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Lipid Signalling Pathways
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ALX-300-078 Revised 09-Dec-04
1-O-Hexadecyl-2-acetyl-sn-glycerol
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PRODUCT LINE Signal Transduction
PRODUCT CATEGORY Mono- & Diacylglycerols
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ALX-300-078-M010   10 mg 50.00 USD Add To Cart
ALX-300-078-M050   50 mg 200.00 USD Add To Cart
Product Specification
FORMULA: C21H42O4
MW: 358.6
PURITY: ≥99%
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
HANDLING: Hygroscopic. Protect from moisture.

Product Specific Literature References
A new class of antihypertensive neutral lipid: 1-alkyl-2-acetyl-sn- glycerols, a precursor of platelet activating factor: M.L. Blank, et al.; BBRC 118, 344 (1984) Abstract
Conversion of 1-alkyl-2-acetyl-sn-glycerols to platelet activating factor and related phospholipids by rabbit platelets: M.L. Blank, et al.; BBRC 124, 156 (1984) Abstract
1-0-Hexadecyl-2-acetyl-sn-glycerol stimulates differentiation of HL-60 human promyelocytic leukemia cells to macrophage-like cells: M.J.C. McNamara, et al.; BBRC 122, 824 (1984) Abstract
Metabolism of 1-O-alkyl-2-acetyl-sn-glycerol by washed rabbit platelets: formation of platelet activating factor: K. Satouchi, et al.; Arch. Biochem. Biophys. 234, 318 (1984) Abstract
 
 
ALX-301-009 Revised 09-Dec-04
1-O-Hexadecyl-2-acetyl-sn-glycero-3-phospho-(N,N,N-trimethyl)-hexanolamine
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PRODUCT LINE Inflammation
PRODUCT CATEGORY Platelet Activating Factors [PAF] & Receptors/Related Products
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ALX-301-009-M005   5 mg 45.00 USD Add To Cart
ALX-301-009-M025   25 mg 180.00 USD Add To Cart
Product Specification
FORMULA: C30H62NO7P
MW: 579.8
CAS NUMBER: 99103-16-9
PURITY: ≥98%
APPEARANCE: White solid.
SOLUBILITY: Soluble in chloroform, 100% ethanol or methanol. Soluble in water after sonification for 1 minute at 40°C.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
HANDLING: Slightly hygroscopic.

Product Description
PAF antagonist. Shows inhibitory behavior on platelet aggregation, secretion and phospholipid turnover.
Product Specific Literature References
Structural analogs of alkylacetylglycerophosphocholine inhibitory behavior on platelet activation: A. Tokumura, et al.; J. Biol. Chem. 260, 12710 (1985) Abstract; Full Text
Platelet activating factor is a potent stimulant of the production of active oxygen species by human monocyte-derived macrophages: M. Rouis, et al.; BBRC 156, 1293 (1988) Abstract
Further Categories Containing This Product:
Phospholipids/Related Products
 
 
ALX-300-073 Revised 02-Dec-04
1-O-Hexadecyl-rac-glycerol
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PRODUCT LINE Signal Transduction
PRODUCT CATEGORY Mono- & Diacylglycerols
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ALX-300-073-G001   1 g 60.00 USD Add To Cart
Product Specification
FORMULA: C19H40O3
MW: 316.5
PURITY: ≥98%
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
 
 
ALX-300-129 Revised 16-Feb-05
1-O-Hexadecyl-sn-glycerol
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SYNONYMS 1-O-Palmitoyl-sn-glycerol
Monoceryl Glyceryl Ether
Chimyl alcohol
PRODUCT LINE Signal Transduction
PRODUCT CATEGORY Mono- & Diacylglycerols
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ALX-300-129-G001   1 g 60.00 USD Add To Cart
ALX-300-129-G005   5 g 240.00 USD Add To Cart
Product Specification
FORMULA: C19H40O3
MW: 316.5
CAS NUMBER: 506-03-6
PURITY: ≥98%
APPEARANCE: White to off-white solid.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C

Product Description
Naturally occuring ether lipid. Reduces myocardial ischemia/reperfusion injury [1,2]. Can be used to improve cellular uptake and to reduce toxicity of phosphorothioated antisense oligodeoxyribonucleotides when conjugated at the 3'-end [3]. Inhibits cellular proliferation, anchorage-independent growth and cellular invasion in human prostate cancer cell lines [4].
Product Specific Literature References
[1] Myocardial salvage by chimyl alcohol: possible role of peroxisomal dysfunction in reperfusion injury: N. Maulik, et al.; Ann. NY Acad. Sci. 723, 380 (1994) Abstract
[2] Myocardial salvage by 1-O-hexadecyl-Sn-glycerol: possible role of peroxisomal dysfunction in ischemia reperfusion injury: N. Maulik, et al.; J. Cardiovasc. Pharmacol. 24, 486 (1994) Abstract
[3] 3'-End conjugates of minimally phosphorothioate-protected oligonucleotides with 1-O-hexadecylglycerol: synthesis and anti-ras activity in radiation-resistant cells: A. Rait, et al.; Bioconjug. Chem. 11, 153 (2000) Abstract
[4] Inhibitory effect of 1-O (2 methoxy) hexadecyl glycerol and phenylbutyrate on the malignant properties of human prostate cancer cells: S. Reynolds, et al.; Clin. Exp. Metastasis 18, 309 (2000) Abstract
General Information
BACKGROUND/TECHNICAL INFORMATION

The product was prepared from 2,3-isopropylidene-sn-glycerol of highest purity [[αD20] -15.0°] via alkylation and removal of the isopropylidene protection group. These reactions do not involve the asymmetric carbon at position sn-2 of the glycerol molecule. The purity of the compound considering the apolar C16-chain is better than 98%. The purity of the C16-chain considering the position in the glycerol molecule and the configuration is also better than 98%.
 
 
ALX-300-072 Revised 02-Dec-04
3-O-Hexadecyl-sn-glycerol
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PRODUCT LINE Signal Transduction
PRODUCT CATEGORY Mono- & Diacylglycerols
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ALX-300-072-M250   250 mg 60.00 USD Add To Cart
ALX-300-072-G001   1 g 180.00 USD Add To Cart
Product Specification
FORMULA: C19H40O3
MW: 316.5
PURITY: ≥98%
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C

 
 
ALX-300-084 Revised 02-Dec-04
1-O-Hexadecyl-2-O-methyl-rac-glycerol
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PRODUCT LINE Signal Transduction
PRODUCT CATEGORY Mono- & Diacylglycerols
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ALX-300-084-M250   250 mg 45.00 USD Add To Cart
ALX-300-084-G001   1 g 150.00 USD Add To Cart
Product Specification
FORMULA: C20H42O3
MW: 330.6
CAS NUMBER: 111188-59-1
PURITY: ≥97%
APPEARANCE: Off-white solid.
SOLUBILITY: Soluble in DMSO or ethanol.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
HANDLING: Hygroscopic.
Product Description
Inhibitor of protein kinase C (PKC).
Product Specific Literature References
1-O-hexadecyl-2-Q-methylglycerol, a novel inhibitor of protein kinase C, inhibits the respiratory burst in human neutrophils: I.M. Kramer, et al.; J. Biol. Chem. 264, 5876 (1989) Abstract; Full Text
Further Categories Containing This Product:
PKC Inhibitors
 
 
ALX-300-085 Revised 06-Dec-04
1-O-Hexadecyl-3-O-methyl-rac-glycerol
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PRODUCT LINE Signal Transduction
PRODUCT CATEGORY Mono- & Diacylglycerols
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ALX-300-085-M250   250 mg 50.00 USD Add To Cart
ALX-300-085-G001   1 g 150.00 USD Add To Cart
Product Specification
FORMULA: C20H42O3
MW: 330.6
PURITY: ≥98%
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
HANDLING: Hygroscopic.
 
 
ALX-300-001 Revised 02-Dec-04
1-O-Hexadecyl-2-palmitoyl-sn-glycero-3-phospho-(N-palmitoyl)-ethanolamide . sodium salt
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PRODUCT LINE Signal Transduction
PRODUCT CATEGORY Phospholipids/Related Products
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ALX-300-001-M005   5 mg 85.00 USD Add To Cart
ALX-300-001-M025   25 mg 335.00 USD Add To Cart
Product Specification
FORMULA: C53H105NO8P . Na
MW: 915.4 . 23.0
PURITY: ≥98%
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C

Product Description
Potent antitumor agent.
Product Specific Literature References
Biologically active ether lipids. Biotransformation of rac-1(3)-O- alkylglycerols in cell suspension cultures of rape and semisynthesis of 1-O-alkyl-2-palmitoyl-sn-glycero-3-phospho-(N-palmitoyl)ethanolamines, potent antitumor agents: S.S. Apte, et al.; FEBS Lett. 265, 104 (1990) Abstract
Further Categories Containing This Product:
Antitumor Reagents Other Products
 
 
ALX-300-095 Revised 30-Jan-08
Hexadecyl-phosphate . sodium salt
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PRODUCT LINE Signal Transduction
PRODUCT CATEGORY Phospholipids/Related Products
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ALX-300-095-G001   1 g 60.00 USD Add To Cart
Product Specification
FORMULA: C16H34O4P . Na
MW: 321.4 . 23.0
PURITY: ≥98%
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C

 
 
ALX-300-093 Revised 23-Mar-05
Hexadecyl-phosphocholine (C16:0)
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SYNONYMS Miltefosine
PRODUCT LINE Signal Transduction
PRODUCT CATEGORY Phospholipids/Related Products
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ALX-300-093-M250   250 mg 50.00 USD Add To Cart
ALX-300-093-G001   1 g 150.00 USD Add To Cart
Product Specification
FORMULA: C21H46NO4P
MW: 407.6
CAS NUMBER: 58066-85-6
MERCK INDEX: 14: 6198
PURITY: ≥99%
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C

Product Description
Potent antitumor agent. Inhibitor of protein kinase C (PKC) and phosphatidylcholine biosynthesis. Costimulates human T cell activation.
Product Specific Literature References
H.R. Berger, et al.; Akt. Onkologie 34, 27 (1987)
The phospholipid analogue, hexadecylphosphocholine, inhibits protein kinase C in vitro and antagonises phorbol ester-stimulated cell proliferation: C.C. Geilen, et al.; Eur. J. Cancer 27, 1650 (1991) Abstract
The phospholipid analogue hexadecylphosphocholine inhibits phosphatidylcholine biosynthesis in Madin-Darby canine kidney cells: R. Haase, et al.; FEBS Lett. 288, 129 (1991) Abstract
Hexadecylphosphocholine-mediated enhancement of T-cell responses to interleukin 2: K. Vehmeyer, et al.; Cellular Immunology 137, 232 (1991) Abstract
Further Categories Containing This Product:
Parasitic Diseases Other Products • Antitumor Agents (Enzyme Inhibitors) • PKC Inhibitors
 
 
ALX-300-099 Revised 09-Dec-04
Hexadecyl-phospho-rac-glycerol . sodium salt
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PRODUCT LINE Signal Transduction
PRODUCT CATEGORY Phospholipids/Related Products
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ALX-300-099-M250   250 mg 80.00 USD Add To Cart
ALX-300-099-G001   1 g 240.00 USD Add To Cart
Product Specification
FORMULA: C19H39O6P . Na
MW: 394.5 . 23.0
PURITY: ≥98%
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
 
 
ALX-300-091 Revised 09-Dec-04
1-O-Hexadecyl-propanediol-3-phosphocholine
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PRODUCT LINE Signal Transduction
PRODUCT CATEGORY Phospholipids/Related Products
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ALX-300-091-M050   50 mg 70.00 USD Add To Cart
ALX-300-091-M250   250 mg 280.00 USD Add To Cart
Product Specification
FORMULA: C24H52NO5P
MW: 465.7
PURITY: ≥98%
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C

 
 
ALX-350-138 Revised 05-Dec-06
Hexaprenylhydroquinone
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SYNONYMS HPH
PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Natural Products - Antiviral/anti-HIV Agents
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ALX-350-138-M001   1 mg