• Home
  • Sitemap
  • Help
  • Technical Support
  • Contact
Hormones & Hormone Receptors/Related Products
You are here: Product Lines > Signal Transduction > Hormones & Hormone Receptors/Related Products
 
Toolbar - View Selection
 
 Items 100-120 of 166 Page 6 of 9 Select Page: << 1 2 3 4 5 6 7 8 9  >>  
ALX-803-005 Revised 23-Jan-06
Monoclonal Antibody to Prolactin Receptor (U5)
Add to Clipboard
PRODUCT LINE Signal Transduction
PRODUCT CATEGORY Prolactin & Prolactin Receptors/Related Products
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-803-005-C100   100 µg 379.00 USD Add To Cart
Product Specification
SPECIES CROSSREACTIVITY:
Human
Rat
Pig
Others
CLONE: U5
ISOTYPE: Mouse IgG1
FORMULATION: Lyophilized. Contains 0.05% sodium azide.
RECONSTITUTION: Reconstitute with 100µl PBS.
IMMUNOGEN: Purified rat liver prolactin receptor.
SPECIFICITY: Recognizes the extracellular domain of human, rat, rabbit and pig prolactin receptor. Does not inhibit the interaction of prolactin with the receptor.
APPLICATION: Flow Cytometry
Immunocytochemistry (5µg/ml)
Immunohistochemistry
Immunoprecipitation
Western Blot (1µg/ml)
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: -20°C
HANDLING: Avoid freeze/thaw cycles.
Product Images
Please click on thumbnails to enlarge.
Product Specific Literature References
Characterization and applications of monoclonal antibodies to the prolactin receptor: H. Okamura, et al.; Endocrinology 124, 2499 (1989) Abstract
The prolactin receptor in the fetal rat: cellular localization of messenger ribonucleic acid, immunoreactive protein, and ligand-binding activity and induction of expression in late gestation: M. Royster, et al.; Endocrinology 136, 3892 (1995) Abstract
Internalization of prolactin receptor and prolactin in transfected cells does not involve nuclear translocation: M. Perrot-Applanat, et al.; J. Cell Sci. 110, 1123 (1997) Abstract; Full Text
The endogenous cannabinoid anandamide inhibits human breast cancer cell proliferation: L. De Petrocellis, et al.; PNAS 95, 8375 (1998) Abstract; Full Text
General Information
Prolactin (PRL) is a hormone involved in a variety of important functions including ion transport and osmoregulation, stimulation of milk, protein synthesis as well as the regulation of numerous reproductive functions. PRL exerts its influence on different cell types through a signal transduction pathway which begins with the binding of the hormone to a transmembrane PRL receptor. Immunoreactive PRL receptor, a member of the cytokine receptor family, varies in size (short and long forms) with tissue source and species, from ~40 kDa to 100 kDa. The PRL receptor consists of at least three separate domains: an extracellular region with 5 cysteines which contains the prolactin binding site, a single transmembrane domain and a cytoplasmic region, the length of which appears to influence ligand binding and regulate cellular function.
Further Categories Containing This Product:
Monoclonal Antibodies
 
 
ALX-BC-6010-S Revised 23-Jun-08
Monoclonal Antibody to Thyroid Peroxidase (human) (TPO 47)
Add to Clipboard
SYNONYMS anti-TPO (human) MAb (TPO 47)
PRODUCT LINE DNA Regulation / Transcription
PRODUCT CATEGORY Thyroid Hormones & Thyroid Hormone Receptors/Related Products
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-BC-6010-S-L001   1 ml 295.00 USD Add To Cart
ALX-BC-6010-S-L005   5 ml 990.00 USD Add To Cart
Product Specification
SPECIES CROSSREACTIVITY:
Human
CLONE: TPO 47
ISOTYPE: Mouse IgG1
FORMULATION: Sterile supernatant. 0.6 - 0.9g/ml. Contains 0.1% sodium azide.
IMMUNOGEN: Human TPO (thyroid peroxidase).
SPECIFICITY: Recognizes a linear epitope (aa 713-721) on human TPO protein. Assists immunocytological diagnosis of malignancy on fine needle aspirates (FNA) of thyroid nodules. Strongly stains human TPO in normal thyroid tissues but does not recognize tumoral human TPO.
APPLICATION: Immunohistochemistry (paraffin sections), Western Blot (dilution 1:2-1:10).
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: +4°C
Product Specific Literature References
[1] Relationship between immunological structure and biochemical properties of human thyroid peroxidase: J. Ruf, et al.; Endocrinology 125, 1211 (1989) Abstract
[2] Immunohistochemical study of thyroid peroxidase in normal, hyperplastic, and neoplastic human thyroid tissues: C. De Micco, et al.; Cancer 67, 3036 (1991) Abstract
[3] Current Evaluation of Thyroid Nodules: H. Gharib; Trends Endocrinol. Metab. 5, 365 (1994)
[4] Malignancy markers in the cytodiagnosis of thyroid nodules. Thyroid peroxidase: C. De Micco, et al.; Ann. Pathol. 14, 378 (1994) Abstract
[5] Thyroperoxidase immunodetection for the diagnosis of malignancy on fine- needle aspiration of thyroid nodules: J.-F. Henry, et al.; World J. Surg. 18, 529 (1994) Abstract
[6] Thyroid peroxidase immunodetection as a tool to assist diagnosis of thyroid nodules on fine-needle aspiration biopsy: C. De Micco, et al.; Eur. J. Endocrinol. 131, 474 (1994) Abstract
[7] Fine-needle aspiration of thyroid follicular neoplasm: diagnostic use of thyroid peroxidase immunocytochemistry with monoclonal antibody 47: C. De Micco, et al.; Surgery 116, 1031 (1994) Abstract
[8] A conformational B-cell epitope on the C-terminal end of the extracellular part of human thyroid peroxidase: V. Estienne, et al.; J. Biol. Chem. 273, 8056 (1998) Abstract; Full Text
[9] Molecular model, calcium sensitivity, and disease specificity of a conformational thyroperoxidase B-cell epitope: V. Estienne, et al.; J. Biol. Chem. 274, 35313 (1999) Abstract; Full Text
[10] Type I interferons modulate the expression of thyroid peroxidase, sodium/iodide symporter, and thyroglobulin genes in primary human thyrocyte cultures: N. Caraccio, et al.; J. Clin. Endocrinol. Metab. 90, 1156 (2005) Abstract; Full Text
[11] Reverse transcriptase inhibitors down-regulate cell proliferation in vitro and in vivo and restore thyrotropin signaling and iodine uptake in human thyroid anaplastic carcinoma: M. Landriscina, et al.; J. Clin. Endocrinol. Metab. 90, 5663 (2005) Abstract; Full Text
BRAFV600E mutation, but not RET/PTC rearrangements, is correlated with a lower expression of both thyroperoxidase and sodium iodide symporter genes in papillary thyroid cancer: C. Romei, et al.; Endocr. Relat. Cancer. 2, 511 (2008) Abstract
General Information
MANUFACTURER Manufactured by BioCytex.
Further Categories Containing This Product:
Monoclonal Antibodies
 
 
ALX-803-052 Revised 07-Mar-06
Monoclonal Antibody to Viable Rat beta Cells and RIN Cells (K14D10)
Add to Clipboard
PRODUCT LINE Obesity & Adipokines
PRODUCT CATEGORY Insulin & Insulin Receptor/Related Products
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-803-052-C100   100 µg 547.00 USD Add To Cart
Product Specification
SPECIES CROSSREACTIVITY:
Rat
CLONE: K14D10
ISOTYPE: Mouse IgG2a
CONCENTRATION: 0.5mg/ml
PURITY DETAIL: Ammonium sulphate precipitation.
FORMULATION: Liquid. In PBS, pH 7.4, containing 0.9mg/ml sodium azide.
IMMUNOGEN: Pig proinsulin.
SPECIFICITY: Recognizes surface structure of viable isolated rat beta cells. Does not recognize mouse islet beta cells. Cross-reactivity with human pancreatic beta cells was not detected.
APPLICATION: Flow Cytometry
Immunohistochemistry (frozen sections)
Note: Not recommended for WB and IP.
SHIPPING: SHIPPED ON BLUE ICE
SHORT TERM STORAGE: +4°C
LONG TERM STORAGE: -20°C
USE/STABILITY: Stable for at least 1 year when stored at +4°C.
HANDLING: Avoid freeze/thaw cycles.
Product Specific Literature References
Influence of target cell preparation on binding of monoclonal islet cell reactive antibodies (mc-ICRA) in cellular enzyme-linked immunosorbent assay (CELISA): M. Schlosser, et al.; J. Immunol. Methods 140, 101 (1991) Abstract
Monoclonal antibody-mediated cytotoxicity against rat beta cells detected in vitro does not cause beta-cell destruction in vivo: B. Ziegler, et al.; Diabetologia 35, 608 (1992) Abstract
Co-culture of pancreatic islets and allogeneic lymphocytes: alterations of responder and stimulator cells: B. Kuttler, et al.; Transplantation 64, 480 (1997) Abstract
Recognition of islet-directed peripheral blood lymphocytes in vitro before rejection of allogeneic grafted islets: B. Kuttler, et al.; Transplantation 69, 1987 (2000) Abstract
Immunomagnetic purification of beta cells from rat islets of Langerhans: V. Hadjivassiliou, et al.; Diabetologia 43, 1170 (2000) Abstract
Further Categories Containing This Product:
Monoclonal Antibodies
 
 
ALX-804-021 Revised 21-Jul-08
Monoclonal Antibody to Vitamin D3 Receptor (9A7)
Add to Clipboard
SYNONYMS anti-VDR MAb (9A7)
PRODUCT LINE Bone Metabolism
PRODUCT CATEGORY Vitamin D3 & Vitamin D3 Receptor/Related Products
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-804-021-C100   100 µg 379.00 USD Add To Cart
Product Specification
SPECIES CROSSREACTIVITY:
Human
Mouse
Rat
Others
CLONE: 9A7
ISOTYPE: Rat IgG2b
CONCENTRATION: 1mg/ml
FORMULATION: Liquid. Purified antibody containing 0.05% sodium azide.
IMMUNOGEN: Partially purified chicken intestinal cytoplasmic VDR (vitamin D3 receptor).
SPECIFICITY: Recognizes the occupied and unoccupied forms of VDR in human, mouse, rat, hamster, chicken, amphibian and fish. Recognizes an epitope between aa 89 and 105 of human VDR. In avians detects bands of ~58kDa and ~60kDa by Western blot, while in mammalian species the VDRs appear as a single band within the ~52-55kDa range.
Does not cross-react with ER (estrogen receptor) or GR (glucocorticoid receptor).
APPLICATION: Gel Supershift Assays
Immunocytochemistry
Immunohistochemistry (paraffin and frozen sections (5µg/ml))
Immunoprecipitation, Chromatin Immunoprecipitation
Western Blot (1µg/ml)
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: -20°C
HANDLING: Avoid freeze/thaw cycles.
Product Images
Please click on thumbnails to enlarge.
Product Specific Literature References
Development of hybridomas secreting monoclonal antibodies to the chicken intestinal 1 alpha,25-dihydroxyvitamin D3 receptor: J.W. Pike, et al.; PNAS 79, 7719 (1982) Abstract
Serum and monoclonal antibodies against the chick intestinal receptor for 1,25-dihydroxyvitamin D3. Generation by a preparation enriched in a 64,000-dalton protein: J.W. Pike, et al.; J. Biol. Chem. 258, 1289 (1983) Abstract; Full Text
Immunocytochemical localization of the 1,25-dihydroxyvitamin D3 receptor in target cells: T.L. Clemens, et al.; Endocrinology 122, 1224 (1988) Abstract
Molecular biology of the vitamin D hormone: M.R. Haussler, et al.; Recent Progr. Horm. Res. 44, 263 (1988) Abstract
Immunohistochemical detection of 1,25-dihydroxyvitamin D3 receptors and estrogen receptors by monoclonal antibodies: comparison of four immunoperoxidase methods: P. Milde, et al.; J. Histochem. Cytochem. 37, 1609 (1989) Abstract
Baculovirus-mediated expression of the human vitamin D receptor. Functional characterization, vitamin D response element interactions, and evidence for a receptor auxiliary factor: P.N. MacDonald, et al.; J. Biol. Chem. 266, 18808 (1991) Abstract; Full Text
Further Categories Containing This Product:
Monoclonal Antibodies
 
 
ALX-370-010 Revised 21-May-08
Muristerone A
Add to Clipboard
SYNONYMS 2β,3β,5β,11α,14α,20R,22R-Heptahydroxycholest-7-en-6-one
PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Ecdysteroids
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-370-010-C100   100 µg 28.00 USD Add To Cart
ALX-370-010-C250   250 µg 50.00 USD Add To Cart
ALX-370-010-C500   500 µg 80.00 USD Add To Cart
ALX-370-010-M001   1 mg 140.00 USD Add To Cart
Product Specification
FORMULA: C27H44O8
MW: 496.6
CAS NUMBER: 38778-30-2
PURITY: ≥94%
APPEARANCE: White to off-white crystals.
SOLUBILITY: Soluble in methanol, 100% ethanol, acetic acid or DMSO. Insoluble in water.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C

Product Description

Ecdysteroid. Due to reduced availability we recommend the alternative use of ponasterone A (Prod. No. ALX-370-014).
Product Specific Literature References
Structure of muri-sterone A, a new phytoecdysone: L. Canonica, et al.; J. C. S. Chem. Commun. 1060 (1972)
A novel method of isolation of phytoecdysones from kaladana seeds: L. Canonica, et al.; Phytochemistry 14, 525 (1975)
New phytoecdysones from kaladana. I. Structure of muristerone A and kaladasterone: L. Canonica, et al.; Gazz. Chim. Ital. 107, 123 (1977)
Ecdysone-inducible gene expression in mammalian cells and transgenic mice: D. No, et al.; PNAS 93, 3346 (1996) Abstract
The ecdysone inducible gene expression system: unexpected effects of muristerone A and ponasterone A on cytokine signaling in mammalian cells: S. Constantino, et al.; Eur. Cytokine Netw. 12, 365 (2001) Abstract
Selected technologies to control genes and their products for experimental and clinical purposes: H.K. Alexander, et al.; Arch. Immunol. Ther. Exp. (Warsz.) 55, 139 (2007), Review Abstract
Further Categories Containing This Product:
Expression Systems/Related Products
 
 
ALX-522-112 Revised 27-Mar-08
Nesfatin-1 (mouse) (recombinant)
Add to Clipboard
PRODUCT LINE Obesity & Adipokines
PRODUCT CATEGORY Food Intake Modulators Other Products
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-522-112-C010   10 µg 320.00 USD Add To Cart
Product Specification
SPECIES CROSSREACTIVITY:
Mouse
MW: ~8kDa
SOURCE/HOST: Recombinant mouse nesfatin-1 (aa 25-106) produced in E. coli.
CONCENTRATION: 1mg/ml after reconstitution.
PURITY: ≥95% (SDS-PAGE)
FORMULATION: Lyophilized. Contains PBS.
ENDOTOXIN CONTENT: <0.1EU/µg purified protein (LAL test; Bio Whittaker).
RECONSTITUTION: Reconstitute with 50µl sterile water. Further dilutions should be made with medium containing 0.2% bovine serum albumin (BSA).
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: -20°C
USE/STABILITY: Stable for at least 6 months after receipt when stored at -20°C.
HANDLING: After reconstitution, prepare aliquots and store at -20°C. Avoid freeze/thaw cycles.
Product Description
Nesfatin-1, a polypeptide produced by cleavage of the NEFA/nucleobindin-2 (NUCB2), is a secreted protein expressed in the appetite-control hypothalamic nuclei. Nesfatin is involved in the regulation of the feeding behaviour. Intracerebroventricular injection of nesfatin-1 reduces body weight in rat by affecting the animal food intake.
General Information
BACKGROUND/TECHNICAL INFORMATION Swiss-Prot link P81117: Nucleobindin-2 (mouse) [Precursor]
MANUFACTURER Manufactured by Apotech Corporation.
General Literature References
Identification of nesfatin-1 as a satiety molecule in the hypothalamus: I.S. Oh, et al.; Nature 443, 709 (2006) Abstract
Related Products
Further Categories Containing This Product:
Recombinant Proteins/Fusion Proteins
 
 
ALX-522-114 Revised 27-Mar-08
Nesfatin-1 (mouse) (recombinant) (tagged)
Add to Clipboard
PRODUCT LINE Obesity & Adipokines
PRODUCT CATEGORY Food Intake Modulators Other Products
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-522-114-C050   50 µg 320.00 USD Add To Cart
Product Specification
SPECIES CROSSREACTIVITY:
Mouse
MW: ~35kDa
SOURCE/HOST: Produced in E. coli. Recombinant mouse nesfatin-1 (aa 25-106) is fused at the N-terminus to a GST-tag.
CONCENTRATION: 1mg/ml after reconstitution.
PURITY: ≥95% (SDS-PAGE)
FORMULATION: Lyophilized. Contains PBS.
ENDOTOXIN CONTENT: <0.1EU/µg purified protein (LAL test; Bio Whittaker).
RECONSTITUTION: Reconstitute with 50µl sterile water. Further dilutions should be made with medium containing 0.2% bovine serum albumin (BSA).
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: -20°C
USE/STABILITY: Stable for at least 6 months after receipt when stored at -20°C.
HANDLING: Avoid freeze/thaw cycles. After reconstitution, prepare aliquots and store at -20°C.
Product Description
Nesfatin-1, a polypeptide produced by cleavage of the NEFA/nucleobindin-2 (NUCB2), is a secreted protein expressed in the appetite-control hypothalamic nuclei. Nesfatin is involved in the regulation of the feeding behaviour. Intracerebroventricular injection of nesfatin-1 reduces body weight in rat by affecting the animal food intake.
General Information
BACKGROUND/TECHNICAL INFORMATION Swiss-Prot link P81117: Nucleobindin-2 (mouse) [Precursor]
MANUFACTURER Manufactured by Apotech Corporation.
General Literature References
Identification of nesfatin-1 as a satiety molecule in the hypothalamus: I.S. Oh, et al.; Nature 443, 709 (2006) Abstract
Related Products
Further Categories Containing This Product:
Recombinant Proteins/Fusion Proteins
 
 
ALX-522-116 Revised 27-Mar-08
Nesfatin-1 (rat) (recombinant)
Add to Clipboard
PRODUCT LINE Obesity & Adipokines
PRODUCT CATEGORY Food Intake Modulators Other Products
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-522-116-C010   10 µg 320.00 USD Add To Cart
Product Specification
SPECIES CROSSREACTIVITY:
Mouse
MW: ~8kDa
SOURCE/HOST: Recombinant rat nesfatin-1 (aa 25-106) produced in E. coli.
CONCENTRATION: 0.1mg/ml after reconstitution.
PURITY: ≥95% (SDS-PAGE)
FORMULATION: Lyophilized. Contains PBS.
ENDOTOXIN CONTENT: <0.1EU/µg purified protein (LAL test; Bio Whittaker).
RECONSTITUTION: Reconstitute with 100µl sterile water. Further dilutions should be made with medium containing 0.2% bovine serum albumin (BSA).
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: -20°C
USE/STABILITY: Stable for at least 6 months after receipt when stored at -20°C.
HANDLING: After reconstitution, prepare aliquots and store at -20°C. Avoid freeze/thaw cycles.
Product Description
Nesfatin-1, a polypeptide produced by cleavage of the NEFA/nucleobindin-2 (NUCB2), is a secreted protein expressed in the appetite-control hypothalamic nuclei. Nesfatin is involved in the regulation of the feeding behaviour. Intracerebroventricular injection of nesfatin-1 reduces body weight in rat by affecting the animal food intake.
General Information
BACKGROUND/TECHNICAL INFORMATION Swiss-Prot link Q9JI85: Nucleobindin-2 (rat) [Precursor]
MANUFACTURER Manufactured by Apotech Corporation.
General Literature References
Identification of nesfatin-1 as a satiety molecule in the hypothalamus: I.S. Oh, et al.; Nature 443, 709 (2006) Abstract
Related Products
Further Categories Containing This Product:
Recombinant Proteins/Fusion Proteins
 
 
ALX-522-118 Revised 27-Mar-08
Nesfatin-1 (rat) (recombinant) (tagged)
Add to Clipboard