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Kinases / Related Products
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ALX-157-013 Revised 04-Jul-03
[Ala9,10, Lys11,12]-Glycogen Synthase (1-12)
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PRODUCT LINE Signal Transduction
PRODUCT CATEGORY PKC Substrates
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Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-157-013-M001   1 mg 80.00 USD Add To Cart
ALX-157-013-M005   5 mg 320.00 USD Add To Cart
Product Specification
SEQUENCE: H-Pro-Leu-Ser-Arg-Thr-Leu-Ser-Val-Ala-Ala-Lys-Lys-OH
FORMULA: C56H103N17O16
MW: 1270.5
PURITY: ≥97%
APPEARANCE: White lyophilized powder.
SOLUBILITY: Soluble in water.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
Product Description
Substrate for protein kinase C (PKC). Peptide comprising the amino acid sequence of the glycogen synthase phosphorylation site.
Product Specific Literature References
The influence of basic residues on the substrate specificity of protein kinase C: C. House, et al.; J. Biol. Chem. 262, 772 (1987) Abstract; Full Text
A tandem chromatographic column method for assaying cAMP-dependent protein kinase and protein kinase C with synthetic peptide substrates: J.J. Egan, et al.; Anal. Biochem. 175, 552 (1988) Abstract
A protein kinase C pseudosubstrate peptide inhibits phosphorylation of the CD3 antigen in streptolysin-O-permeabilized human T lymphocytes: D.R. Alexander, et al.; Biochem. J. 260, 893 (1989) Abstract
Further Categories Containing This Product:
Peptides
 
 
ALX-850-005 Revised 24-Feb-05
cGMP EIA Kit
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PRODUCT LINE Signal Transduction
PRODUCT CATEGORY PKG Kits
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Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-850-005-KI01   1 Kit 412.00 USD Add To Cart
Product Specification
QUANTITY: 96 wells (~80 tests).
APPLICATION: For the measurement of cGMP.
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: -20°C
Further Categories Containing This Product:
Guanylyl Cyclases, Guanosine Phosphate Metabolism / Related Products • ELISA & EIA Kits
 
 
ALX-202-049 Revised 14-Jun-05
cGMP-dependent Protein Kinase Iα (bovine)
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SYNONYMS Protein Kinase G Iα (bovine)
cGK Iα (bovine)
PKG Iα (bovine)
PRODUCT LINE Signal Transduction
PRODUCT CATEGORY PKG
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ALX-202-049-C005   5 µg 310.00 USD Add To Cart
Product Specification
MW: ~74kDa; monomer.
EC: 2.7.1.37
SOURCE/HOST: Native protein isolated from bovine lung.
CONCENTRATION: 100µg/ml
PURITY: ≥95% (SDS-PAGE)
FORMULATION: Liquid. In 10mM phosphate buffer, pH 6.8, containing 1mM EDTA, 15mM β-mercaptoethanol, 10U/ml Trasylol and 50% glycerol.
SPECIFIC ACTIVITY: 2U/mg protein. 10-fold stimulation by cGMP (5µM). One unit is defined as 1µmol/min/mg using VASPtide (RRKVSKQE) as substrate, under the following optimal conditions: 10mM HEPES, pH 7.4, containing 5mM MgCl2, 1mM DTE, 0.2mM EDTA.
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: -20°C
Product Specific Literature References
Immunological distinction between guanosine 3':5'-monophosphate- dependent and adenosine 3':5'-monophosphate-dependent protein kinases: U. Walter, et al.; J. Biol. Chem. 255, 3757 (1980) Abstract; Full Text
General Information
BACKGROUND/TECHNICAL INFORMATION Swiss-Prot link P00516: cGMP-dependent Kinase Ia (bovine)
AfCS Signalling Gateway link A000043: cGMP-dependent Kinase I (mouse)
Further Categories Containing This Product:
Enzymes • Natural Proteins
 
 
ALX-201-071 Revised 12-Jul-06
cGMP-dependent Protein Kinase Iβ (human) (recombinant)
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SYNONYMS Protein Kinase G Iβ (human) (recombinant)
cGK Iβ (bovine) (recombinant)
PKG Iβ (human) (recombinant)
PRODUCT LINE Signal Transduction
PRODUCT CATEGORY PKG
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ALX-201-071-C005   5 µg 320.00 USD Add To Cart
Product Specification
MW: ~76kDa; monomer.
EC: 2.7.1.37
SOURCE/HOST: Produced in Sf9 cells [1].
CONCENTRATION: 50µg/ml
PURITY: ≥95% (SDS-PAGE)
FORMULATION: Liquid. In 20mM TRIS, pH 7.4, containing 1mM EDTA, 1mM β-mercaptoethanol, 100mM NaCl, 10U/ml trasylol and 50% glycerol.
SPECIFIC ACTIVITY: ~1.5-5U/mg protein. 25-fold stimulation by cGMP (5µM). One unit corresponds to 1µmol/mg/min using VASPtide (RRKVSKQE) as substrate under the following optimal conditions: 10mM HEPES, pH 7.4, containing 5mM MgCl2, 1mM DTE, 0.2mM EDTA.
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: -20°C
USE/STABILITY: Enzyme is relatively unstable. To prevent loss of activity when performing experiments, keep the stock vial of the enzyme on ice at all times. Enzyme loses activity during a single freeze/thaw cycle.
HANDLING: After opening, prepare aliquots and store at -20°C. Avoid freeze/thaw cycles.
Product Specific Literature References
[1] Expression, purification, and characterization of the cGMP-dependent protein kinases I beta and II using the baculovirus system: D. Pöhler, et al.; FEBS Lett. 374, 419 (1995) Abstract
General Information
BACKGROUND/TECHNICAL INFORMATION Swiss-Prot link P14619: PKG Iβ (human)
AfCS Signalling Gateway link A000043: PKG I (mouse)
Further Categories Containing This Product:
Recombinant Proteins / Fusion Proteins • Enzymes
 
 
ALX-201-072 Revised 06-Oct-06
cGMP-dependent Protein Kinase II (rat) (recombinant)
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SYNONYMS PKG II (rat) (recombinant)
cGK II (rat) (recombinant)
Protein Kinase G II (rat) (recombinant)
PRODUCT LINE Signal Transduction
PRODUCT CATEGORY PKG
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ALX-201-072-C005   5 µg 320.00 USD Add To Cart
Product Specification
MW: ~86kDa; monomer.
EC: 2.7.1.37
SOURCE/HOST: Produced in Sf9 cells [1].
CONCENTRATION: 50µg/ml
PURITY: ≥90% (SDS-PAGE)
FORMULATION: Liquid. In 20mM TRIS, pH 7.4, containing 1mM EDTA, 5mM β-mercaptoethanol, 100mM NaCl, 10U/ml trasylol, 0.015% NP40 and 50% glycerol.
SPECIFIC ACTIVITY: ~0.5-2.0U/mg protein. 5-fold activation by cGMP (5µM). One unit corresponds to 1µmol/mg/min using VASPtide (RRKVSKQE) as substrate, under the following optimal conditions: 10mM HEPES (pH 7.4), 5mM MgCl2, 1mM DTE, 0.2mM EDTA.
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: -20°C
USE/STABILITY: The enzyme is relatively unstable. To prevent loss of activity when performing experiments, keep the stock vial of the enzyme on ice (0-4°C) at all times. The enzyme loses activity during a single freeze/thaw cycle.
To avoid adherence of the product to plastic, the use of siliconized vials and tips is recommended.
HANDLING: Avoid freeze/thaw cycles. After opening, prepare aliquots and store at -20°C.
Product Specific Literature References
[1] Expression, purification, and characterization of the cGMP-dependent protein kinases I beta and II using the baculovirus system: D. Pöhler, et al.; FEBS Lett. 374, 419 (1995) Abstract
General Information
BACKGROUND/TECHNICAL INFORMATION Swiss-Prot link Q64595: cGMP-dependent Kinase II (rat)
AfCS Signalling Gateway link A000044:  cGMP-dependent Kinase II (mouse)
Further Categories Containing This Product:
Recombinant Proteins / Fusion Proteins • Enzymes
 
 
ALX-270-021 Revised 03-Jul-08
Gö 6976
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SYNONYMS 12-(2-Cyanoethyl)-6,7,12,13-tetrahydro-13-methyl-5-oxo-5H-indolo[2,3-a]pyrrolo[3,4-c]carbazole
PRODUCT LINE Signal Transduction
PRODUCT CATEGORY PKC Inhibitors
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ALX-270-021-MC05   0.5 mg 160.00 USD Add To Cart
Product Specification
FORMULA: C24H18N4O
MW: 378.4
CAS NUMBER: 136194-77-9
PURITY: ≥95% (HPLC)
APPEARANCE: Off-white to yellow solid.
SOLUBILITY: Soluble in DMSO (25mg/ml).
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
USE/STABILITY: Stock solutions are stable for at least 3-4 months when  stored at -20°C.
HANDLING: Protect from light.

Product Description
Very potent protein kinase C (PKC) inhibitor with high selectivity for the PKC isotypes (α, β and γ). Potent antagonist of HIV-1 induction.
Product Specific Literature References
Non-glycosidic/non-aminoalkyl-substituted indolocarbazoles as inhibitors of protein kinase C: J. Kleinschroth, et al.; Bioorg. Med. Chem. Lett 3, 1959 (1993)
Selective inhibition of protein kinase C isozymes by the indolocarbazole Go 6976: G. Martiny-Baron, et al.; J. Biol. Chem. 268, 9194 (1993) Abstract; Full Text
Go 6976, a selective inhibitor of protein kinase C, is a potent antagonist of human immunodeficiency virus 1 induction from latent/low- level-producing reservoir cells in vitro: K.O. Qatsha, et al.; PNAS 90, 4674 (1993) Abstract
N-protein kinase C isoenzymes may be involved in the regulation of various neutrophil functions: K. Wenzel-Seifert, et al.; BBRC 200, 1536 (1994) Abstract
Atypical isoforms of pKc and insulin secretion from pancreatic beta- cells: evidence using Go 6976 and Ro 31-8220 as Pkc inhibitors: T.E. Harris, et al.; BBRC 227, 672 (1996) Abstract
 
 
ALX-350-113 Revised 28-May-08
Gossypol
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SYNONYMS 2,2’-bis[8-Formyl-1,6,7-trihydroxy-5-isopropyl-3-
methylnaphthalene]
PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Natural Products - Antitumor Reagents
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ALX-350-113-M100   100 mg 90.00 USD Add To Cart
Product Specification
FORMULA: C30H30O8
MW: 518.6
CAS NUMBER: 303-45-7
MERCK INDEX: 14: 4528
RTECS: DU3100000
SOURCE/HOST: Isolated from Gossypium genus, Malvaceae.
PURITY: ≥90%
APPEARANCE: Off-white to yellow solid.
SOLUBILITY: Soluble in acetone or DMSO; sparingly soluble in 100% ethanol (2mg/ml) or methanol (2mg/ml). Insoluble in water.
SHIPPING: AMBIENT
LONG TERM STORAGE: +4°C
HANDLING: Protect from light.
HAZARD: MAY BE CARCINOGENIC. HARMFUL.

Product Description
Mixture of ~65% (+)- and ~35% (-)-enantiomers. Male antifertility agent. Shows antitumor, antiviral and antioxidant actions. Small molecule inhibitor of Bcl-2/Bcl-XL. Induces apoptosis. Synergizes with radiation and chemotherapy in vitro. Reversible inhibitor of protein phosphatase 2B (PP2B; calcineurin). Protein kinase C (PKC) inhibitor.
Product Specific Literature References
Binding of gossypol to purified tubulin and inhibition of its assembly into microtubules: F.J. Medrano and J.M. Andreu; Eur. J. Biochem. 158, 63 (1986) Abstract
Differential inhibition of protein kinase C subtypes: J.M. Pelosin, et al.; BBRC 169, 1040 (1990) Abstract
Induction of apoptotic DNA fragmentation and cell death in HL-60 human promyelocytic leukemia cells by pharmacological inhibitors of protein kinase C: W.D. Jarvis, et al.; Cancer Res. 54, 1707 (1994) Abstract
Gossypol arrests human benign prostatic hyperplastic cell growth at G0/G1 phase of the cell cycle: F. Shidaifat, et al.; Anticancer Res. 17, 1003 (1997) Abstract
Inhibition of huntingtin fibrillogenesis by specific antibodies and small molecules: implications for Huntington’s disease therapy: V. Heiser, et al.; PNAS 97, 6739 (2000) Abstract; Full Text
Cytotoxic effect of gossypol on colon carcinoma cells: X. Wang, et al.; Life Sci. 67, 2663 (2000) Abstract
Reversible inhibition of calcineurin by the polyphenolic aldehyde gossypol: R. Baumgrass, et al.; J. Biol. Chem. 276, 47914 (2001) Abstract; Full Text
Toxicity of (+)- and (-)-gossypol to the plant pathogen, Rhizoctonia solani: L.S. Puckhaber, et al.; J. Agric. Food Chem. 50, 7017 (2002) Abstract
Telomerase inhibitors in anticancer therapy: gossypol as a potential telomerase inhibitor: M. Mego; Bratisl. Lek. Listy 103, 378 (2002) Abstract
An in vitro study of inhibitory activity of gossypol, a cottonseed extract, in human carcinoma cell lines: M. Le Blanc, et al.; Pharmacol. Res. 46, 551 (2002) Abstract
Gossypol induces chloride secretion in rat proximal colon: G. Kuhn, et al.; Eur. J. Pharmacol. 457, 187 (2002) Abstract
Determination of the absolute configuration and solution conformation of gossypol by vibrational circular dichroism: T.B. Freedman, et al.; Chirality 15, 196 (2003) Abstract
In vitro effects of the BH3 mimetic, (-)-gossypol, on head and neck squamous cell carcinoma cells: C.L. Oliver, et al.; Clin. Cancer Res. 10, 7757 (2004) Abstract; Full Text
The inhibitory effects of gossypol on human prostate cancer cells-PC3 are associated with transforming growth factor beta1 (TGFbeta1) signal transduction pathway: J. Jiang, et al.; Anticancer Res. 24, 19 (2004) Abstract
(-)-Gossypol enhances response to radiation therapy and results in tumor regression of human prostate cancer: L. Xu, et al.; Mol. Cancer Ther. 4, 197 (2005) Abstract; Full Text
Investigations on gossypol: past and present developments: K. Dodou; Expert Opin. Investig. Drugs 14, 1419 (2005) Abstract
An in vitro study of cytotoxic effects of gossypol on human epidermoid larynx carcinoma cell line (HEp-2): E. Konac, et al.; Exp. Oncol. 27, 81 (2005) Abstract; Full Text
Further Categories Containing This Product:
Bcl-2 Family Modulators • PKC Inhibitors • Natural Products - Protein Kinase Inhibitors • PP2B [Calcineurin] / Related Products • Natural Products - Antioxidants • Antitumor Agents (Apoptosis Inducers) • Polyphenols Other Products • Natural Products - Apoptosis Inducers & Inhibitors • Natural Products - Antiviral / anti-HIV Agents
 
 
ALX-480-072 Revised 16-Jun-06
Guanosine 3',5'-cyclic Monophosphothioate, Rp-Isomer . sodium salt
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SYNONYMS Rp-cGMPS . Na
cGMPS . Na, Rp-Isomer
PRODUCT LINE Signal Transduction
PRODUCT CATEGORY cGMP Derivatives
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ALX-480-072-M001   1 mg 240.00 USD Add To Cart
Product Specification
FORMULA: C10H11N5O6SP . Na
MW: 360.3 . 23.0
CAS NUMBER: 86562-09-6 (free acid)
PURITY: ≥98%
APPEARANCE: White to off-white solid.
SOLUBILITY: Soluble in water.
SHIPPING: AMBIENT
LONG TERM STORAGE: +4°C

Product Description
Inhibitor of cGMP-dependent protein kinase (PKG) 1α (cGMP antagonist). Resistant against mammalian cyclic nucleotid-dependent phosphodiesterases. No metabolic side effects. Low membrane permeability.
Product Specific Literature References
Inhibition of cGMP-dependent protein kinase by (Rp)-guanosine 3',5'- monophosphorothioates: E. Butt, et al.; FEBS Lett. 263, 47 (1990) Abstract
Inhibition of cyclic GMP-dependent protein kinase-mediated effects by (Rp)-8-bromo-PET-cyclic GMPS: E. Butt, et al.; Br. J. Pharmacol. 116, 3110 (1995) Abstract
Further Categories Containing This Product:
PKG Inhibitors
 
 
ALX-480-073 Revised 06-Dec-04
Guanosine-3',5'-cyclic Monophosphothioate, Sp-Isomer . sodium salt
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SYNONYMS Sp-cGMPS . Na
cGMPS . Na, Sp-Isomer
PRODUCT LINE Signal Transduction
PRODUCT CATEGORY cGMP Derivatives
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ALX-480-073-MC05   0.5 mg 95.00 USD Add To Cart
ALX-480-073-M001   1 mg 150.00 USD Add To Cart
Product Specification
FORMULA: C10H11N5O6SP . Na
MW: 360.3 . 23.0
CAS NUMBER: 86562-10-9 (free acid)
PURITY: ≥98%
APPEARANCE: White solid.
SOLUBILITY: Soluble in water.
SHIPPING: AMBIENT
LONG TERM STORAGE: +4°C

Product Description
Metabolically resistant activator of cGMP-dependent protein kinases (PKGs). Low membrane permeability.
Product Specific Literature References
Inhibition of cGMP-dependent protein kinase by (Rp)-guanosine 3',5'- monophosphorothioates: E. Butt, et al.; FEBS Lett. 263, 47 (1990) Abstract
Nitric oxide and cGMP cause vasorelaxation by activation of a charybdotoxin-sensitive K channel by cGMP-dependent protein kinase: S.L. Archer, et al.; PNAS 91, 7583 (1994) Abstract
Inhibition of cyclic GMP-dependent protein kinase-mediated effects by (Rp)-8-bromo-PET-cyclic GMPS: E. Butt, et al.; Br. J. Pharmacol. 116, 3110 (1995) Abstract
Further Categories Containing This Product:
PKG Activators
 
 
ALX-270-016 Revised 05-May-08
H-7 . dihydrochloride
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SYNONYMS (±)-1-(5-Isoquinolinesulfonyl)-2-methylpiperazine . 2HCl
PRODUCT LINE Signal Transduction
PRODUCT CATEGORY PKC Inhibitors
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ALX-270-016-M010   10 mg 60.00 USD Add To Cart
ALX-270-016-M025   25 mg 120.00 USD Add To Cart
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Product Specification
FORMULA: C14H17N3O2S . 2 HCl
MW: 291.4 . 73.0
CAS NUMBER: 108930-17-2
PURITY: ≥98%
APPEARANCE: White to light yellow solid.
SOLUBILITY: Soluble in water, 100% ethanol or DMSO.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
HANDLING: Protect from light.

Product Description
Inhibitor of protein kinase C (PKC), cAMP- and cGMP-dependent protein kinase (PKA and PKG). Also inhibits myosin light chain kinase. Induces apoptotic DNA fragmentation and cell death. Inhibits telomerase activity in treated NPC-076 cells.
Product Specific Literature References
1-(5-Isoquinolinesulfonyl)-2-methylpiperazine (H-7) is a selective inhibitor of protein kinase C in rabbit platelets: S. Kawamoto & H. Hidaka; BBRC 125, 258 (1984) Abstract
Stimulus-dependent inhibition of platelet aggregation by the protein kinase C inhibitors polymyxin B, H-7 and staurosporine: C. Schächtele, et al.; BBRC 151, 542 (1988)