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Calcium Signalling (Intracellular)
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ALX-270-152 Revised 04-Apr-03
W-5 Analog . hydrochloride
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SYNONYMS N-(5-Aminopentyl)-1-naphthalenesulfonamide . HCl
PRODUCT LINE Signal Transduction
PRODUCT CATEGORY Calmodulin Inhibitors
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Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-270-152-M001   1 mg 30.00 USD Add To Cart
ALX-270-152-M005   5 mg 90.00 USD Add To Cart
Product Specification
FORMULA: C15H20N2O2S . HCl
MW: 292.4 . 36.5
PURITY: ≥98%
SOLUBILITY: Soluble in methanol.
SHIPPING: AMBIENT
LONG TERM STORAGE: +4°C

Product Description
Antagonist of calmodulin.
Product Specific Literature References
N-(6-aminohexyl)-5-chloro-1-naphthalenesulfonamide, a calmodulin antagonist, inhibits cell proliferation: H. Hidaka, et al.; PNAS 78, 4354 (1981) Abstract
 
 
ALX-270-161 Revised 26-Nov-04
W-5 Isomer . hydrochloride
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SYNONYMS N-(6-Aminohexyl)-2-naphthalenesulfonamide . HCl
PRODUCT LINE Signal Transduction
PRODUCT CATEGORY Calmodulin Inhibitors
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ALX-270-161-M001   1 mg 30.00 USD Add To Cart
ALX-270-161-M005   5 mg 90.00 USD Add To Cart
Product Specification
FORMULA: C16H22N2O2S . HCl
MW: 306.4 . 36.5
PURITY: ≥98%
SOLUBILITY: Soluble in methanol.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
HANDLING: Protect from light.

Product Description
Isomer of W-5 (Prod. No. ALX-270-151).
Product Specific Literature References
N-(6-aminohexyl)-5-chloro-1-naphthalenesulfonamide, a calmodulin antagonist, inhibits cell proliferation: H. Hidaka, et al.; PNAS 78, 4354 (1981) Abstract
Further Categories Containing This Product:
Myosin Light Chain Kinase Inhibitors • Phosphodiesterases / Related Products
 
 
ALX-270-153 Revised 29-Feb-08
W-7 . hydrochloride
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SYNONYMS N-(6-Aminohexyl)-5-chloro-1-naphthalenesulfonamide . HCl
PRODUCT LINE Signal Transduction
PRODUCT CATEGORY Calmodulin Inhibitors
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-270-153-M005   5 mg 20.00 USD Add To Cart
ALX-270-153-M025   25 mg 60.00 USD Add To Cart
Product Specification
FORMULA: C16H21ClN2O2S . HCl
MW: 340.9 . 36.5
CAS NUMBER: 61714-27-0
PURITY: ≥98% (TLC)
APPEARANCE: White to off-white solid.
SOLUBILITY: Soluble in water (warm), methanol, 100% ethanol (warm), DMSO, dimethyl formamide or ethylene glycol.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
HANDLING: Protect from light.
IDENTITY:

Determined by H-NMR.

Product Description
Antagonist of calmodulin, inhibiting activation of Ca2+/calmodulin-regulated phosphodiesterase (PDE I) and myosin light chain kinase.
Product Specific Literature References
N-(6-aminohexyl)-5-chloro-1-naphthalenesulfonamide, a calmodulin antagonist, inhibits cell proliferation: H. Hidaka, et al.; PNAS 78, 4354 (1981) Abstract
Activity-structure relationship of calmodulin antagonists, Naphthalenesulfonamide derivatives: H. Hidaka, et al.; Mol. Pharmacol. 20, 571 (1981) Abstract
Calmodulin antagonists enhance calcium binding to calmodulin: M. Inagaki, et al.; Pharmacology 27, 125 (1983) Abstract
Direct interaction of calmodulin antagonists with Ca2+/calmodulin- dependent cyclic nucleotide phosphodiesterase: H. Itoh & H. Hidaka; J. Biochem. 96, 1721 (1984) Abstract
Related Products
Further Categories Containing This Product:
Myosin Light Chain Kinase Inhibitors • Phosphodiesterases / Related Products
 
 
ALX-270-175 Revised 28-Feb-08
W-7 Isomer . hydrochloride
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SYNONYMS N-(6-Aminohexyl)-5-chloro-2-naphthalenesulfonamide . HCl
PRODUCT LINE Signal Transduction
PRODUCT CATEGORY Calmodulin Inhibitors
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ALX-270-175-M005   5 mg 40.00 USD Add To Cart
ALX-270-175-M025   25 mg 160.00 USD Add To Cart
Product Specification
FORMULA: C16H21ClN2O2S . HCl
MW: 340.9 . 36.5
CAS NUMBER: 69762-85-2
PURITY: ≥98% (TLC)
APPEARANCE: White to off-white solid.
SOLUBILITY: Soluble in methanol.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
HANDLING: Protect from light.
IDENTITY: Determined by 1H-NMR.

Product Description
Inhibitor of calmodulin. Isomer of W-7 (Prod. No. ALX-270-153).
Product Specific Literature References
N-(6-aminohexyl)-5-chloro-1-naphthalenesulfonamide, a calmodulin antagonist, inhibits cell proliferation: H. Hidaka, et al.; PNAS 78, 4354 (1981) Abstract
Related Products
 
 
ALX-270-155 Revised 04-Mar-05
W-12 . hydrochloride
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SYNONYMS N-(4-Aminobutyl)-2-naphthalenesulfonamide . HCl
PRODUCT LINE Signal Transduction
PRODUCT CATEGORY Calmodulin Inhibitors
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ALX-270-155-M005   5 mg 40.00 USD Add To Cart
ALX-270-155-M025   25 mg 160.00 USD Add To Cart
Product Specification
FORMULA: C14H18N2O2S . HCl
MW: 278.4 . 36.5
CAS NUMBER: 89108-46-3
PURITY: ≥98%
APPEARANCE: White solid.
SOLUBILITY: Soluble in 100% ethanol or water.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
HANDLING: Protect from light.

Product Description
Antagonist of calmodulin, inhibiting activation of Ca2+/calmodulin-dependent phosphodiesterase (PDE I) and myosin light chain kinase.
Product Specific Literature References
T. Tanaka and H. Hidaka; J. Biol. Chem. 255, 11078 (1980) Abstract; Full Text
[Pharmacology of calmodulin: calmodulin antagonist (author's transl)]: H. Hidaka; Prot. Nucl. Acid Enz. 26, 977 (1981) Abstract
N-(6-aminohexyl)-5-chloro-1-naphthalenesulfonamide, a calmodulin antagonist, inhibits cell proliferation: H. Hidaka, et al.; PNAS 78, 4354 (1981) Abstract
Further Categories Containing This Product:
Myosin Light Chain Kinase Inhibitors • Phosphodiesterases / Related Products
 
 
ALX-270-156 Revised 20-Feb-07
W-13 . hydrochloride
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SYNONYMS N-(4-Aminobutyl)-5-chloro-2-naphthalenesulfonamide . HCl
PRODUCT LINE Signal Transduction
PRODUCT CATEGORY Calmodulin Inhibitors
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-270-156-M005   5 mg 60.00 USD Add To Cart
ALX-270-156-M025   25 mg 240.00 USD Add To Cart
Product Specification
FORMULA: C14H17ClN2O2S . HCl
MW: 312.8 . 36.5
CAS NUMBER: 88519-57-7
SOURCE/HOST: Synthetic.
PURITY: ≥98%
APPEARANCE: White to off-white solid.
SOLUBILITY: Soluble in water (warm) or methanol.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
HANDLING: Protect from light.

Product Description
Antagonist of calmodulin, inhibiting activation of Ca2+/calmodulin-dependent phosphodiesterase (PDE I) and myosin light chain kinase.
Product Specific Literature References
Hydrophobic regions function in calmodulin-enzyme(s) interactions: T. Tanaka & H. Hidaka; J. Biol. Chem. 255, 11078 (1980) Abstract; Full Text
[Pharmacology of calmodulin: calmodulin antagonist (author's transl)]: H. Hidaka; Prot. Nucl. Acid Enz. 26, 977 (1981) Abstract
Activity-structure relationship of calmodulin antagonists, Naphthalenesulfonamide derivatives: H. Hidaka, et al.; Mol. Pharmacol. 20, 571 (1981) Abstract
Naphthalenesulfonamides as calmodulin antagonists: H. Hidaka & T. Tanaka; Meth. Enzymol. 102, 185 (1983) Abstract
Calmodulin antagonists enhance calcium binding to calmodulin: M. Inagaki, et al.; Pharmacology 27, 125 (1983) Abstract
Direct interaction of calmodulin antagonists with Ca2+/calmodulin- dependent cyclic nucleotide phosphodiesterase: H. Itoh & H. Hidaka; J. Biochem. 96, 1721 (1984) Abstract
Tamoxifen-resistant human breast cancer cell growth: inhibition by thioridazine, pimozide and the calmodulin antagonist, W-13: J.S. Stroble & V.A. Peterson; J. Pharm. Exp. Ther. 263, 186 (1992) Abstract
Further Categories Containing This Product:
Myosin Light Chain Kinase Inhibitors • Phosphodiesterases / Related Products
 
 
ALX-270-176 Revised 04-Apr-03
W-13 Isomer . hydrochloride
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SYNONYMS N-(4-Aminobutyl)-5-chloro-1-naphthalenesulfonamide . HCl
PRODUCT LINE Signal Transduction
PRODUCT CATEGORY Calmodulin Inhibitors
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-270-176-M001   1 mg 30.00 USD Add To Cart
ALX-270-176-M005   5 mg 120.00 USD Add To Cart
Product Specification
FORMULA: C14H17ClN2O2S . HCl
MW: 312.8 . 36.5
PURITY: ≥98%
APPEARANCE: Off-white solid.
SOLUBILITY: Soluble in hot water or methanol.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
HANDLING: Protect from light.

Product Description
Isomer of W-13 (Prod. No. ALX-270-156).
Product Specific Literature References
N-(6-aminohexyl)-5-chloro-1-naphthalenesulfonamide, a calmodulin antagonist, inhibits cell proliferation: H. Hidaka, et al.; PNAS 78, 4354 (1981) Abstract
 
 
ALX-270-158 Revised 09-Nov-07
W-13 Isomer, Decyl Analog . hydrochloride
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SYNONYMS N-(10-Aminodecyl)-5-chloro-1-naphthalenesulfonamide . HCl
PRODUCT LINE Signal Transduction
PRODUCT CATEGORY Calmodulin Inhibitors
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ALX-270-158-M005   5 mg 30.00 USD Add To Cart
ALX-270-158-M025   25 mg 90.00 USD Add To Cart
Product Specification
FORMULA: C20H29ClN2O2S . HCl
MW: 397.0 . 36.5
PURITY: ≥98%
APPEARANCE: White to off-white solid.
SOLUBILITY: Soluble in 100% ethanol, methanol or DMSO; almost insoluble in water.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
HANDLING: Protect from light.

Product Description
Most potent isomer of the naphthalenesulfonamide family of calmodulin inhibitors.
Product Specific Literature References
Naphthalenesulfonamides as calmodulin antagonists: H. Hidaka & T. Tanaka; Meth. Enzymol. 102, 185 (1983) Abstract
 
 
ALX-380-087 Revised 08-Apr-08
X-206
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SYNONYMS Desmethylalborixin
PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Antibiotics - Ionophores
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ALX-380-087-M001   1 mg 25.00 USD Add To Cart
ALX-380-087-M005   5 mg 100.00 USD Add To Cart
Product Specification
FORMULA: C47H82O14
MW: 871.2
CAS NUMBER: 36505-48-3
SOURCE/HOST: Isolated from Streptomyces sp.
PURITY: ≥98%
SOLUBILITY: Soluble in alcohols, DMSO or halogenated hydrocarbons.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
HAZARD: TOXIC.

Product Description
Ionophoric. Chelates monovalent cations, preferably sodium ions and transports them passively through biological membranes. Displays antimicrobial and cytotoxic properties and selective and potent antimalarial activity.
Product Specific Literature References
Potent antimalarial activities of polyether antibiotic, X-206: K. Otoguro, et al.; J. Antibiot. (Tokyo) 54, 658 (2001) Abstract
Further Categories Containing This Product:
Antibiotics - Antimalarial • Malaria / Related Products
 
 
ALX-350-382 Revised 13-Aug-08 New product
Xestospongin C
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SYNONYMS XeC
Araguspongine E
PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Natural Products - Other Signal Transduction Pathway Modulators
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ALX-350-382-C100   100 µg 490.00 USD Add To Cart
Product Specification
FORMULA: C28H50N2O2
MW: 446.7
CAS NUMBER: 88903-69-9
SOURCE/HOST: Isolated from an Okinawan marine sponge Xestospongia sp.
PURITY: ≥90% (HPLC)
APPEARANCE: White to off-white powder.
FORMULATION: Lyophilized from 20mM HEPES, pH 7.3, containing 0.1% BSA.
SOLUBILITY: Soluble in ethyl acetate, acetone or 100% ethanol; slightly soluble in DMSO or water.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
HANDLING: Protect from light. Packaged under inert gas.

Product Description
Potent, selective, reversible and membrane-permeable inhibitor of the inositol 1,4,5-triphosphate (IP3) receptor (IC50=350nM). Inhibits IP3 receptor-mediated Ca2+ release. Has vasodilatory properties.
Product Specific Literature References
Structures of xestospongin A,B,C, and D, novel vasodilative compounds from marine sponge, Xestospongia exigua: M. Nakagawa, et al.; THL 25, 3227 (1984)
Xestospongins: potent membrane permeable blockers of the inositol 1,4,5-trisphosphate receptor: J. Gafni, et al.; Neuron 19, 723 (1997) Abstract
New developments in the molecular pharmacology of the myo-inositol 1,4,5-trisphosphate receptor: R. A. Wilcox, et al.; TIPS 19, 467 (1998) Abstract
Isomerization of dimeric 2,9-disubstituted 1-oxa-quinolizidine alkaloids and structural revision of aragusponjines B and E, isolated from a marine sponge of Xesospongia sp.: M. Kobayashi, et al.; Heterocycles 47, 195 (1998)
Xestospongin C is an equally potent inhibitor of the inositol 1,4,5-trisphosphate receptor and the endoplasmic-reticulum Ca(2+) pumps: P. De Smet, et al.; Cell Calcium 26, 9 (1999) Abstract
Xestospongin C, a selective and membrane-permeable inhibitor of IP(3) receptor, attenuates the positive inotropic effect of alpha-adrenergic stimulation in guinea-pig papillary muscle: S. Miyamoto, et al.; Br. J. Pharmacol. 130, 650 (2000) Abstract; Full Text
In vivo signal transduction of nociceptive response by kyotorphin (tyrosine-arginine) through Galpha(i)- and inositol trisphosphate-mediated Ca(2+) influx: H. Ueda & M. Inoue; Mol. Pharmacol. 57, 108 (2000) Abstract; Full Text
Ca2+ entry mediated by store depletion, S-nitrosylation, and TRP3 channels. Comparison of coupling and function: D.B. van Rossum, et al.; J. Biol. Chem. 275, 28562 (2000) Abstract; Full Text
Xestospongin C is a potent inhibitor of SERCA at a vertebrate synapse: A. Castonguay & R. Robitaille; Cell Calcium 32, 39 (2002) Abstract
Inhibitory mechanism of xestospongin-C on contraction and ion channels in the intestinal smooth muscle: H. Ozaki, et al.; Br. J. Pharmacol. 137, 1207 (2002) Abstract; Full Text
Xestospongin C empties the ER calcium store but does not inhibit InsP3-induced Ca2+ release in cultured dorsal root ganglia neurones: N. Solovyova, et al.; Cell Calcium 21, 49 (2002) Abstract
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