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ALX-210-240
Revised 16-Mar-07
Polyclonal Antibody to Caveolin-2
PRODUCT LINE
Protein Synthesis, Modification & Degradation
PRODUCT CATEGORY
Caveolae / Related Products
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
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ALX-210-240-C100
100 µg
379.00 USD
Product Specification
SPECIES CROSSREACTIVITY:
Mouse
Rat
SOURCE/HOST:
From rabbit.
CONCENTRATION:
1mg/ml.
PURITY DETAIL:
Epitope-affinity purified IgG.
FORMULATION:
Liquid. In PBS containing 1mg/ml BSA and 0.05% sodium azide.
IMMUNOGEN:
Synthetic peptide corresponding to aa 1-19 (M
1
GLETEKADVQLF
MADDAY
19
C) of rat caveolin-2.
SPECIFICITY:
Recognizes mouse and rat caveolin-2. Detects a band of ~21kDa by Western blot. Does not cross-react with caveolin-1 or -3.
APPLICATION:
Immunoprecipitation
Western Blot (2µg/ml)
SHIPPING:
SHIPPED ON BLUE ICE
LONG TERM STORAGE:
-20°C
HANDLING:
Avoid freeze/thaw cycles.
BLOCKING PEPTIDE:
For Blocking Peptide see Prod. No.
ALX-153-029
.
Product Images
Please click on thumbnails to enlarge.
Further Categories Containing This Product:
NOS Regulation
•
Polyclonal Antibodies
ALX-210-888
Revised 25-May-07
Polyclonal Antibody to Caveolin-2 (mouse) (phosphorylated) (pTyr19)
PRODUCT LINE
Protein Synthesis, Modification & Degradation
PRODUCT CATEGORY
Caveolae / Related Products
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-210-888-C100
100 µg
385.00 USD
Product Specification
SPECIES CROSSREACTIVITY:
Mouse
SOURCE/HOST:
From rabbit.
PURITY DETAIL:
Epitope-affinity purified.
FORMULATION:
Liquid. Contains 1mg/ml BSA and 0.05% sodium azide.
IMMUNOGEN:
Synthetic peptide corresponding to aa 14-25 (M
14
ADDApYSHHSGC
25
) of mouse caveolin-2 phosphorylated at Tyr
19
.
SPECIFICITY:
Recognizes mouse phosphorylated caveolin-2. Detects a band of ~21kDa by Western blot.
APPLICATION:
Immunocytochemistry (5µg/ml)
Western Blot (2µg/ml)
SHIPPING:
SHIPPED ON BLUE ICE
LONG TERM STORAGE:
-20°C
BLOCKING PEPTIDE:
For Blocking Peptide see Prod. No.
ALX-153-060
.
Related Products
ALX-153-060
Blocking Peptide for PAb to Caveolin-2 (mouse) (phosphorylated) (pTyr
19
) (Prod. No.
ALX-210-888
)
Further Categories Containing This Product:
Phospho-specific Antibodies
•
NOS Regulation
•
Polyclonal Antibodies
ALX-210-241
Revised 24-Apr-08
Polyclonal Antibody to Caveolin-3
PRODUCT LINE
Protein Synthesis, Modification & Degradation
PRODUCT CATEGORY
Caveolae / Related Products
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-210-241-C100
100 µg
379.00 USD
Product Specification
SPECIES CROSSREACTIVITY:
Mouse
Rat
SOURCE/HOST:
From rabbit.
CONCENTRATION:
1mg/ml
PURITY DETAIL:
Epitope affinity-purified IgG.
FORMULATION:
Liquid. In PBS containing 1mg/ml BSA and 0.05% sodium azide.
IMMUNOGEN:
Synthetic peptide corresponding to aa 1-18 (M
1
MTEEHTDLEARIIKDIH
18
C) of rat caveolin-3.
SPECIFICITY:
Recognizes mouse and rat caveolin-3. Detects a band of ~21kDa by Western blot. Does not cross-react with caveolin-1 or -2.
APPLICATION:
Immunocytochemistry
Immunoprecipitation
Western Blot (1µg/ml)
SHIPPING:
SHIPPED ON BLUE ICE
LONG TERM STORAGE:
-20°C
HANDLING:
Avoid freeze/thaw cycles.
BLOCKING PEPTIDE:
For Blocking Peptide see Prod. No.
ALX-153-030
.
Product Images
Please click on thumbnails to enlarge.
Further Categories Containing This Product:
NOS Regulation
•
Polyclonal Antibodies
ALX-210-564
Revised 29-Nov-04
Polyclonal Antibody to Lck-interacting Molecule (human)
SYNONYMS
anti-LIME (human) PAb
PRODUCT LINE
Immunology
PRODUCT CATEGORY
Adaptor Proteins in T Cell Signal Transduction / Related Products
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-210-564-C100
100 µg
270.00 USD
Product Specification
SPECIES CROSSREACTIVITY:
Human
SOURCE/HOST:
From rabbit.
CONCENTRATION:
1mg/ml.
PURITY:
>95% (SDS-PAGE).
FORMULATION:
Liquid. In PBS, pH 7.4, containing 15mM sodium azide.
IMMUNOGEN:
Recombinant intracellular fragment corresponding to aa 141-295 of human LIME (Lck-interacting molecule).
SPECIFICITY:
Recognizes human LIME. Does not cross-react with mouse LIME.
APPLICATION:
Western Blot
Optimal conditions must be determined individually for each application.
SHIPPING:
SHIPPED ON BLUE ICE
SHORT TERM STORAGE:
+4°C
LONG TERM STORAGE:
-20°C
USE/STABILITY:
Stable for at least 6 months after receipt when stored at +4°C.
HANDLING:
After opening, prepare aliquots and store at -20°C. Avoid freeze/thaw cycles.
Further Categories Containing This Product:
Src Family Kinases / Related Products
•
Polyclonal Antibodies
ALX-210-565
Revised 29-Nov-04
Polyclonal Antibody to Lck-interacting Molecule (mouse)
SYNONYMS
anti-LIME (mouse) PAb
PRODUCT LINE
Immunology
PRODUCT CATEGORY
Adaptor Proteins in T Cell Signal Transduction / Related Products
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-210-565-C100
100 µg
270.00 USD
Product Specification
SPECIES CROSSREACTIVITY:
Mouse
SOURCE/HOST:
From rabbit.
CONCENTRATION:
1mg/ml.
PURITY:
>95% (SDS-PAGE).
FORMULATION:
Liquid. Protein A affinity purified antibody in PBS, pH 7.4, containing 15mM sodium azide.
IMMUNOGEN:
Recombinant fragment of mouse LIME (Lck-interacting molecule).
SPECIFICITY:
Recognizes mouse LIME. Does not cross-react with human LIME.
APPLICATION:
Immunoprecipitation
Western Blot
Optimal conditions must be determined individually for each application.
SHIPPING:
SHIPPED ON BLUE ICE
SHORT TERM STORAGE:
+4°C
LONG TERM STORAGE:
-20°C
USE/STABILITY:
Stable for at least 6 months after receipt when stored at +4°C.
HANDLING:
After opening, prepare aliquots and store at -20°C. Avoid freeze/thaw cycles.
Further Categories Containing This Product:
Src Family Kinases / Related Products
•
Polyclonal Antibodies
ALX-210-935
Revised 20-Feb-08
Polyclonal Antibody to MDA5 (human) (AT113)
SYNONYMS
anti-Melanoma Differentiation-associated Gene 5 (human) PAb (AT113)
anti-Helicard (human) PAb (AT113)
PRODUCT LINE
DNA Regulation / Transcription
PRODUCT CATEGORY
RNA Helicases / Related Products
Ordering Information
Product Numbers:
Format:
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ALX-210-935-C100
100 µg
360.00 USD
Product Specification
SPECIES CROSSREACTIVITY:
Human
SOURCE/HOST:
From rabbit.
CONCENTRATION:
1mg/ml
PURITY DETAIL:
Epitope-affinity purified.
FORMULATION:
Liquid. In PBS containing 0.02% sodium azide.
IMMUNOGEN:
Recombinant human MDA5 (melanoma differentiation-associated gene 5) (aa 78-555).
SPECIFICITY:
Recognizes human MDA5.
APPLICATION:
Immunoprecipitation (1:100)
Western Blot (1:1‘000)
SHIPPING:
SHIPPED ON BLUE ICE
SHORT TERM STORAGE:
+4°C
LONG TERM STORAGE:
-20°C
USE/STABILITY:
Stable for at least 1 year after receipt when stored as recommended.
HANDLING:
Avoid freeze/thaw cycles.
Product Images
Please click on thumbnails to enlarge.
Product Specific Literature References
Distinct RIG-I and MDA5 signaling by RNA viruses in innate immunity:
Y.M. Loo, et al.; J. Virol.
82
, 335 (2008)
Abstract
General Information
MDA5 is a highly conserved helicase whose ATPase activity can be stimulated by RNA and less potently by DNA. It contains two N-terminal CARD domains and a C-terminal helicase domain. The helicase domain, once freed from the CARD domains, then translocates from the cytoplasm to the nucleus where it acts on chromatin architecture. This could allow a more easy access of CAD, thereby accelerating the degradation of genomic DNA.
MANUFACTURER
Manufactured by Apotech Corporation.
General Literature References
Mda-5: An interferon-inducible putative RNA helicase with double-stranded RNA-dependent ATPase activity and melanoma growth-suppressive properties
:
D.C. Kang, et al.; PNAS
99
, 637 (2002)
Abstract
Further Categories Containing This Product:
NF-kB Pathway Other Products
•
Caspase Recruitment Domain [CARD] Proteins / Related Products
•
Polyclonal Antibodies
•
Antiviral Signalling / Related Products
•
Interferons & Interferon Receptors Other Products
ALX-210-352
Revised 30-Oct-06
Polyclonal Antibody to MDA5 (mouse) (AL180)
SYNONYMS
anti-Melanoma Differentiation-associated Gene 5 (mouse) PAb (AL180)
anti-Helicard (mouse) PAb (AL180)
PRODUCT LINE
DNA Regulation / Transcription
PRODUCT CATEGORY
RNA Helicases / Related Products
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-210-352-C100
100 µg
270.00 USD
Product Specification
SPECIES CROSSREACTIVITY:
Mouse
SOURCE/HOST:
From rabbit.
FORMULATION:
Liquid. Contains 0.02% sodium azide.
IMMUNOGEN:
Recombinant mouse MDA5 (melanoma differentiation-associated gene 5) (aa 2-208).
SPECIFICITY:
Recognizes mouse MDA5.
APPLICATION:
Western Blot
SHIPPING:
SHIPPED ON BLUE ICE
SHORT TERM STORAGE:
+4°C
LONG TERM STORAGE:
-20°C
USE/STABILITY:
Stable for at least 1 year after receipt when stored as recommended.
HANDLING:
Avoid freeze/thaw cycles.
Product Specific Literature References
Overexpression of Helicard, a CARD-Containing Helicase Cleaved during Apoptosis, Accelerates DNA Degradation:
M. Kovacsovics, et al.; Curr. Biol.
12
, 838 (2002)
Abstract
General Information
MDA5 is a highly conserved helicase whose ATPase activity can be stimulated by RNA and less potently by DNA. It contains two N-terminal CARD domains and a C-terminal helicase domain. The helicase domain, once freed from the CARD domains, then translocates from the cytoplasm to the nucleus where it acts on chromatin architecture. This could allow a more easy access of CAD, thereby accelerating the degradation of genomic DNA.
MANUFACTURER
Manufactured by Apotech Corporation.
General Literature References
Mda-5: An interferon-inducible putative RNA helicase with double-stranded RNA-dependent ATPase activity and melanoma growth-suppressive properties
:
D.C. Kang, et al.; PNAS
99
, 637 (2002)
Abstract
Further Categories Containing This Product:
NF-kB Pathway Other Products
•
Polyclonal Antibodies
•
Antiviral Signalling / Related Products
•
Interferons & Interferon Receptors Other Products
•
Caspase Recruitment Domain [CARD] Proteins / Related Products
ALX-210-900
Revised 25-Jan-08
Polyclonal Antibody to MyD88
SYNONYMS
anti-Myeloid Differentiation Primary Response Protein PAb
PRODUCT LINE
Inflammation
PRODUCT CATEGORY
Toll-IL-1 Receptor Adaptors / Related Products
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-210-900-R100
100 µl
360.00 USD
Product Specification
SPECIES CROSSREACTIVITY:
Human
Mouse
SOURCE/HOST:
From rabbit.
FORMULATION:
Liquid. Neat serum.
IMMUNOGEN:
Recombinant human MyD88 (myeloid differentiation primary response protein) (aa 1-172).
SPECIFICITY:
Recognizes the death domain of human and mouse MyD88.
APPLICATION:
Western Blot (1:5'000-1:8'000)
SHIPPING:
SHIPPED ON BLUE ICE
LONG TERM STORAGE:
+4°C
USE/STABILITY:
Stable for at least 6 months after receipt when stored at +4°C undiluted.
HANDLING:
Do not freeze/thaw.
Product Images
Please click on thumbnails to enlarge.
Product Specific Literature References
Tollip, a new component of the IL-1RI pathway, links IRAK to the IL-1 receptor
:
K. Burns, et al.; Nat. Cell Biol.
2
, 346 (2000)
Abstract
Roles of toll-like receptors in C-C chemokine production by renal tubular epithelial cells
:
N. Tsuboi, et al.; J. Immunol.
169
, 2026 (2002)
Abstract
General Information
MANUFACTURER
Manufactured by Apotech Corporation.
General Literature References
IRAK (Pelle) family member IRAK-2 and MyD88 as proximal mediators of IL- 1 signaling :
M. Muzio, et al.; Science
278
, 1612 (1997)
Abstract
Targeted disruption of the MyD88 gene results in loss of IL-1- and IL- 18-mediated function :
O. Adachi, et al.; Immunity
9
, 143 (1998)
Abstract
MyD88, an adapter protein involved in interleukin-1 signaling :
K. Burns, et al.; J. Biol. Chem.
273
, 12203 (1998)
Abstract
;
Full Text
MyD88 is an adaptor protein in the hToll/IL-1 receptor family signaling pathways:
R. Medzhitov, et al.; Mol. Cell
2
, 253 (1998)
Abstract
Unresponsiveness of MyD88-deficient mice to endotoxin:
T. Kawai, et al.; Immunity
11
, 115 (1999)
Abstract
The apoptotic signaling pathway activated by toll-like receptor-2
:
A.O. Aliprantis, et al.; EMBO J.
19
, 3325 (2000)
Abstract
;
Full Text
Further Categories Containing This Product:
Polyclonal Antibodies
ALX-210-904
Revised 25-Jan-08
Polyclonal Antibody to NALP1 (human) (AL176)
SYNONYMS
anti-NACHT-, LRR- and PYD-containing Protein 1 (human) PAb (AL176)
anti-DEFCAP (human) PAb (AL176)
anti-NAC (human) PAb (AL176)
anti-CARD7 (human) PAb (AL176)
anti-Caspase Recruitment Domain-containing Protein 7 (human) PAb (AL176)
PRODUCT LINE
Inflammation
PRODUCT CATEGORY
Inflammasome
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-210-904-R100
100 µl
270.00 USD
Product Specification
SPECIES CROSSREACTIVITY:
Human
SOURCE/HOST:
From rabbit.
PURITY:
Affinity purified.
FORMULATION:
Liquid. Neat serum.
IMMUNOGEN:
Synthetic peptide corresponding to aa 2-25 (A
2
GGAWGRLACYLEFLKKEELKEFQ
25
) of N-terminal human NALP1 (NACHT-, LRR- and PYD-containing protein 1).
SPECIFICITY:
Recognizes human NALP1. Does not cross-react with mouse NALP1.
APPLICATION:
Western Blot
SHIPPING:
SHIPPED ON BLUE ICE
SHORT TERM STORAGE:
+4°C
LONG TERM STORAGE:
-20°C
USE/STABILITY:
Stable for at least 1 year after receipt when stored as recommended.
HANDLING:
Avoid freeze/thaw cycles.
POSITIVE CONTROL:
For Positive Control (Western blot) see Prod. No.
ALX-840-603
.
Product Images
Please click on thumbnails to enlarge.
Product Specific Literature References
The inflammasome: a molecular platform triggering activation of inflammatory caspases and processing of proIL-beta
:
F. Martinon; Mol. Cell.
10
, 417 (2002)
Abstract
General Information
MANUFACTURER
Manufactured by Apotech Corporation.
General Literature References
Signalling: Initiation of pro-IL-1beta processing
:
E. Bell; Nat. Rev. Immunol.
2
, 719 (2002), (Review)
Abstract
The PYRIN-CARD protein ASC is an activating adaptor for caspase-1
:
S.M. Srinivasula, et al.; J. Biol. Chem.
277
, 21119 (2002)
Abstract
NALPS: a novel protein family involved in inflammation
:
J. Tschopp, et al.; Nat. Rev. Mol. Cell Biol.
4
, 95 (2003), (Review)
Abstract
;
Full Text
Further Categories Containing This Product:
Polyclonal Antibodies
•
Caspase Recruitment Domain [CARD] Proteins / Related Products
ALX-210-017
Revised 12-Apr-07
Polyclonal Antibody to NALP1 (human) (CT) (Bur 242)
SYNONYMS
anti-NACHT-, LRR- and PYD-containing Protein 1 (human) (CT) PAb (Bur 242)
anti-DEFCAP (human) (CT) PAb (Bur 242)
anti-NAC (human) (CT) PAb (Bur 242)
anti-CARD7 (human) (CT) PAb (Bur 242)
anti-Caspase Recruitment Domain-containing Protein 7 (human) (CT) PAb (Bur 242)
PRODUCT LINE
Inflammation
PRODUCT CATEGORY
Inflammasome
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-210-017-R050
50 µl
190.00 USD
Product Specification
SPECIES CROSSREACTIVITY:
Human
SOURCE/HOST:
From rabbit.
FORMULATION:
Liquid. Antiserum containing PBS and 0.05% sodium azide.
IMMUNOGEN:
Synthetic peptide corresponding to aa 1058-1077 (C
1058
VPSPASQGDLHTKPLGTDD
1077
) of C-terminal human NALP1 (NACHT-, LRR- and PYD-containing protein 1).
SPECIFICITY:
Recognizes human NALP1. Does not cross-react with mouse NALP1.
APPLICATION:
Immunohistochemistry (paraffin sections)
Immunoprecipitation
Western Blot
SHIPPING:
SHIPPED ON BLUE ICE
SHORT TERM STORAGE:
+4°C
LONG TERM STORAGE:
-80°C
HANDLING:
Avoid freeze/thaw cycles.
POSITIVE CONTROL:
For Positive Control (Western blot) see Prod. No.
ALX-840-603
.
Product Specific Literature References
A novel enhancer of the Apaf1 apoptosome involved in cytochrome c-dependent caspase activation and apoptosis
:
Z.L. Chu, et al.; J. Biol. Chem.
276
, 9239 (2001)
Abstract
;
Full Text
General Information
MANUFACTURER
Manufactured by Apotech Corporation.
Further Categories Containing This Product:
Poly
