (5mg/ml), 100% ethanol (10mg/ml) or dimethyl formamide (6mg/ml). Slight warming may be required.
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: -20°C
USE/STABILITY: Stock solutions are stable for up to 3 months when stored at -20°C.
HANDLING: After reconstitution, prepare aliquots and store at -20°C.
HAZARD: HARMFUL. MAY BE TERATOGENIC.

Product Description
Cell permeable steroidal alkaloid. Structurally similar to cyclopamine (Prod. No. ALX-430-159). Inhibits the sonic hedgehog pathway (shh) by interacting with smoothened. Tomatidine (Prod. No. ALX-430-377) is a useful negative control.
Product Specific Literature References
Teratogen-mediated inhibition of target tissue response to Shh signaling: M.K. Cooper, et al.; Science 280, 1603 (1998) Abstract
Cyclopamine inhibition of Sonic hedgehog signal transduction is not mediated through effects on cholesterol transport: J.P. Incardona, et al.; Dev. Biol. 224, 440 (2000) Abstract
Prx1 and Prx2 are upstream regulators of sonic hedgehog and control cell proliferation during mandibular arch morphogenesis: D. ten Berge, et al.; Development 128, 2929 (2001) Abstract; Full Text
Cyclopamine and jervine in embryonic rat tongue cultures demonstrate a role for Shh signaling in taste papilla development and patterning: fungiform papillae double in number and form in novel locations in dorsal lingual epithelium: C.M. Mistretta, et al.; Dev. Biol. 254, 1 (2003) Abstract
Identification of a small molecule inhibitor of the hedgehog signaling pathway: effects on basal cell carcinoma-like lesions: J.A. Williams, et al.; PNAS 100, 4616 (2003) Abstract; Full Text
A defective response to Hedgehog signaling in disorders of cholesterol biosynthesis: M.K. Cooper, et al.; Nat. Genet. 33, 508 (2003) Abstract
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ALX-420-045 Revised 19-Aug-08 New product
Purmorphamine
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SYNONYMS 2-(1-Naphthoxy)-6-(4-morpholinoanilino)-9-cyclohexylpurine
PRODUCT LINE Signal Transduction
PRODUCT CATEGORY Hedgehog [Hh] Signalling Pathway
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-420-045-M001   1 mg 40.00 USD Add To Cart
ALX-420-045-M005   5 mg 145.00 USD Add To Cart
ALX-420-045-M025   25 mg 510.00 USD Add To Cart
Product Specification
FORMULA: C31H32N6O2
MW: 520.6
CAS NUMBER: 483367-10-8
PURITY: ≥98% (HPLC)
APPEARANCE: Beige solid.
SOLUBILITY: Soluble in DMSO.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
USE/STABILITY: Stock solutions are stable for up to 3 months when stored at -20°C.
HANDLING: After reconstitution, prepare aliquots and store at -20°C. Packaged under inert gas. Protect from light.
HAZARD: HARMFUL. MAY BE CARCINOGENIC. MAY BE TERATOGENIC.

Product Description
Cell permeable purine compound. Induces osteoblast differentiation. Agonist of smoothened by activation of the hedgehog pathway. Also shown to induce transdifferentiation in pre-adipocytes and myoblasts.
Product Specific Literature References
A small molecule with osteogenesis-inducing activity in multipotent mesenchymal progenitor cells: X. Wu, et al.; JACS 124, 14520 (2002) Abstract
Purmorphamine induces osteogenesis by activation of the hedgehog signaling pathway: X. Wu, et al.; Chem. Biol. 11, 1229 (2004) Abstract
Purmorphamine enhances osteogenic activity of human osteoblasts derived from bone marrow mesenchymal cells: M.M. Beloti, et al.; Cell Biol. Int. 29, 537 (2005) Abstract
Purmorphamine activates the Hedgehog pathway by targeting Smoothened: S. Sinha & J.K. Chen; Nat. Chem. Biol. 2, 29 (2006) Abstract
Further Categories Containing This Product:
Cell Differentiation
 
 
ALX-430-159 Revised 19-Aug-08 New product
Cyclopamine
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SYNONYMS 11-Deoxyjervine
PRODUCT LINE Signal Transduction
PRODUCT CATEGORY Hedgehog [Hh] Signalling Pathway
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ALX-430-159-M001   1 mg 80.00 USD Add To Cart
ALX-430-159-M005   5 mg 320.00 USD Add To Cart
Product Specification
FORMULA: C27H41NO2
MW: 411.6
CAS NUMBER: 4449-51-8
MERCK INDEX: 14: 10201
RTECS: GY0750000
PURITY: ≥98% (TLC)
APPEARANCE: White to off-white powder.
SOLUBILITY: Soluble in 100% ethanol (20mg/ml), DMF (10mg/ml), methanol (7mg/ml) or DMSO (4mg/ml). Heating to 50-60°C may be necessary. Insoluble in water.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
HANDLING: Protect from light.
HAZARD: MAY BE TERATOGENIC. HARMFUL.

Product Description
Steroidal alkaloid. Blocks activation of the Hedgehog (Hh) response pathway. Binds to the heptahelical protein bundle of Smoothened. Induces expression of the transcription factor Pdx-1. Disrupts cholesterol biosynthesis. Displays anti-tumor properties. Induces apoptosis. Causes cyclopia.
Product Specific Literature References
The teratogenic Veratrum alkaloid cyclopamine inhibits sonic hedgehog signal transduction: J.P. Incardona, et al.; Development 125, 3553 (1998) Abstract; Full Text
Pancreas development is promoted by cyclopamine, a hedgehog signaling inhibitor: S.K. Kim & D.A. Melton; PNAS 95, 13036 (1998) Abstract; Full Text
Teratogen-mediated inhibition of target tissue response to Shh signaling: M.K. Cooper, et al.; Science 280, 1603 (1998) Abstract
Effects of oncogenic mutations in Smoothened and Patched can be reversed by cyclopamine: J. Taipale, et al.; Nature 406, 1005 (2000) Abstract
Cyclopamine inhibition of Sonic hedgehog signal transduction is not mediated through effects on cholesterol transport: J.P. Incardona, et al.; Dev. Biol. 224, 440 (2000) Abstract
Inhibition of Hedgehog signaling by direct binding of cyclopamine to Smoothened: J.K. Chen, et al.; Genes Dev. 16, 2743 (2002) Abstract; Full Text
Small molecule modulation of Smoothened activity: J.K. Chen, et al.; PNAS 99, 14071 (2002) Abstract; Full Text
Medulloblastoma growth inhibition by hedgehog pathway blockade: D.M. Berman, et al.; Science 297, 1559 (2002) Abstract
Hedgehog signalling within airway epithelial progenitors and in small-cell lung cancer: D.N. Watkins, et al.; Nature 422, 313 (2003) Abstract
Widespread requirement for Hedgehog ligand stimulation in growth of digestive tract tumours: D.M. Berman, et al.; Nature 425, 846 (2003) Abstract
Hedgehog is an early and late mediator of pancreatic cancer tumorigenesis: S.P. Thayer, et al.; Nature 425, 851 (2003) Abstract
Hedgehog signalling in colorectal tumour cells: induction of apoptosis with cyclopamine treatment: D. Qualtrough, et al.; Int. J. Cancer 110, 831 (2004) Abstract
Induction of the differentiation and apoptosis of tumor cells in vivo with efficiency and selectivity: S. Tabs & O. Avci; Eur. J. Dermatol. 14, 96 (2004) Abstract; Full Text
In vitro directed differentiation of mouse embryonic stem cells into insulin-producing cells: T. Leon-Quinto, et al.; Diabetologia 47, 1442 (2004) Abstract
Transforming growth factor (TGF)beta, fibroblast growth factor (FGF) and retinoid signalling pathways promote pancreatic exocrine gene expression in mouse embryonic stem cells: A. Skoudy, et al.; Biochem. J. 379, 749 (2004) Abstract; Full Text
Purmorphamine induces osteogenesis by activation of the hedgehog signaling pathway: X. Wu, et al.; Chem. Biol. 11, 1229 (2004) Abstract
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