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ALX-850-013
Revised 24-Feb-05
cAMP EIA Kit
PRODUCT LINE
Signal Transduction
PRODUCT CATEGORY
cAMP Derivatives
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-850-013-KI01
1 Kit
412.00 USD
Product Specification
QUANTITY:
96 wells (~80 tests).
APPLICATION:
For the measurement of cAMP.
SHIPPING:
SHIPPED ON BLUE ICE
LONG TERM STORAGE:
-20°C
Further Categories Containing This Product:
ELISA & EIA Kits
ALX-202-027
Revised 09-Aug-06
cAMP-dependent Protein Kinase (bovine heart) (catalytic subunit)
SYNONYMS
Protein Kinase A (bovine heart) (catalytic subunit)
PKA (bovine heart) (catalytic subunit)
PRODUCT LINE
Signal Transduction
PRODUCT CATEGORY
PKA
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-202-027-U500
500 U
250.00 USD
Product Specification
MW:
~40kDa.
EC:
2.7.1.37
SOURCE/HOST:
Isolated from bovine heart.
CONCENTRATION:
20µg/ml.
PURITY:
≥95% (SDS-PAGE)
FORMULATION:
Liquid. In 20mM MES, pH 6.5, containing 0.1mM EDTA, 30mM β-mercaptoethanol, 100mM sodium chloride and 50% ethylene glycol.
SPECIFIC ACTIVITY:
~1000 Units/µg using histone as the substrate. One unit is defined as the amount of enzyme that transfers 1pmol phosphate to histone per min. at 30°C.
APPLICATION:
For studying PKA phosphorylation
in vitro
.
SHIPPING:
SHIPPED ON DRY ICE
LONG TERM STORAGE:
-80°C
HANDLING:
Do not freeze/thaw.
General Information
BACKGROUND/TECHNICAL INFORMATION
Swiss-Prot link: cAMP-dependent Protein Kinase (bovine)
α catalytic subunit
(P00517)
,
β-1 catalytic subunit
(P05131),
β-2 catalytic subunit
(P24256)
AfCS Signalling Gateway link: cAMP-dependent Protein Kinase (mouse)
α catalytic subunit
(A001914),
β catalytic subunit
(A001815)
,
γ catalytic subunit
(A001916)
Further Categories Containing This Product:
Natural Proteins
•
Enzymes
ALX-151-016
Revised 17-Jan-05
cAMP-dependent Protein Kinase Inhibitor (5-22) amide
SYNONYMS
PKA Inhibitor (5-22) amide
PRODUCT LINE
Signal Transduction
PRODUCT CATEGORY
PKA Inhibitors
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-151-016-MC05
0.5 mg
110.00 USD
ALX-151-016-M001
1 mg
180.00 USD
Product Specification
SEQUENCE:
H-Thr-Thr-Tyr-Ala-Asp-Phe-Ile-Ala-Ser-Gly-Arg-Thr-Gly-Arg-Arg-Asn-Ala-Ile-NH
2
FORMULA:
C
84
H
137
N
29
O
26
MW:
1969.2
PURITY:
≥97%
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
Product Description
Potent inhibitor of cAMP-dependent protein kinase (PKA).
Product Specific Literature References
A potent synthetic peptide inhibitor of the cAMP-dependent protein kinase:
H.-C. Cheng, et al.; J. Biol. Chem.
261
, 989 (1986)
Abstract
;
Full Text
Primary structural determinants essential for potent inhibition of cAMP- dependent protein kinase by inhibitory peptides corresponding to the active portion of the heat-stable inhibitor protein:
D.B. Glass, et al.; J. Biol. Chem.
264
, 8802 (1989)
Abstract
;
Full Text
Further Categories Containing This Product:
Peptides
ALX-151-014
Revised 15-Dec-04
cAMP-dependent Protein Kinase Inhibitor (5-24)
SYNONYMS
PKA Inhibitor (5-24)
PRODUCT LINE
Signal Transduction
PRODUCT CATEGORY
PKA Inhibitors
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
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ALX-151-014-MC05
0.5 mg
90.00 USD
ALX-151-014-M001
1 mg
160.00 USD
Product Specification
SEQUENCE:
H-Thr-Thr-Tyr-Ala-Asp-Phe-Ile-Ala-Ser-Gly-Arg-Thr-Gly-Arg-Arg-Asn-Ala-Ile-His-Asp-OH
FORMULA:
C
94
H
148
N
32
O
31
MW:
2222.4
PURITY:
≥97%
APPEARANCE:
White to off-white powder.
FORMULATION:
Lyophilized.
SOLUBILITY:
Soluble in water or 5 % acetic acid.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
HANDLING:
Keep cool and dry.
Product Description
Potent inhibitor of cAMP-dependent protein kinase (PKA). The peptide corresponds to the active site of the skeletal muscle inhibitor protein.
Product Specific Literature References
A potent synthetic peptide inhibitor of the cAMP-dependent protein kinase:
H.-C. Cheng, et al.; J. Biol. Chem.
261
, 989 (1986)
Abstract
;
Full Text
Phosphorylation of Avena phytochrome in vitro as a probe of light- induced conformational changes:
Y.S. Wong, et al.; J. Biol. Chem.
261
, 12089 (1986)
Abstract
;
Full Text
Further Categories Containing This Product:
Peptides
ALX-151-018
Revised 13-Feb-06
cAMP-dependent Protein Kinase Inhibitor (5-24) amide
SYNONYMS
PKA Inhibitor (5-24) amide
PRODUCT LINE
Signal Transduction
PRODUCT CATEGORY
PKA Inhibitors
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-151-018-MC05
0.5 mg
90.00 USD
ALX-151-018-M001
1 mg
160.00 USD
Product Specification
SEQUENCE:
H-Thr-Thr-Tyr-Ala-Asp-Phe-Ile-Ala-Ser-Gly-Arg-Thr-Gly-Arg-Arg-Asn-Ala-Ile-His-Asp-NH
2
FORMULA:
C
94
H
149
N
33
O
30
MW:
2221.4
PURITY:
≥97%
APPEARANCE:
White to off-white lyophilized powder.
SOLUBILITY:
Soluble in water or DMSO.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
Product Specific Literature References
A potent synthetic peptide inhibitor of the cAMP-dependent protein kinase:
H.-C. Cheng, et al.; J. Biol. Chem.
261
, 989 (1986)
Abstract
;
Full Text
Further Categories Containing This Product:
Peptides
ALX-151-017
Revised 15-Dec-04
cAMP-dependent Protein Kinase Inhibitor (14-24) amide
SYNONYMS
PKA Inhibitor (14-24) amide
PRODUCT LINE
Signal Transduction
PRODUCT CATEGORY
PKA Inhibitors
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-151-017-M001
1 mg
90.00 USD
ALX-151-017-M005
5 mg
360.00 USD
Product Specification
SEQUENCE:
H-Gly-Arg-Thr-Gly-Arg-Arg-Asn-Ala-Ile-His-Asp-NH
2
FORMULA:
C
49
H
86
N
24
O
15
MW:
1251.4
PURITY:
≥97%
APPEARANCE:
White powder.
SOLUBILITY:
Soluble in water.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
Further Categories Containing This Product:
Peptides
ALX-151-019
Revised 15-Dec-04
cAMP-dependent Protein Kinase Substrate
SYNONYMS
PKA Substrate
PRODUCT LINE
Signal Transduction
PRODUCT CATEGORY
PKA Substrates
Ordering Information
Product Numbers:
Format:
Size:
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Quantity:
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ALX-151-019-MC05
0.5 mg
95.00 USD
ALX-151-019-M001
1 mg
165.00 USD
Product Specification
SEQUENCE:
H-Asp-Leu-Asp-Val-Pro-Ile-Pro-Gly-Arg-Phe-Asp-Arg-Arg-Val-Ser-Val-Ala-Ala-Glu-OH
FORMULA:
C
92
H
150
N
28
O
29
MW:
2112.4
PURITY:
≥95%
APPEARANCE:
White powder.
SOLUBILITY:
Soluble in water.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
Product Description
Derived from the RII subunit of cAMP-dependent protein kinase (PKA). Substrate for PKA. Has been used in a non-radioactive assay of calcineurin (protein phosphatase 2B) for screening purposes.
Product Specific Literature References
Dephosphorylation of cAMP-dependent protein kinase regulatory subunit (type II) by calmodulin-dependent protein phosphatase. Determinants of substrate specificity:
D.K. Blumenthal, et al.; J. Biol. Chem.
261
, 8140 (1986)
Abstract
;
Full Text
Nonradioactive assay for protein phosphatase 2B (calcineurin) activity using a partial sequence of the subunit of cAMP-dependent protein kinase as substrate:
A. Enz, et al.; Anal. Biochem.
216
, 147 (1994)
Abstract
Further Categories Containing This Product:
PP2B [Calcineurin]/Related Products
•
Peptides
ALX-550-016
Revised 08-Nov-07
(S)-AMPA
SYNONYMS
(S)-α-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid
PRODUCT LINE
Neurobiology
PRODUCT CATEGORY
AMPA Receptors/Related Products
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-550-016-M005
5 mg
95.00 USD
ALX-550-016-M025
25 mg
380.00 USD
Product Specification
FORMULA:
C
7
H
10
N
2
O
4
MW:
186.2
CAS NUMBER:
83643-88-3
PURITY:
≥98% (HPLC)
APPEARANCE:
White to off-white powder.
SOLUBILITY:
Soluble in water or dilute aqueous base.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
+4°C
HANDLING:
Hygroscopic.
Product Description
Active enantiomer of (R,S)-AMPA (Prod. No.
ALX-550-023
).
Product Specific Literature References
Enzymic resolution and binding to rat brain membranes of the glutamic acid agonist alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid:
J.J. Hansen, et al.; J. Med. Chem.
26
, 901 (1983)
Abstract
Ibotenic acid analogues. Synthesis, molecular flexibility, and in vitro activity of agonists and antagonists at central glutamic acid receptors:
J. Lauridsen, et al.; J. Med. Chem.
28
, 668 (1985)
Abstract
Pharmacological agents acting at subtypes of metabotropic glutamate receptors
:
D.D. Schoepp, et al.; Neuropharmacology
38
, 1431 (1999), (Review)
Abstract
Further Categories Containing This Product:
Special Amino Acids
ALX-550-023
Revised 04-Apr-08
(R,S)-AMPA
SYNONYMS
(R,S)-α-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid
PRODUCT LINE
Neurobiology
PRODUCT CATEGORY
AMPA Receptors/Related Products
Ordering Information
Product Numbers:
Format:
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Unit Price:
Quantity:
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ALX-550-023-M005
5 mg
65.00 USD
ALX-550-023-M025
25 mg
260.00 USD
Product Specification
FORMULA:
C
7
H
10
N
2
O
4
MW:
186.2
CAS NUMBER:
74341-63-2
PURITY:
≥97% (HPLC)
APPEARANCE:
White powder.
SOLUBILITY:
Soluble in water (10mM).
SHIPPING:
AMBIENT
LONG TERM STORAGE:
+4°C
IDENTITY:
Identity determined by
1
H-NMR and MS.
Product Description
Potent and selective quisqualate analog that interacts with the AMPA subgroup of ionotropic glutamate receptors.
Product Specific Literature References
New class of glutamate agonist structurally related to ibotenic acid:
P. Krogsgaard-Larsen, et al.; Nature
284
, 64 (1980)
Abstract
The binding of [3H]AMPA, a structural analogue of glutamic acid, to rat brain membranes:
T. Honoré, et al.; J. Neurochem.
38
, 173 (1982)
Abstract
Pharmacological agents acting at subtypes of metabotropic glutamate receptors
:
D.D. Schoepp; Neuropharmacology
38
, 1431 (1999), (Review)
Abstract
ALX-350-106
Revised 29-Nov-07
Ampullosporin A
PRODUCT LINE
Natural Products / Antibiotics
PRODUCT CATEGORY
Antibiotics - Other Signal Transduction Pathway Modulators
Ordering Information
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Format:
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ALX-350-106-M001
1 mg
50.00 USD
Product Specification
SEQUENCE:
Ac-Trp-Ala-Aib-Aib-Leu-Aib-Gln-Aib-Aib-Aib-Gln-Leu-Aib-Gln-Leucinol
FORMULA:
C
77
H
127
N
19
O
19
MW:
1623.0
SOURCE/HOST:
Antibiotic isolated from
Sepedonium ampullosporum
.
PURITY:
≥98% (HPLC)
SOLUBILITY:
Soluble in alcohols, chloroform or dichloromethane. Insoluble in water.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
+4°C
HAZARD:
TOXIC.
Product Description
Peptaibol-type polypeptide. Induces pigment formation by the fungus
Phoma destructiva
, causes hypothermia in mice, displays neuroleptic activity in rats and forms instable pores in artificial bilayer membranes.
Product Specific Literature References
Ampullosporin, a new peptaibol-type antibiotic from
Sepedonium ampullosporum
HKI-0053 with neuroleptic activity in mice:
M. Ritzau, et al.; J. Antibiot.
50
, 722 (1997)
Abstract
Differences in ion permeability of an artificial bilayer membrane caused by ampullosporin and bergofungin, new 15-membered peptaibol-type antibiotics:
P. Grigoriev, et al.; Bioelectrochemistry
44
, 155 (1997)
Differences in ion-channel formation by ampullosporins B, C, D and semisynthetic desacetyltryptophanyl ampullosporin A:
P. Grigoriev, et al.; Bioelectrochemistry
57
, 119 (2002)
Abstract
Synthesis and biological evaluation of analogues of the peptaibol ampullosporin A:
H.H. Nguyen, et al.; J. Med. Chem.
45
, 2781 (2002)
Abstract
Crystal structure and conformational analysis of ampullosporin A:
M. Kronen, et al.; J. Pept. Sci.
9
, 729 (2003)
Abstract
Membrane association and activity of 15/16-membered peptide antibiotics: zervamicin IIB, ampullosporin A and antiamoebin I:
T.N. Kropacheva, et al.; Biochim. Biophys. Acta
1715
, 6 (2005)
Abstract
Transcriptional response to the neuroleptic-like compound Ampullosporin A in the rat ketamine model:
H. Krugel, et al.; J. Neurochem.
97, Suppl. 1
, 74 (2006)
Abstract
Further Categories Containing This Product:
Alzheimer Research Other Products
•
Ion Channels & Transporters Other Products
•
Peptides
ALX-350-112
Revised 29-Nov-07
Anabasine . hydrochloride
SYNONYMS
3-(2-Piperidinyl)pyridine
2-(3-Pyridyl)piperidine
Neonicotine
PRODUCT LINE
Natural Products / Antibiotics
PRODUCT CATEGORY
Natural Products for Neurological Research
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-350-112-M025
25 mg
20.00 USD
ALX-350-112-M100
100 mg
60.00 USD
Product Specification
FORMULA:
C
10
H
14
N
2
. HCl
MW:
162.2 . 36.5
CAS NUMBER:
15251-47-5
MERCK INDEX:
14:
619
SOURCE/HOST:
Isolated from
Anabasis aphylla.
PURITY:
≥97%
APPEARANCE:
White to off-white solid.
SOLUBILITY:
Soluble in alcohol or water.
SHIPPING:
