ALEXIS Biochemicals: Zoledronic acid

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ALX-550-257

Revised 10-Feb-05

Amiloride, 5-(N-Methyl-N-isobutyl)-
SYNONYMS	5-(N-Methyl-N-isobutyl)amiloride MIA
PRODUCT LINE	Signal Transduction
PRODUCT CATEGORY	Na+ Channels

Ordering Information

Product Numbers:	Format:	Size:	Unit Price:	Quantity:	Add To Cart
ALX-550-257-M005		5 mg	25.00 USD

Product Specification

FORMULA:	C₁₁H₁₈ClN₇O
MW:	299.8
CAS NUMBER:	96861-65-3
PURITY:	≥98%
APPEARANCE:	Yellow solid.
SOLUBILITY:	Soluble in dilute aqueous acid or DMSO; insoluble in water.
SHIPPING:	AMBIENT
LONG TERM STORAGE:	+4°C
HANDLING:	Protect from light.

Product Description

Potent inhibitor of the Na⁺/H⁺ antiporter. Possible antitumor agent.

Product Specific Literature References

Interactions of chloride and amiloride with the renal Na+/H/ antiporter: D.G. Warnock, et al.; J. Biol. Chem. 263, 7216 (1988) Abstract; Full Text
Methyl isobutyl amiloride: a new probe to assess the number of Na-H antiporters: Z. Talor, et al.; Life Sci. 45, 517 (1989) Abstract
Therapeutic potential of analogues of amiloride: inhibition of the regulation of intracellular pH as a possible mechanism of tumour selective therapy: R.P. Maidorn, et al.; Br. J. Cancer. 67, 297 (1993) Abstract
Study of fibroblast spreading: pH dependence, involvement of the Na+/H(+)-antiporter and PKC: I.Y. Novikova, et al.; Biochim. Biophys. Acta 1178, 267 (1993) Abstract
Methyl isobutyl amiloride alters regional brain reperfusion after resuscitation from cardiac arrest in rats: K.L. Lauro, et al.; Brain Res. 831, 64 (1999) Abstract
Role of Na(+)/H(+) exchanger during ischemia and preconditioning in the isolated rat heart: X.H. Xiao & D.G. Allen; Circ. Res. 85, 723 (1999) Abstract

Further Categories Containing This Product:

Imidazoline Binding Site Ligands • Ca2+ Channels (T-type) • Antitumor Reagents Other Products

ALX-400-041

Revised 11-Oct-05

Carboplatin
SYNONYMS	cis-Diammine [1,1-cyclobutanedicarboxylato] platinum (II)
PRODUCT LINE	Cancer
PRODUCT CATEGORY	Antitumor Reagents Other Products

Ordering Information

Product Numbers:	Format:	Size:	Unit Price:	Quantity:	Add To Cart
ALX-400-041-M025		25 mg	50.00 USD
ALX-400-041-M100		100 mg	175.00 USD
ALX-400-041-M250		250 mg	340.00 USD

Product Specification

FORMULA:	C₆H₁₂N₂O₄Pt
MW:	371.3
CAS NUMBER:	41575-94-4
MERCK INDEX:	14: 1822
PURITY:	≥98% (Assay)
APPEARANCE:	White to off-white powder.
SOLUBILITY:	Soluble in water.
SHIPPING:	AMBIENT
LONG TERM STORAGE:	-20°C
HANDLING:	Protect from light.

Product Description

An analog of cisplatin (Prod. No. ALX-400-040). Antitumor agent.

ALX-480-029

Revised 30-Nov-04

8-Chloroadenosine 3',5'-Cyclic Monophosphate . sodium salt
SYNONYMS	8-Cl-cAMP . Na
PRODUCT LINE	Signal Transduction
PRODUCT CATEGORY	cAMP Derivatives

Ordering Information

Product Numbers:	Format:	Size:	Unit Price:	Quantity:	Add To Cart
ALX-480-029-M001		1 mg	27.00 USD
ALX-480-029-M005		5 mg	108.00 USD

Product Specification

FORMULA:	C₁₀H₁₁ClN₅O₆P . Na
MW:	363.7 . 23.0
CAS NUMBER:	41941-56-4
PURITY:	≥98%
APPEARANCE:	White lyophilized powder.
SOLUBILITY:	Soluble in water. May produce hazy solutions.
SHIPPING:	AMBIENT
LONG TERM STORAGE:	-20°C

Product Description

cAMP analog with high selectivity for cAMP-dependent protein kinase type I. Induces growth inhibition and differentiation in cultured cancer cell lines.

Product Specific Literature References

Selective modulation of protein kinase isozymes by the site-selective analog 8-chloroadenosine 3',5'-cyclic monophosphate provides a biological means for control of human colon cancer cell growth: S. Ally, et al.; PNAS 85, 6319 (1988) Abstract

Further Categories Containing This Product:

Antitumor Reagents Other Products

ALX-400-040

Revised 13-Aug-07

Cisplatin
SYNONYMS	cis-Platinum(ll)diamine dichloride
PRODUCT LINE	Cancer
PRODUCT CATEGORY	Antitumor Reagents Other Products

Ordering Information

Product Numbers:	Format:	Size:	Unit Price:	Quantity:	Add To Cart
ALX-400-040-M050		50 mg	42.00 USD
ALX-400-040-M250		250 mg	90.00 USD

Product Specification

FORMULA:	Cl₂H₆N₂Pt
MW:	300.0
CAS NUMBER:	15663-27-1
MERCK INDEX:	14: 2317
RTECS:	TP2450000
PURITY:	≥99% (Assay)
APPEARANCE:	Off-white to orange powder.
ENDOTOXIN CONTENT:	≤1.0EU/mg
SOLUBILITY:	Soluble in dimethyl formamide.
SHIPPING:	AMBIENT
LONG TERM STORAGE:	+20°C
HANDLING:	Protect from light.
HAZARD:	TOXIC.

Product Specific Literature References

Cisplatin induces a persistent activation of JNK that is related to cell death: I. Sanchez-Perez, et al.; Oncogene 16, 533 (1998) Abstract
Telomere loss in cells treated with cisplatin: T. Ishibashi & S.J. Lippard; PNAS 95, 4219 (1998) Abstract
Mitochondrial changes during the apoptotic process of HeLa cells exposed to cisplatin: J. Melendez-Zajgla, et al.; Biochem. Mol. Biol. Int. 47, 765 (1999) Abstract
The tyrosine kinase c-Abl regulates p73 in apoptotic response to cisplatin-induced DNA damage: J.G. Gong, et al.; Nature 399, 806 (1999) Abstract
Cisplatin-induced apoptosis in human proximal tubular epithelial cells is associated with the activation of the Fas/Fas ligand system: M.S. Razzaque, et al.; Histochem. Cell Biol. 111, 359 (1999) Abstract
Cisplatin (CDDP) specifically induces apoptosis via sequential activation of caspase-8, -3 and -6 in osteosarcoma: K. Seki, et al.; Cancer Chemother. Pharmacol. 45, 199 (2000) Abstract
Effectiveness of hsp90 inhibitors as anti-cancer drugs: L. Xiao, et al.; Mini Rev. Med. Chem. 6, 1137 (2006), (Review) Abstract

Further Categories Containing This Product:

HSP90/HtpG/Related Products

ALX-300-152

Revised 09-Feb-05

1-Elaidylphosphocholine (C18:1, trans)
PRODUCT LINE	Signal Transduction
PRODUCT CATEGORY	Phospholipids/Related Products

Ordering Information

Product Numbers:	Format:	Size:	Unit Price:	Quantity:	Add To Cart
ALX-300-152-M250		250 mg	80.00 USD
ALX-300-152-G001		1 g	240.00 USD

Product Specification

FORMULA:	C₂₃H₄₈NO₄P
MW:	433.6
PURITY:	≥98%
SHIPPING:	AMBIENT
LONG TERM STORAGE:	-20°C
HANDLING:	Hygroscopic.

Product Description

Cytotoxic alkylphosphocholine for a variey of tumor cells and protozoal diseases (leishmaniasis).

General Literature References

Hexadecylphosphocholine: a new and selective antitumor drug: H. Eibl & C. Unger; Cancer Treat. Rev. 17, 233 (1990), (Review) Abstract
Induction of tumor cell differentiation by alkylphosphocholines: a new approach for in vitro screening: H.R. Maurer & P. Hilgard; Prog. Exp. Tumor Res. 34, 90 (1992), (Review) Abstract
Alkylphosphocholines: a new class of membrane-active anticancer agents: P. Hilgard, et al.; Cancer Chemother. Pharmacol. 32, 90 (1993), (Review) Abstract
Current concepts of treatment in medical oncology: new anticancer drugs: C. Unger; J. Cancer Res. Clin. Oncol. 122, 189 (1996), (Review) Abstract

Further Categories Containing This Product:

Antitumor Reagents Other Products

ALX-270-482

Revised 23-Apr-08

GANT61
SYNONYMS	NSC 136476 2,2’-[[Dihydro-2-(4-pyridinyl)-1,3(2H,4H)-pyrimidinediyl]bis(methylene)]bis[N,N-dimethyl]-benzenamine
PRODUCT LINE	Signal Transduction
PRODUCT CATEGORY	Hedgehog [Hh] Signalling Pathway

Ordering Information

Product Numbers:	Format:	Size:	Unit Price:	Quantity:	Add To Cart
ALX-270-482-M001		1 mg	190.00 USD

Product Specification

FORMULA:	C₂₇H₃₅N₅
MW:	429.6
CAS NUMBER:	500579-04-4
PURITY:	≥95%
APPEARANCE:	White to off-white waxy solid.
SOLUBILITY:	Soluble in DMSO (5mg/ml).
SHIPPING:	AMBIENT
LONG TERM STORAGE:	-20°C
HANDLING:	Hygroscopic. Protect from light.
IDENTITY:	Identity determined by ¹H-NMR, ¹³C-NMR and MS.

Product Description

Inhibitor of Hedgehog (Hh) signalling pathway. Blocks the GLI function which constitutes the final step in the Hh pathway. Interferes with GLI1 DNA binding in living cells. Inhibits cell proliferation of tumor cells in vitro in a GLI-dependent manner. Blocks cell growth in an in vivo xenograft model using human prostate cancer cells.

Product Specific Literature References

Inhibition of GLI-mediated transcription and tumor cell growth by small-molecule antagonists: M. Lauth, et al.; PNAS 104, 8455 (2007) Abstract; Full Text

Further Categories Containing This Product:

Antitumor Reagents Other Products

ALX-300-001

Revised 02-Dec-04

1-O-Hexadecyl-2-palmitoyl-sn-glycero-3-phospho-(N-palmitoyl)-ethanolamide . sodium salt
PRODUCT LINE	Signal Transduction
PRODUCT CATEGORY	Phospholipids/Related Products

Ordering Information

Product Numbers:	Format:	Size:	Unit Price:	Quantity:	Add To Cart
ALX-300-001-M005		5 mg	85.00 USD
ALX-300-001-M025		25 mg	335.00 USD

Product Specification

FORMULA:	C₅₃H₁₀₅NO₈P . Na
MW:	915.4 . 23.0
PURITY:	≥98%
SHIPPING:	AMBIENT
LONG TERM STORAGE:	-20°C

Product Description

Potent antitumor agent.

Product Specific Literature References

Biologically active ether lipids. Biotransformation of rac-1(3)-O- alkylglycerols in cell suspension cultures of rape and semisynthesis of 1-O-alkyl-2-palmitoyl-sn-glycero-3-phospho-(N-palmitoyl)ethanolamines, potent antitumor agents: S.S. Apte, et al.; FEBS Lett. 265, 104 (1990) Abstract

Further Categories Containing This Product:

Antitumor Reagents Other Products

ALX-270-361

Revised 28-Sep-07

Indirubin
PRODUCT LINE	Cell Cycle
PRODUCT CATEGORY	CDK & Cyclin Inhibitors

Ordering Information

Product Numbers:	Format:	Size:	Unit Price:	Quantity:	Add To Cart
ALX-270-361-M001		1 mg	50.00 USD
ALX-270-361-M005		5 mg	200.00 USD

Product Specification

FORMULA:	C₁₆H₁₀N₂O₂
MW:	262.3
CAS NUMBER:	479-41-4
SOURCE/HOST:	Synthetic.
PURITY:	≥98% (¹H-NMR, HPLC)
APPEARANCE:	Purple powder.
SOLUBILITY:	Soluble in DMSO (10mg/ml) or methanol (0.3mg/ml). Sparingly soluble in aqueous buffers (12.5µg/ml).
SHIPPING:	AMBIENT
LONG TERM STORAGE:	+4°C
USE/STABILITY:	Stable for at least 2 years when stored at +4°C in the dark. Stock solutions should be stored in the dark and used within 1 month.
HANDLING:	Keep cool and dry. Protect from light.
IDENTITY:	Identity determined by ¹H-NMR, ¹³C-NMR, IR, ESI-MS and UV.

Product Description

Inhibitor of cyclin-dependent kinases (CDK1/cyclin B (IC₅₀=10µM), CDK2/cyclin A (IC₅₀=2.2µM), CDK2/cyclin E (IC₅₀=7.5µM), CDK4/cyclin D1 (IC₅₀=12µM), CDK5/p35 (IC₅₀=5.5µM)) [1] and of GSK-3β (IC₅₀=600nM) [2]. Inhibits inflammatory reaction in delayed-type hypersensitivity in mice [3]. Ligand of human aryl hydrocarbon receptor [4]. Exhibits anti-cancer activity [5] [6].

Product Specific Literature References

[1] Indirubin, the active constituent of a Chinese antileukaemia medicine, inhibits cyclin-dependent kinases: R. Hoessel, et al.; Nature Cell Biol. 1, 60 (1999) Abstract
[2] Indirubins inhibit glycogen synthase kinase-3 beta and CDK5/p25, two protein kinases involved in abnormal tau phosphorylation in Alzheimer’s disease. A property common to most cyclin-dependent kinase inhibitors?: S. Leclerc, et al.; J. Biol. Chem. 276, 251 (2001) Abstract; Full Text
[3] Indirubin inhibits inflammatory reactions in delayed-type hypersensitivity: T. Kunikata, et al.; Eur. J. Pharmacol. 410, 93 (2000) Abstract
[4] Indirubin and indigo are potent aryl hydrocarbon receptor ligands present in human urine: J. Adachi, et al.; J. Biol. Chem. 276, 31475 (2001) Abstract; Full Text
[5] Molecular mechanisms of indirubin and its derivatives: novel anticancer molecules with their origin in traditional Chinese phytomedicine: G. Eisenbrand, et al.; J. Cancer Res. Clin. Oncol. 130, 627 (2004) Abstract
[6] Indirubin enhances tumor necrosis factor-induced apoptosis through modulation of nuclear factor-kappa B signaling pathway: G. Sethi, et al.; J. Biol. Chem. 281, 23425 (2006) Abstract

General Information

BACKGROUND/TECHNICAL INFORMATION

Indirubin is derived from various natural sources, such as Indigofera indica, Isatis tinctoria and I. indigotica by fermentation, oxidation and the presence of light as a by product of indigo formation. Indirubin is also present in human urine and fetal bovine serum [4]. Preclinical studies of indirubin its confirmed anti-tumor activity. Efficacy against chronic myelocytic leukemia was demonstrated in clinical trials in China [2].

ALX-270-271	Indirubin-3'-monoxime
ALX-270-296	Indirubin-5-sulfonic acid . sodium salt
ALX-270-424	5-Iodo-indirubin-3'-monoxime
ALX-430-149	7BIO
ALX-430-157	Me-7BIO
ALX-430-156	6BIO

MW:	~12.2kDa.
SOURCE/HOST:	Produced in E. coli.
PURITY:	≥95% (SDS-PAGE)
FORMULATION:	Liquid. In 20mM potassium phosphate, pH 7.5, containing 150mM potassium chloride.
ENDOTOXIN CONTENT:	<0.05EU/µg protein.
BIOLOGICAL ACTIVITY:	Inhibits tumor growth in vitro.
SHIPPING:	SHIPPED ON BLUE ICE
SHORT TERM STORAGE:	+4°C
LONG TERM STORAGE:	-20°C
USE/STABILITY:	Stable for up to 5 weeks after receipt when stored at +4°C and for at least 1 year when stored at -20°C.
HANDLING:	Avoid freeze/thaw cycles. After opening, prepare aliquots and store at -20°C. For maximum product recovery after thawing, centrifuge the vial before opening the cap.

FORMULA:	C₂₃H₅₀NO₄P
MW:	435.6
PURITY:	≥99% (HPLC)
APPEARANCE:	White to off-white solid.
SOLUBILITY:	Soluble in 100% ethanol, methanol or water.
SHIPPING:	AMBIENT
LONG TERM STORAGE:	-20°C
HANDLING:	Hygroscopic.