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ALX-201-225
Revised 26-Jul-05
cAMP-dependent Protein Kinase (Regulatory Subunit RIα) (bovine) (recombinant)
SYNONYMS
Protein Kinase A (Regulatory Subunit RIα) (bovine) (recombinant)
PKA (Regulatory Subunit RIα) (bovine) (recombinant)
PRODUCT LINE
Signal Transduction
PRODUCT CATEGORY
PKA
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-201-225-C025
25 µg
474.00 USD
ALX-201-225-C050
50 µg
812.00 USD
ALX-201-225-C100
100 µg
1'489.00 USD
Product Specification
MW:
~43kDa/subunit; homodimer
SOURCE/HOST:
Produced in
E. coli
.
PURITY:
≥95% (SDS-PAGE)
FORMULATION:
Liquid. In 10mM potassium phosphate, pH 6.8, containing 150mM NaCl, 14mM 2-mercaptoethanol, 1mM EDTA and 50% glycerol.
BIOLOGICAL ACTIVITY:
Reversibly inhibits the catalytic subunit Cα of cAMP-dependent protein kinase (PKA) (Prod. No.
ALX-201-224
). The inhibition of the catalytic subunit can be reversed by the addition of the second messenger cAMP (>1µM) (Prod. No.
ALX-480-011
).
SHIPPING:
SHIPPED ON DRY ICE
SHORT TERM STORAGE:
-20°C
LONG TERM STORAGE:
-80°C
USE/STABILITY:
Keep the glycerol stock solution of the enzyme permanently at -20°C while pipetting to avoid loss of inhibitory activity.
HANDLING:
Avoid freeze/thaw cycles.
Further Categories Containing This Product:
Enzymes
•
Recombinant Proteins/Fusion Proteins
ALX-201-226
Revised 18-Jan-06
cAMP-dependent Protein Kinase (Regulatory Subunit RIIα) (human) (recombinant)
SYNONYMS
Protein Kinase A (Regulatory Subunit RIIα) (human) (recombinant)
PKA (Regulatory Subunit RIIα) (human) (recombinant)
PRODUCT LINE
Signal Transduction
PRODUCT CATEGORY
PKA
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-201-226-C025
25 µg
474.00 USD
ALX-201-226-C050
50 µg
812.00 USD
ALX-201-226-C100
100 µg
1'489.00 USD
Product Specification
MW:
45kDa/subunit; homodimer
SOURCE/HOST:
Produced in
E. coli
.
CONCENTRATION:
PURITY:
≥95% (SDS-PAGE)
FORMULATION:
Liquid. In 10mM potassium phosphate, pH 6.8, containing 150mM NaCl, 14mM β-mercaptoethanol, 1mM EDTA and 50% glycerol.
BIOLOGICAL ACTIVITY:
Reversibly inhibits the catalytic subunit Cα of cAMP-dependent protein kinase (PKA) (Prod. No.
ALX-201-224
). The inhibition of the catalytic subunit can be reversed by the addition of the second messenger cAMP (>1µM) (Prod. No.
ALX-480-011
).
APPLICATION:
Suitable for the analysis of interactions with so-called A-kinase anchoring proteins (AKAPs).
SHIPPING:
SHIPPED ON DRY ICE
SHORT TERM STORAGE:
-20°C
LONG TERM STORAGE:
-80°C
USE/STABILITY:
Keep the glycerol stock solution of the enzyme permanently at -20°C while pipetting to avoid loss of inhibitory activity.
HANDLING:
Avoid freeze/thaw cycles.
Further Categories Containing This Product:
Enzymes
•
Recombinant Proteins/Fusion Proteins
ALX-201-227
Revised 14-Nov-07
cAMP-dependent Protein Kinase (Regulatory Subunit RIIβ) (rat) (recombinant)
SYNONYMS
Protein Kinase A (Regulatory Subunit RIIβ) (rat) (recombinant)
PKA (Regulatory Subunit RIIβ) (rat) (recombinant)
PRODUCT LINE
Signal Transduction
PRODUCT CATEGORY
PKA
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-201-227-C025
25 µg
474.00 USD
ALX-201-227-C050
50 µg
812.00 USD
ALX-201-227-C100
100 µg
1'489.00 USD
Product Specification
MW:
45kDa/subunit; homodimer
SOURCE/HOST:
Produced in
E. coli
.
CONCENTRATION:
PURITY:
≥95% (SDS-PAGE)
FORMULATION:
Liquid. In 10mM potassium phosphate, pH 6.8, containing 150mM NaCl, 14mM 2-mercaptoethanol, 1mM EDTA and 50% glycerol.
BIOLOGICAL ACTIVITY:
Reversibly inhibits the catalytic subunit Cα of cAMP-dependent protein kinase (PKA) (Prod. No.
ALX-201-224
). The inhibition of the catalytic subunit can be reversed by the addition of the second messenger cAMP (>1µM) (Prod. No.
ALX-480-011
).
APPLICATION:
Suitable for inhibition studies and for the analysis of interactions with so-called A-kinase anchoring proteins (AKAPs).
SHIPPING:
SHIPPED ON DRY ICE
SHORT TERM STORAGE:
-20°C
LONG TERM STORAGE:
-80°C
USE/STABILITY:
Keep the glycerol stock solution of the enzyme permanently at -20°C while pipetting to avoid loss of inhibitory activity.
HANDLING:
Avoid freeze/thaw cycles.
General Literature References
cAMP signaling in neurons: patterns of neuronal expression and intracellular localization for a novel protein, AKAP 150, that anchors the regulatory subunit of cAMP-dependent protein kinase II beta:
S.B. Glantz, et al.; Mol. Biol. Cell
3
, 1215 (1992)
Abstract
Cloning and expression of an intron-less gene for AKAP 75, an anchor protein for the regulatory subunit of cAMP-dependent protein kinase II beta:
A.H. Hirsch, et al.; J. Biol. Chem.
267
, 2131 (1992)
Abstract
Regional localization of the regulatory subunit (RII beta) of the type II cAMP-dependent protein kinase in human brain:
V. Licameli, et al.; Brain. Res.
578
, 61 (1992)
Abstract
Identification of a high affinity binding protein for the regulatory subunit RII beta of cAMP-dependent protein kinase in Golgi enriched membranes of human lymphoblasts:
R.M. Rios, et al.; EMBO J.
11
, 1723 (1992)
Abstract
Characterization of distinct tethering and intracellular targeting domains in AKAP75, a protein that links cAMP-dependent protein kinase II beta to the cytoskeleton:
S.B. Glantz, et al.; J. Biol. Chem.
268
, 12796 (1993)
Abstract
Phosphorylation of the regulatory subunit of type II beta cAMP-dependent protein kinase by cyclin B/p34cdc2 kinase impairs its binding to microtubule-associated protein 2:
G. Keryer, et al.; PNAS
90
, 5418 (1993)
Abstract
Mutagenesis of the regulatory subunit (RII beta) of cAMP-dependent protein kinase II beta reveals hydrophobic amino acids that are essential for RII beta dimerization and/or anchoring RII beta to the cytoskeleton:
Y. Li & C.S. Rubin; J. Biol. Chem.
270
, 1935 (1995)
Abstract
Overexpression of RII beta regulatory subunit of protein kinase A in human colon carcinoma cell induces growth arrest and phenotypic changes that are abolished by site-directed mutation of RII beta:
M. Nesterova, et al.; Eur. J. Biochem.
235
, 486 (1996)
Abstract
Defective motor behavior and neural gene expression in RIIbeta-protein kinase A mutant mice:
E.P. Brandon, et al.; J. Neurosci.
18
, 3639 (1998)
Abstract
Further Categories Containing This Product:
Enzymes
•
Recombinant Proteins/Fusion Proteins
ALX-201-228
Revised 07-Sep-05
cAMP-dependent Protein Kinase (Holoenzyme Type Iα, Cα2 (mouse)/RIα2 (bovine)) (recombinant)
SYNONYMS
Protein Kinase A (Holoenzyme Type Iα, Cα
2
(mouse)/RIα
2
(bovine)) (recombinant)
PKA (Holoenzyme Type Iα, Cα
2
(mouse)/RIα
2
(bovine)) (recombinant)
PRODUCT LINE
Signal Transduction
PRODUCT CATEGORY
PKA
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-201-228-C020
20 µg
474.00 USD
ALX-201-228-C050
50 µg
812.00 USD
ALX-201-228-C100
100 µg
1'489.00 USD
Product Specification
MW:
~168kDa
SOURCE/HOST:
Produced in
E. coli
. Inactive holoenzyme consisting of one dimeric bovine regulatory subunit type Iα and two monomeric mouse catalytic subunits. Can be activated by adding the second messenger cAMP (Prod. No.
ALX-480-011
) releasing two monomeric catalytic subunits.
FORMULATION:
Liquid. In 20mM MOPS, pH 7.0, containing 5mM MgCl
2
, 100µM ATP, 150mM NaCl and 50% glycerol.
SPECIFIC ACTIVITY:
1.5 x 10
7
U/mg (for the Cα catalytic subunit of the activated holoenzyme). One unit is defined as the amount of enzyme required to incorporate 1pmol phosphate per min into the specific substrate kemptide (Prod. No.
ALX-160-006
) at 30°C.
APPLICATION:
Suitable for analyzing PKA type I agonists (cAMP analogs) or antagonists.
SHIPPING:
SHIPPED ON DRY ICE
SHORT TERM STORAGE:
-20°C
LONG TERM STORAGE:
-80°C
USE/STABILITY:
In order to prevent dissociation of the holoenzyme complex use always buffer with 5-10mM MgCl
2
and 0.1-1mM ATP.
HANDLING:
Avoid freeze/thaw cycles.
Further Categories Containing This Product:
Enzymes
•
Recombinant Proteins/Fusion Proteins
ALX-153-003
Revised 03-Feb-05
Casein Kinase II Substrate
PRODUCT LINE
Signal Transduction
PRODUCT CATEGORY
Casein Kinase Substrates
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-153-003-M001
1 mg
70.00 USD
ALX-153-003-M005
5 mg
280.00 USD
Product Specification
SEQUENCE:
H-Arg-Arg-Arg-Glu-Glu-Glu-Thr-Glu-Glu-Glu-OH
FORMULA:
C
52
H
87
N
19
O
24
MW:
1362.4
PURITY:
≥96%
APPEARANCE:
White lyophilized powder.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
Product Description
Specific substrate for casein kinase II, derived from the kinase II phosphorylation site found in casein. Is not being phosphorylated by casein kinase I, cAMP-dependent protein kinase, protein kinase G, myosin light chain kinase, phosphorylase kinase and EGF receptor kinase.
Product Specific Literature References
A synthetic peptide substrate specific for casein kinase II:
E.A. Kuenzel & E.D. Krebs; PNAS
82
, 737 (1985)
Abstract
Further Categories Containing This Product:
Peptides
ALX-270-442
Revised 12-Jun-08
CDK1/2 Inhibitor III
SYNONYMS
5-Amino-3-((4-(aminosulfonyl)phenyl)amino)-N-(2,6-difluorophenyl)-1
H
-1,2,4-triazole-1-carbothioamide
PRODUCT LINE
Cell Cycle
PRODUCT CATEGORY
CDK & Cyclin Inhibitors
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-270-442-M001
1 mg
118.00 USD
Product Specification
FORMULA:
C
15
H
13
F
2
N
7
O
2
S
2
MW:
425.4
PURITY:
≥95% (HPLC)
APPEARANCE:
White to off-white solid.
SOLUBILITY:
Soluble in DMSO (10mg/ml).
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
USE/STABILITY:
Stock solutions are stable for up to 6 months when stored at -20°C.
HANDLING:
Protect from light.
HAZARD:
HARMFUL.
IDENTITY:
Identity determined by NMR.
Product Description
Cell permeable triazolo-diamine compound that displays anti-proliferative properties in various human cancer cells (IC
50
=20nM, 35nM and 92nM in HCT-116, HeLa, and A375 cells). Acts as a highly potent, ATP-competitive inhibitor of CDK1/cyclin B and CDK2/cyclin A (IC
50
=600pM and 500pM) with selectivity over VEGF-R2 and GSK-3β (IC
50
=32nM and 140nM).
Product Specific Literature References
1-Acyl-1H-[1,2,4]triazole-3,5-diamine analogues as novel and potent anticancer cyclin-dependent kinase inhibitors: synthesis and evaluation of biological activities:
R. Lin, et al.; J. Med. Chem.
48
, 4208 (2005)
Abstract
Further Categories Containing This Product:
Tyrosine Kinase Inhibitors
•
Antitumor Agents (Anti-proliferative)
•
VEGFs & VEGF-Rs Other Products
•
GSK-3 Inhibitors
ALX-270-391
Revised 18-Jul-07
CGP 74514A
SYNONYMS
N-(
cis
-
2-Aminocyclohexyl)-N-(3-chlorophenyl)-9-ethyl-9
H
-purine-2,6-diamine
PRODUCT LINE
Cell Cycle
PRODUCT CATEGORY
CDK & Cyclin Inhibitors
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-270-391-M001
1 mg
35.00 USD
ALX-270-391-M005
5 mg
70.00 USD
ALX-270-391-M025
25 mg
280.00 USD
Product Specification
FORMULA:
C
19
H
24
ClN
7
MW:
385.9
PURITY:
≥95%
APPEARANCE:
White to yellow solid.
SOLUBILITY:
Soluble in DMSO.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
HANDLING:
Protect from light. Packaged under inert gas.
Product Description
Cell permeable, potent and selective inhibitor of CDK1/cyclin B (IC
50
=25nM). Reported to affect the activities of other kinases only at much higher concentrations: PKCα (IC
50
=6.1µM), PKA (IC
50
=125µM) and EGFR (IC
50
>10µM). Induces mitochondrial damage and apoptosis in several human leukemia cell lines (>3µM).
Product Specific Literature References
2,6,9-trisubstituted purines: optimization towards highly potent and selective CDK1 inhibitors
:
P. Imbach, et al.; Bioorg. Med. Chem. Lett.
9
, 91 (1999)
Abstract
The lethal effects of pharmacological cyclin-dependent kinase inhibitors in human leukemia cells proceed through a phosphatidylinositol 3-kinase/Akt-dependent process
:
C. Yu, et al.; Cancer Res.
63
, 1822 (2003)
Abstract
Further Categories Containing This Product:
Apoptosis Inducers & Inhibitors Other Products
ALX-350-008
Revised 02-Oct-07
Chelerythrine chloride
SYNONYMS
1,2-Dimethoxy-N-methyl-[1,3]benzodioxolo[5,6-
c
]phenanthridinium chloride
PRODUCT LINE
Natural Products / Antibiotics
PRODUCT CATEGORY
Natural Products - Protein Kinase Inhibitors
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-350-008-M001
1 mg
25.00 USD
ALX-350-008-M005
5 mg
75.00 USD
ALX-350-008-M025
25 mg
300.00 USD
Product Specification
FORMULA:
C
21
H
18
NO
4
Cl
MW:
383.8
CAS NUMBER:
3895-92-9
MERCK INDEX:
14:
2051
RTECS:
FL9200000
SOURCE/HOST:
Synthetic.
PURITY:
≥97% (completely free of biologically active impurities, such as sanguinarine)
APPEARANCE:
Yellow to orange solid.
SOLUBILITY:
Soluble in DMSO, water, 100% ethanol or methanol.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
USE/STABILITY:
Heating to 40-50°C with gentle agitation may support complete solubilization. Further dilute with buffer just prior to use. Stock solutions should be refrigerated or frozen between for storage.
HAZARD:
HARMFUL.
Product Description
Potent, selective and cell permeable protein kinase C (PKC) inhibitor. Induces apoptosis. BH3 mimetic which inhibits Bcl-X
L
function.
Product Specific Literature References
Antiplatelet effects of chelerythrine chloride isolated from Zanthoxylum simulans:
F.-N. Ko, et al.; Biochim. Biophys. Acta
1052
, 360 (1990)
Abstract
Chelerythrine is a potent and specific inhibitor of protein kinase C:
J.M. Herbert, et al.; BBRC
172
, 993 (1990)
Abstract
Induction of apoptotic DNA fragmentation and cell death in HL-60 human promyelocytic leukemia cells by pharmacological inhibitors of protein kinase C:
W.D. Jarvis, et al.; Cancer Res.
54
, 1707 (1994)
Abstract
Identification of chelerythrine as an inhibitor of BclXL function
:
S.L. Chan, et al.; J. Biol. Chem.
278
, 20453 (2003)
Abstract
Chelerythrine and sanguinarine dock at distinct sites on BclXL that are not the classic BH3 binding cleft:
Y.H. Zhang, et al.; J. Mol. Biol.
364
, 536 (2006)
Abstract
The effect of chelerythrine on cell growth, apoptosis, and cell cycle in human normal and cancer cells in comparison with sanguinarine:
J. Malikova, et al.; Cell Biol. Toxicol.
22
, 439 (2006)
Abstract
Further Categories Containing This Product:
Bcl-2 Family Modulators
•
Alkaloids
•
PKC Inhibitors
•
Natural Products - Apoptosis Inducers & Inhibitors
ALX-350-353
Revised 16-Jun-08
Chlorogenic acid
SYNONYMS
1,3,4,5-Tetrahydroxycyclohexanecarboxylic acid 3-(3,4-dihydroxycinnamate)
3-O-Caffeoylquinic acid
Heriguard
NSC 407296
PRODUCT LINE
Natural Products / Antibiotics
PRODUCT CATEGORY
Antibiotics - Chemopreventive Agents
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-350-353-M500
500 mg
35.00 USD
ALX-350-353-G001
1 g
65.00 USD
Product Specification
FORMULA:
C
16
H
18
O
9
MW:
354.3
CAS NUMBER:
327-97-9
MERCK INDEX:
14:
2142
RTECS:
GU8480000
SOURCE/HOST:
Isolated from the leaves and fruits of dicotyledonous plants (e.g. coffee beans).
PURITY:
≥95%
APPEARANCE:
White to off-white solid.
SOLUBILITY:
25mg/ml soluble in 100% ethanol, DMSO, dimethyl formamide or PBS (pH 7.2).
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
USE/STABILITY:
We do not recommend storing the aqueous solution for more than one day.
Product Description
Analog of caffeic acid (Prod. No.
ALX-270-231
). Shows antioxidant, analgesic, antipyretic and chemopreventive activity. Inhibits Bcr-Abl tyrosine kinase and triggers MAP kinases p38-dependent apoptosis. Inhibitor of the tumor promoting activity of phorbol esters.
Product Specific Literature References
[Chlorogenic acid in coffee beans and their change during the roasting process. Report 1. Qualitative studies]:
R. Krasemann; Arch. Pharm.
293
, 721 (1960)
Abstract
Studies on the activities of tannins and related compounds, X. Effects of caffeetannins and related compounds on arachidonate metabolism in human polymorphonuclear leukocytes:
Y. Kimura, et al.; J. Nat. Prod.
50
, 392 (1987)
Abstract
Inhibitory effect of curcumin, chlorogenic acid, caffeic acid, and ferulic acid on tumor promotion in mouse skin by 12-O-tetradecanoylphorbol-13-acetate:
M.T. Huang, et al.; Cancer Res.
48
, 5941 (1988)
Abstract
;
Full Text
Inhibitory effect of curcumin and some related dietary compounds on tumor promotion and arachidonic acid metabolism in mouse skin:
A.H. Conney, et al.; Adv. Enzyme Regul.
31
, 385 (1991)
Abstract
Chlorogenic acid inhibits Bcr-Abl tyrosine kinase and triggers p38 mitogen-activated protein kinase-dependent apoptosis in chronic myelogenous leukemic cells:
G. Bandyopadhyay, et al.; Blood
104
, 2514 (2004)
Abstract
;
Full Text
Inhibition of activator protein-1, NF-kappaB, and MAPKs and induction of phase 2 detoxifying enzyme activity by chlorogenic acid:
R. Feng, et al.; J. Biol. Chem.
280
, 27888 (2005)
Abstract
;
Full Text
The chemopreventive properties of chlorogenic acid reveal a potential new role for the microsomal glucose-6-phosphate translocase in brain tumor progression:
A. Belkaid, et al.; Cancer Cell Int.
6
, 7 (2006)
Abstract
;
Full Text
Evaluation of the anti-inflammatory, analgesic and antipyretic activities of the natural polyphenol chlorogenic acid:
M.D. dos Santos, et al.; Biol. Pharm. Bull.
29
, 2236 (2006)
Abstract
;
Full Text
Inhibition of DNA methylation by caffeic acid and chlorogenic acid, two common catechol-containing coffee polyphenols:
W.J. Lee & B.T. Zhu; Carcinogenesis
27
, 269 (2006)
Abstract
;
Full Text
