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Signal Transduction
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 Items 160-180 of 2937 Page 9 of 147 Select Page: << 1 2 3 4 5 6 7 8 9 10  >>  
ALX-270-169 Revised 07-Dec-04
Dephostatin
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SYNONYMS 2,5-Dihydroxy-N-methyl-N-nitrosoaniline
PRODUCT LINE Signal Transduction
PRODUCT CATEGORY Protein Tyrosine Phosphatases Other Products
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Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-270-169-M001   1 mg 120.00 USD Add To Cart
Product Specification
FORMULA: C7H8N2O3
MW: 168.2
CAS NUMBER: 151606-30-3
SOURCE/HOST: Synthetic.
PURITY: ≥90%
APPEARANCE: Red to brown solid.
SOLUBILITY: Soluble in DMSO, chloroform or methanol.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
HANDLING: Protect from light. Keep under inert gas.

Product Description
Competitive protein tyrosine phosphatase inhibitor. Protein S-nitrosating reagent.
Product Specific Literature References
Dephostatin, a novel protein tyrosine phosphatase inhibitor produced by Streptomyces. I. Taxonomy, isolation, and characterization: M. Imoto, et al.; J. Antibiot. 46, 1342 (1993) Abstract
Dephostatin, a novel protein tyrosine phosphatase inhibitor produced by Streptomyces. II. Structure determination: H. Kakeya, et al.; J. Antibiot. 46, 1716 (1993) Abstract
Synthesis and protein tyrosine phosphatase inhibitory activity of dephostatin analogs: T. Watanabe, et al.; J. Antibiot. 48, 1460 (1995) Abstract
Synthesis and Bioassay of a Protein Tyrosine Phosphatase Inhibitor, Dephostatin: L. Yu, et al.; Bioorg. Med. Chem. Lett. 5, 1003 (1995)
Further Categories Containing This Product:
Nitric Oxide Donors
 
 
ALX-270-171 Revised 30-Jun-08
Chlorpromazine . hydrochloride
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SYNONYMS 2-Chloro-10-(3-dimethylaminopropyl)phenothiazine . HCl
PRODUCT LINE Signal Transduction
PRODUCT CATEGORY Calmodulin Inhibitors
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Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-270-171-G001   1 g 22.00 USD Add To Cart
ALX-270-171-G005   5 g 66.00 USD Add To Cart
Product Specification
FORMULA: C17H19ClN2S . HCl
MW: 318.9 . 36.5
CAS NUMBER: 69-09-0
MERCK INDEX: 14: 2185
RTECS: SO1750000
PURITY: ≥98% (HPLC)
APPEARANCE: White to off-white powder.
SOLUBILITY: Soluble in 100% ethanol, methanol or water (50mg/ml).
SHIPPING: AMBIENT
LONG TERM STORAGE: +4°C
USE/STABILITY: Not stable in aqueous solution. We strongly recommend always to use freshly prepared solutions.
HANDLING: Protect from light.
HAZARD: VERY TOXIC.

Product Description
Inhibits calmodulin stimulation of cyclic nucleotide phosphodiesterase. Dopamine antagonist. D2 antagonist. Hantagonist. Inhibits TNF-α production. Potent PLA2 inhibitor. Inhibits nitric oxide synthase (NOS) in mouse brain and prevents lipopolysaccharide induction of NOS in mouse lung. Antipsychotic.
Product Specific Literature References
Chlorpromazine as a substitute for ortho-dianisidine and ortho-tolidine in the determination of chlorine, hemoglobin, and peroxidase activity: H.B. Collier; Clin. Biochem. 7, 331 (1974) Abstract
Drug-protein interactions: binding of chlorpromazine to calmodulin, calmodulin fragments, and related calcium binding proteins: D.R. Marshak, et al.; Biochemistry 24, 144 (1985) Abstract
Selective inhibition of group II phospholipase A2 by quercetin: M. Lindahl & C. Tagesson; Inflammation 17, 573 (1993) Abstract
Chlorpromazine inhibits both the constitutive nitric oxide synthase and the induction of nitric oxide synthase after LPS challenge: M. Palacios, et al.; BBRC 196, 280 (1993) Abstract
Protective effect of calmodulin inhibitors against acute cyanide- induced lethality and convulsions in mice: H. Yamamoto; Toxicol. Lett. 66, 73 (1993) Abstract
Pharmacologic inhibitors of tumor necrosis factor production exert differential effects in lethal endotoxemia and in infection with live microorganisms in mice: M.G. Netea, et al.; J. Infect. Dis. 171, 393 (1995) Abstract
Pharmacological regulation of mitochondrial nitric oxide synthase: A. Boveris, et al.; Methods Enzymol. 359, 328 (2002) Abstract
Brain mitochondrial nitric oxide synthase: in vitro and in vivo inhibition by chlorpromazine: S. Lores-Arnaiz, et al.; Arch. Biochem. Biophys. 430, 170 (2004) Abstract
 
 
ALX-270-172 Revised 04-Dec-07
RHC-80267
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SYNONYMS U-57908
1,6-bis(Cyclohexyloximinocarbonylamino)hexane
PRODUCT LINE Neurobiology
PRODUCT CATEGORY Diacylglycerol Lipase [DAGL] & Monoacylglycerol Lipase [MGL] / Related Products
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ALX-270-172-M005   5 mg 40.00 USD Add To Cart
ALX-270-172-M010   10 mg 65.00 USD Add To Cart
Product Specification
FORMULA: C20H34N4O4
MW: 394.5
CAS NUMBER: 83654-05-1
PURITY: ≥98%
APPEARANCE: White to off-white solid.
SOLUBILITY: Soluble in DMSO or 100% ethanol.
SHIPPING: AMBIENT
LONG TERM STORAGE: +20°C

Product Description
Selective inhibitor of diacylglycerol lipase activity. Also inhibits glucose- and carbachol-induced insulin release from intact islets.
Product Specific Literature References
Relative activities of rat and dog platelet phospholipase A2 and diglyceride lipase. Selective inhibition of diglyceride lipase by RHC 80267: C.A. Southerland & D. Amin; J. Biol. Chem. 257, 14006 (1982) Abstract; Full Text
RHC 80267 inhibits thyrotropin-stimulated prostaglandin release from rat thyroid lobes: S. Levasseur, et al.; Prostaglandins 27, 673 (1984) Abstract
Inhibitors of diacylglycerol lipase and diacylglycerol kinase inhibit carbamylcholine-stimulated responses in guinea pig pancreatic minilobules: M. Chandra Sekar & L.E. Hokin; Arch. Biochem. Biophys. 256, 509 (1987) Abstract
Diacylglycerol provides arachidonic acid for lipoxygenase products that mediate angiotensin II-induced aldosterone synthesis: R. Natarajan, et al.; BBRC 156, 717 (1988) Abstract
Arachidonic acid liberated by diacylglycerol lipase is essential for the release mechanism in chromaffin cells from bovine adrenal medulla: B. Rindlisbacher, et al.; J. Neurochem. 54, 1247 (1990) Abstract
Arachidonic acid release from diacylglycerol in human neutrophils. Translocation of diacylglycerol-deacylating enzyme activities from an intracellular pool to plasma membrane upon cell activation: J. Balsinde, et al.; J. Biol. Chem. 266, 15638 (1991) Abstract; Full Text
 
 
ALX-270-175 Revised 28-Feb-08
W-7 Isomer . hydrochloride
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SYNONYMS N-(6-Aminohexyl)-5-chloro-2-naphthalenesulfonamide . HCl
PRODUCT LINE Signal Transduction
PRODUCT CATEGORY Calmodulin Inhibitors
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ALX-270-175-M005   5 mg 40.00 USD Add To Cart
ALX-270-175-M025   25 mg 160.00 USD Add To Cart
Product Specification
FORMULA: C16H21ClN2O2S . HCl
MW: 340.9 . 36.5
CAS NUMBER: 69762-85-2
PURITY: ≥98% (TLC)
APPEARANCE: White to off-white solid.
SOLUBILITY: Soluble in methanol.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
HANDLING: Protect from light.
IDENTITY: Determined by 1H-NMR.

Product Description
Inhibitor of calmodulin. Isomer of W-7 (Prod. No. ALX-270-153).
Product Specific Literature References
N-(6-aminohexyl)-5-chloro-1-naphthalenesulfonamide, a calmodulin antagonist, inhibits cell proliferation: H. Hidaka, et al.; PNAS 78, 4354 (1981) Abstract
Related Products
 
 
ALX-270-176 Revised 04-Apr-03
W-13 Isomer . hydrochloride
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SYNONYMS N-(4-Aminobutyl)-5-chloro-1-naphthalenesulfonamide . HCl
PRODUCT LINE Signal Transduction
PRODUCT CATEGORY Calmodulin Inhibitors
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ALX-270-176-M001   1 mg 30.00 USD Add To Cart
ALX-270-176-M005   5 mg 120.00 USD Add To Cart
Product Specification
FORMULA: C14H17ClN2O2S . HCl
MW: 312.8 . 36.5
PURITY: ≥98%
APPEARANCE: Off-white solid.
SOLUBILITY: Soluble in hot water or methanol.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
HANDLING: Protect from light.

Product Description
Isomer of W-13 (Prod. No. ALX-270-156).
Product Specific Literature References
N-(6-aminohexyl)-5-chloro-1-naphthalenesulfonamide, a calmodulin antagonist, inhibits cell proliferation: H. Hidaka, et al.; PNAS 78, 4354 (1981) Abstract
 
 
ALX-270-179 Revised 30-Mar-07
SB203580
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SYNONYMS 4-(4-Fluorophenyl)-2-(4-methylsulfinylphenyl)-5-(4-pyridyl)1H-imidazole
PRODUCT LINE Signal Transduction
PRODUCT CATEGORY MAPK Pathway Inhibitors
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ALX-270-179-M001   1 mg 60.00 USD Add To Cart
ALX-270-179-M005   5 mg 250.00 USD Add To Cart
ALX-270-179-M050   50 mg 1'200.00 USD Add To Cart
Product Specification
FORMULA: C21H16N3FOS
MW: 377.4
PURITY: ≥98%
APPEARANCE: White to off-white powder.
SOLUBILITY: Soluble in DMSO or methanol.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
HAZARD: IRRITANT.

Product Description
Cell permeable, specific inhibitor of p38 (SAPK2a).  Can inhibit the key cell cycle event of retinoblastoma protein phosphorylation in interleukin-2-stimulated T cells. Studies on the proximal regulator of this event, the PI(3)K (phosphoinositide 3-kinase)/Akt (protein kinase B; PKB) pathway, showed that SB203580 blocks the phosphorylation and activation of Akt by inhibiting the Akt kinase, phosphoinositide-dependent protein kinase 1 (PDK1). The concentrations of SB203580 required to block Akt phosphorylation (IC50= 3-5µM) are only approximately 10-fold higher than those required to inhibit p38 MAP kinase (IC50=0.3-0.5µM). These data define a new activity for this drug and suggest that extreme caution should be used when interpreting data when SB203580 has been used at concentrations above 1-2µM [1].
Product Specific Literature References
A protein kinase involved in the regulation of inflammatory cytokine biosynthesis: J.C. Lee, et al.; Nature 372, 739 (1994) Abstract
SB 203580 is a specific inhibitor of a MAP kinase homologue which is stimulated by cellular stresses and interleukin-1: A. Cuenda, et al.; FEBS Lett. 364, 229 (1995) Abstract
Characterization of the structure and function of a new mitogen-activated protein kinase (p38beta): Y. Jiang, et al.; J. Biol. Chem. 271, 17920 (1996) Abstract; Full Text
The primary structure of p38 gamma: a new member of p38 group of MAP kinases: Z. Li, et al.; BBRC 228, 334 (1996) Abstract
Regulation of stress-induced cytokine production by pyridinylimidazoles; inhibition of CSBP kinase: T.F. Gallagher, et al.; Bioorg. Med. Chem. 5, 49 (1997) Abstract
A p38 MAP kinase inhibitor SB203580 inhibits CD28-dependent T cell proliferation and IL-2 production: S.G. Ward, et al.; Biochem. Soc. Trans. 25, 304S (1997) Abstract
p38 mitogen activated protein kinase regulates endothelial VCAM-1 expression at the post-transcriptional level: A. Pietersma, et al.; BBRC 230, 44 (1997) Abstract
Direct inhibition of cyclooxygenase-1 and -2 by the kinase inhibitors SB 203580 and PD 98059. SB 203580 also inhibits thromboxane synthase: A.G. Börsch-Haubold, et al.; J. Biol. Chem. 273, 28766 (1998) Abstract; Full Text
Conversion of SB 203580-insensitive MAP kinase family members to drug-sensitive forms by a single amino-acid substitution: P.A. Eyers, et al.; Chem. Biol. 5, 321 (1998) Abstract
Low density lipoprotein phosphorylates the focal adhesion-associated kinase p125(FAK) in human platelets independent of integrin alphaIIb beta3: C.M. Hackeng, et al.; J. Biol. Chem. 274, 384 (1999) Abstract; Full Text
Effect of SB 203580 on the activity of c-Raf in vitro and in vivo: C.A. Hall-Jackson, et al.; Oncogene 18, 2047 (1999) Abstract
Raf-1 is activated by the p38 mitogen-activated protein kinase inhibitor, SB203580: A. Kalmes, et al.; FEBS Lett. 444, 71 (1999) Abstract
SB 203580, an inhibitor of p38 mitogen-activated protein kinase, enhances constitutive apoptosis of cytokine-deprived human eosinophils: H. Kankaanranta, et al.; J. Pharmacol. Exp. Ther. 290, 621 (1999) Abstract
[1] The pyridinyl imidazole inhibitor SB203580 blocks phosphoinositide-dependent protein kinase activity, protein kinase B phosphorylation, and retinoblastoma hyperphosphorylation in interleukin-2-stimulated T cells independently of p38 mit: F.V. Lali, et al.; J. Biol. Chem. 275, 7395 (2000) Abstract; Full Text
 
 
ALX-270-181 Revised 28-Jul-08
Damnacanthal
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SYNONYMS 3-Hydroxy-1-methoxyanthraquinone-2-aldehyde
PRODUCT LINE Immunology
PRODUCT CATEGORY Kinases in T Cell Signal Transduction / Related Products
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ALX-270-181-M001   1 mg 165.00 USD Add To Cart
Product Specification
FORMULA: C16H10O5
MW: 282.3
CAS NUMBER: 477-84-9
PURITY: ≥95% (HPLC)
APPEARANCE: Yellow to orange solid.
SOLUBILITY: 10mg/ml soluble in DMSO.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
HANDLING: Protect from light.

Product Description
Potent and selective inhibitor of p56lck tyrosine kinase activity. Inhibition of p56lck by damnacanthal appears to be reversible, not time-dependent and not significantly affected by the presence of sulfhydryl reagents.
Product Specific Literature References
S. Nonomura; J. Pharm. Soc. Jpn. 75, 219 (1955)
N.R. Ayyangar, et al.; Tetrahedron 6, 331 (1959)
Effects of three compounds extracted from Morinda lucida on Plasmodium falciparum: K.Koumaglo, et al.; Planta Medica 58, 533 (1992) Abstract
Induction of normal phenotypes in ras-transformed cells by damnacanthal from Morinda citrifolia: T. Hiramatsu, et al.; Cancer Lett. 73, 161 (1993) Abstract
Damnacanthal is a highly potent, selective inhibitor of p56lck tyrosine kinase activity: C.R. Faltynek, et al.; Biochemistry 34, 12404 (1995) Abstract
Further Categories Containing This Product:
Src Family Kinases / Related ProductsTyrosine Kinase Inhibitors
 
 
ALX-270-183 Revised 11-Dec-04
Tyrphostin AG 17
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SYNONYMS Tyrphostin A9
Tyrphostin RG 50872
(3,5-Di-t-butyl-4-hydroxybenzylidene)-malononitrile
α-Cyano-(3,5-di-tert.butyl-4-hydroxy)cinnamonitrile
PRODUCT LINE Signal Transduction
PRODUCT CATEGORY Tyrphostins
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ALX-270-183-M005   5 mg 40.00 USD Add To Cart
ALX-270-183-M025   25 mg 105.00 USD Add To Cart
Product Specification
FORMULA: C18H22N2O
MW: 282.4
CAS NUMBER: 10537-47-0
PURITY: ≥98%
APPEARANCE: Off-white solid.
SOLUBILITY: Soluble in DMSO or 100% ethanol.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
HANDLING: Store tightly sealed in the dark. Protect from light.

Product Specific Literature References
Tyrphostins inhibit PDGF-induced DNA synthesis and associated early events in smooth muscle cells: G.E. Bilder, et al.; Am. J. Physiol. 260, C721 (1991) Abstract
Tyrphostins as molecular tools and potential antiproliferative drugs: A. Levitzki and C. Gilon; TIPS 12, 171 (1991), (Review) Abstract
Tyrphostin AG17, [(3,5-Di-tert-butyl-4-hydroxybenzylidene)- malononitrile], inhibits cell growth by disrupting mitochondria: A.M. Burger, et al.; Cancer Res. 55, 2794 (1995) Abstract
The tryphostin AG17 induces apoptosis and inhibition of cdk2 activity in a lymphoma cell line that overexpresses bcl-2: G.A. Palumbo, et al.; Cancer Res. 57, 2434 (1997) Abstract
Chemosensitization of glioblastoma cells to bis-dichloroethyl- nitrosourea with tyrphostin AG17: B.C. Liang & E. Ullyatt; Clin. Cancer Res. 4, 773 (1998) Abstract
 
 
ALX-270-193 Revised 04-Mar-05
Nimesulide
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SYNONYMS N-(4-Nitro-2-phenoxyphenyl)methanesulfonamide
PRODUCT LINE Inflammation
PRODUCT CATEGORY Non-Steroidal Anti-Inflammatory Drugs [NSAIDS]
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ALX-270-193-G005   5 g 80.00 USD Add To Cart
Product Specification
FORMULA: C13H12N2O5S
MW: 308.3
CAS NUMBER: 51803-78-2
MERCK INDEX: 14: 6548
PURITY: ≥99%
APPEARANCE: Light tan crystals.
SOLUBILITY: Soluble in 100% ethanol, methanol, DMSO or acetonitrile. Ethanol is most commonly used for stock solutions, but solubility is only about 4mg/ml.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
HAZARD: TOXIC.

Product Description
Selective inhibitor of cyclooxygenase 2 (COX-2). Platelet aggregation inhibitor.
Product Specific Literature References
Purification, characterization and selective inhibition of human prostaglandin G/H synthase 1 and 2 expressed in the baculovirus system: J. Barnett, et al.; Biochim. Biophys. Acta 1209, 130 (1994) Abstract
A structural feature of N-[2-(cyclohexyloxy)-4-nitrophenyl] methanesulfonamide (NS-398) that governs its selectivity and affinity for cyclooxygenase 2 (COX2): R. Huff, et al.; Inflamm. Res. 44, S145 (1995) Abstract
Purification and characterization of prostaglandin H synthase-2 from sheep placental cotyledons: J.L. Johnson, et al.; Arch. Biochem. Biophys. 324, 26 (1995) Abstract
 
 
ALX-270-194 Revised 19-Sep-05
Valeryl salicylate