Advanced Search
© 2008 Alexis Corporation
You are here:
Product Lines
>
Signal Transduction
> Signal Transduction Enzymes/Related Products
ATPases/Related Products
Coenzymes & Vitamins/Related Products
Cyclases/Related Products
Kinases/Related Products
Oxygenases/Related Products
Phosphatases/Related Products
Phosphodiesterases/Related Products
Proteases/Related Products
Transglutaminases/Related Products
Toolbar - View Selection
Current View:
Price List
Brief
Detail
Search Results
Current Sort:
Sort by Product Name
Sort by Product ID
Sort by Result Relevance
Sort by Class
Show:
20 Products
50 Products
100 Products
All Products
Show Selected Products Only
Show
Products Only
Items
80-100
of 1313
Page 5
of 66
Select Page:
<<
1
2
3
4
5
6
7
8
9
10
>>
ALX-250-001
Revised 05-Sep-06
4-Aminophenylphosphate . sodium salt
PRODUCT LINE
Signal Transduction
PRODUCT CATEGORY
Phosphatases Other Products
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-250-001-M010
10 mg
30.00 USD
ALX-250-001-M050
50 mg
120.00 USD
ALX-250-001-M100
100 mg
195.00 USD
Product Specification
FORMULA:
188.1 . 23.0 . 72.1
MW:
C
6
H
7
NO
4
P . Na . 4.0H
2
O
PURITY:
≥97% (HPLC)
APPEARANCE:
Off-white to light gray crystalline solid.
SOLUBILITY:
Soluble in methanol.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
Product Description
Substrate for the electrochemical measurement of alkaline phosphatase.
ALX-440-041
Revised 25-Nov-04
Aminopterin
SYNONYMS
4-Aminofolic acid
4-Aminopteroylglutamic acid
4-Amino-PGA
PRODUCT LINE
Signal Transduction
PRODUCT CATEGORY
Folic Acid & Folate Receptors/Related Products
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-440-041-M010
10 mg
20.00 USD
ALX-440-041-M050
50 mg
80.00 USD
Product Specification
FORMULA:
C
19
H
20
N
8
O
5
MW:
440.4
CAS NUMBER:
54-62-6
MERCK INDEX:
14:
472
PURITY:
≥98%
APPEARANCE:
Yellow solid.
SOLUBILITY:
Soluble in dilute aqeuous base or DMSO; slightly soluble in water or ethanol.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
+20°C
HANDLING:
Protect from light.
Product Description
Folic acid antagonist. Potent dihydrofolate reductase inhibitor.
ALX-270-249
Revised 28-Jul-05
Aminopurvalanol A
SYNONYMS
(2R)-2-((6-((3-Amino-5-chlorophenyl)amino)-9-(1-methylethyl)-
9H-purin-2-yl)amino)-3-methyl-1-butanol
NG-97
PRODUCT LINE
Cell Cycle
PRODUCT CATEGORY
CDK & Cyclin Inhibitors
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-270-249-M001
1 mg
45.00 USD
ALX-270-249-M005
5 mg
135.00 USD
Product Specification
FORMULA:
C
19
H
26
N
7
OCl
MW:
403.9
CAS NUMBER:
220792-57-4
PURITY:
≥97% (
1
H-NMR)
APPEARANCE:
White to brownish solid.
SOLUBILITY:
Soluble in DMSO or methanol.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
+4°C
HANDLING:
Protect from light. Packaged under inert gas.
HAZARD:
IRRITANT.
Product Description
Cell permeable, reversible and competitive inhibitor of CDK1/cyclin B (IC
50
=33nM), CDK2/cyclin A (IC
50
=33nM), CDK2/cyclin E (IC
50
=28nM) and CDK5/p35 (IC
50
=20nM).
Product Specific Literature References
Synthesis and application of functionally diverse 2,6,9-trisubstituted purine libraries as CDK inhibitors:
Y.T. Chang, et al.; Chem. Biol.
6
, 361 (1999)
Abstract
A cyclin-dependent kinase inhibitor inducing cancer cell differentiation: biochemical identification using Xenopus egg extracts:
G.R. Rosania, et al.; PNAS
96
, 4797 (1999)
Abstract
;
Full Text
M-phase regulation of the recruitment of mRNAs onto polysomes using the CDK1/cyclin B inhibitor aminopurvalanol:
M. Le Breton, et al.; BBRC
306
, 880 (2003)
Abstract
ALX-270-387
Revised 18-Jul-07
3-Amino-1H-pyrazolo[3,4-b]quinoxaline
PRODUCT LINE
Cell Cycle
PRODUCT CATEGORY
CDK & Cyclin Inhibitors
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-270-387-M001
1 mg
40.00 USD
ALX-270-387-M005
5 mg
160.00 USD
Product Specification
FORMULA:
C
9
H
7
N
5
MW:
185.2
CAS NUMBER:
40254-90-8
PURITY:
≥98% (HPLC)
APPEARANCE:
Red solid.
SOLUBILITY:
Soluble in DMSO.
SHIPPING:
SHIPPED ON BLUE ICE
LONG TERM STORAGE:
+4°C
HANDLING:
Protect from light. Packaged under inert gas.
Product Description
Selective inhibitor of CDK1/cyclin B (IC
50
=600nM), CDK5/p25 (IC
50
=400nM) and GSK-3β (IC
50
=1µM). Does not inhibit Cdc25 phosphatase activity (IC
50
>10µM).
Product Specific Literature References
Pyrazolo[3,4-b]quinoxalines. A new class of cyclin-dependent kinases inhibitors
:
M.A. Ortega, et al.; Bioorg. Med. Chem.
10
, 2177 (2002)
Abstract
Further Categories Containing This Product:
GSK-3 Inhibitors
ALX-202-027
Revised 09-Aug-06
cAMP-dependent Protein Kinase (bovine heart) (catalytic subunit)
SYNONYMS
Protein Kinase A (bovine heart) (catalytic subunit)
PKA (bovine heart) (catalytic subunit)
PRODUCT LINE
Signal Transduction
PRODUCT CATEGORY
PKA
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-202-027-U500
500 U
250.00 USD
Product Specification
MW:
~40kDa.
EC:
2.7.1.37
SOURCE/HOST:
Isolated from bovine heart.
CONCENTRATION:
20µg/ml.
PURITY:
≥95% (SDS-PAGE)
FORMULATION:
Liquid. In 20mM MES, pH 6.5, containing 0.1mM EDTA, 30mM β-mercaptoethanol, 100mM sodium chloride and 50% ethylene glycol.
SPECIFIC ACTIVITY:
~1000 Units/µg using histone as the substrate. One unit is defined as the amount of enzyme that transfers 1pmol phosphate to histone per min. at 30°C.
APPLICATION:
For studying PKA phosphorylation
in vitro
.
SHIPPING:
SHIPPED ON DRY ICE
LONG TERM STORAGE:
-80°C
HANDLING:
Do not freeze/thaw.
General Information
BACKGROUND/TECHNICAL INFORMATION
Swiss-Prot link: cAMP-dependent Protein Kinase (bovine)
α catalytic subunit
(P00517)
,
β-1 catalytic subunit
(P05131),
β-2 catalytic subunit
(P24256)
AfCS Signalling Gateway link: cAMP-dependent Protein Kinase (mouse)
α catalytic subunit
(A001914),
β catalytic subunit
(A001815)
,
γ catalytic subunit
(A001916)
Further Categories Containing This Product:
Enzymes
•
Natural Proteins
ALX-151-016
Revised 17-Jan-05
cAMP-dependent Protein Kinase Inhibitor (5-22) amide
SYNONYMS
PKA Inhibitor (5-22) amide
PRODUCT LINE
Signal Transduction
PRODUCT CATEGORY
PKA Inhibitors
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-151-016-MC05
0.5 mg
110.00 USD
ALX-151-016-M001
1 mg
180.00 USD
Product Specification
SEQUENCE:
H-Thr-Thr-Tyr-Ala-Asp-Phe-Ile-Ala-Ser-Gly-Arg-Thr-Gly-Arg-Arg-Asn-Ala-Ile-NH
2
FORMULA:
C
84
H
137
N
29
O
26
MW:
1969.2
PURITY:
≥97%
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
Product Description
Potent inhibitor of cAMP-dependent protein kinase (PKA).
Product Specific Literature References
A potent synthetic peptide inhibitor of the cAMP-dependent protein kinase:
H.-C. Cheng, et al.; J. Biol. Chem.
261
, 989 (1986)
Abstract
;
Full Text
Primary structural determinants essential for potent inhibition of cAMP- dependent protein kinase by inhibitory peptides corresponding to the active portion of the heat-stable inhibitor protein:
D.B. Glass, et al.; J. Biol. Chem.
264
, 8802 (1989)
Abstract
;
Full Text
Further Categories Containing This Product:
Peptides
ALX-151-014
Revised 15-Dec-04
cAMP-dependent Protein Kinase Inhibitor (5-24)
SYNONYMS
PKA Inhibitor (5-24)
PRODUCT LINE
Signal Transduction
PRODUCT CATEGORY
PKA Inhibitors
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-151-014-MC05
0.5 mg
90.00 USD
ALX-151-014-M001
1 mg
160.00 USD
Product Specification
SEQUENCE:
H-Thr-Thr-Tyr-Ala-Asp-Phe-Ile-Ala-Ser-Gly-Arg-Thr-Gly-Arg-Arg-Asn-Ala-Ile-His-Asp-OH
FORMULA:
C
94
H
148
N
32
O
31
MW:
2222.4
PURITY:
≥97%
APPEARANCE:
White to off-white powder.
FORMULATION:
Lyophilized.
SOLUBILITY:
Soluble in water or 5 % acetic acid.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
HANDLING:
Keep cool and dry.
Product Description
Potent inhibitor of cAMP-dependent protein kinase (PKA). The peptide corresponds to the active site of the skeletal muscle inhibitor protein.
Product Specific Literature References
A potent synthetic peptide inhibitor of the cAMP-dependent protein kinase:
H.-C. Cheng, et al.; J. Biol. Chem.
261
, 989 (1986)
Abstract
;
Full Text
Phosphorylation of Avena phytochrome in vitro as a probe of light- induced conformational changes:
Y.S. Wong, et al.; J. Biol. Chem.
261
, 12089 (1986)
Abstract
;
Full Text
Further Categories Containing This Product:
Peptides
ALX-151-018
Revised 13-Feb-06
cAMP-dependent Protein Kinase Inhibitor (5-24) amide
SYNONYMS
PKA Inhibitor (5-24) amide
PRODUCT LINE
Signal Transduction
PRODUCT CATEGORY
PKA Inhibitors
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-151-018-MC05
0.5 mg
90.00 USD
ALX-151-018-M001
1 mg
160.00 USD
Product Specification
SEQUENCE:
H-Thr-Thr-Tyr-Ala-Asp-Phe-Ile-Ala-Ser-Gly-Arg-Thr-Gly-Arg-Arg-Asn-Ala-Ile-His-Asp-NH
2
FORMULA:
C
94
H
149
N
33
O
30
MW:
2221.4
PURITY:
≥97%
APPEARANCE:
White to off-white lyophilized powder.
SOLUBILITY:
Soluble in water or DMSO.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
Product Specific Literature References
A potent synthetic peptide inhibitor of the cAMP-dependent protein kinase:
H.-C. Cheng, et al.; J. Biol. Chem.
261
, 989 (1986)
Abstract
;
Full Text
Further Categories Containing This Product:
Peptides
ALX-151-017
Revised 15-Dec-04
cAMP-dependent Protein Kinase Inhibitor (14-24) amide
SYNONYMS
PKA Inhibitor (14-24) amide
PRODUCT LINE
Signal Transduction
PRODUCT CATEGORY
PKA Inhibitors
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-151-017-M001
1 mg
90.00 USD
ALX-151-017-M005
5 mg
360.00 USD
Product Specification
SEQUENCE:
H-Gly-Arg-Thr-Gly-Arg-Arg-Asn-Ala-Ile-His-Asp-NH
2
FORMULA:
C
49
H
86
N
24
O
15
MW:
1251.4
PURITY:
≥97%
APPEARANCE:
White powder.
SOLUBILITY:
Soluble in water.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
Further Categories Containing This Product:
Peptides
ALX-151-019
Revised 15-Dec-04
cAMP-dependent Protein Kinase Substrate
SYNONYMS
PKA Substrate
PRODUCT LINE
Signal Transduction
PRODUCT CATEGORY
PKA Substrates
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-151-019-MC05
0.5 mg
95.00 USD
ALX-151-019-M001
1 mg
165.00 USD
Product Specification
SEQUENCE:
H-Asp-Leu-Asp-Val-Pro-Ile-Pro-Gly-Arg-Phe-Asp-Arg-Arg-Val-Ser-Val-Ala-Ala-Glu-OH
FORMULA:
C
92
H
150
N
28
O
29
MW:
2112.4
PURITY:
≥95%
APPEARANCE:
White powder.
SOLUBILITY:
Soluble in water.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
Product Description
Derived from the RII subunit of cAMP-dependent protein kinase (PKA). Substrate for PKA. Has been used in a non-radioactive assay of calcineurin (protein phosphatase 2B) for screening purposes.
Product Specific Literature References
Dephosphorylation of cAMP-dependent protein kinase regulatory subunit (type II) by calmodulin-dependent protein phosphatase. Determinants of substrate specificity:
D.K. Blumenthal, et al.; J. Biol. Chem.
261
, 8140 (1986)
Abstract
;
Full Text
Nonradioactive assay for protein phosphatase 2B (calcineurin) activity using a partial sequence of the subunit of cAMP-dependent protein kinase as substrate:
A. Enz, et al.; Anal. Biochem.
216
, 147 (1994)
Abstract
Further Categories Containing This Product:
PP2B [Calcineurin]/Related Products
•
Peptides
ALX-270-381
Revised 28-Sep-07
Anacardic acid
SYNONYMS
2-Hydroxy-6-pentadecylbenzoic acid
6-Pentadecylsalicylic acid
AA
PRODUCT LINE
DNA Regulation / Transcription
PRODUCT CATEGORY
Histone Acetyl- & Methyl-Transferases/Related Products
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-270-381-M005
5 mg
40.00 USD
ALX-270-381-M025
25 mg
140.00 USD
Product Specification
FORMULA:
C
22
H
36
O
3
MW:
348.5
MERCK INDEX:
14:
621
SOURCE/HOST:
Synthetic.
PURITY:
≥95% (
1
H-NMR)
APPEARANCE:
White to off-white solid.
SOLUBILITY:
Soluble in 100% ethanol, methanol, DMSO, dichloromethane or ethylacetate.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
+4°C
USE/STABILITY:
Stock solutions are stable for up to 3 months when stored at -20°C.
HANDLING:
Protect from light. After reconstitution, pr
