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ALX-202-035
Revised 28-Jun-07
Phosphodiesterase 3':5'-cyclic Nucleotide (bovine brain)
PRODUCT LINE
Signal Transduction
PRODUCT CATEGORY
Phosphodiesterases/Related Products
Ordering Information
Product Numbers:
Format:
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ALX-202-035-U001
1 U
440.00 USD
Product Specification
CAS NUMBER:
9040-59-9
SOURCE/HOST:
Isolated from bovine brain.
QUANTITY:
1-5U/mg protein without activation.
15-30U/mg protein with activator.
PURITY DETAIL:
Affinity-purified product. Depleted of protein activator.
FORMULATION:
Lyophilized. Contains ~5% protein (Lowry), buffer salts (TRIS-Cl) and lactose.
SOLUBILITY:
Soluble in water.
ACTIVITY:
~15-30U/mg protein in the presence of 0.03mM Ca
2+
and a saturating level (10units/mg) of calmodulin (Prod. No.
ALX-200-005
). Sold on the basis of activated units. One unit is defined as the amount of enzyme that hydrolyzes 1µM of 3’:5’-cyclic-AMP (Prod. No.
ALX-480-011
) to 5’-AMP per min. at pH 7.5 at 30°C.
SHIPPING:
SHIPPED ON BLUE ICE
LONG TERM STORAGE:
-20°C
Further Categories Containing This Product:
Enzymes
•
Phosphodiesterases/Related Products
•
Natural Proteins
ALX-210-126
Revised 07-Aug-07
Polyclonal Antibody to Calreticulin
PRODUCT LINE
Signal Transduction
PRODUCT CATEGORY
Calreticulin/Related Products
Ordering Information
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ALX-210-126-R100
100 µl
379.00 USD
Product Specification
SPECIES CROSSREACTIVITY:
Human
Mouse
Rat
Others
SOURCE/HOST:
From rabbit.
FORMULATION:
Liquid. Antiserum containing 0.05% sodium azide.
IMMUNOGEN:
Recombinant human calreticulin.
SPECIFICITY:
Recognizes human, mouse, rat, rabbit and monkey calreticulin.
APPLICATION:
Immunohistochemistry (1:100)
Immunocytochemistry
Immunoprecipitation
Western Blot (1:1’000)
SHIPPING:
SHIPPED ON BLUE ICE
LONG TERM STORAGE:
-20°C
HANDLING:
Avoid freeze/thaw cycles.
Product Images
Please click on thumbnails to enlarge.
Product Specific Literature References
Redistribution of intracellular Ca2+ stores during phagocytosis in human neutrophils:
O. Stendahl, et al.; Science
265
, 1439 (1994)
Abstract
Cell surface calreticulin is a putative mannoside lectin which triggers mouse melanoma cell spreading:
T.K. White, et al.; J. Biol. Chem.
270
, 15926 (1995)
Abstract
;
Full Text
Calreticulin interacts with newly synthesized human immunodeficiency virus type 1 envelope glycoprotein, suggesting a chaperone function similar to that of calnexin:
A. Otteken & B. Moss; J. Biol. Chem.
271
, 97 (1996)
Abstract
;
Full Text
Further Categories Containing This Product:
Endoplasmatic Reticulum Stress
•
ER-Golgi Intermediate Compartment [ERGIC]/Related Products
•
Polyclonal Antibodies
ALX-210-171
Revised 03-Jun-05
Polyclonal Antibody to Calreticulin (CT)
PRODUCT LINE
Signal Transduction
PRODUCT CATEGORY
Calreticulin/Related Products
Ordering Information
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Format:
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ALX-210-171-R100
100 µl
379.00 USD
Product Specification
SPECIES CROSSREACTIVITY:
Human
Mouse
Rat
Dog
Others
SOURCE/HOST:
From chicken.
FORMULATION:
Liquid. Contains 1mg/ml BSA and 0.05% sodium azide.
IMMUNOGEN:
Synthetic peptide corresponding to aa 399-414 (D
399
EKEEDEEESPGQAKD
414
) of mouse calreticulin.
SPECIFICITY:
Recognizes human, mouse, rat, rabbit, dog and hamster calreticulin. Detects a band of ~60kDa and and unidentified band of ~120kDa by Western blot.
APPLICATION:
Western Blot.
SHIPPING:
SHIPPED ON BLUE ICE
LONG TERM STORAGE:
-20°C
BLOCKING PEPTIDE:
For Blocking Peptide see Prod. No.
ALX-153-016
.
Product Images
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Related Products
ALX-153-016
Blocking Peptide for PAb to Calreticulin (CT) (Prod. No.
ALX-210-171
)
Further Categories Containing This Product:
Endoplasmatic Reticulum Stress
•
ER-Golgi Intermediate Compartment [ERGIC]/Related Products
•
Polyclonal Antibodies
ALX-210-170/1
Revised 19-May-08
Polyclonal Antibody to Calreticulin (NT)
PRODUCT LINE
Signal Transduction
PRODUCT CATEGORY
Calreticulin/Related Products
Ordering Information
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ALX-210-170/1-R100
100 µl
379.00 USD
Product Specification
SPECIES CROSSREACTIVITY:
Human
Mouse
Rat
Dog
Others
SOURCE/HOST:
From chicken.
CONCENTRATION:
1.1mg/ml
PURITY DETAIL:
Epitope-affinity purified IgY.
FORMULATION:
Liquid. Contains 1mg/ml BSA and 0.05% sodium azide.
IMMUNOGEN:
Synthetic peptide corresponding to aa 24-43 (K
24
EQFLDGDAWTNRWVESKHK
43
) of mouse calreticulin.
SPECIFICITY:
Recognizes human, mouse, rat, dog and hamster calreticulin. Detects a band of ~60-66kDa by Western blot.
APPLICATION:
Immunocytochemistry
Western Blot (1:1’000)
SHIPPING:
SHIPPED ON BLUE ICE
LONG TERM STORAGE:
-20°C
BLOCKING PEPTIDE:
For Blocking Peptide See Prod. No.
ALX-153-017
.
Product Images
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Related Products
ALX-153-017
Blocking Peptide for PAb to Calreticulin (NT) (Prod. No.
ALX-210-170/1
)
Further Categories Containing This Product:
Endoplasmatic Reticulum Stress
•
ER-Golgi Intermediate Compartment [ERGIC]/Related Products
•
Polyclonal Antibodies
ALX-210-290
Revised 11-May-07
Polyclonal Antibody to Calsequestrin
PRODUCT LINE
Signal Transduction
PRODUCT CATEGORY
Calcium Signalling (Intracellular) Other Products
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ALX-210-290-R100
100 µl
379.00 USD
Product Specification
SPECIES CROSSREACTIVITY:
Human
Mouse
Rat
Sheep
Dog
SOURCE/HOST:
From rabbit.
FORMULATION:
Liquid. In PBS containing 0.05% sodium azide.
IMMUNOGEN:
Purified dog cardiac calsequestrin.
SPECIFICITY:
Recognizes human, mouse, rat, dog and sheep calsequestrin. Recognizes both cardiac and skeletal muscle calsequestrin. Detects a band of ~55kDa by Western blot.
CROSSREACTIVITY PROTEINS:
Additional bands at ~97kDa may be observed and have been reported to be calsequestrin-like proteins.
APPLICATION:
Immunoprecipitation
Western Blot (1:2'500)
SHIPPING:
SHIPPED ON BLUE ICE
LONG TERM STORAGE:
-20°C
HANDLING:
Avoid freeze/thaw cycles.
Product Specific Literature References
Developmental changes in cardiac sarcoplasmic reticulum in sheep
:
L. Mahony & L.R. Jones; J. Biol. Chem.
261
, 15257 (1986)
Abstract
;
Full Text
Complex formation between junctin, triadin, calsequestrin, and the ryanodine receptor. Proteins of the cardiac junctional sarcoplasmic reticulum membrane
:
L. Zhang, et al.; J. Biol. Chem.
272
, 23389 (1997)
Abstract
;
Full Text
Identification of triadin 1 as the predominant triadin isoform expressed in mammalian myocardium
:
Y.M. Kobayashi & L.R. Jones; J. Biol. Chem.
274
, 28660 (1999)
Abstract
;
Full Text
General Information
The sarcoplasmic reticulum (SR) is in part responsible for maintaining the level of intracellular Ca
2+
in cardiac and skeletal muscle by storing and releasing Ca
2+
. Several intralumenal SR Ca
2+
binding proteins have been identified, the most prominent of these is calsequestrin. Calsequestrin is a calcium binding protein known to sequester calcium accumulated in the sarcoplasmic reticulum of muscle cells during relaxation and is found discretely localized to the junctional and corbular (terminal cisternae) SR. Calsequestrin functions to localize Ca
2+
near the junctional face of the terminal cisternae from which Ca
2+
can be released into the cytosol via the ryanodine receptor. This protein is highly acidic and has a large capacity and moderate to low affinity for Ca
2+
. Two mammalian isoforms of calequestrin exist, a cardiac and a skeletal muscle isoform, which are the products of different genes and are 63% identical. This antibody recognizes both cardiac and skeletal muscle calsequestrin from a variety of species.
Further Categories Containing This Product:
Polyclonal Antibodies
ALX-210-292
Revised 13-Jan-05
Polyclonal Antibody to Na+/Ca2+/K+Exchanger (rat)
SYNONYMS
anti-NCKX2 (rat) PAb
PRODUCT LINE
Signal Transduction
PRODUCT CATEGORY
Calcium Signalling (Intracellular) Other Products
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ALX-210-292-R200
200 µl
379.00 USD
Product Specification
SPECIES CROSSREACTIVITY:
Rat
SOURCE/HOST:
From rabbit.
CONCENTRATION:
1mg/ml.
FORMULATION:
Liquid. Epitope-affinity purified IgG in PBS containing 1mg/ml BSA and 0.05% sodium azide.
IMMUNOGEN:
Synthetic peptide corresponding to aa 90-102 (D
90
LNDKIRDYTPQP
102
C) of rat NCKX2 (Na
+
/ Ca
2+
/K
+
exchanger).
SPECIFICITY:
Recognizes rat NCKX2. Detects a band of ~78kDa by Western blot.
APPLICATION:
Immunohistochemistry (frozen sections (1:100))
Western Blot (1:100)
SHIPPING:
SHIPPED ON BLUE ICE
LONG TERM STORAGE:
-20°C
HANDLING:
Avoid freeze/thaw cycles.
BLOCKING PEPTIDE:
For Blocking Peptide see Prod. No.
ALX-163-008
.
Product Images
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Product Description
Na
+
/Ca
2+
-K
+
exchanger proteins (NCKX1) have been reported to occur in retinal photoreceptors and in brain (NCKX2). Unlike the abundant and widely expressed Na
+
/Ca
2+
exchanger which catalyzes the exchange of 3 Na
+
ions for 1 Ca
2+
ion to modulate intracellular Ca
2+
levels, NCKX isoforms exchange 4 Na
+
ions for 1 Ca
2+
and 1 K
+
ion. The Na
+
/Ca
2+
-K
+
exchanger uses the transmembrane Na
+
gradient to catalyze countertransport of Ca
2+
in a K
+
-dependent mechanism against its electrochemical gradient. It is hypothesized that NCKX2 plays a significant role in calcium homeostasis and the regulation of neuronal function.
Further Categories Containing This Product:
Polyclonal Antibodies
ALX-210-460
Revised 26-Apr-07
Polyclonal Antibody to Nucleobindin-2 (mouse)
SYNONYMS
anti-NUCB2 (mouse) PAb
anti-DNA-binding Protein NEFA (mouse) PAb
anti-Nesfatin (mouse) PAb
PRODUCT LINE
Signal Transduction
PRODUCT CATEGORY
Calcium Signalling (Intracellular) Other Products
Ordering Information
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ALX-210-460-C100
100 µg
310.00 USD
Product Specification
SPECIES CROSSREACTIVITY:
Mouse
SOURCE/HOST:
From rabbit.
CONCENTRATION:
1mg/ml.
PURITY DETAIL:
Purified IgG.
FORMULATION:
Liquid. In PBS, pH 7.4. Contains no preservatives.
IMMUNOGEN:
Recombinant mouse nucleobindin-2 (NUCB2).
SPECIFICITY:
Recognizes mouse nucleobindin-2.
APPLICATION:
ELISA
(direct and indirect: 1:2’000-1:5’000)
Western Blot
(1:2’000-1:5’000 using ECL. Suggested blocking and dilution buffer is PBST containing 0.05% Tween 20 and 5% skim milk. Suggested incubation time is 1 hour at room temperature).
Optimal conditions must be determined individually for each application.
SHIPPING:
SHIPPED ON BLUE ICE
SHORT TERM STORAGE:
+4°C
LONG TERM STORAGE:
-20°C
USE/STABILITY:
Stable for 1-2 weeks when stored at +4°C.
HANDLING:
Avoid freeze/thaw cycles. After opening, prepare aliquots and store at -20°C.
Product Images
Please click on thumbnails to enlarge.
General Information
MANUFACTURER
Manufactured by AdipoGen, Inc.
Further Categories Containing This Product:
Food Intake Modulators Other Products
•
Polyclonal Antibodies
ALX-210-099
Revised 04-Jan-07
Polyclonal Antibody to PDE5A
SYNONYMS
anti-Phosphodiesterase 5A PAb
anti-cGMP-specific 3’,5’-cyclic phosphodiesterase PAb
anti-CGB-PDE PAb
PRODUCT LINE
Signal Transduction
PRODUCT CATEGORY
Phosphodiesterases/Related Products
Ordering Information
Product Numbers:
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ALX-210-099-C050
50 µg
150.00 USD
Product Specification
SPECIES CROSSREACTIVITY:
Mouse
SOURCE/HOST:
From rabbit.
CONCENTRATION:
2.5mg/ml
PURITY DETAIL:
Epitope-affinity purified.
FORMULATION:
Liquid. In PBS containing 30% glycerol and 0.02% sodium azide.
IMMUNOGEN:
Synthetic peptide corresponding to aa 857-875 (CA
857
EQQEKMLINGESGQAKRN
875
) of human PDE5A (phosphodiesterase 5A).
SPECIFICITY:
Recognizes mouse and bovine PDE5A.
APPLICATION:
Western Blot (1:10’000).
SHIPPING:
SHIPPED ON BLUE ICE
SHORT TERM STORAGE:
+4°C
LONG TERM STORAGE:
-20°C
HANDLING:
After opening, prepare aliquots and store at -20°C. Avoid freeze/thaw cycles.
Product Images
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Further Categories Containing This Product:
Polyclonal Antibodies
ALX-260-070
Revised 24-Apr-08
Proteasome Substrate III (Fluorogenic)
SYNONYMS
Calpain Substrate (Fluorogenic)
Suc-LLVY-AMC
Suc-Leu-Leu-Val-Tyr-AMC
PRODUCT LINE
Ubiquitin & Proteasome
PRODUCT CATEGORY
Proteasome/Related Products
Ordering Information
Product Numbers:
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ALX-260-070-M001
1 mg
25.00 USD
ALX-260-070-M005
5 mg
60.00 USD
Product Specification
SEQUENCE:
Suc-Leu-Leu-Val-Tyr-AMC (AMC=7-Amino-4-methylcoumarin)
FORMULA:
C
40
H
52
N
5
O
10
MW:
762.9
PURITY:
≥98% (HPLC)
APPEARANCE:
White to off-white lyophilized powder.
SOLUBILITY:
Soluble in DMSO.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
Product Description
Fluorogenic proteasome substrate. Also acts as a substrate for many other proteinases.
Product Specific Literature References
Comparative specificity and kinetic studies on porcine calpain I and calpain II with naturally occurring peptides and synthetic fluorogenic substrates:
T. Sasaki, et al.; J. Biol. Chem.
259
, 12489 (1984)
Abstract
;
Full Text
Purification and characterization of a Z-Leu-Leu-Leu-MCA degrading protease expected to regulate neurite formation: a novel catalytic activity in proteasome:
S. Tsubuki, et al.; BBRC
196
, 1195 (1993)
Abstract
Modulation of hypoxia-induced calpain activity in rat renal proximal tubules:
C.L. Edelstein, et al.; Kidney Int.
50
, 1150 (1996)
Abstract
Kinetic characterization of the chymotryptic activity of the 20S proteasome:
R.L. Stein, et al.; Biochemistry
35
, 3899 (1996)
Abstract
An alpha-mercaptoacrylic acid derivative is a selective nonpeptide cell-permeable calpain inhibitor and is neuroprotective:
K.K.W. Wang, et al.; PNAS
93
, 6687 (1996)
Abstract
Reovirus-Induced Apoptosis Is Preceded by Increased Cellular Calpain Activity and Is Blocked by Calpain Inhibitors
:
R.L. Debiasi, et al.; J. Virology
73
, 695 (1999)
Abstract
;
Full Text
General Information
BACKGROUND/TECHNICAL INFORMATION
AMC has an excitation maximum of 380nm and an emission maximum of 460nm.
Further Categories Containing This Product:
Calpains/Related Products
•
Proteases Other Products
ALX-270-116
Revised 15-Jan-08
Quazinone
SYNONYMS
Ro 13-6438
PRODUCT LINE
Signal Transduction
PRODUCT CATEGORY
Phosphodiesterases/Related Products
Ordering Information
Product Numbers:
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ALX-270-116-M005
5 mg
45.00 USD
ALX-270-116-M025
25 mg
195.00 USD
Product Specification
FORMULA:
C
11
H
10
ClN
3
O
MW:
235.7
CAS NUMBER:
70018-51-8
PURITY:
≥98% (TLC)
APPEARANCE:
White to off-white solid.
SOLUBILITY:
Soluble in DMSO (3mg/ml), 100% ethanol (1mg/ml) or water (5mg/ml).
SHIPPING:
AMBIENT
LONG TERM STORAGE:
+20°C
Product Description
Selective inhibitor of cGMP-specific phosphodiesterase. The product is not sterile.
Product Specific Literature References
Studies on the mechanism of positive inotropic activity of Ro 13-6438, a structurally novel cardiotonic agent with vasodilating properties:
M. Holck, et al.; J. Cardiovasc. Pharmacol.
6
, 520 (1984)
Abstract
Further Categories Containing This Product:
Phosphodiesterases/Related Products
ALX-385-001
Revised 08-Apr-08
Quercetin . dihydrate
SYNONYMS
3,3',4',5,7-Pentahydroxyflavone . 2H
2
O
PRODUCT LINE
Natural Products / Antibiotics
PRODUCT CATEGORY
Flavonoids/Related Products
Ordering Information
