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Receptors
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ALX-550-117 Revised 16-Aug-02
(2R,4R)-(+)-Azetidine-2,4-dicarboxylic acid
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PRODUCT LINE Neurobiology
PRODUCT CATEGORY Glutamate Receptors (Metabotropic) / Related Products
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ALX-550-117-M001   1 mg 90.00 USD Add To Cart
Product Specification
FORMULA: C5H7NO4
MW: 145.1
PURITY: ≥98%
APPEARANCE: White powder.
SOLUBILITY: Soluble in water.
SHIPPING: AMBIENT
LONG TERM STORAGE: +4°C

Product Specific Literature References
Synthesis and metabotropic receptor activity of the novel rigidified glutamate analogues (+)- and (-)-trans-azetidine-2,4-dicarboxylic acid and their N-methyl derivatives: A.P. Kozikowski, et al.; J. Med. Chem. 36, 2706 (1993) Abstract
Pharmacological agents acting at subtypes of metabotropic glutamate receptors: D.D. Schoepp, et al.; Neuropharmacology 38, 1431 (1999), (Reviev) Abstract
 
 
ALX-550-116 Revised 16-Aug-02
(2S,4S)-(-)-Azetidine-2,4-dicarboxylic acid
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PRODUCT LINE Neurobiology
PRODUCT CATEGORY Glutamate Receptors (Metabotropic) / Related Products
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ALX-550-116-M001   1 mg 90.00 USD Add To Cart
Product Specification
FORMULA: C5H7NO4
MW: 145.1
PURITY: ≥98%
APPEARANCE: White powder.
SOLUBILITY: Soluble in water.
SHIPPING: AMBIENT
LONG TERM STORAGE: +4°C

Product Specific Literature References
Synthesis and metabotropic receptor activity of the novel rigidified glutamate analogues (+)- and (-)-trans-azetidine-2,4-dicarboxylic acid and their N-methyl derivatives: A.P. Kozikowski, et al.; J. Med. Chem. 36, 2706 (1993) Abstract
Pharmacological agents acting at subtypes of metabotropic glutamate receptors: D.D. Schoepp, et al.; Neuropharmacology 38, 1431 (1999), (Review) Abstract
 
 
ALX-270-353 Revised 16-Feb-07
BADGE
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SYNONYMS Bisphenol A diglycidyl ether
2,2'-[(1-Methylethylidene)bis(4,1-phenyleneoxymethylene)]bis-oxirane
PRODUCT LINE DNA Regulation / Transcription
PRODUCT CATEGORY PPAR Antagonists
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ALX-270-353-G025   25 g 19.00 USD Add To Cart
Product Specification
FORMULA: C21H24O4
MW: 340.4
CAS NUMBER: 1675-54-3
PURITY: ≥85%
FORMULATION: Neat oil.
SOLUBILITY: Miscible in organic solvents as 100% ethanol, DMSO or dimethyl formamide. Insoluble in PBS, pH 7.2.
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: -20°C
USE/STABILITY: Stock solutions in 100% ethanol, DMSO or dimethyl formamide are stable for at least 1 year if stored at -20°C.

Product Description
Antagonist of PPARγ. Binds to PPARγ with an apparent Kd of 100µM.
Product Specific Literature References
A synthetic antagonist for the peroxisome proliferator-activated receptor gamma inhibits adipocyte differentiation: H.M. Wright, et al.; J. Biol. Chem. 275, 1873 (2000) Abstract; Full Text
Bisphenol A diglycidyl ether induces apoptosis in tumour cells independently of peroxisome proliferator-activated receptor-gamma, in caspase-dependent and -independent manners: S. Fehlberg, et al.; Biochem. J. 362, 573 (2002) Abstract; Full Text
Bisphenol a diglycidyl ether (BADGE) suppresses tumor necrosis factor-alpha production as a PPARgamma agonist in the murine macrophage-like cell line, RAW 264.7: M. Nakamuta, et al.; Cell Biol. Int. 26, 235 (2002) Abstract
Induction of apoptosis in human and rat glioma by agonists of the nuclear receptor PPARgamma: T. Zander, et al.; J. Neurochem. 81, 1052 (2002) Abstract
General Information
Interferes with the ability of 3T3-L1 and 3T3-F442A cells to undergo hormone-mediated cell differentiation.
 
 
ALX-522-025 Revised 25-Aug-08
BAFF, Soluble (human) (recombinant)
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SYNONYMS BlyS, Soluble (human) (recombinant)
TALL-1, Soluble (human) (recombinant)
THANK, Soluble (human) (recombinant)
zTNF4, Soluble (human) (recombinant)
TNFSF 13B/20, Soluble (human) (recombinant)
CD257, Soluble (human) (recombinant)
PRODUCT LINE Chemokines & Cytokines
PRODUCT CATEGORY BAFF
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ALX-522-025-C010   10 µg 365.00 USD Add To Cart
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Product Specification
SPECIES CROSSREACTIVITY:
Human
Mouse
MW: ~28kDa (SDS-PAGE).
SOURCE/HOST: Produced in E. coli. The extracellular domain of human BAFF (aa 83-285) is fused at the N-terminus to a linker peptide (6 aa) and a FLAG®-tag.
CONCENTRATION: 0.1mg/ml after reconstitution.
PURITY: ≥95% (SDS-PAGE)
FORMULATION: Lyophilized. Contains PBS.
ENDOTOXIN CONTENT: <0.1EU/µg purified protein (LAL test; Bio Whittaker).
RECONSTITUTION: Reconstitute with 100µl sterile water. Further dilutions should be made with medium containing 5% fetal calf serum.
SPECIFICITY: Binds to human and mouse (weak) BCMA, TACI and BAFF-R.
BIOLOGICAL ACTIVITY: Mediates splenocyte survival. Induces monocyte survival.
APPLICATION: Detection of receptors of human soluble BAFF on target cells.
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: -20°C
USE/STABILITY: Stable for at least 6 months after receipt when stored at -20°C.
HANDLING: Avoid freeze/thaw cycles. After reconstitution, prepare aliquots and store at -20°C.
Product Images
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Product Specific Literature References
BAFF binds to the tumor necrosis factor receptor-like molecule B cell maturation antigen and is important for maintaining the peripheral B cell population: J.S. Thompson, et al.; J. Exp. Med. 192, 129 (2000) Abstract; Full Text
BAFF mediates survival of peripheral immature B lymphocytes: M. Batten, et al.; J. Exp. Med. 192, 1453 (2000) Abstract; Full Text
Maturation of marginal zone and follicular B cells requires B cell activating factor of the tumor necrosis factor family and is independent of B cell maturation antigen: P. Schneider, et al.; J. Exp. Med. 194, 1691 (2001) Abstract
T cell costimulation by the TNF ligand BAFF: B. Huard, et al.; J. Immunol. 167, 6225 (2001) Abstract
Aberrant expression of B-lymphocyte stimulator by B chronic lymphocytic leukemia cells: a mechanism for survival: A.J. Novak, et al.; Blood 100, 2973 (2002) Abstract; Full Text
BAFF is a survival and maturation factor for mouse B cells: A.G. Rolink, et al.; Eur. J. Immunol. 32, 2004 (2002) Abstract
Expression of BLyS and its Receptors in B-Cell Non-Hodgkin Lymphoma: Correlation with Disease Activity and Patient Outcome: A.J. Novak, et al.; Blood 104, 2247 (2004) Abstract
TACI is mutant in common variable immunodeficiency and IgA deficiency: E. Castigli, et al.; Nat. Genet. 37, 829 (2005) Abstract
A role for BLyS in the activation of innate immune cells: S.K. Chang, et al.; Blood 108, 2687 (2006) Abstract; Full Text
Viral Double-Stranded RNA Triggers Ig Class Switching by Activating Upper Respiratory Mucosa B Cells through an Innate TLR3 Pathway Involving BAFF: W. Xu, et al.; J. Immunol. 181, 276 (2008) Abstract
General Information
BACKGROUND/TECHNICAL INFORMATION

Swiss-Prot link Q9Y275: BAFF (human)
AfCS Signalling Gateway link A000383: BAFF (mouse)

FLAG is a registered trademark of Sigma-Aldrich Co.
MANUFACTURER Manufactured by Apotech Corporation.
General Literature References
TNFR-associated factor-3 is associated with BAFF-R and negatively regulates BAFF-R-mediated NF-kappa B activation and IL-10 production: L.G. Xu & H.B. Shu; J. Immunol. 169, 6883 (2002) Abstract; Full Text
Further Categories Containing This Product:
Recombinant Proteins / Fusion Proteins
 
 
ALX-522-052 Revised 02-May-07
BAFF, Soluble (mouse) (recombinant)
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SYNONYMS BLyS, Soluble (mouse) (recombinant)
TALL-1, Soluble (mouse) (recombinant)
THANK, Soluble (mouse) (recombinant)
zTNF4, Soluble (mouse) (recombinant)
TNFSF 13B/20, Soluble (mouse) (recombinant)
CD257, Soluble (mouse) (recombinant)
PRODUCT LINE Chemokines & Cytokines
PRODUCT CATEGORY BAFF
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ALX-522-052-C010   10 µg 365.00 USD Add To Cart
Product Specification
SPECIES CROSSREACTIVITY:
Human
Mouse
MW: ~17kDa (SDS-PAGE).
SOURCE/HOST: Produced in HEK 293 cells. The extracellular domain of mouse BAFF (aa 127-309) is fused at the N-terminus to a linker peptide (10 aa) and a FLAG®-tag.
CONCENTRATION: 0.1mg/ml after reconstitution.
PURITY: ≥90% (SDS-PAGE)
FORMULATION: Lyophilized. Contains PBS.
ENDOTOXIN CONTENT: <0.1EU/µg purified protein (LAL test; Bio Whittaker).
RECONSTITUTION: Reconstitute with 100µl sterile water. Further dilutions should be made with medium containing 5% fetal calf serum or other carrier protein.
SPECIFICITY: Binds to human (weak) and mouse BCMA, TACI and BAFF-R.
BIOLOGICAL ACTIVITY: Mediates splenocyte survival.
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: -20°C
USE/STABILITY: Stable for at least 6 months after receipt when stored at -20°C.
HANDLING: After reconstitution, prepare aliquots and store at -20°C. Avoid freeze/thaw cycles.
Product Images
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Product Specific Literature References
Act1, a negative regulator in CD40- and BAFF-mediated B cell survival: Y. Qian, et al.; Immunity 21, 575 (2004) Abstract
BAFF regulates B cell survival by downregulating the BH3-only family member Bim via the ERK pathway: A. Craxton, et al.; J. Exp. Med. 202, 1363 (2005) Abstract
General Information
BACKGROUND/TECHNICAL INFORMATION

Swiss-Prot link Q9WU72: BAFF (mouse)
AfCS Signalling Gateway link A000383: BAFF (mouse)

FLAG is a registered trademark of Sigma-Aldrich Co.
MANUFACTURER Manufactured by Apotech Corporation.
Further Categories Containing This Product:
Recombinant Proteins / Fusion Proteins
 
 
APO-54N-022 Revised 01-Apr-08
BAFF, Soluble (human) Detection Set [For ELISA Application]
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SYNONYMS BLyS, Soluble (human) Detection Set [For ELISA Application]
TALL-1, Soluble (human) Detection Set [For ELISA Application]
zTNF4, Soluble (human) Detection Set [For ELISA Application]
TNFSF 13B/20, Soluble (human) Detection Set [For ELISA Application]
CD257, Soluble (human) Detection Set [For ELISA Application]
PRODUCT LINE Chemokines & Cytokines
PRODUCT CATEGORY BAFF
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Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
APO-54N-022-KI01   1 Set 560.00 USD Add To Cart
Product Specification
SPECIES CROSSREACTIVITY:
Human
SENSITIVITY: 0.3ng/ml (range 0 to 30ng/ml).
QUANTITY: For 5x96 wells.
KIT/SET CONTAINS: 1 vial Standard (lyophilized) (STD)
1 vial Coating Antibody (COAT)
1 vial Detection Antibody (DET)
1 vial Goat anti-rat IgG-HRP (HRP)
APPLICATION: For the quantitative determination of soluble human BAFF from biological fluids (serum and cell culture supernatant). Does not cross-react with mouse BAFF.
SHIPPING: SHIPPED ON BLUE ICE
SHORT TERM STORAGE: +4°C
LONG TERM STORAGE: -20°C
HANDLING: Avoid freeze/thaw cycles.
General Information
BAFF (B cell activation factor of the TNF family, also known as BLyS or TALL1) is a cytokine expressed predominantly by cells of the immune system such as neutrophils, monocytes, macrophages, dendritic cells, follicular dendritic cells, activated T cells and some malignant B cells. BAFF binds three distinct receptors (BAFF-R, TACI and BCMA) expressed predominantly on B cells, although activated T cells also express BAFF-R. BAFF is a master regulator of peripheral B cell survival, and also acts in processes such as immunoglobulin isotype switch and B cell co-stimulation. Besides its major role in B cell biology, BAFF co-stimulates activated T cells. Deregulated expression of this membrane-bound protein, which can readily be released in a soluble form, leads to autoimmune disorders in mice. In humans, elevated levels of soluble BAFF have been detected in the serum of patients with various autoimmune diseases. 
BACKGROUND/TECHNICAL INFORMATION Swiss-Prot link Q9Y275: BAFF (human)
MANUFACTURER Manufactured by Apotech Corporation.
General Literature References
The TNF family members BAFF and APRIL: the growing complexity: F. Mackay & C. Ambrose; Cytokine Growth Factor Rev. 14, 311 (2003) Abstract
TNF deficiency fails to protect BAFF transgenic mice against autoimmunity and reveals a predisposition to B cell lymphoma: M. Batten, et al.; J. Immunol. 172, 812 (2004) Abstract
BAFF Augments Certain Th1-Associated Inflammatory Responses: A.P. Sutherland, et al.; J. Immunol. 174, 5537 (2005) Abstract; Full Text
The BAFF/APRIL system: life beyond B lymphocytes: L.G. Ng, et al.; Mol. Immunol. 42, 763 (2005) Abstract
The BAFF/APRIL system: an important player in systemic rheumatic diseases: F. Mackay, et al.; Curr. Dir. Autoimmun. 8, 243 (2005) Abstract
Further Categories Containing This Product:
ELISA Sets
 
 
APO-54N-013 Revised 20-Jun-08
BAFF, Soluble (mouse) Detection Set [For ELISA Application]
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SYNONYMS BLyS, Soluble (mouse) Detection Set [For ELISA Application]
TALL-1, Soluble (mouse) Detection Set [For ELISA Application]
zTNF4, Soluble (mouse) Detection Set [For ELISA Application]
TNFSF 13B/20, Soluble (mouse) Detection Set [For ELISA Application]
CD257, Soluble (mouse) Detection Set [For ELISA Application]
PRODUCT LINE Chemokines & Cytokines
PRODUCT CATEGORY BAFF
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
APO-54N-013-KI01   1 Set 1'050.00 USD Add To Cart
Product Specification
SENSITIVITY: 0.3ng/ml (range 0 to 20ng/ml)
QUANTITY: For 4x96 wells.
KIT/SET CONTAINS: 1 vial Standard (lyophilized) (STD).
1 vial Coating Antibody (COAT).
1 vial Detection Antibody (DET).
APPLICATION: For the quantitative determination of soluble mouse BAFF from biological fluids (serum and cell culture supernatant).
SHIPPING: SHIPPED ON BLUE ICE
SHORT TERM STORAGE: +4°C
LONG TERM STORAGE: -20°C
HANDLING: Avoid freeze/thaw cycles.
Product Images
Please click on thumbnails to enlarge.
Product Specific Literature References
Toll-like Receptor 9-Dependent and -Independent Dendritic Cell Activation by Chromatin-Immunoglobulin G Complexes: M.W. Boule, et al.; J. Exp. Med. 199, 1631 (2004) Abstract
Regulation of B-cell survival by BAFF-dependent PKCdelta-mediated nuclear signalling: I. Mecklenbrauker, et al.; Nature 431, 456 (2004) Abstract
BAFF Augments Certain Th1-Associated Inflammatory Responses: A.P. Sutherland, et al.; J. Immunol. 174, 5537 (2005) Abstract; Full Text
A role for B cell-activating factor of the TNF family in chemically induced autoimmunity: Y. Zheng, et al.; J. Immunol. 175, 6163 (2005) Abstract
Development of autoantibody responses in NC/Nga mice: its prevention by pulverized konjac glucomannan feeding: N. Onishi, et al.; Arch. Dermatol. Res. 300, 95 (2008) Abstract
General Information
BAFF (B cell activation factor of the TNF family, also known as BLyS or TALL1) is a cytokine expressed predominantly by cells of the immune system such as neutrophils, monocytes, macrophages, dendritic cells, follicular dendritic cells, activated T cells and some malignant B cells. BAFF binds three distinct receptors (BAFF-R, TACI and BCMA) expressed predominantly on B cells, although activated T cells also express BAFF-R. BAFF is a master regulator of peripheral B cell survival, and also acts in processes such as immunoglobulin isotype switch and B cell co-stimulation. Besides its major role in B cell biology, BAFF co-stimulates activated T cells. Deregulated expression of this membrane-bound protein, which can readily be released in a soluble form, leads to autoimmune disorders in mice. In humans, elevated levels of soluble BAFF have been detected in the serum of patients with various autoimmune diseases.
BACKGROUND/TECHNICAL INFORMATION Swiss-Prot link : BAFF (mouse)
MANUFACTURER Manufactured by Apotech Corporation.
General Literature References
The TNF family members BAFF and APRIL: the growing complexity: F. Mackay & C. Ambrose; Cytokine Growth Factor Rev. 14, 311 (2003) Abstract
TNF deficiency fails to protect BAFF transgenic mice against autoimmunity and reveals a predisposition to B cell lymphoma: M. Batten, et al.; J. Immunol. 172, 812 (2004) Abstract
The BAFF/APRIL system: an important player in systemic rheumatic diseases: F. Mackay, et al.; Curr. Dir. Autoimmun. 8, 243 (2005) Abstract
Further Categories Containing This Product:
ELISA Sets
 
 
ALX-840-605 Revised 09-Jun-05
Positive Control (Cell Lysate) for Antibodies to BAFF (human)
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SYNONYMS Positive Control (Cell Lysate) for Antibodies to BlyS (human)
Positive Control (Cell Lysate) for Antibodies to TALL-1 (human)
Positive Control (Cell Lysate) for Antibodies to THANK (human)
Positive Control (Cell Lysate) for Antibodies to zTNF4 (human)
Positive Control (Cell Lysate) for Antibodies to TNFSF 13B/20 (human)
Positive Control (Cell Lysate) for Antibodies to CD257 (human)
PRODUCT LINE Immunology
PRODUCT CATEGORY Positive Controls (Cell Lysates & Extracts)
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ALX-840-605-R100   100 µl 70.00 USD Add To Cart
Product Specification
SOURCE/HOST: Whole cell lysate of HEK 293T cells transfected with an expression plasmid for human BAFF (aa 83-285).
QUANTITY: 100µl corresponding to 2 x 105 cells.
FORMULATION: Liquid. In 5x sample buffer (312.5mM TRIS, pH 6.8, containing 10% SDS, 6% glycerol, 0.075% bromophenol blue, 10% β-mercaptoethanol and 10mM DTT).
APPLICATION: Positive control in Western blot for MAb to BAFF (human) (Buffy-1) (Prod. No. ALX-804-128) and the MAb to BAFF (Buffy-2) (Prod. No. ALX-804-131).
Add 13µl sterile water and 2µl DTT (100mM) to 5µl of cell lysate.
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: -20°C
HANDLING: After opening, prepare aliquots and store at -20°C. Avoid freeze/thaw cycles.
Product Images
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General Information
MANUFACTURER Manufactured by Apotech Corporation.
Further Categories Containing This Product:
BAFF
 
 
APO-54N-020 Revised 02-Apr-08
BAFF, Soluble (human) ELISA Kit
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SYNONYMS BlyS, Soluble (human) ELISA Kit
TALL-1, Soluble (human) ELISA Kit
THANK, Soluble (human) ELISA Kit
zTNF4, Soluble (human) ELISA Kit
TNFSF 13B/20, Soluble (human) ELISA Kit
CD257, Soluble (human) ELISA Kit
PRODUCT LINE Chemokines & Cytokines
PRODUCT CATEGORY BAFF
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Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
APO-54N-020-KI01   1 Kit 630.00 USD Add To Cart
Product Specification
SPECIES CROSSREACTIVITY:
Human
SENSITIVITY: 0.95ng/ml (range 0 to 128ng/ml)
QUANTITY: For 96 wells (~80 tests)
APPLICATION: For the quantitative determination of soluble human BAFF from biological fluids (serum and cell culture supernatant).
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: +4°C
General Information
BAFF (B cell activating factor belonging to the TNF family, also known as BLyS or TALL1) is a cytokine expressed predominantly by cells of the immune system such as neutrophils, monocytes, macrophages, dendritic cells, follicular dendritic cells, activated T cells and some malignant B cells. BAFF binds three distinct receptors (BAFFR, TACI and BCMA) predominantly expressed on B cells, although activated T cells also express BAFFR. BAFF is a master regulator of peripheral B cell survival, and also acts in processes such as immunoglobulin isotype switch and B cell co-stimulation. Beside its major role in B cell biology, BAFF co-stimulates activated T cells. Deregulated expression of this membrane-bound protein, which can readily be released in a soluble form by proteolytic cleavage, leads to autoimmune disorders in mice. In the human, elevated levels of soluble BAFF have been detected in the serum of patients with various autoimmune diseases, such as rheumatoid arthritis (RA), Sjögren’s syndrome (SS) and systemic lupus erythematosus (SLE). BAFF levels are also elevated in patients with multiple myeloma and B-cell chronic lymphoid leukemia (B-CCL).
BACKGROUND/TECHNICAL INFORMATION Swiss-Prot link Q9Y275: BAFF (human)
MANUFACTURER Manufactured by Apotech Corporation & Immundiagnostik AG.
General Literature References
The BAFF/APRIL system: life beyond B lymphocytes: L.G. Ng, et al.; Mol. Immunol. 42, 763 (2005) Abstract
BAFF is produced by astrocytes and up-regulated in multiple sclerosis lesions and primary central nervous system lymphoma: M. Krumbholz, et al.; J. Exp. Med. 201, 195 (2005) Abstract
Further Categories Containing This Product:
ELISA & EIA Kits