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SOCS / Related Products
You are here: Product Lines > Signal Transduction > JAK / STAT Signalling Pathway > SOCS / Related Products
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ALX-804-637 Revised 31-Oct-06
Monoclonal Antibody to SOCS-3 (human) (SO1)
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PRODUCT LINE Signal Transduction
PRODUCT CATEGORY SOCS / Related Products
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-804-637-C100   100 µg 270.00 USD Add To Cart
Product Specification
SPECIES CROSSREACTIVITY:
Human
CLONE: SO1
ISOTYPE: Mouse IgG2b
CONCENTRATION: 1mg/ml
PURITY: >95% (SDS-PAGE)
PURITY DETAIL: Protein A-affinity purified.
FORMULATION: Liquid. In PBS, pH 7.4, containing 15mM sodium azide.
IMMUNOGEN: Full-length human SOCS-3 (suppressor of cytokine signalling-3).
SPECIFICITY: Recognizes human SOCS-3.
APPLICATION: ELISA
Western Blot
Optimal conditions must be determined individually for each application.
SHIPPING: SHIPPED ON BLUE ICE
SHORT TERM STORAGE: +4°C
LONG TERM STORAGE: -20°C
HANDLING: After opening, prepare aliquots and store at -20°C. Avoid freeze/thaw cycles.
Further Categories Containing This Product:
Monoclonal Antibodies
 
 
ALX-210-392 Revised 12-Jul-06
Polyclonal Antibody to SOCS-1
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SYNONYMS anti-Suppressor of Cytokine Signalling-1 PAb
anti-JAB PAb
anti-SSI-1 PAb
anti-TIP-3 PAb
PRODUCT LINE Signal Transduction
PRODUCT CATEGORY SOCS / Related Products
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-210-392-R200   200 µl 267.00 USD Add To Cart
Product Specification
SPECIES CROSSREACTIVITY:
Human
Mouse
SOURCE/HOST: From rabbit.
PURITY DETAIL: Protein G-affinity purified.
FORMULATION: Liquid. In PBS containing 0.1mg/ml BSA and 0.02% sodium azide.
IMMUNOGEN: Synthetic peptide containing aa residues of human SOCS-1 (suppressor of cytokine signalling-1).
SPECIFICITY: Recognizes human and mouse SOCS-1.
APPLICATION: Western Blot (1:500 - 1:1'000)
SHIPPING: SHIPPED ON BLUE ICE
SHORT TERM STORAGE: +4°C
LONG TERM STORAGE: -20°C
HANDLING: Avoid freeze/thaw cycles.
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General Information
SOCS-1 also known as JAB and (STAT)-induced STAT inhibitor 1 (SSI-1) is an SH2-domain-containing protein that is induced by and negatively regulates signalling by a number of cytokines including interleukin-4 (IL-4), IL-6, interferon (IFN)-gamma, prolactin, growth hormone, and erythropoietin. SOCS1/JAB is rapidly induced by LPS and negatively regulates LPS signalling.
General Literature References
SOCS proteins: negative regulators of cytokine signaling: D.L. Krebs and D.J. Hilton; Stem Cells 19, 378 (2001) Abstract
SOCS1/JAB is a negative regulator of LPS-induced macrophage activation: I. Kinjyo, et al.; Immunity 17, 583 (2002) Abstract
A positive regulatory role for suppressor of cytokine signaling 1 in IFN-gamma-induced MHC class II expression in fibroblasts: S. Ilangumaran, et al.; J. Immunol. 169, 5010 (2002) Abstract
Further Categories Containing This Product:
Toll-IL-1 Receptor Adapters & TLR Downstream Signalling Other Products • Polyclonal Antibodies
 
 
ALX-201-334 Revised 09-Jul-08
SOCS-3 (human) (recombinant) (His)
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SYNONYMS Suppressor of Cytokine Signalling-3 (human) (recombinant) (His)
CIS-3 (human) (recombinant) (His)
Cytokine-inducible SH2-containing Protein-3 (human) (recombinant) (His)
SSI-3 (human) (recombinant) (His)
PRODUCT LINE Signal Transduction
PRODUCT CATEGORY SOCS / Related Products
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-201-334-C050   50 µg 395.00 USD Add To Cart
Product Specification
SOURCE/HOST: Produced in E. coli. Full length human SOCS-3 (suppressor of cytokine signalling-3) (aa 1-225) is fused at the C-terminus to a His-tag.
CONCENTRATION:  
PURITY: ≥90% (SDS-PAGE)
FORMULATION: Liquid. 0.2µm-filtered solution in 20mM sodium phosphate, pH 6.5, containing 20mM sodium chloride, 50mM glutamate, 50mM arginine, 2mM dithiothreitol, 1mM EDTA.
ENDOTOXIN CONTENT: <1.0EU/µg protein (LAL test).
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: -20°C
USE/STABILITY: Working aliquots are stable for up to 3 months when stored at -20°C.
HANDLING: After reconstitution, prepare aliquots and store at -20°C. Avoid freeze/thaw cycles. For maximum product recovery after thawing, centrifuge the vial before opening the cap.
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General Information
BACKGROUND/TECHNICAL INFORMATION Swiss-Prot link O14543: Suppressor of Cytokine Signaling 3 (human)
MANUFACTURER Manufactured by AdipoGen, Inc.
Further Categories Containing This Product:
Recombinant Proteins / Fusion Proteins
 
 
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