• Home
  • Sitemap
  • Help
  • Technical Support
  • Contact
K+ Channels
You are here: Product Lines > Signal Transduction > Ion Channels & Transporters / Related Products > K+ Channels
 
Toolbar - View Selection
 
 Items 1-20 of 39 Page 1 of 2 Select Page: 1 2  >>  
ALX-480-066 Revised 20-May-08
Adenosine 5'-O-(3-thiotriphosphate) . tetralithium salt
Add to Clipboard
SYNONYMS ATP-γS . 4Li
PRODUCT LINE Signal Transduction
PRODUCT CATEGORY Adenosine Derivatives Other Products
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-480-066-M001   1 mg 25.00 USD Add To Cart
ALX-480-066-M005   5 mg 80.00 USD Add To Cart
Product Specification
FORMULA: C10H12N5O12P3S . 4Li
MW: 520.2 . 27.8
CAS NUMBER: 93889-89-5
PURITY: ≥90%
APPEARANCE: White to off-white solid.
SOLUBILITY: Soluble in water.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
USE/STABILITY: Stock solutions may be stored at -80°C for up to 1 month. Product is not sterile.
HANDLING: Protect from moisture.

Product Description
ATP analog that can substitute ATP in various kinase reactions. Substrate and inhibitor of ATP-dependent enzyme systems. The resulting thiophosphorylated proteins are resistant to dephosphorylation by protein phosphatases. Increases the activity of Ca2+-activated K+ channels.
Product Specific Literature References
The structure of recA protein-DNA filaments. 2 recA protein monomers unwind 17 base pairs of DNA by 11.5 degrees/base pair in the presence of adenosine 5'-O-(3-thiotriphosphate): S. Chrysogelos, et al.; J. Biol. Chem. 258, 12624 (1983) Abstract; Full Text
Regulation of phosphoinositide breakdown by guanine nucleotides: I. Litosch & J.N. Fain; Life Sci. 39, 187 (1986) Abstract
Regulation of protein serine-threonine phosphatase type-2A by tyrosine phosphorylation: J. Chen, et al.; Science 257, 1261 (1992) Abstract
Further Categories Containing This Product:
K+ Channel Activators
 
 
ALX-550-141 Revised 17-Jan-05
4-Aminopyridine
Add to Clipboard
SYNONYMS Fampridine
4-Pyridylamine
PRODUCT LINE Signal Transduction
PRODUCT CATEGORY K+ Channel Blockers & Inhibitors
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-550-141-G005   5 g 20.00 USD Add To Cart
Product Specification
FORMULA: C5H6N2
MW: 94.1
CAS NUMBER: 504-24-5
MERCK INDEX: 14: 3933
PURITY: ≥98%
APPEARANCE: Off-white solid.
SOLUBILITY: Soluble in water or 100% ethanol.
SHIPPING: AMBIENT
LONG TERM STORAGE: +4°C
HANDLING: Protect from light.
HAZARD: TOXIC.

Product Description
Induces depolarization of GABA neurons. Non-selective K+ channel blocker. Reverses saxitoxin- and tetrodotoxin-induced cardiorespiratory depression. Increases stimulation-induced release of acetylcholine.
Product Specific Literature References
Effects of 4-aminopyridine on normal and demyelinated mammalian nerve fibres: R.M. Sherratt, et al.; Nature 283, 570 (1980) Abstract
The origin, structure, and pharmacological activity of botulinum toxin: L.L. Simpson; Pharmacol. Rev. 33, 155 (1981) Abstract
Further Categories Containing This Product:
GABA-ergics & GABA Receptors / Related Products
 
 
ALX-151-013 Revised 05-Dec-06
Apamin
Add to Clipboard
PRODUCT LINE Signal Transduction
PRODUCT CATEGORY K+ Channel Blockers & Inhibitors
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-151-013-MC05   0.5 mg 150.00 USD Add To Cart
Product Specification
SEQUENCE: H-Cys-Asn-Cys-Lys-Ala-Pro-Glu-Thr-Ala-Leu-Cys-Ala-Arg-Arg-Cys-Gln-Gln-His-NH2
(Disulfide bonds between Cys1-Cys11and Cys3-Cys15)
FORMULA: C131H131N31O24S4
MW: 2027.3
CAS NUMBER: 24345-16-2
MERCK INDEX: 14: 725
RTECS: CD6899900
SOURCE/HOST: Synthetic.
PURITY: ≥97% (HPLC)
APPEARANCE: Lyophilized.
SOLUBILITY: Soluble in 0.05M acetic acid; slightly soluble in water.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
Product Description
Originally isolated from Apis mellifera. A small conductance Ca2+-activated K+ channel blocker.
Product Specific Literature References
Toxins in the characterization of potassium channels: N.A. Castle, et al.; TINS 12, 59 (1989), (Review) Abstract
Potassium channel toxins: P.N. Strong; Pharmacol. Ther. 46, 137 (1990) Abstract
Further Categories Containing This Product:
Peptides
 
 
ALX-550-040 Revised 06-Feb-07
(-)-Bicuculline methobromide
Add to Clipboard
PRODUCT LINE Neurobiology
PRODUCT CATEGORY GABA-ergics & GABA Receptors / Related Products
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-550-040-M010   10 mg 20.00 USD Add To Cart
ALX-550-040-M050   50 mg 80.00 USD Add To Cart
Product Specification
FORMULA: C21H20BrNO6
MW: 462.3
CAS NUMBER: 73604-30-5
PURITY: ≥98%
APPEARANCE: White to off-white solid.
SOLUBILITY: Soluble in water, 100% ethanol, methanol or DMSO.
SHIPPING: AMBIENT
LONG TERM STORAGE: +4°C
HANDLING: Protect from light.

Product Description
GABAA receptor antagonist. Blocks Ca2+-activated K+ channels.
Product Specific Literature References
3H-baclofen and 3H-GABA bind to bicuculline-insensitive GABA B sites in rat brain: D.R. Hill & N.G. Bowery; Nature 290, 149 (1981) Abstract
Further Categories Containing This Product:
K+ Channel Blockers & Inhibitors
 
 
ALX-630-050 Revised 31-Oct-07
β-Bungarotoxin
Add to Clipboard
SYNONYMS β-BuTx
PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Neurotoxins
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-630-050-M001   1 mg 60.00 USD Add To Cart
Product Specification
MW: 6979.0
CAS NUMBER: 12778-32-4
MERCK INDEX: 14: 1488
SOURCE/HOST: Isolated from Bungarus multicinctus.
PURITY: ≥98%
APPEARANCE: Lyophilized powder.
SOLUBILITY: Soluble in water or aqueous buffers.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
HAZARD: POTENT NEUROTOXIN.
Product Description
Presynaptic, neurotoxic phospholipase A2 activity.
Product Specific Literature References
Use of a snake venom toxin to characterize the cholinergic receptor protein: J.P. Changeux, et al.; PNAS 67, 1241 (1970) Abstract
Amino acid sequence of alpha-bungarotoxin from the venom of Bungarus multicinctus: D. Mebs, et al; BBRC 44, 711 (1971) Abstract
Alpha-bungarotoxin binding and central nervous system nicotinic acetylcholine receptors: R.E. Oswald; Neuroscience 6, 1 (1981) Abstract
Amino acid sequence of beta 2-bungarotoxin from Bungarus multicinctus venom. The amino acid substitutions in the B chains: K. Kondo, et al.; J. Biochem. 91, 1519 (1982) Abstract
Amino acid sequences of three beta-bungarotoxins (beta 3-, beta 4-, and beta 5- bungarotoxins) from Bungarus multicinctus venom. Amino acid substitutions in the A chains: K. Kondo; J. Biochem. 91, 1531 (1982) Abstract
Biochemical and electrophysiological demonstrations of the actions of beta-bungarotoxin on synapses in brain: J.V. Halliwell; J. Neurochem. 39, 543 (1982) Abstract
Solubilization and characterization of the beta-bungarotoxin-binding protein of chick brain membranes: H. Rehm & H. Betz; J. Biol. Chem. 259, 6865 (1984) Abstract; Full Text
Beta-bungarotoxin inhibits a non-inactivating potassium current in guinea pig dorsal root ganglion neurones: M. Petersen, et al.; Neurosci. Lett. 68, 141 (1986) Abstract
Cross-linking of beta-bungarotoxin to chick brain membranes. Identification of subunits of a putative voltage-gated K+ channel: R.R. Schmidt & H. Betz; Biochemistry 28, 8346 (1989) Abstract
Nucleotide sequence encoding beta-bungarotoxin A2-chain from the venom glands of Bungarus multicinctus: J.M. Danse, et al.; Nucl. Acids Res. 18, 4609 (1990) Abstract
Potassium channel toxins: P.N. Strong; Pharmacol. Ther. 46, 137 (1990), (Review) Abstract
Mechanism of action of beta-bungarotoxin, a presynaptically acting phospholipase A2 neurotoxin: its effect on protein phosphorylation in rat brain synaptosomes: E. Ueno & P. Rosenberg; Toxicon 34, 1219 (1996) Abstract
What does beta-bungarotoxin do at the neuromuscular junction?: E.G. Rowan; Toxicon 39, 107 (2001), (Review) Abstract
Induction by beta-bungarotoxin of apoptosis in cultured hippocampal neurons is mediated by Ca(2+)-dependent formation of reactive oxygen species: O. Shakhman, et al.; J. Neurochem. 87, 598 (2003) Abstract
Phospholipase A(2) activity of beta-bungarotoxin is essential for induction of cytotoxicity on cerebellar granule neurons: Y.J. Chen; J. Neurobiol. 64, 213 (2005) Abstract
Mechanism of beta-bungarotoxin in facilitating spontaneous transmitter release at neuromuscular synapse: J.C. Liou, et al.; Neuropharmacology 51, 671 (2006) Abstract
Further Categories Containing This Product:
K+ Channel Blockers & Inhibitors • PLA2
 
 
ALX-630-059 Revised 15-Jul-08
Charybdotoxin
Add to Clipboard
SYNONYMS ChTx
PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Neurotoxins
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-630-059-C100   100 µg 490.00 USD Add To Cart
Product Specification
SEQUENCE: Pyr-Phe-Thr-Asn-Val-Ser-Cys-Thr-Thr-Ser-Lys-Glu-Cys-Trp-Ser-Val-Cys-Gln-Arg-Leu-His-Asn-Thr-Ser-Arg-Gly-Lys-Cys-Met-Asn-Lys-Lys-Cys-Arg-Cys-Tyr-Ser-OH
(Disulfide bonds between Cys7-Cys28, Cys13-Cys33 and Cys17-Cys35)
FORMULA: C176H277N57O55S7
MW: 4295.9
CAS NUMBER: 95751-30-7
MERCK INDEX: 14: 2046
SOURCE/HOST: Synthetic.
FORMULATION: Lyophilized.
RECONSTITUTION: Do not remove cap. Inject distilled water into the vial using a calibrated syringe. Dissolve all contents thoroughly to receive a 0.1mM solution. Prepare aliquots (100–200µl) and store at -20°C. The aqueous solution should be used within a few weeks.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
Product Description
Highly potent blocker of a variety of Ca2+-activated K+-channels in a wide range of cell types. Acts in nanomolar concentration and does not affect apamin-sensitive channels.
Product Specific Literature References
Charybdotoxin, a protein inhibitor of single Ca2+-activated K+ channels from mammalian skeletal muscle: C. Miller, et al.; Nature 313, 316 (1985) Abstract
C. Smith, et al.; J. Biol. Chem. 261, 14607 (1986) Abstract; Full Text
Purification, sequence, and model structure of charybdotoxin, a potent selective inhibitor of calcium-activated potassium channels: G. Gimenez-Gallego, et al.; PNAS 85, 3329 (1988) Abstract
Toxins in the characterization of potassium channels: N.A. Castle, et al.; TINS 12, 59 (1989) Abstract
Characterization of high affinity binding sites for charybdotoxin in sarcolemmal membranes from bovine aortic smooth muscle. Evidence for a direct association with the high conductance calcium-activated potassium channel: J. Vazquez, et al.; J. Biol. Chem. 264, 20902 (1989) Abstract; Full Text
Solution synthesis of charybdotoxin (ChTX), a K+ channel blocker: P. Lambert, et al.; BBRC 170, 684 (1990) Abstract
Potassium channel toxins: P.N. Strong; Pharmacol. Ther. 46, 137 (1990), (Review) Abstract
Characterization of high affinity binding sites for charybdotoxin in synaptic plasma membranes from rat brain. Evidence for a direct association with an inactivating, voltage-dependent, potassium channel: J. Vazquez, et al.; J. Biol. Chem. 265, 15564 (1990) Abstract; Full Text
Refined structure of charybdotoxin: common motifs in scorpion toxins and insect defensins: F. Bontems, et al.; Science 254, 1521 (1991) Abstract
Design, synthesis, and functional expression of a gene for charybdotoxin, a peptide blocker of K+ channels: C.S. Park, et al.; PNAS 88, 2046 (1991) Abstract
Synthesis of charybdotoxin and of two N-terminal truncated analogues. Structural and functional characterisation: C. Vita, et al.; Eur. J. Biochem. 217, 157 (1993) Abstract
Charybdotoxin and its effects on potassium channels: M.L. Garcia, et al.; Am. J. Physiol. 269, C1 (1995), ( Abstract
Effects of charybdotoxin on K+ channel (KV1.2) deactivation and inactivation kinetics: L.K. Sprunger, et al.; Eur. J. Pharmacol. 314, 357 (1996) Abstract
A charybdotoxin-insensitive conductance in human T lymphocytes: T cell membrane potential is set by distinct K+ channels: J. A. Verheugen & H. Korn; J. Physiol. 503, 317 (1997) Abstract
Interaction of agitoxin2, charybdotoxin, and iberiotoxin with potassium channels: selectivity between voltage-gated and Maxi-K channels: Y. D. Gao & M. L. Garcia; Proteins 52, 146 (2003) Abstract
Block of maurotoxin and charybdotoxin on human intermediate-conductance calcium-activated potassium channels (hIKCa1): V. Visan, et al.; Toxicon 43, 973 (2004) Abstract
Further Categories Containing This Product:
K+ Channel Blockers & Inhibitors
 
 
ALX-550-242 Revised 23-Jul-04
Clofilium . tosylate
Add to Clipboard
SYNONYMS 4-Chloro-N,N-diethyl-N-heptylbenzenebutanaminium . tosylate
PRODUCT LINE Signal Transduction
PRODUCT CATEGORY K+ Channel Blockers & Inhibitors
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-550-242-M025   25 mg 40.00 USD Add To Cart
ALX-550-242-M100   100 mg 120.00 USD Add To Cart
ALX-550-242-M250   250 mg 240.00 USD Add To Cart
Product Specification
FORMULA: C21H37ClN . C7H7O3S
MW: 339.0 . 171.2
CAS NUMBER: 92953-10-1
PURITY: ≥97%
APPEARANCE: White solid.
SOLUBILITY: Soluble in water, methanol or DMSO.
SHIPPING: AMBIENT
LONG TERM STORAGE: +20°C

Product Description
K+ channel blocker. Antiarrhytmic. Cardiac depressant.
Product Specific Literature References
The differential response of normal and ischaemic Purkinje fibres to clofilium, d-sotalol and bretylium: W.B. Gough & N. el-Sherif; Cardiovasc. Res. 23, 554 (1989) Abstract
Block of heart potassium channels by clofilium and its tertiary analogs: relationship between drug structure and type of channel blocked: J.P. Arena & R.S. Kass; Mol. Pharmacol. 34, 60 (1988) Abstract
 
 
ALX-430-042 Revised 24-Sep-02
Dequaliniumchloride
Add to Clipboard
PRODUCT LINE Signal Transduction
PRODUCT CATEGORY K+ Channel Blockers & Inhibitors
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-430-042-G001   1 g 25.00 USD Add To Cart
Product Specification
FORMULA: C30H40Cl2N4
MW: 527.6
CAS NUMBER: 522-51-0
MERCK INDEX: 14: 2913
PURITY: ≥95%
APPEARANCE: Off-white powder.
SOLUBILITY: Slightly soluble in water.
SHIPPING: AMBIENT
LONG TERM STORAGE: +20°C
HAZARD: IRRITANT.

Product Description
Potent and selective non-peptide blocker of the apamin-sensitive small conductance Ca2+-activated K+ channel.
Product Specific Literature References
Dequalinium, a selective blocker of the slow afterhyperpolarization in rat sympathetic neurones in culture: P.M. Dunn; Eur. J. Pharmacol. 252, 189 (1994) Abstract
 
 
ALX-550-260 Revised 29-Apr-08
Diazoxide
Add to Clipboard
SYNONYMS 7-Chloro-3-methyl-2H-1,2,4-benzothiadiazine 1,1-dioxide
PRODUCT LINE Signal Transduction
PRODUCT CATEGORY K+ Channel Activators
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-550-260-M500   500 mg 47.00 USD Add To Cart
ALX-550-260-G001   1 g 75.00 USD Add To Cart
Product Specification
FORMULA: C8H7ClN2O2S
MW: 230.7
CAS NUMBER: 364-98-7
MERCK INDEX: 14: 3004
PURITY: ≥98%
APPEARANCE: White to off-white powder.
SOLUBILITY: Soluble in DMSO (25mg/ml); insoluble in water.
SHIPPING: AMBIENT
LONG TERM STORAGE: +4°C
HAZARD: HARMFUL.

Product Description
ATP-sensitive K+ channel activator. Blocks desensitization of AMPA receptors. Acts in pancreatic β-cells, where it is more potent than pinacidil (Prod. No. ALX-550-285). Antihypertensive and vasodilatory agent.
Product Specific Literature References
Opposite effects of tolbutamide and diazoxide on the ATP-dependent K+ channel in mouse pancreatic beta-cells: G. Trube, et al.; Pflugers Arch. Eur. J. Physiol. 407, 493 (1986) Abstract
Protein phosphorylation is required for diazoxide to open ATP-sensitive potassium channels in insulin (RINm5F) secreting cells: M.J. Dunne; FEBS Lett. 250, 262 (1989) Abstract
In vitro and in vivo comparison of two K+ channel openers, diazoxide and cromakalim, and their inhibition by glibenclamide: U. Quast & N.S. Cook; J. Pharmacol. Exp. Ther. 250, 261 (1989) Abstract
The action of diazoxide and minoxidil sulphate on rat blood vessels: a comparison with cromakalim: D.T. Newgreen, et al.; Br. J. Pharmacol. 100, 605 (1990) Abstract
Comparative study of the effects of cromakalim (BRL 34915) and diazoxide on membrane potential, [Ca2+]i and ATP-sensitive potassium currents in insulin-secreting cells: M.J. Dunne, et al.; J. Membr. Biol. 114, 53 (1990) Abstract
Diazoxide-sensitivity of the adenosine 5'-triphosphate-dependent K+ channel in mouse pancreatic beta-cells: C. Schwanstecher, et al.; Br. J. Pharmacol. 107, 87 (1992) Abstract
Further Categories Containing This Product:
AMPA Receptors / Related Products
 
 
ALX-550-263 Revised 03-Feb-05
R-(+)-DIOA
Add to Clipboard
SYNONYMS R-(+)-Butylindazone
(Dihydroindenyl)oxy alkanoic acid
PRODUCT LINE Signal Transduction
PRODUCT CATEGORY K+ Channel Blockers & Inhibitors
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-550-263-M005   5 mg 40.00 USD Add To Cart
ALX-550-263-M025   25 mg 160.00 USD Add To Cart
Product Specification
FORMULA: