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ALX-260-108
Revised 03-Jun-05
Ac-YVAD-AFC
SYNONYMS
Caspase-1 Substrate (Fluorogenic)
Caspase-4 Substrate (Fluorogenic)
PRODUCT LINE
Cell Death / Apoptosis / Autophagy
PRODUCT CATEGORY
Caspase Substrates
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-260-108-M005
5 mg
147.00 USD
ALX-260-108-M010
10 mg
275.00 USD
Product Specification
SEQUENCE:
Ac-Tyr-Val-Ala-Asp-AFC (AFC=7-Amino-4-trifluoromethylcoumarin)
FORMULA:
C
33
H
36
F
3
N
5
O
10
MW:
719.7
PURITY:
≥99% (HPLC)
APPEARANCE:
White to off-white powder.
SOLUBILITY:
Soluble in DMSO.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
USE/STABILITY:
Solid product is stable for 1 year in desiccator when stored at room temperature. Stock solutions are stable for 6 – 8 months when stored at –20°C. Keep sealed after removing from the freezer until its temperature equilibrates with room temperature.
HANDLING:
Keep cool and dry.
Product Description
Fluorogenic substrate for caspase-1 and -4.
Product Specific Literature References
Caspase-7 is activated during lovastatin-induced apoptosis of the prostate cancer cell line LNCaP:
M. Marcelli, et al.; Cancer Res.
58
, 76 (1998)
Abstract
General Information
BACKGROUND/TECHNICAL INFORMATION
AFC has an excitation maximum of 400nm and an emission maximum of 505nm.
ALX-260-024
Revised 17-Jan-06
Ac-YVAD-AMC
SYNONYMS
Caspase-1 Substrate (Fluorogenic)
PRODUCT LINE
Cell Death / Apoptosis / Autophagy
PRODUCT CATEGORY
Caspase Substrates
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-260-024-M001
1 mg
37.00 USD
ALX-260-024-M005
5 mg
98.00 USD
Product Specification
SEQUENCE:
Ac-Tyr-Val-Ala-Asp-AMC (AMC = 7-Amino-4-methylcoumarin)
FORMULA:
C
33
H
39
N
5
O
10
MW:
665.7
PEPTIDE CONTENT:
75-95%
PURITY:
≥99% (HPLC)
APPEARANCE:
White to off-white powder.
SOLUBILITY:
Soluble in DMSO. Dilute with distilled water or buffer, pH 7.0-7.5 (e. g. TRIS, HEPES).
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
HANDLING:
Keep cool and dry.
Product Description
Fluorogenic substrate for caspase-1.
Product Specific Literature References
A novel heterodimeric cysteine protease is required for interleukin-1 β processing in monocytes:
N.A. Thornberry, et al.; Nature
356
, 768 (1992)
Abstract
Interleukin-1 β converting enzyme:
N.A. Thornberry; Meth. Enzymol.
244
, 615 (1994)
Abstract
Crystal structure of the cysteine protease interleukin-1 β-converting enzyme: a (p20/p10)2 homodimer:
N.P.C. Walker, et al.; Cell
78
, 343 (1994)
Abstract
General Information
BACKGROUND/TECHNICAL INFORMATION
AMC has an excitation maximum of 380nm and an emission maximum of 460nm.
ALX-260-027
Revised 03-May-07
Ac-YVAD-CHO
SYNONYMS
Caspase-1 Inhibitor (Aldehyde)
PRODUCT LINE
Cell Death / Apoptosis / Autophagy
PRODUCT CATEGORY
Caspase Inhibitors
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-260-027-M001
1 mg
42.00 USD
ALX-260-027-M005
5 mg
163.00 USD
Product Specification
SEQUENCE:
Ac-Tyr-Val-Ala-Asp-CHO
FORMULA:
C
23
H
32
N
4
O
8
MW:
492.5
PEPTIDE CONTENT:
70-90%
PURITY:
≥96% (HPLC)
APPEARANCE:
White powder.
FORMULATION:
Lyophilized. TFA salt.
SOLUBILITY:
Soluble in DMSO or water.
RECONSTITUTION:
Add 0.2ml DMSO per 1.0mg peptide. Shake well until all the contents are dissolved. This furnishes a 10mM solution of this material.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
USE/STABILITY:
Stock solutions should be divided into aliquots and stored at -20°C.
HANDLING:
Keep cool and dry. Keep under inert gas.
Product Description
Potent and reversible inhibitor of caspase-1. Also inhibits caspase-4. Strongly inhibits anti-Fas induced apoptosis in L929-Fas cells.
Product Specific Literature References
K.T. Chapman; Bioorg. Med. Chem. Lett.
2
, 613 (1992)
A novel heterodimeric cysteine protease is required for interleukin-1 beta processing in monocytes:
N.A. Thornberry, et al.; Nature
356
, 768 (1992)
Abstract
Interleukin 1 β (IL-1 β) processing in murine macrophages requires a structurally conserved homologue of human IL-1 β converting enzyme:
S.M. Molineaux, et al.; PNAS
90
, 1809 (1993)
Abstract
Crystal structure of the cysteine protease interleukin-1 beta- converting enzyme: a (p20/p10)2 homodimer:
N.P.C. Walker, et al.; Cell
78
, 343 (1994)
Abstract
Structure and mechanism of interleukin-1 β converting enzyme:
K.P. Wilson, et al.; Nature
370
, 270 (1994)
Abstract
Requirement of an ICE/CED-3 protease for Fas/APO-1-mediated apoptosis:
M. Los, et al.; Nature
375
, 81 (1995)
Abstract
Peptide inhibitors of the ICE protease family arrest programmed cell death of motoneurons in vivo and in vitro:
C.E. Milligan, et al.; Neuron
15
, 385 (1995)
Abstract
Sequential activation of ICE-like and CPP32-like proteases during Fas- mediated apoptosis:
M. Enari, et al.; Nature
380
, 723 (1996)
Abstract
Role of the nuclear localization sequence in fibroblast growth factor-1-stimulated mitogenic pathways:
Y.Z. Lin, et al.; J. Biol. Chem.
271
, 3505 (1996)
Abstract
;
Full Text
Inhibition of human caspases by peptide-based and macromolecular inhibitors:
M. Garcia-Calvo, et al.; J. Biol. Chem.
273
, 32608 (1998)
Abstract
;
Full Text
ALX-260-028
Revised 27-Mar-08
Ac-YVAD-CMK
SYNONYMS
Caspase-1 Inhibitor (Chloromethylketone)
PRODUCT LINE
Cell Death / Apoptosis / Autophagy
PRODUCT CATEGORY
Caspase Inhibitors
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
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ALX-260-028-M001
1 mg
55.00 USD
ALX-260-028-M005
5 mg
220.00 USD
Product Specification
SEQUENCE:
Ac-Tyr-Val-Ala-Asp-chloromethylketone
FORMULA:
C
24
H
33
N
4
O
8
Cl
MW:
541.0
PURITY:
≥96% (HPLC)
APPEARANCE:
White to off-white powder.
SOLUBILITY:
Soluble in DMSO (50mg/ml).
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
USE/STABILITY:
Stock solutions should be divided into aliquots and stored at -20°C.
Product Description
Irreversible, cell permeable inhibitor of caspase-1. Also inhibits caspase-4. Inhibits Fas-mediated apoptosis.
Product Specific Literature References
Cleavage of poly(ADP-ribose) polymerase by a proteinase with properties like ICE:
Y.A. Lazebnik, et al.; Nature
371
, 346 (1994)
Abstract
Crystal structure of the cysteine protease interleukin-1 beta- converting enzyme: a (p20/p10)2 homodimer:
N.P.C. Walker, et al.; Cell
78
, 343 (1994)
Abstract
Involvement of an ICE-like protease in Fas-mediated apoptosis:
M. Enari, et al.; Nature
375
, 78 (1995)
Involvement of interleukin-1 beta-converting enzyme in apoptosis of bFGF-deprived murine aortic endothelial cells:
S. Kondo, et al.; FASEB J.
10
, 1192 (1996)
Abstract
Peptide inhibitors of the ICE protease family arrest programmed cell death of motoneurons in vivo and in vitro:
C.E. Milligan, et al.; Neuron
15
, 385 (1995)
Abstract
Sequential activation of ICE-like and CPP32-like proteases during Fas- mediated apoptosis:
M. Enari, et al.; Nature
380
, 723 (1996)
Abstract
ICE inhibitor YVADcmk is a potent therapeutic agent against in vivo liver apoptosis:
N. Rouquet, et al.; Curr. Biol.
6
, 1192 (1996)
Abstract
Caspase-1-inhibitor ac-YVAD-cmk reduces LPS-lethality in rats without affecting haematology or cytokine responses:
G. Mathiak, et al.; Br. J. Pharmacol.
131
, 383 (2000)
Abstract
ALX-260-016
Revised 10-Feb-05
Ac-YVAD-2,6-dimethylbenzoyloxymethylketone
SYNONYMS
Caspase-1 Inhibitor
PRODUCT LINE
Cell Death / Apoptosis / Autophagy
PRODUCT CATEGORY
Caspase Inhibitors
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-260-016-M001
1 mg
75.00 USD
ALX-260-016-M005
5 mg
290.00 USD
Product Specification
SEQUENCE:
Ac-Tyr-Val-Ala-Asp-2,6-dimethylbenzoyloxymethylketone
FORMULA:
C
33
H
42
N
4
O
10
MW:
654.7
PEPTIDE CONTENT:
78-99%
PURITY:
≥95% (HPLC)
APPEARANCE:
White powder.
SOLUBILITY:
Soluble in DMSO or methanol.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
USE/STABILITY:
Stock solutions should be divided into aliquots and stored at -20°C.
HANDLING:
Keep cool and dry.
Product Description
Irreversible, cell permeable inhibitor of caspase-1. Also inhibits caspase-4.
Product Specific Literature References
Inactivation of interleukin-1 beta converting enzyme by peptide (acyloxy)methyl ketones:
N.A. Thornberry, et al.; Biochemistry
33
, 3934 (1994)
Abstract
ALX-260-026
Revised 24-Feb-05
Ac-YVAD-pNA
SYNONYMS
Caspase-1 Substrate (Chromogenic)
PRODUCT LINE
Cell Death / Apoptosis / Autophagy
PRODUCT CATEGORY
Caspase Substrates
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-260-026-M001
1 mg
32.00 USD
ALX-260-026-M005
5 mg
68.00 USD
Product Specification
SEQUENCE:
Ac-Tyr-Val-Ala-Asp-pNA (pNA=p-Nitroaniline)
FORMULA:
C
29
H
36
N
6
O
10
MW:
628.6
PEPTIDE CONTENT:
75-95%
PURITY:
≥99% (HPLC)
APPEARANCE:
White to off-white powder.
FORMULATION:
Lyophilized.
SOLUBILITY:
Soluble in DMSO. Dilute with buffer pH 7.5.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
HANDLING:
Keep cool and dry.
Product Description
Chromogenic substrate for caspase-1.
Product Specific Literature References
A novel heterodimeric cysteine protease is required for interleukin-1 β processing in monocytes:
N.A. Thornberry, et al.; Nature
356
, 768 (1992)
Abstract
Peptidic p-nitroanilide substrates of interleukin-1 β-converting enzyme:
L.A. Reiter; Int. J. Pept. Protein Res.
43
, 87 (1994)
Abstract
Interleukin-1 β converting enzyme:
N.A. Thornberry; Meth. Enzymol.
244
, 615 (1994)
Abstract
General Information
BACKGROUND/TECHNICAL INFORMATION
λmax of pNA is 400nm.
AG-AE0631
Revised 11-Jan-08
ACE2 (human) ELISA Kit
SYNONYMS
Angiotensin-converting Enzyme 2 (human) ELISA Kit
SARS Receptor (human) ELISA Kit
PRODUCT LINE
Signal Transduction
PRODUCT CATEGORY
Angiotensin Converting Enzyme [ACE] & ACE2/Related Products
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
AG-AE0631EK-KI01
96 wells
590.00 USD
AG-AE0631TP-KI01
Twin Plex
2x96 wells
890.00 USD
AG-AE0631PP-KI01
Penta Plex
5x96 wells
1'870.00 USD
Product Specification
SPECIES CROSSREACTIVITY:
Human
SENSITIVITY:
293pg/ml (range 0 to 50ng/ml)
APPLICATION:
For the quantitative determination of ACE2 in human urine samples or cell culture supernatants.
SHIPPING:
SHIPPED ON BLUE ICE
LONG TERM STORAGE:
+4°C
Product Images
Please click on thumbnails to enlarge.
General Information
MANUFACTURER
Manufactured by AdipoGen, Inc.
Further Categories Containing This Product:
SARS Coronavirus/Related Products
•
ELISA & EIA Kits
ALX-201-330
Revised 24-Jul-06
ACE2 (human):Fc (human) (recombinant)
SYNONYMS
Angiotensin-converting Enzyme 2 (human):Fc (human) (recombinant)
SARS Receptor (human):Fc (human) (recombinant)
PRODUCT LINE
Signal Transduction
PRODUCT CATEGORY
Angiotensin Converting Enzyme [ACE] & ACE2/Related Products
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-201-330-C050
50 µg
370.00 USD
Product Specification
SOURCE/HOST:
Produced in HEK 293 cells. The signal peptide sequence and the extracellular domain of human ACE2 (angiotensin-converting enzyme 2) (aa 1-740) are fused at the C-terminus to the Fc portion of human IgG1.
CONCENTRATION:
1mg/ml
PURITY:
≥90% (SDS-PAGE)
FORMULATION:
Liquid. 0.2µm-filtered solution in PBS.
ENDOTOXIN CONTENT:
<0.1EU/µg protein (LAL test).
BIOLOGICAL ACTIVITY:
Converts angiotensin I to angiotensin-(1-9).
SHIPPING:
SHIPPED ON BLUE ICE
LONG TERM STORAGE:
-20°C
USE/STABILITY:
Working aliquots are stable for up to 3 months when stored at -20°C.
HANDLING:
Avoid freeze/thaw cycles. After opening, prepare aliquots and store at -20°C.
Product Images
Please click on thumbnails to enlarge.
General Information
BACKGROUND/TECHNICAL INFORMATION
Swiss-Prot link Q9NRA7:
Angiotensin converting enzyme-like protein (human)
MANUFACTURER
Manufactured by Adipogen, Inc.
Further Categories Containing This Product:
Recombinant Proteins/Fusion Proteins
•
SARS Coronavirus/Related Products
ALX-201-356
Revised 18-Mar-08
ACE2, Soluble (human) (recombinant)
SYNONYMS
Angiotensin-converting Enzyme 2, Soluble (human) (recombinant)
SARS Receptor, Soluble (human) (recombinant)
PRODUCT LINE
Signal Transduction
PRODUCT CATEGORY
Angiotensin Converting Enzyme [ACE] & ACE2/Related Products
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-201-356-C010
10 µg
295.00 USD
ALX-201-356-C050
50 µg
795.00 USD
Product Specification
EC:
3.4.17.-
SOURCE/HOST:
Produced in HEK 293 cells. The signal peptide sequence and the extracellular domain of human ACE2 (angiotensin-converting enzyme 2) (aa 1-740) are fused at the C-terminus to a FLAG
®
-tag.
CONCENTRATION:
1mg/ml
PURITY:
≥90% (SDS-PAGE)
FORMULATION:
Liquid. 0.2µm-filtered solution in PBS.
ENDOTOXIN CONTENT:
<0.1EU/µg protein (LAL-test).
BIOLOGICAL ACTIVITY:
Converts angiotensin I to angiotensin-(1-9).
SHIPPING:
SHIPPED ON BLUE ICE
LONG TERM STORAGE:
-20°C
USE/STABILITY:
Working aliquots are stable for up to 3 months when stored at -20°C.
HANDLING:
After opening, prepare aliquots and store at -20°C. Avoid freeze/thaw cycles.
Product Images
Please click on thumbnails to enlarge.
General Information
BACKGROUND/TECHNICAL INFORMATION
Swiss-Prot link Q9NRA7:
Angiotensin converting enzyme-like protein (human)
FLAG is a registered trademark of Sigma-Aldrich Co.
MANUFACTURER
Manufactured by AdipoGen, Inc.
Further Categories Containing This Product:
Recombinant Proteins/Fusion Proteins
•
SARS Coronavirus/Related Products
ALX-151-020
Revised 10-Feb-05
N-Acetyl-Asp-Glu-OH
SYNONYMS
α-NAAG
Spaglumic acid
PRODUCT LINE
Neurobiology
PRODUCT CATEGORY
Glutamate Receptors (Metabotropic)/Related Products
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-151-020-M010
10 mg
35.00 USD
ALX-151-020-M050
50 mg
140.00 USD
Product Specification
FORMULA:
C
11
H
16
N
2
O
8
MW:
304.3
CAS NUMBER:
3106-85-2
PURITY:
≥98%
SOLUBILITY:
Soluble in water.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
+4°C
Product Description
Endogenous neurotransmitter with high affinity for the brain glutamate receptor. N-acetylated α-linked acidic dipeptidase (NAALADase), a membrane-bound peptidase, hydrolyzes α
-
NAAG, a major brain peptide, to N-acetylaspartate and glutamate. Discriminates between mGluR2 and mGluR3. mGluR3 activator. NMDA receptor antagonist. Neuroprotective.
